دورية أكاديمية
Bacteriotherapy with Streptococcus salivarius 24SMB and Streptococcus oralis 89a nasal spray for treatment of upper respiratory tract infections in children: A pilot study on short-term efficacy
| العنوان: | Bacteriotherapy with Streptococcus salivarius 24SMB and Streptococcus oralis 89a nasal spray for treatment of upper respiratory tract infections in children: A pilot study on short-term efficacy |
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| المؤلفون: | Manti S., Parisi G. F., Papale M., Licari A., Salpietro C., Miraglia Del Giudice M., Marseglia G. L., Leonardi S. |
| المساهمون: | Manti, S., Parisi, G. F., Papale, M., Licari, A., Salpietro, C., Miraglia Del Giudice, M., Marseglia, G. L., Leonardi, S. |
| سنة النشر: | 2020 |
| المجموعة: | IRIS UNIPV (Università degli studi di Pavia) |
| مصطلحات موضوعية: | Bacteriotherapy, Children, RRI, Treatment, URTI |
| الوصف: | Background: Recurrent respiratory infections (RRIs) are defined by the presence of at least one of the following criteria: (i) > 6 annual respiratory infections (RIs); (ii) > 1 monthly RIs involving the upper airways from September to April; (iii) > 3 annual RIs involving the lower airways represent a very common health problem in the first years of life. We conducted a multi-centre, prospective, single-open study to assess the efficacy and the safety of Streptococcus salivarius 24SMBc and Streptococcus oralis 89a in the prevention of upper respiratory tract infections (URTIs) in children. Methods: Ninety-one children (M:F = 47:44, mean age 7.4 ± 2.3 years) with RRIs were enrolled in the study between September and November 2018. At baseline, children received Streptococcus salivarius 24SMBc and Streptococcus oralis 89a as 2 puffs for nostril twice/day for 7 days/months. The treatment lasted for 3 consecutive months. Efficacy was expressed in terms of absence or presence of fever, cough, bronchospasm, rhinorrhea and otalgia, at 1 month (T1), and 3 (T3) months. Safety and tolerability of the probiotic were evaluated on the basis of the number and type of adverse events (AEs) recorded during the treatment. Results: Children treated with Streptococcus salivarius 24SMBc and Streptococcus oralis 89a showed a significant decrease of symptoms including episodes of fever, cough, bronchospasm, rhinorrhea, and otalgia (p < 0.001) compared to baseline. The treatment significantly reduced the number of episodes of fever, cough, bronchospasm, rhinorrhea, otalgia, and cough also in patients with positive familial history for atopy and in atopic children (p < 0.05). No significant differences in symptoms among children with negative familial history for atopy and children with positive familial history for atopy subgroups, not atopic and atopic children subgroups, and smoke-exposed and not smoke-exposed subgroups were observed (p > 0.05). Conducting a subgroup analysis according to the age, it has been ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/32245500; info:eu-repo/semantics/altIdentifier/wos/WOS:000523744800002; volume:46; issue:1; firstpage:42; journal:THE ITALIAN JOURNAL OF PEDIATRICS; http://hdl.handle.net/11571/1344457Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85083041949 |
| DOI: | 10.1186/s13052-020-0798-4 |
| الإتاحة: | https://doi.org/10.1186/s13052-020-0798-4Test http://hdl.handle.net/11571/1344457Test |
| رقم الانضمام: | edsbas.A1BFC02A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s13052-020-0798-4 |
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