التفاصيل البيبلوغرافية
| العنوان: |
Predicting Eye and Hair Color in a Turkish Population Using the HIrisPlex System |
| المؤلفون: |
Sarı O, İlksen, Şimşek, Sümeyye Zülal, Filoğlu, Gönül, Bülbül, Özlem |
| المساهمون: |
Sarı O, İlksen |
| بيانات النشر: |
MDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND |
| سنة النشر: |
2022 |
| المجموعة: |
IGU Institutional Open Access Repository (İstanbul Gelişim University) |
| مصطلحات موضوعية: |
HIrisPlex, population differences, prediction accuracy, forensic DNA phenotyping |
| الوصف: |
Forensic DNA Phenotyping (FDP) can reveal the appearance of an unknown individual by predicting the ancestry, phenotype (i.e., hair, eye, skin color), and age from DNA obtained at the crime scene. The HIrisPlex system has been developed to simultaneously predict eye and hair color. However, the prediction accuracy of the system needs to be assessed for the tested population before implementing FDP in casework. In this study, we evaluated the performance of the HIrisPlex system on 149 individuals from the Turkish population. We applied the single-based extension (SNaPshot chemistry) method and used the HIrisPlex online tool to test the prediction of the eye and hair colors. The accuracy of the HIrisPlex system was assessed through the calculation of the area under the receiver characteristic operating curves (AUC), sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). The results showed that the proposed method successfully predicted the eye and hair color, especially for blue (100%) and brown (95.60%) eye and black (95.23) and brown (98.94) hair colors. As observed in previous studies, the system failed to predict intermediate eye color, representing 25% in our cohort. The majority of incorrect predictions were observed for blond hair color (40.7%). Previous HIrisPlex studies have also noted difficulties with these phenotypes. Our study shows that the HIrisPlex system can be applied to forensic casework in Turkey with careful interpretation of the data, particularly intermediate eye color and blond hair color. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
2073-4425 |
| العلاقة: |
Genes; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11363/6189Test; 13; 11 |
| الإتاحة: |
https://hdl.handle.net/11363/6189Test |
| حقوق: |
info:eu-repo/semantics/openAccess ; Attribution-NonCommercial-NoDerivs 3.0 United States ; http://creativecommons.org/licenses/by-nc-nd/3.0/usTest/ |
| رقم الانضمام: |
edsbas.BEC578B5 |
| قاعدة البيانات: |
BASE |
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