دورية أكاديمية
A multimarker study of degenerative aortic valve disease: Stenoinsufficiency shows more indices of bad prognosis
| العنوان: | A multimarker study of degenerative aortic valve disease: Stenoinsufficiency shows more indices of bad prognosis |
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| المؤلفون: | Vianello, Annamaria, Cappelli, Stefania, Epistolato, Maria Carmela, Della Latta, Daniele, Cerillo, Alfredo, Berti, Sergio, Chiappino, Dante, Tanganelli, Piero, Glauber, Mattia, Mazzone, Annamaria, PERLINI, STEFANO, PALLADINI, GIUSEPPINA |
| المساهمون: | Vianello, Annamaria, Perlini, Stefano, Cappelli, Stefania, Palladini, Giuseppina, Epistolato, Maria Carmela, Della Latta, Daniele, Cerillo, Alfredo, Berti, Sergio, Chiappino, Dante, Tanganelli, Piero, Glauber, Mattia, Mazzone, Annamaria |
| سنة النشر: | 2013 |
| المجموعة: | IRIS UNIPV (Università degli studi di Pavia) |
| مصطلحات موضوعية: | Atherosclerosi, Clinical outcome, Degenerative aortic valve disease, Stenoinsufficiency, Aged, Aortic Valve Insufficiency, Aortic Valve Stenosi, Biomarker, Bioprosthesi, Carotid Stenosi, Case-Control Studie, Female, Heart Valve Prosthesis Implantation, Human, Male, Metalloprotease, Natriuretic Peptide, Brain, Osteopontin, Prognosi, Prospective Studie, Tissue Inhibitor of Metalloproteinase, Vascular Calcification, Cardiology and Cardiovascular Medicine, Pharmacology (medical) |
| الوصف: | OBJECTIVES: It was the aim of this study to assess the pathophysiological, prognostic role of aortic regurgitation (AR) in the 'mixed pictures' of degenerative aortic valve stenoinsufficiency (ASI) by a multimarker clinical approach. METHODS: We enrolled 112 consecutive surgical PATIENTS: 19 with pure valve stenosis (PAS), 39 with mild regurgitation, 29 with severe regurgitation, and 25 controls with annulo-ectatic AR. All underwent complete echocardiography, carotid ultrasound and aortic/coronary multislice computed tomography calcium score evaluation. We determined tissue semiquantitative osteopontin, metalloproteinases (MMPs), tissue inhibitors of MMPs (TIMPs) and circulating brain natriuretic peptide. We evaluated major adverse cardiac events and cardiovascular early, long-term mortality after bioprosthetic valve implantation. RESULTS: Tissue calcification, carotid and coronary atherosclerotic disease were prevalent in PAS versus ASI and AR patients. The multislice computed tomography calcium score (Agatston) was comparable between PAS and ASI (PAS 3,507.3 + 2,442.6; mild AR 4,270.7 + 2,213.5; severe AR 3,568.5 + 1,823.4), but much lower in AR (1,247.8 + 2,708.6). In ASI, a plasma/tissue 'profibrotic' MMP/TIMP balance prevailed, with circulating and echocardiographic indices of myocardial dysfunction. Percentages of major adverse cardiac events and early, long-term mortality were higher in ASI. CONCLUSIONS: In ASI, different, still unknown, genetic and dysplastic factors could work synergically with cardiovascular risk factors, determining a much more adverse myocardial and valve remodeling, resulting in worse clinical outcome. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/23428667; volume:124; issue:2; firstpage:126; lastpage:137; numberofpages:12; journal:CARDIOLOGY; http://hdl.handle.net/11571/1167040Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84874009183; http://www.ncbi.nlm.nih.gov/pubmed/23428667Test |
| DOI: | 10.1159/000346396 |
| الإتاحة: | https://doi.org/10.1159/000346396Test http://hdl.handle.net/11571/1167040Test http://www.ncbi.nlm.nih.gov/pubmed/23428667Test |
| رقم الانضمام: | edsbas.4749191 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000346396 |
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