دورية أكاديمية
Nuclear expression of β-catenin in endometrial hyperplasia as marker of premalignancy
| العنوان: | Nuclear expression of β-catenin in endometrial hyperplasia as marker of premalignancy |
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| المؤلفون: | Travaglino A., Raffone A., Saccone G., Mascolo M., D'Alessandro P., Arduino B., Mollo A., Insabato L., Zullo F. |
| المساهمون: | Travaglino, A., Raffone, A., Saccone, G., Mascolo, M., D'Alessandro, P., Arduino, B., Mollo, A., Insabato, L., Zullo, F. |
| سنة النشر: | 2019 |
| المجموعة: | IRInSubria - Institutional Repository Insubria (Università degli Studi dell’Insubria) |
| مصطلحات موضوعية: | Atypical endometrial hyperplasia, endometrial hyperplasia without atypia, endometrial intraepithelial neoplasia, endometrial precancer, Biomarker, Cell Nucleu, Endometrial Hyperplasia, Endometrial Neoplasm, Female, Human, Immunohistochemistry, Precancerous Condition, beta Catenin |
| الوصف: | We aimed to assess (1)-whether nuclear β-catenin is a marker of endometrial precancer, and (2)-the diagnostic accuracy of β-catenin immunohistochemistry in the differential diagnosis between benign and premalignant endometrial hyperplasia (EH), defining criteria for its use. Electronic databases were searched for studies evaluating β-catenin immunohistochemistry in normal endometrium (NE), benign and/or premalignant EH, and endometrioid carcinoma (EC). Odds ratio (OR; p < 0.05), sensitivity, specificity, diagnostic OR (DOR), positive and negative likelihood ratios (LR+, LR-) were calculated. Subgroup analyses were based on the classification system used (WHO or EIN) and criteria to define aberrant β-catenin expression (only nuclear or cytoplasmic/nuclear). Twelve studies with 1510 specimens were included. Nuclear β-catenin rate significantly increased from NE to benign EH (OR = 26.01; p = 0.0002, only in WHO subgroup), and from benign EH to premalignant EH (OR = 3.89; p = 0.0002; more markedly in EIN subgroup), but not from premalignant EH to EC (OR = 0.78; p = 0.29). Nuclear β-catenin accuracy was very low in WHO subgroup (sensitivity = 0.40, specificity = 0.76, LR+ = 1.85, LR- = 0.72; DOR = 2.89) and moderate in EIN subgroup (sensitivity = 0.19, specificity = 1.00, LR+ = 14.80, LR- = 0.83; DOR = 18.14). Cytoplasmic/nuclear β-catenin accuracy was absent in WHO subgroup (sensitivity = 0.45, specificity = 0.54, LR+ = 1.01, LR- = 1.01; DOR = 0.99) and low in EIN subgroup (sensitivity = 0.57, specificity = 0.86, LR+ = 3.63, LR- = 0.51; DOR = 8.30). Considering nuclear expression and using EIN system, β-catenin immunohistochemistry might be reliable as rule-in test for diagnosis of endometrial precancer, with perfect specificity and moderate overall accuracy. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/31403731; info:eu-repo/semantics/altIdentifier/wos/WOS:000485359300001; volume:127; issue:11; firstpage:699; lastpage:709; numberofpages:11; journal:APMIS. ACTA PATHOLOGICA, MICROBIOLOGICA ET IMMUNOLOGICA SCANDINAVICA; https://hdl.handle.net/11383/2162243Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85071340129; http://onlinelibrary.wiley.com/journal/10.1111Test/(ISSN)1600-0463 |
| DOI: | 10.1111/apm.12988 |
| DOI: | 10.1111/(ISSN)1600-0463 |
| الإتاحة: | https://doi.org/10.1111/apm.12988Test https://hdl.handle.net/11383/2162243Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.1D5F2896 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/apm.12988 |
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