دورية أكاديمية
Tyrosine kinase inhibitors: new molecules in non-small cell lung cancer (EGFR AND ALK)
| العنوان: | Tyrosine kinase inhibitors: new molecules in non-small cell lung cancer (EGFR AND ALK) |
|---|---|
| المؤلفون: | Franco, Fernando, Mendez, Miriam, Gutierrez, Lourdes, Provencio, Mariano |
| المصدر: | ADMET and DMPK ; ISSN 1848-7718 (Online) ; Volume 5 ; Issue 1 |
| بيانات النشر: | International Association of Physical Chemists |
| سنة النشر: | 2017 |
| المجموعة: | Hrčak - Portal of scientific journals of Croatia / Portal znanstvenih časopisa Republike Hrvatske |
| مصطلحات موضوعية: | Lung cancer, EGFR inhibitors, ALK inhibitors |
| الوصف: | Lung cancer is a tumor pathology that includes a group of neoplasms with different biological characteristics, which determine the course of the disease and the potential treatment response depending on the subtype diagnosed. Non-small lung carcinoma corresponds to 85 % of all lung cancers. Adenocarcinoma is the most common histologic subtype of this group. In the United States approximately 130,000 new cases a year are diagnosed and in the world around a million. Adenocarcinoma is the most likely subtype, with possible molecular alterations (EGFR mutations and translocations in ALK), which are a therapeutic target. Knowledge of the molecular profile of the tumor and its biology has led us to identify therapeutic targets as protein tyrosine kinase, whose inhibition have demonstrated impact in terms of survival and quality of life for patients with these molecular alterations. However, the complex biology of non-small cell lung carcinoma gives the malignant cell the ability to generate mechanisms of resistance to these drugs and has forced us to extend the studies to control the disease by blocking these mechanisms. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | http://hrcak.srce.hr/178352Test |
| الإتاحة: | https://doi.org/10.5599/admet.5.1.352Test http://hrcak.srce.hr/178352Test http://hrcak.srce.hr/file/262864Test |
| حقوق: | info:eu-repo/semantics/openAccess ; ADMET and DMPK publishes articles under the Creative Commons Attribution License. This means that all articles published by ADMET and DMPK, including data, graphics tables and supplement materials, can be reused by other autors, linked on websites, crawled by search engines, or reused by blogs. , free of charge under the sole condition of proper accreditation of the source and the original Publisher. ADMET and DMPK believes that open access publishing can foster the exchange of research results amongst electrochemists world-wide, including from developing countries, as well as to an interested general public. We believe that open access is an enriching part of the science communication that could and should co-exist with all other forms of communication and publication. |
| رقم الانضمام: | edsbas.A654D6AC |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |