دورية أكاديمية
Matrix metalloproteinase-2, -9, and tissue inhibitor of metalloproteinase-1 in patients with hypertension
| العنوان: | Matrix metalloproteinase-2, -9, and tissue inhibitor of metalloproteinase-1 in patients with hypertension |
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| المؤلفون: | DEROSA, GIUSEPPE, D'ANGELO, ANGELA, Ciccarelli L, Piccinni MN, Pricolo F, Salvadeo S, Montagna L, Gravina A, Ferrari I, Galli S, Paniga S, Tinelli C, Cicero AFG |
| المساهمون: | Derosa, Giuseppe, D'Angelo, Angela, Ciccarelli, L, Piccinni, Mn, Pricolo, F, Salvadeo, S, Montagna, L, Gravina, A, Ferrari, I, Galli, S, Paniga, S, Tinelli, C, Cicero, Afg |
| سنة النشر: | 2006 |
| المجموعة: | IRIS UNIPV (Università degli studi di Pavia) |
| مصطلحات موضوعية: | Adult, Blood Glucose, analysis, Blood Pressure Determination, Case-Control Studies, Female, Fibrinolysis, Humans, Hypertension, blood/enzymology, Inflammation, Lipid, blood, Male, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Middle Aged, Plasminogen Activator Inhibitor 1, Tissue Inhibitor of Metalloproteinase-1 |
| الوصف: | There are conflicting data in the literature regarding the expression pattern of the vascular matrix metalloproteinase (MMP) system and their inhibitors (TIMPs) in human hypertension. The authors hypothesized that MMP-2, MMP-9, and TIMP-1 would be abnormal in hypertension, reflecting alterations in extracellular matrix (ECM) turnover. The authors measured plasma levels and activities of MMP-2, MMP-9, and TIMP-1 in 44 hypertensive patients and 44 controls. MMP-2 levels and activity were significantly higher in hypertensive group (p < .0001). Significant increase was also observed for MMP-9 level and activity (p < .0001) and for TIMP-1 (p < .0001) in hypertensive patients. Plasma levels and activities of MMP-2, MMP-9, and TIMP-1 are increased in hypertensive patients, which may reflect abnormal ECM metabolism. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/16840178; info:eu-repo/semantics/altIdentifier/wos/000239391800007; volume:13; firstpage:227; lastpage:231; numberofpages:5; journal:ENDOTHELIUM; http://hdl.handle.net/11571/379043Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-33746380241; http://dx.doi.org/10.1080/10623320600780942Test |
| DOI: | 10.1080/10623320600780942 |
| الإتاحة: | https://doi.org/10.1080/10623320600780942Test http://hdl.handle.net/11571/379043Test |
| رقم الانضمام: | edsbas.C571F64F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1080/10623320600780942 |
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