التفاصيل البيبلوغرافية
| العنوان: |
HLA-A, B, C, DR and DQ expression and hepatocellular carcinoma: study of 205 Italian subjects |
| المؤلفون: |
Ricci, G, Colombo, C, Ghiazza, B, Porta, C, Moroni, M, Illeni, M T |
| المساهمون: |
Ricci, G, Colombo, C, Ghiazza, B, Porta, C, Moroni, M, Illeni, M T |
| سنة النشر: |
1995 |
| المجموعة: |
IRIS UNIPV (Università degli studi di Pavia) |
| مصطلحات موضوعية: |
Aged, 80 and over, Carcinoma, Hepatocellular, Case-Control Studie, Chi-Square Distribution, Disease Susceptibility, Female, Gene Frequency, HLA Antigen, HLA-A Antigen, HLA-A3 Antigen, HLA-B35 Antigen, HLA-C Antigen, HLA-DQ Antigen, HLA-DR3 Antigen, Hepaciviru, Hepatitis Antibodie, Hepatitis B, Hepatitis B viru, Hepatitis C, Human, Italy, Liver Neoplasm, Male, Middle Aged, Phenotype |
| الوصف: |
We have evaluated the frequency of HLA class I and II antigens in 205 Italian patients with hepatocellular carcinoma (HCC) and 749 blood donors (controls). Moreover, we have looked for correlations between HLA antigen frequencies and HBV and/or HCV infections in HCC patients. We found great differences in HLA antigen frequencies considering only two groups: HCC patients and controls. The polymorphism is smaller when we consider the different groups of HCC patients in regard to the previous viral infections (HBV and/or HCV). The most interesting finding is the higher frequency of Cw7, B8 and DR3 in almost all groups of HCC patients. It is well known, that the HLA A1, Cw7, B8, DR3 antigen haplotype is associated with a rapid decline of CD4 cells, and HLA B8, DR3 positive subjects may display some changes in immune parameters and are prone to develop several immunological diseases. Thus HCC might be the result of a lower sensitivity (genetically given) to mitogenic stimuli of HBV and HCV. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
STAMPA |
| اللغة: |
English |
| العلاقة: |
info:eu-repo/semantics/altIdentifier/pmid/8529200; info:eu-repo/semantics/altIdentifier/wos/WOS:A1995TK51700018; volume:98; issue:1; firstpage:121; lastpage:125; numberofpages:5; journal:CANCER LETTERS; http://hdl.handle.net/11571/1272646Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0028819701 |
| الإتاحة: |
http://hdl.handle.net/11571/1272646Test |
| رقم الانضمام: |
edsbas.65B0E33A |
| قاعدة البيانات: |
BASE |
