دورية أكاديمية

Sotagliflozin in patients with diabetes and recent worsening heart failure

التفاصيل البيبلوغرافية
العنوان: Sotagliflozin in patients with diabetes and recent worsening heart failure
المؤلفون: Bhatt D. L., Szarek M., Gabriel Steg P., Cannon C. P., Leiter L. A., McGuire D. K., Lewis J. B., Riddle M. C., Voors A. A., Metra M., Lund L. H., Komajda M., Testani J. M., Wilcox C. S., Ponikowski P., Lopes R. D., Verma S., Lapuerta P., Pitt B. SOLOIST-WHF Trial Investigators: Deepak L Bhatt, Christopher P Cannon, Lawrence A Leiter, Julia B Lewis, Darren K McGuire, Bertram Pitt, Matthew C Riddle, Gabriel Steg, Hertzel C Gerstein, Gary S Francis, John E Gerich, Johannes F E Mann, Weichung Joe Shih, James B Young, Michel Komajda, Lars H Lund, Marco Metra, Piotr Ponikowski, Jeffrey M Testani, Adriaan Voors, Christopher Wilcox, Renato D Lopes, Jennifer B Green, Karen P Alexander, Bryan C Batch, W Schuyler Jones, J Dedrick Jordan, Bradley J Kolls, David F Kong, Wanda C Lakey, Richard H Lee, Robin Mathews, Robert W McGarrah, Rajendra H Mehta, Chiara Melloni, John P Middleton, Thomas J Povsic, Patrick H Pun, Julia J Scialla, Shreyansh Shah, Luciano A Sposato, Thomas J Weber, Casey Norris, Jill Marcus, Nikieia Hayden, Dimitrios Stournaras, Z Sophie Wang, Linley Brown, Dominique Larrey, James Lewis, Joshua Beckman, Marc Bonaca, Nicholas Leeper, Phillip Banks, Eshetu Tesfaye, Kenneth Kassler-Taub, Chris Warner, Mark O'Neill, Rosemary Molinari Covance, Robert Mentz, Frank Peacock, Barry Greenberg, United States, Subodh Verma, Justin Ezekowitz, Stefan Janssens, Jeroen Schaap, Andrew Lawrence Clark, Morten Schou, Veli-Pekka Harjola, Andrejs Erglis, Jelena Celutkiene, Jindrich Spinar, Jan Murin, Béla Peter Merkely, Jadwiga Maria Nessler, Hans-Dirk Dungen, Kurt Huber, Christian Eugen Muller, Nicolas Lamblin, Piergiuseppe Agostoni, Maria Frigerio, John Parissis, Gheorghe Andrei Dan, Maria Generosa Crespo-Leiro, Tuvia Ben-Gal, Cândida Fonseca, Mehmet Birhan Yilmaz, Olga Barbarash, José Carlos Nicolau, Eduardo Roque Perna, Ramon Luis Corbalan Herreros, Kyu-Hyung Ryu, Harvey D White, Lana Tsao, Neil Pendril Lewis, Jean Foucauld, Mahfouz El Shahawy, William J French, Carsten Schmalfuss, Lily Zhang, Bruce M Graham, Michael J Koren, Charles Landau, Bruce Martin Ennis, James J Fulmer, Sheba Meymandi, George Gus Sokos, Saurabh Sharma, K John Heilman 3rd, Ramona Gelzer Bell, Gabriel Sayer, Michael Rosenberg, Matthew Jay Budoff, David Hotchkiss, Clive Rosendorff, Robert Williams, Steven Lupovitch, Prakash Deedwania, Douglas Stoller, Supratim Banerjee, Cristina Tita, John Sokolowicz, Barry Uretsky, Ahmed Aboeata, Matthew S White, Kodangudi Ramanathan, Timothy J Vittorio, Jason L Guichard, Ashish Gupta, Kimberly A Boddicker, John McGinty, Mirta Diez, Viviana Elizabeth Arias, Melina Nancy Mana, Jorge Marcos Schmidberg, Marcelo Alejandro Garrido, Guillermo Daniel Caime, Ricardo Alfonso León de la Fuente, Alejandro Rubén Hershson, Daniela Garcia Brasca, Lilia Beatriz Schiavi, Sebastián Nani, Gerardo Oscar Zapata, Sandra Marcela Del Valle Almagro, Miguel Angel Hominal, Mario Alberto Berli, Carlos Alberto Poy, Aldo Daniel Prado, Rodolfo Andres Ahuad Guerrero, Raúl Andrés Duarte, Alberto Alfredo Fernández, Clara Maria Huerta, Hugo Armando Luquez, Guillermo Adolfo Mercau, María Cecilia Beltrano, Lilia Luz Lobo Marquez, Sergey Tereschenko, Yuri Karpov, Ivan Gordeev, Anastasiya Lebedeva, Svetlana Alexandrovna Berns, Svetlana Boldueva, Alexander Vishnevsky, Mikhail Ruda, Dmitry Pevzner, Boris Goloshchekin, Maria Sitnikova, Larisa Khaisheva, Vyacheslav Ryabov, Lilly Kruberg, Mikhail Zykov, Evgeny Baranov, Zhanna Kobalava, Elena Isaeva, Elena Pavlikova, Sergey Eryshev, Elena Shutemova, Antonio Reyes Domínguez, Enrique Garcia Del Rio, Alejandro López Suárez, José Manuel García Pinilla, Antonio Garcia Quintana, Domingo A Pascual Figal, Ramón Bover Freire, Jorge Francisco Gomez Cerezo, Luis Almenar, José Pérez Silvestre, Clara Bonanad Lozano, Julio Nuñez, Estíbaliz Jarauta, Joan Carles Trullàs Vila, Antoni Bayés Genís, Pere Llorens, Juan Luis Bonilla Palomas, Rafáel Jesus Híldalgo Urbano, Josep Comin-Colet, Pau Llacer Iborra, Lilia Nigro Maia, Adrian Paulo Morales Kormann, Joao Batista Moraes Jr, José Francisco Kerr Saraiva, Maria Helena Vidotti, Alexandre Schaan de Quadros, Fernando Reis Menezes, Maria da Consolação Vieira Moreira, Luciano Nogueira Liderato de Sousa, Almir Sergio Ferraz, Pedro Pimentel Filho, Mauro Esteves Hernandes, Aguinaldo Figueiredo Freitas Jr, Luis Beck Da Silva Neto, Luiz Carlos Bodanese, Béla Péter Merkely, Elod Papp, Ebrahim Noori, József Lippai, Geza Károly Lupkovics, Istvan Edes, Attila Pálinkás, Ignác Imre Szakál, Gabriella Hodi, Róbert Gábor Kiss, Kalman Toth, András Csaba Nagy, Andras Papp, Lászó Márk, Papp Anikó, Robert Jozsef Kirschner, Heyder Omran, Thomas Horacek, Stephan Burkhard Felix, Jana Bourgeois, Henrik Fox, Kristof Graf, Veselin Mitrovic, Harm Wienbergen, Christoph Stellbrink, Marcus-Franz-Dieter Felix Mittag, Oliver Husser, Christoph Kadel, Steffen Schnupp, Petr Kala, Ales Linhart, Tomas Brabec, Miroslav Soucek, Tomas Roubicek, Blažej Rácz, Pavel Trestik, Dan Marek, Michal Hudcovic, Marek Houra, Tuvia Ben Gal, Elisha Ouzan, Michael Kleiner Shochat, Shmuel Rispler, Tal Hasin, Tanya Weitsman, David Leibowitz, Majdi Halabi, Shaul Atar, Sorel Goland, Offer Amir, Wadi Kinany, Chaim Yosefy, Mario Barbiero, Franco Cosmi, Claudio Bilato, Alessandro Fucili, Mauro Molteni, Gaetano Maria de Ferrarri, Sergio Leonardi, Eugenio Vilei, Giovanni Carlo Piccinni, Massimo Volpe, Carlos Raffo, Fernando Lanas, Constanza Bravo, Patricio Avendaño, Pablo Castro, Leonardo Cobos, Mario Yañez, Gerardo Palma, Marcelo Edmundo Medina Fariña, María Schnettler, Janusz Bednarski, Danuta Czarnecka, Marek Jacek Kuch, Mariusz Janusz Kafara, Grzegorz Skonieczny, Bozena Sobkowicz, Marcin Skorski, Miroslaw Wiesław Dluzniewski, Andrzej Jacek Budaj, Okan Onur Turgut, Zerrin Yigit, Tayfun Sahin, Turkay Ismail Ozcan, Yuksel Carusoĝlu, Lütfü Bekar, Ibrahim Basarici, Muhammet Raşit Başarici, Raşit Sayin, Zehra Lale Koldas, Őzer Badak, Sotirios Patsilinakos, Ioannis Mantas, Apostolos Karavidas, Filippos Triposkiadis, Aikaterina Naka, Charalampos Karvounis, Konstantinos Papadopoulos, Cristian Podoleanu, Calin Florin Pop, Tiberiu Ioan Ioan Nanea, Daniel Florin Lighezan, Mariana Tudoran, Imre Benedek, Doina Luminita Serban, Alina Carmen Roatis, Jolanta Sobolewska, Kristian Mark Bailey, Carey Peredur Edwards, Philip John Keeling, Christopher Howell Critoph, Paul Foley, Christopher Ruslan Hayes, Andrew Beresford Johnson, Hassan Kahal, Timo Lauri, Johan Lassus, Michel Galinier, Etienne Puymirat, Jean-Noel Trochu, Muriel Salvat, Denis Angoulvant, Nicolas Girerd, John van Hal, Machiel van de Wetering, Jacob van Eck, Rudolph Ferdinand Spee, A H Liem, Eelko Ronner, Antonius Oomen, Pedro Monteiro, Pedro Morais Sarmento, Sandra Filipa Canario de Almeida, Ana Baptista, Mário Santos, Aurora Andrade, Stefan P Janssens, Maria Melissopoulou, David Derthoo, Harry Striekwold, Stéphane Guy Carlier, Hans Vandekerckhove, Gintare Sakalyte, Žaneta Petrulioniene, Roma Kavaliauskiene, Diana Žalaiduonytė-Pekšienė, Nora Kupstyte-Kristapone, Hae-Young Lee, Sung-Hee Shin, Jun Kwon, Kee Sik Kim, Dong-Ju Choi, Jin-Oh Choi, Denmark Denmark, Bochra Zareini, Jørgen Jeppesen, Steen Hvitfeldt Poulsen, Søren Vraa, Christian Ditlev Tuxen, Diana Bonderman, Michael Lichtenauer, Uta Hoppe, Johann Auer, Dirk von Lewinski, Janina Romanova, Iveta Šime, Aldis Strēnieks, Renáte Helda, Natalja Pontaga, Vijay Anand Dhakshinamurthy, Raewyn Ann Fisher, Susan Claire DeCaigney, Richard William Troughton, Jocelyne Rachelle Benatar, Milan Behuncik, Martin Kokles, Peter Letavay, Lubomir Antalik, Frederik Andreas von Wowern, Patric Karlström, Kurt Boman, Ida Haugen Löfman, Michel White, Ram Vijayaraghavan, François Dubé, Astin Kwang Yoong Lee, Kaitlyn My-Tu Lam, Christian Eugen Müller, Tiziano Moccetti
المساهمون: D. L., Bhatt, M., Szarek, P., Gabriel Steg, C. P., Cannon, L. A., Leiter, D. K., Mcguire, J. B., Lewi, M. C., Riddle, A. A., Voor, M., Metra, L. H., Lund, M., Komajda, J. M., Testani, C. S., Wilcox, P., Ponikowski, R. D., Lope, S., Verma, P., Lapuerta, SOLOIST-WHF Trial Investigators: Deepak L Bhatt, Pitt B., P Cannon, Christopher, A Leiter, Lawrence, B Lewis, Julia, K McGuire, Darren, Pitt, Bertram, C Riddle, Matthew, Steg, Gabriel, C Gerstein, Hertzel, S Francis, Gary, E Gerich, John, E Mann, Johannes F, Joe Shih, Weichung, B Young, Jame, Komajda, Michel, H Lund, Lar, Metra, Marco, Ponikowski, Piotr, M Testani, Jeffrey, Voors, Adriaan, Wilcox, Christopher, D Lopes, Renato, B Green, Jennifer, P Alexander, Karen, C Batch, Bryan, Schuyler Jones, W, Dedrick Jordan, J, J Kolls, Bradley, F Kong, David, C Lakey, Wanda, H Lee, Richard, Mathews, Robin, W McGarrah, Robert, H Mehta, Rajendra, Melloni, Chiara, P Middleton, John, J Povsic, Thoma, H Pun, Patrick, J Scialla, Julia, Shah, Shreyansh, A Sposato, Luciano, J Weber, Thoma, Norris, Casey, Marcus, Jill, Hayden, Nikieia, Stournaras, Dimitrio, Sophie Wang, Z, Brown, Linley, Larrey, Dominique, Lewis, Jame, Beckman, Joshua, Bonaca, Marc, Leeper, Nichola, Banks, Phillip, Tesfaye, Eshetu, Kassler-Taub, Kenneth, Warner, Chri, O'Neill, Mark, Molinari Covance, Rosemary, Mentz, Robert, Peacock, Frank, Greenberg, Barry, States, United, Verma, Subodh, Ezekowitz, Justin, Janssens, Stefan, Schaap, Jeroen, Lawrence Clark, Andrew, Schou, Morten, Harjola, Veli-Pekka, Erglis, Andrej, Celutkiene, Jelena, Spinar, Jindrich, Murin, Jan, Peter Merkely, Béla, Maria Nessler, Jadwiga, Dungen, Hans-Dirk, Huber, Kurt, Eugen Muller, Christian, Lamblin, Nicola, Agostoni, Piergiuseppe, Frigerio, Maria
سنة النشر: 2021
المجموعة: IRIS UNIPV (Università degli studi di Pavia)
مصطلحات موضوعية: Acute Kidney Injury, Aged, Cardiovascular Disease, Diabetes Mellitus, Type 2, Double-Blind Method, Female, Glycoside, Heart Failure, Hospitalization, Human, Hypotension, Male, Middle Aged, Sodium-Glucose Transporter 1, Sodium-Glucose Transporter 2 Inhibitors
الوصف: BACKGROUND Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of hospitalization for heart failure or death from cardiovascular causes among patients with stable heart failure. However, the safety and efficacy of SGLT2 inhibitors when initiated soon after an episode of decompensated heart failure are unknown. METHODS We performed a multicenter, double-blind trial in which patients with type 2 diabetes mellitus who were recently hospitalized for worsening heart failure were randomly assigned to receive sotagliflozin or placebo. The primary end point was the total number of deaths from cardiovascular causes and hospitalizations and urgent visits for heart failure (first and subsequent events). The trial ended early because of loss of funding from the sponsor. RESULTS A total of 1222 patients underwent randomization (608 to the sotagliflozin group and 614 to the placebo group) and were followed for a median of 9.0 months; the first dose of sotagliflozin or placebo was administered before discharge in 48.8% and a median of 2 days after discharge in 51.2%. Among these patients, 600 primary end-point events occurred (245 in the sotagliflozin group and 355 in the placebo group). The rate (the number of events per 100 patient-years) of primary end-point events was lower in the sotagliflozin group than in the placebo group (51.0 vs. 76.3; hazard ratio, 0.67; 95% confidence interval [CI], 0.52 to 0.85; P<0.001). The rate of death from cardiovascular causes was 10.6 in the sotagliflozin group and 12.5 in the placebo group (hazard ratio, 0.84; 95% CI, 0.58 to 1.22); the rate of death from any cause was 13.5 in the sotagliflozin group and 16.3 in the placebo group (hazard ratio, 0.82; 95% CI, 0.59 to 1.14). Diarrhea was more common with sotagliflozin than with placebo (6.1% vs. 3.4%), as was severe hypoglycemia (1.5% vs. 0.3%). The percentage of patients with hypotension was similar in the sotagliflozin group and the placebo group (6.0% and 4.6%, respectively), as was the percentage with acute kidney injury ...
نوع الوثيقة: article in journal/newspaper
اللغة: English
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33200892; info:eu-repo/semantics/altIdentifier/wos/WOS:000609886200011; volume:384; issue:2; firstpage:117; lastpage:128; numberofpages:12; journal:NEW ENGLAND JOURNAL OF MEDICINE; http://hdl.handle.net/11571/1438755Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85099764927
DOI: 10.1056/NEJMoa2030183
الإتاحة: https://doi.org/10.1056/NEJMoa2030183Test
http://hdl.handle.net/11571/1438755Test
رقم الانضمام: edsbas.A8044C4F
قاعدة البيانات: BASE