دورية أكاديمية
Osteoporosis in rheumatoid arthritis
| العنوان: | Osteoporosis in rheumatoid arthritis |
|---|---|
| المؤلفون: | Salman, Fadul |
| بيانات النشر: | MedEspera |
| سنة النشر: | 2020 |
| المجموعة: | Institutional Repository in Medical Sciences of Nicolae Testemitanu State University of Medicine and Pharmacy |
| مصطلحات موضوعية: | osteoporosis, rheumatoid arthritis, biomarkers, fracture risk, hip, forearm, lumbar spine, bone mineral density |
| الوصف: | Department of Internal Medicine Rheumatology and Nephrology, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova, The 8th International Medical Congress for Students and Young Doctors, September 24-26, 2020 ; Introduction. Osteoporosis is a disease where bones lose their bone mineral density (BMD) which causes bone fragility and leads to fractures, Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that affects the joints symmetrically and is known to cause secondary osteoporosis Aim of the study. To study literatures that focus on the risk factors of osteoporosis and the correlation between it and rheumatoid arthritis. Materials and methods. A literature search using, PubMed, Medscape and the national scientific information archive was performed. among the most relevant articles we selected 70, the data were analyzed by content structure and summarized,as well as statistical analysis where possible. Results. In patients with RA four biomarkers are found to predict fracture sites, Tartrateresistant acid phosphate 5b (TRACP-5b), undercarboxynated osteocalcin (Uc-OC) and bone specific alkaline phosphate (BAP) are able to realize both BMD and bone quality while homocysteine is able to realize only bone quality, In RA patients annual bone mineral density changes are 0.14 + 2.70 in lumbar spine, 0.46 + in proximal hip and 1.14 + 1.85 in forearm. Some studies show that in lumbar spine Homocysteine is the significant predictor for fractures, while in the proximal hip and forearm homocysteine does not have any significance. The most potent predictors for hip and forearm fractures are DAS28-ESR, blood pressure and Vitamin D levels other authors consider a better predictor to be ACPA and Methotrexate dosage use. Another hypothesis suggests that mycobacterium Avium Paratuberculosis (MAP) infection associated with TNF polymorphisms in patients with rheumatoid arthritis might cause secondary osteoporosis and it was found that the association between MAP infection in ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | SALMAN, Fadul. Osteoporosis in rheumatoid arthritis. In: MedEspera: the 8th Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2020, p. 161-162.; https://medespera.asr.md/wp-content/uploads/ABSTRACT-BOOK.pdfTest; http://repository.usmf.md/handle/20.500.12710/12275Test |
| الإتاحة: | https://doi.org/20.500.12710/12275Test http://repository.usmf.md/handle/20.500.12710/12275Test https://hdl.handle.net/20.500.12710/12275Test https://medespera.asr.md/wp-content/uploads/ABSTRACT-BOOK.pdfTest |
| رقم الانضمام: | edsbas.62F4C6AD |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |