كتاب
Induced Pluripotent Stem Cell-Derived Human Glutamatergic Neurons as a Platform for Mechanistic Assessment of Inducible Excitotoxicity in Drug Discovery
| العنوان: | Induced Pluripotent Stem Cell-Derived Human Glutamatergic Neurons as a Platform for Mechanistic Assessment of Inducible Excitotoxicity in Drug Discovery |
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| المؤلفون: | Chen, Yafei |
| المصدر: | https://www.intechopen.com/books/5894Test. |
| بيانات النشر: | IntechOpen |
| سنة النشر: | 2018 |
| المجموعة: | IntechOpen (E-Books) |
| مصطلحات موضوعية: | Neurotoxins |
| الوصف: | Since the guiding principles of Replace, Reduce, and Refine were published, wider context-of-use for alternatives to animal testing have emerged. Induced pluripotent stem cell-derived human glutamatergic-enriched cortical neurons can be leveraged as 2- and 3-dimensional platforms to enable candidate drug screening. Uniquely so, 2-dimensional models are useful considering that they exhibit spontaneous firing, while, 3-dimensional models show spontaneous synchronized calcium transient oscillations. Here, the limitations of selected induced acute seizure models as well as the early utilization of fully differentiated glutamatergic neuron models for interrogation of inducible excitotoxicity following exposure to neuromodulators will be described. The context of use for candidate biomarkers of inducible seizure is also discussed. |
| نوع الوثيقة: | book part |
| اللغة: | English |
| ردمك: | 978-1-78923-168-7 1-78923-168-X |
| العلاقة: | https://mts.intechopen.com/articles/show/title/induced-pluripotent-stem-cell-derived-human-glutamatergic-neurons-as-a-platform-for-mechanistic-asseTest |
| DOI: | 10.5772/intechopen.77043 |
| الإتاحة: | https://doi.org/10.5772/intechopen.77043Test https://mts.intechopen.com/articles/show/title/induced-pluripotent-stem-cell-derived-human-glutamatergic-neurons-as-a-platform-for-mechanistic-asseTest |
| حقوق: | https://creativecommons.org/licenses/by/3.0Test/ |
| رقم الانضمام: | edsbas.436368C8 |
| قاعدة البيانات: | BASE |
| ردمك: | 9781789231687 178923168X |
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| DOI: | 10.5772/intechopen.77043 |