دورية أكاديمية
The Expression of Human Corneal MMP-2, MMP-9, proMMP-13 and TIMP-1 in Bullous Keratopathy and Keratoconus
| العنوان: | The Expression of Human Corneal MMP-2, MMP-9, proMMP-13 and TIMP-1 in Bullous Keratopathy and Keratoconus |
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| المؤلفون: | Predović, Jurica, Balog, Tihomir, Marotti, Tanja, Gabrić, Nikica, Bohač, Maja, Romac, Ivana, Dekaris, Iva |
| المصدر: | Collegium Antropologicum (croantro@inantro.hr ); Vol.32 - Supplement 2 No.2 |
| بيانات النشر: | Croatian Anthropological Society; croantro@inantro.hr |
| سنة النشر: | 2008 |
| المجموعة: | Hrčak - Portal of scientific journals of Croatia / Portal znanstvenih časopisa Republike Hrvatske |
| مصطلحات موضوعية: | corneal transplantation, keratoconus, corneal edema, metalloproteinases, tissue inhibitor of metalloproteinase- 1 |
| الوصف: | We aim to find a link between keratokonus (KC) and bullous keratopathy (BK), and extra cellular matrix re-modellation molecules. The activities of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), pro-matrix metalloproteinase-13 (proMMP-13) and tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) were measured using immunoassay in three human corneal tissue layers (epithelium, stroma and endothelium) supernatants of the patients with KC and BK which underwent the perforative keratoplasty. MPP-2, MMP-9, proMMP-13 and TIMP-1 activity was detected in all samples. The epithelial layer showed significantly higher levels of MMP-9 and proMMP-13 in BK than in KC. Increased levels of MMP-2 (p=0.07) levels were found in bullous keratopathy compared to keratoconus patients. Epithelial TIMP-1 showed no significant difference in activity between KC and BK. All these findings suggest an active degradation of the extra-cellular matrix in epithelial corneal layer in Bullous Keratopathy. No difference in the concentration of MMP-2, MMP-9, proMMP-13 and TIMP-1 between KC and BK in corneal stroma and endothelium suggest that neither of these molecules play important role in KC or BK pathogenesis, at least not in stroma and endothelium. |
| نوع الوثيقة: | text |
| وصف الملف: | |
| اللغة: | English |
| العلاقة: | http://hrcak.srce.hr/34533Test; http://hrcak.srce.hr/file/54730Test |
| الإتاحة: | http://hrcak.srce.hr/34533Test http://hrcak.srce.hr/file/54730Test |
| حقوق: | Gudielines for authors, any further information as well as the complete archive of Collegium can be found on the official web page of the journal: www.CollAntropol.hr |
| رقم الانضمام: | edsbas.6E257159 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |