دورية أكاديمية
Pancreas fat content, insulin homeostasis and circulating endothelial microparticles in male essential hypertensive patients
| العنوان: | Pancreas fat content, insulin homeostasis and circulating endothelial microparticles in male essential hypertensive patients |
|---|---|
| المؤلفون: | Alfaro Lara, Verónica Inmaculada, Muñoz Hernández, Rocío, Giménez Miranda, Luis, Beltrán Romero, Luis Matías, Castell Montsalve, Francisco Javier, Stiefel García-Junco, Pablo Enrique |
| المساهمون: | Universidad de Sevilla. Departamento de Fisiología, Instituto de Salud Carlos III |
| بيانات النشر: | Wiley Open Access |
| سنة النشر: | 2024 |
| المجموعة: | idUS - Deposito de Investigación Universidad de Sevilla |
| مصطلحات موضوعية: | endothelialdysfunction, endothelialmicroparticle, HOMA, pancreasfatcontent, QUICKI |
| الوصف: | Thepancreasfatcontenthasbeenpoorlyinvestigatedinessentialhypertension.Theauthorsaimtorelatepancreasandliverfatcontentwithparametersmeasuringinsulinresistance, beta-cell function and also with markers of endothelial dysfunction andplateletorendothelialcelldestruction.Theauthorsstudiedagroupof40malehyper-tensivepatientswithwell-controlledbloodpressure,maintainingastableweight,andhavingnotchangedtheirmedicationduringthelastyear.Pancreasfatcontentwascor-relatedwithHOMA-IR(r=.616,p<.001),HOMA-S(r=−.439,p<.005),betacellfunctionparameter(r=.457,p<.005),andQUICKI(r=.412,p<.01),whereasliverfatwasnotpatientsinthehighestquartileofpancreasfatcontenthadmorecirculatingendothelialmicroparticlesthanpatientsintheotherquartiles(median129[94.3–200]vs.60.9[49.4–88.8],p=.002).However,patientsinthehighestquartileofthepancreasfat content distribution did not differ from the lowest in hyperemic response afterischemianorcirculatingplateletmicroparticlescount.Liverfatcontentwasnotrelatedto any of the parameters studied. In a multivariate stepwise binary logistic regres-sionanalysis(WaldMethod)circulatingendothelialmicroparticlesremainsignificantlyassociatedwithpancreasfatcontentafteradjustingforconfoundingfactors,suchastobacco,diabetesmellitus,hypercholesterolemia,ormetabolicsyndrome.Ourresultsreflectthatinessentialhypertension,pancreasfatcontentissuperiortoliverfattostudybeta-cellfunctionalityandinsulinresistance.Moreover,theauthorsdescribedforthefirsttimethatpancreasfatcontentisrelatedtoendothelialcelldestruction.Furtherstudiesareneededtoconfirmthispoint. ; Instituto de Salud Carlos III PI13/01917 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | Journal of Clinical Hypertension, 25 (1), 38-46.; PI13/01917; https://doi.org/10.1111/jch.14600Test; https://idus.us.es/handle//11441/156709Test |
| الإتاحة: | https://doi.org/10.1111/jch.14600Test https://idus.us.es/handle//11441/156709Test |
| حقوق: | Attribution-NonCommercial-NoDerivatives 4.0 Internacional ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.2A5B9BE3 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |