دورية أكاديمية
Glucuronic Esters. VI. Syntheses of Fully Protected 1-0-Acylaminoacyl-D-Glucuronic Acids by the Imidazole Promoted Active Ester and Drydohexylcarbodi-imide Methods
| العنوان: | Glucuronic Esters. VI. Syntheses of Fully Protected 1-0-Acylaminoacyl-D-Glucuronic Acids by the Imidazole Promoted Active Ester and Drydohexylcarbodi-imide Methods |
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| المؤلفون: | Roglić, G., Keglević, D. |
| المصدر: | Croatica Chemica Acta ; ISSN 0011-1643 (Print) ; ISSN 1334-417X (Online) ; Volume 44 ; Issue 2 |
| بيانات النشر: | Croatian Chemical Society |
| سنة النشر: | 1972 |
| المجموعة: | Hrčak - Portal of scientific journals of Croatia / Portal znanstvenih časopisa Republike Hrvatske |
| الوصف: | Fully protected o-glucuronic estern linked at C-1 to the carboxyl group of N-acyl-DL and L-amino acids were synthesized by two methods involving direct participation of imidazole in the ester linkage formation: (a) accelerated active ester method and (b) imidazole promoted DCC condensation. The synthesis was performed with fully-methylated and -benzylated C-1 free o-glucuronic acid as the sugar component and with pentachlorophenyl esters of benzyloxycarbonyl- and tert-butyloxycarbonyl- amino acids in method (a), or with benzyloxycarbonyl- and acetylamino acids in method (b). Fully methylated o-glucuronic acid I, prepared from o-glucurono-6,3-lactone and dimethyl sulphate, was used as the starting material for the synthesis of methylated sugar component II; GLC and chemical studies indicate the furanose structure for I. The corresponding glucuronic esters were obtained as anomeric mixtures which were resolved and characterized. Conditions for the cleavage of the amino acid protecting group were studied and the fully methylated 1-0-glycyl-~-n-glucuronate was obtained as the monooxalate salt in crystalline form. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://hrcak.srce.hr/197269Test |
| الإتاحة: | https://hrcak.srce.hr/197269Test https://hrcak.srce.hr/file/290599Test |
| حقوق: | info:eu-repo/semantics/openAccess ; Croatica Chemica Acta is at the highest possible level of Open Access, meaning that all content is immediately and freely available to anyone, anywhere, to be downloaded, printed, distributed, read, reused, self archived, and re-mixed (including commercially) without restriction, as long as the author and the original source are properly at-tributed according to the Creative Commons Attribution 4.0 International License (CC BY). The author(s) hold the copyright and retain publishing rights without restrictions. CC BY (Creative Commons Attribution) is the most accommodating of public copyright licenses as defined by Creative Commons, a nonprofit organization that provides legal tools for sharing and use of creative works and research. The CC BY license is recommended for maximum dissemination and use of licensed materials. All content published in Croatica Chemica Acta is available under CC BY, meaning anyone is free to use and reuse the content provided the original source and authors are credited. The copyright is held and retained. The author(s) hold the copyright without restrictions. CC BY is the appropriate license for publicly funded research; it maximizes the potential for both economic and scholarly impact, protects the rights of authors and strengthens the long-standing tradition of appropriate attribution and credit for scholarship. |
| رقم الانضمام: | edsbas.FC3A98E7 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |