دورية أكاديمية
SATB2 is expressed in neuroendocrine carcinoma of the uterine cervix
العنوان: | SATB2 is expressed in neuroendocrine carcinoma of the uterine cervix |
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المؤلفون: | Inzani F., Angelico G., Santoro A., Travaglino A., Insabato L., Raffone A., Arciuolo D., Scaglione G., D'Alessandris N., Valente M., Carlino A., Rindi G., Zannoni G. F. |
المساهمون: | Inzani, F., Angelico, G., Santoro, A., Travaglino, A., Insabato, L., Raffone, A., Arciuolo, D., Scaglione, G., D'Alessandris, N., Valente, M., Carlino, A., Rindi, G., Zannoni, G. F. |
سنة النشر: | 2022 |
المجموعة: | IRInSubria - Institutional Repository Insubria (Università degli Studi dell’Insubria) |
مصطلحات موضوعية: | Cervical cancer, Gynecological neuroendocrine neoplasm, Immunohistochemistry, NET, Neuroendocrine tumor, SATB2, Biomarker, Tumor, Female, Human, Infant, Newborn, Transcription Factor, Carcinoma, Neuroendocrine, Matrix Attachment Region Binding Protein, Skin Neoplasm, Uterine Cervical Neoplasms |
الوصف: | Neuroendocrine carcinoma (NEC) of the uterine cervix is less characterized than neuroendocrine neoplasms of other sites such as of the digestive system and the lung. Special AT-rich sequence-binding protein 2 (SATB2) recently emerged as a marker of well-differentiated neuroendocrine tumors of the lower gastrointestinal (GI) tract. Among NECs, SATB2 is more frequently expressed in cutaneous Merkel cell carcinoma than in NEC of other anatomical sites. In our study, we performed an immunohistochemical study of SATB2 in 16 NECs of the uterine cervix, where the expression of these markers is still undefined. SATB2 was expressed in 12/16 cervical NECs (75%), with 7/16 cases (44%) showing SATB2 positivity in ≥ 50% of cells. In 7 cervical NECs associated with a non-neuroendocrine component, the expression of SATB2 was restricted to the neuroendocrine component. SATB2 was positive in all cases that expressed CDX2 (n = 7) and TTF1 (n = 5), with no evident association with p16 and p53. Our study demonstrated that SATB2 is often expressed in NECs of the uterine cervix. This information should be taken into account when assessing the origin of a NEC. |
نوع الوثيقة: | article in journal/newspaper |
وصف الملف: | ELETTRONICO |
اللغة: | English |
العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35091815; info:eu-repo/semantics/altIdentifier/wos/WOS:000749110700001; volume:480; issue:4; firstpage:873; lastpage:877; numberofpages:5; journal:VIRCHOWS ARCHIV; https://hdl.handle.net/11383/2162358Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85123760474 |
DOI: | 10.1007/s00428-021-03255-7 |
الإتاحة: | https://doi.org/10.1007/s00428-021-03255-7Test https://hdl.handle.net/11383/2162358Test |
حقوق: | info:eu-repo/semantics/closedAccess |
رقم الانضمام: | edsbas.9254AA68 |
قاعدة البيانات: | BASE |
DOI: | 10.1007/s00428-021-03255-7 |
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