دورية أكاديمية
Circular and L50-like leaderless enterocins share a common ABC-transporter immunity gene
العنوان: | Circular and L50-like leaderless enterocins share a common ABC-transporter immunity gene |
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المؤلفون: | Teso Pérez, Claudia, Martínez Bueno, Manuel, Peralta Sánchez, Juan Manuel, Valdivia, Eva, Fárez Vidal, María Esther, Martín Platero, Antonio Manuel |
المساهمون: | Universidad de Sevilla. Departamento de Zoología, Junta de Andalucía, Ministerio de Ciencia e Innovación (MICIN). España |
بيانات النشر: | Springer Nature |
سنة النشر: | 2023 |
المجموعة: | idUS - Deposito de Investigación Universidad de Sevilla |
مصطلحات موضوعية: | ABC transporter, Carnocyclin, Cross-resistance, Enterocin AS-48, Enterocin MR10A/B, Enterococcus |
الوصف: | Microbes live within complex communities of interacting populations, either free-living in waters and soils or symbionts of animals and plants. Their interactions include the production of antimicrobial peptides (bacteriocins) to antagonize competitors, and these producers must carry their own immunity gene for self-protection. Whether other coexisting populations are sensitive or resistant to the bacteriocin producer will be key for the population dynamics within the microbial community. The immunity gene frequently consists of an ABC transporter to repel its own bacteriocin but rarely protects against a nonrelated bacteriocin. A case where this cross-resistance occurs mediated by a shared ABC transporter has been shown between enterocins MR10A/B and AS-48. The first is an L50-like leaderless enterocin, while AS-48 is a circular enterocin. In addition, L50-like enterocins such as MR10A/B have been found in E. faecalis and E. faecium, but AS-48 appears only in E. faecalis. Thus, using the ABC transporter of the enterocin MR10A/B gene cluster of Enterococcus faecalis MRR10-3 as a cross-resistance model, we aimed to unravel to what extent a particular ABC transporter can be shared across multiple bacteriocinogenic bacterial populations. To this end, we screened the MR10A/B-ABC transporters in available microbial genomes and analyzed their sequence homologies and distribution. Overall, our main findings are as follows: (i) the MR10A/B-ABC transporter is associated with multiple enterocin gene clusters; (ii) the different enterocins associated with this transporter have a saposin-like fold in common; (iii) the Mr10E component of the transporter is more conserved within its associated enterocin, while the Mr10FGH components are more conserved within the carrying species. This is the least known component of the transporter, but it has shown the greatest specificity to its corresponding enterocin. Bacteriocins are now being investigated as an alternative to antibiotics; hence, the wider or narrower distribution of the ... |
نوع الوثيقة: | article in journal/newspaper |
اللغة: | English |
العلاقة: | BMC Genomics, 24 (1), 639.; A-BIO-083-UGR18; BIO 309; PEJ2018-003019-A; https://doi.org/10.1186/s12864-023-09750-2Test; https://idus.us.es/handle//11441/150141Test |
الإتاحة: | https://doi.org/10.1186/s12864-023-09750-2Test https://idus.us.es/handle//11441/150141Test |
حقوق: | Atribución 4.0 Internacional ; http://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess |
رقم الانضمام: | edsbas.610AF5BB |
قاعدة البيانات: | BASE |
الوصف غير متاح. |