دورية أكاديمية
Effects of dual blockade of renin-angiotensin system on concentric left ventricular hypertrophy in essential hypertension: A randomized, controlled pilot study
| العنوان: | Effects of dual blockade of renin-angiotensin system on concentric left ventricular hypertrophy in essential hypertension: A randomized, controlled pilot study |
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| المؤلفون: | GRANDI, ANNA MARIA, SOLBIATI, FRANCESCO, MARESCA, ANDREA MARIA, NICOLINI, ELEONORA, MARCHESI, CHIARA, GIANNI, MONICA, GUASTI, LUIGINA, VENCO, ACHILLE, LAURITA E |
| المساهمون: | Grandi, ANNA MARIA, Solbiati, Francesco, Laurita, E, Maresca, ANDREA MARIA, Nicolini, Eleonora, Marchesi, Chiara, Gianni, Monica, Guasti, Luigina, Venco, Achille |
| سنة النشر: | 2008 |
| المجموعة: | IRInSubria - Institutional Repository Insubria (Università degli Studi dell’Insubria) |
| مصطلحات موضوعية: | CONVERTING ENZYME-INHIBITION, DIASTOLIC HEART-FAILURE, CENTRAL AORTIC PRESSURE, RECEPTOR BLOCKER, ANTIHYPERTENSIVE TREATMENT, COMBINATION THERAPY, BLOOD-PRESSURE, II GENERATION, ACE-INHIBITOR, MASS |
| الوصف: | Background: The renin-angiotensin system (RAS) plays a major role in promoting left ventricular (LV) remodeling in essential hypertension. We designed a controlled, randomized pilot study aimed to test the hypothesis that the dual RAS blockade with angiotensin-converting enzyme (ACE) inhibitor (ACEi) + angiotensin II receptor blocker (ARB) can be more effective in decreasing LV hypertrophy and improving diastolic function than a largely employed association such as ACEi + calcium-antagonist (Ca-A). Methods: Twenty-four never-treated hypertensive patients with LV concentric hypertrophy were randomized to ramipril + candesartan or ramipril + lercanidipine. Before and after the 6-month treatment they underwent a 24-h blood pressure (BP) monitoring and echocardiographic examination. Results: At baseline, age, body mass index (BMI), 24-h BP, and LV morpho-functional parameters were similar between the two groups. The 6-month treatment induced in both groups a significant decrease of 24-h BP, septal and posterior wall thickness, and LV mass index (LVMi) (ACEi + ARB 155 ± 19 to 122 ± 17 g/m2, P < 0.0001; ACEi + Ca-A 146 ± 18 to 127 ± 20 g/m2, P < 0.0001). Systolic function remained unchanged; LV diastolic parameters increased significantly in both groups. The extent of 24-h BP decrease was similar between the two groups (-13.3/16.3% vs. -12.3/15.8%, P = 0.63/P = 0.71), whereas the decrease of LV mass (-22% vs. -12.8%, P < 0.005) and the improvement of diastolic function were greater in ACEi + ARB group. Conclusions: In comparison with ACEi + Ca-A, ACEi + ARB treatment showed a greater antiremodeling effect, that can be reasonably ascribed to a BP-independent effect of the dual RAS blockade. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/18174880; info:eu-repo/semantics/altIdentifier/wos/WOS:000252621800025; volume:21(2); firstpage:231; lastpage:237; numberofpages:7; journal:AMERICAN JOURNAL OF HYPERTENSION; http://hdl.handle.net/11383/1707792Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-38949092516 |
| DOI: | 10.1038/ajh.2007.47 |
| الإتاحة: | https://doi.org/10.1038/ajh.2007.47Test http://hdl.handle.net/11383/1707792Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.861258B4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/ajh.2007.47 |
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