دورية أكاديمية
Priprava i evaluacija dvofazičnih plutajućih tableta fenoverina ; Formulation and evaluation of multiple tablets as a biphasic gastroretentivefloating drug delivery system for fenoverine
| العنوان: | Priprava i evaluacija dvofazičnih plutajućih tableta fenoverina ; Formulation and evaluation of multiple tablets as a biphasic gastroretentivefloating drug delivery system for fenoverine |
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| المؤلفون: | BANDARI, SURESH, Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506 009 (A.P.), India, EAGA, CHANDRA MOHAN, THADISHETTY, ASHOK, YAMSANI, MADHUSUDAN RAO, yamsani123@gmail.com |
| المصدر: | Acta pharmaceutica (hfd-fg-ap@zg.htnet.hr); Vol.60 No.1 |
| بيانات النشر: | Croatian Pharmaceutical Society |
| سنة النشر: | 2010 |
| المجموعة: | Hrčak - Portal of scientific journals of Croatia / Portal znanstvenih časopisa Republike Hrvatske |
| مصطلحات موضوعية: | bifazično oslobađanje, zadržavanje u želucu, višeslojne matriksne tablete, kinetika oslobađanja, biphasic release, gastroretention, multiple matrix tablet, release kinetics |
| الوصف: | U radu je opisan razvoj bifazičnog sustava za isporuku fenoverina s produljenim zadržavanjem u želucu radi održavanja konstantne koncentracije lijeka u plazmi. Sustav je dobiven metodom izravne kompresije, a sastoji se od tablete za inicijalno doziranje i matriksne tablete za plutanje. Oslobađanje lijeka iz bifazičnog GRDDS u 0,1 mol L1 HCl i SGF (bez enzima) bilo je produljeno više od 12 h, a sustav je pokazao plutajuća svojstva. Ispitivanja stabilnosti pokazala su da nema značajne promjene u profilu oslobađanja (f2 > 50). Na temelju kinetike oslobađanja može se zaključiti da su plutajuće višeslojne matriksne tablete s HPMC posebno pogodan sustav za isporuku fenoverina u želucu s kinetikom oslobađanja nultog reda. ; A biphasic gastroretentive drug delivery system of fenoverine was developed to maintain constant plasma concentration. The delivery system consisted of a loading-dose tablet and a floating multiple matrix tablet prepared by the direct compression process. The drug release from biphasic GRDDS in 0.1 mol L1 HCl and SGF (enzyme free) was sustained over 12 h with buoyant properties. Stability studies showed no significant change in dissolution profiles (f2 value > 50). Based on the release kinetics, it can be concluded that the floating multiple matrix tablet containing HPMC was a particularly suitable gastroretentive drug delivery system with a zero-order release profile. |
| نوع الوثيقة: | text |
| وصف الملف: | |
| اللغة: | English |
| العلاقة: | http://hrcak.srce.hr/41962Test; http://hrcak.srce.hr/file/65792Test |
| الإتاحة: | http://hrcak.srce.hr/41962Test http://hrcak.srce.hr/file/65792Test |
| حقوق: | Only abstracts published in the Journal may be reproduced without prior permission; reproduction of other materials requires publisher's consent. |
| رقم الانضمام: | edsbas.E8B160CC |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |