التفاصيل البيبلوغرافية
| العنوان: |
BAL cytokine profile in different interstitial lung diseases: a focus on systemic sclerosis |
| المؤلفون: |
MELONI, FEDERICA, CAPORALI, ROBERTO, MOROSINI, MONICA, FIETTA, ANNA MARIA, POZZI, ERNESTO, MONTECUCCO, CARLOMAURIZIO, Marone Bianco A, Paschetto E, Patrizio V, Bobbio Pallavicini F |
| المساهمون: |
Meloni, Federica, Caporali, Roberto, Marone Bianco, A, Paschetto, E, Morosini, Monica, Fietta, ANNA MARIA, Patrizio, V, Bobbio Pallavicini, F, Pozzi, Ernesto, Montecucco, Carlomaurizio |
| سنة النشر: |
2004 |
| المجموعة: |
IRIS UNIPV (Università degli studi di Pavia) |
| مصطلحات موضوعية: |
Interstitial lung disease, systemic sclerosi, idiopathic pulmonary fibrosis |
| الوصف: |
BACKGROUND AND AIM: Fibrosing alveolitis develops in up to 80% of systemic sclerosis patients (SSc) but progression to end stage fibrosis occurs in about 15% of cases. Mechanisms leading to the process remain mostly unknown. We compared cytokine profiles of broncho-alveolar lavage fluids (BAL-f) from patients with SSc associated interstitial lung disease (SSc-ILD) (n. 34), idiopathic pulmonary fibrosis (IPF) (n. 13), stage II sarcoidosis (n. 14) and 9 controls. METHODS: Interleukin (IL) 8, monocyte chemoattractant protein 1 (MCP-1), gamma-interferon (IFN-gamma), IL12, IL18 and IL10 and transforming growth factor-beta (TGF-beta) were assessed by ELISA in concentrated BAL-f. RESULTS: Levels of IL8 and MCP-1 were significantly elevated in SSc-ILD and in IPF as compared with controls (Mann Whitney test p < 0.05), while MCP-1 values were significantly lower in SSc-ILD than in IPF. A significant correlation between neutrophils and IL8 levels (p = 0.047), as well as between eosinophils and MCP-1 levels (p = 0.004) was also observed. IFN-gamma levels were slightly higher than normal only in sarcoidosis (p = 0.06), whereas IL12 levels increased both in sarcoidosis and SSc-ILD (p < 0.05). No differences were found in IL18 and TGF-beta levels. Finally, IL10 levels were higher in SSc-ILD and sarcoidosis than in controls and IPF (p < 0.05). CONCLUSION: BAL-f cytokine profile differentiates ILD associated with SSc from IPF. The lower expression of MCP-1 and the higher expression of the anti-fibrotic IL12 and the anti-inflammatory IL10, observed both in sarcoidosis and in SSc-ILD, could account for the better prognosis of these ILDs. Further longitudinal studies are required to confirm whether a different cytokine phenotype may be considered predictive of clinical outcome in SSc-ILD. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
STAMPA |
| اللغة: |
English |
| العلاقة: |
info:eu-repo/semantics/altIdentifier/pmid/15281432; volume:21; issue:2; firstpage:111; lastpage:118; numberofpages:8; journal:SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES; http://hdl.handle.net/11571/134142Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-3242667093 |
| الإتاحة: |
http://hdl.handle.net/11571/134142Test |
| رقم الانضمام: |
edsbas.F99673F8 |
| قاعدة البيانات: |
BASE |
