دورية أكاديمية
Increased IL-6 and IL-4 in exhaled breath condensate of patients with nasal polyposis.
| العنوان: | Increased IL-6 and IL-4 in exhaled breath condensate of patients with nasal polyposis. |
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| المؤلفون: | Carpagnano GE, Carratú P, Gelardi M, SPANEVELLO, ANTONIO, Di Gioia G, Condreva T, Resta O, Barbaro M.P. |
| المساهمون: | Carpagnano, Ge, Carratú, P, Gelardi, M, Spanevello, Antonio, Di Gioia, G, Condreva, T, Resta, O, Barbaro, M. P. |
| سنة النشر: | 2009 |
| المجموعة: | IRInSubria - Institutional Repository Insubria (Università degli Studi dell’Insubria) |
| مصطلحات موضوعية: | Exhaled breath condensate, Nasal polyposi, IL-6, IL-4, Polypectomy |
| الوصف: | BACKGROUND AND AIM: Nasal polyposis (NP) occurs in about 1-4% of the worldwide population. Increased plasma concentrations of different pro-inflammatory cytokines have been observed in NP, and might be related to the pathogenesis of this syndrome. The present study was designed to investigate IL-6 and IL-4 concentrations in nasal and oral exhaled breath condensate of patients with early and advanced NP, and following polypectomy. METHODS: Ten individuals with polyposis in early status, twenty-three patients affected by advanced status of NP and ten healthy controls were enrolled into the study. Exhaled breath condensate was collected by all individuals, according to a previous standardised method. An immunoassay kit was used to measure IL-6 and IL-4 levels. RESULTS: Concentrations of oral and nasal exhaled IL-6 and IL-4 were significantly higher in patients with early nasal polyposis and advanced nasal polyposis, compared to healthy controls. A statistically significant decrease of nasally but not of orally exhaled IL-6 (p < 0.001) and IL-4 (p < 0.05) was observed after polypectomy. CONCLUSIONS: We consider oral and nasal exhaled condensate of IL-6 and IL-4 as valid inflammatory and oxidative stress marker in patients with nasal polyposis. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | unknown |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/19522158; volume:71(1); firstpage:3; lastpage:7; numberofpages:5; journal:MONALDI ARCHIVES FOR CHEST DISEASE; http://hdl.handle.net/11383/1759078Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-65749103572; http://www.monaldi-archives.org/index.php/macd/issue/view/65Test |
| DOI: | 10.4081/monaldi.2009.369 |
| الإتاحة: | https://doi.org/10.4081/monaldi.2009.369Test http://hdl.handle.net/11383/1759078Test http://www.monaldi-archives.org/index.php/macd/issue/view/65Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.D53472E2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.4081/monaldi.2009.369 |
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