المؤلفون: Teumer, Alexander, Li, Yong, Ghasemi, Sahar, Prins, Bram P, Wuttke, Matthias, Hermle, Tobias, Giri, Ayush, Sieber, Karsten B, Qiu, Chengxiang, Kirsten, Holger, Tin, Adrienne, Chu, Audrey Y, Bansal, Nisha, Feitosa, Mary F, Wang, Lihua, Chai, Jin-Fang, Cocca, Massimiliano, Fuchsberger, Christian, Gorski, Mathias, Hoppmann, Anselm, Horn, Katrin, Li, Man, Marten, Jonathan, Noce, Damia, Nutile, Teresa, Sedaghat, Sanaz, Sveinbjornsson, Gardar, Tayo, Bamidele O, van der Most, Peter J, Xu, Yizhe, Yu, Zhi, Gerstner, Lea, Ärnlöv, Johan, Bakker, Stephan J L, Baptista, Daniela, Biggs, Mary L, Boerwinkle, Eric, Brenner, Hermann, Burkhardt, Ralph, Carroll, Robert J, Chee, Miao-Li, Chee, Miao-Ling, Chen, Mengmeng, Cheng, Ching-Yu, Cook, James P, Coresh, Josef, Corre, Tanguy, Danesh, John, de Borst, Martin H, De Grandi, Alessandro, de Mutsert, Renée, de Vries, Aiko P J, Degenhardt, Frauke, Dittrich, Katalin, Divers, Jasmin, Eckardt, Kai-Uwe, Ehret, Georg, Endlich, Karlhans, Felix, Janine F, Franco, Oscar H, Franke, Andre, Freedman, Barry I, Freitag-Wolf, Sandra, Gansevoort, Ron T, Giedraitis, Vilmantas, Gögele, Martin, Grundner-Culemann, Franziska, Gudbjartsson, Daniel F, Gudnason, Vilmundur, Hamet, Pavel, Harris, Tamara B, Hicks, Andrew A, Holm, Hilma, Foo, Valencia Hui Xian, Hwang, Shih-Jen, Ikram, M Arfan, Ingelsson, Erik, Jaddoe, Vincent W V, Jakobsdottir, Johanna, Josyula, Navya Shilpa, Jung, Bettina, Kähönen, Mika, Khor, Chiea-Chuen, Kiess, Wieland, Koenig, Wolfgang, Körner, Antje, Kovacs, Peter, Kramer, Holly, Krämer, Bernhard K, Kronenberg, Florian, Lange, Leslie A, Langefeld, Carl D, Lee, Jeannette Jen-Mai, Lehtimäki, Terho, Lieb, Wolfgang, Lim, Su-Chi, Lind, Lars, Lindgren, Cecilia M, Liu, Jianjun, Loeffler, Markus, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Maranville, Joseph C, Mascalzoni, Deborah, McMullen, Barbara, Meisinger, Christa, Meitinger, Thomas, Miliku, Kozeta, Mook-Kanamori, Dennis O, Müller-Nurasyid, Martina, Mychaleckyj, Josyf C, Nauck, Matthias, Nikus, Kjell, Ning, Boting, Noordam, Raymond, Connell, Jeffrey O', Olafsson, Isleifur, Palmer, Nicholette D, Peters, Annette, Podgornaia, Anna I, Ponte, Belen, Poulain, Tanja, Pramstaller, Peter P, Rabelink, Ton J, Raffield, Laura M, Reilly, Dermot F, Rettig, Rainer, Rheinberger, Myriam, Rice, Kenneth M, Rivadeneira, Fernando, Runz, Heiko, Ryan, Kathleen A, Sabanayagam, Charumathi, Saum, Kai-Uwe, Schöttker, Ben, Shaffer, Christian M, Shi, Yuan, Smith, Albert V, Strauch, Konstantin, Stumvoll, Michael, Sun, Benjamin B, Szymczak, Silke, Tai, E-Shyong, Tan, Nicholas Y Q, Taylor, Kent D, Teren, Andrej, Tham, Yih-Chung, Thiery, Joachim, Thio, Chris H L, Thomsen, Hauke, Thorsteinsdottir, Unnur, Tönjes, Anke, Tremblay, Johanne, Uitterlinden, André G, van der Harst, Pim, Verweij, Niek, Vogelezang, Suzanne, Völker, Uwe, Waldenberger, Melanie, Wang, Chaolong, Wilson, Otis D, Wong, Charlene, Wong, Tien-Yin, Yang, Qiong, Yasuda, Masayuki, Akilesh, Shreeram, Bochud, Murielle, Böger, Carsten A, Devuyst, Olivier, Edwards, Todd L, Ho, Kevin, Morris, Andrew P, Parsa, Afshin, Pendergrass, Sarah A, Psaty, Bruce M, Rotter, Jerome I, Stefansson, Kari, Wilson, James G, Susztak, Katalin, Snieder, Harold, Heid, Iris M, Scholz, Markus, Butterworth, Adam S, Hung, Adriana M, Pattaro, Cristian, Köttgen, Anna

المساهمون: 1 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. ateumer@uni-greifswald.de. 2 DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany. ateumer@uni-greifswald.de. 3 Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany. 4 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. 5 DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany. 6 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 7 Renal Division, Department of Medicine, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany. 8 Division of Quantitative Sciences, Department of Obstetrics & Gynecology, Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA. 9 Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA. 10 Target Sciences - Genetics, GlaxoSmithKline, Collegeville, PA, USA. 11 Renal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA. 12 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. 13 LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany. 14 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 15 Epidemiology and Clinical Research, Welch Centre for Prevention, Baltimore, MD, USA. 16 Genetics, Merck & Co., Inc., Kenilworth, NJ, USA. 17 Division of Nephrology, University of Washington, Seattle, WA, USA. 18 Kidney Research Institute, University of Washington, Seattle, WA, USA. 19 Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. 20 Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore. 21 Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy. 22 Eurac Research, Institute for Biomedicine (affiliated to the University of Lübeck), Bolzano, Italy. 23 Department of Nephrology, University Hospital Regensburg, Regensburg, Germany. 24 Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. 25 Department of Medicine, Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT, USA. 26 Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. 27 Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" - CNR, Naples, Italy. 28 Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. 29 deCODE Genetics, Amgen Inc., Reykjavik, Iceland. 30 Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA. 31 Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 32 Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 33 Department of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden. 34 School of Health and Social Studies, Dalarna University, Falun, Sweden. 35 Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 36 Cardiology, Geneva University Hospitals, Geneva, Switzerland. 37 Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. 38 Department of Biostatistics, University of Washington, Seattle, WA, USA. 39 Human Genetics Centre, University of Texas Health Science Centre, Houston, TX, USA. 40 Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany. 41 Network Aging Research, University of Heidelberg, Heidelberg, Germany. 42 Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany. 43 Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany. 44 Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA. 45 Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. 46 Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore. 47 Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore. 48 Department of Biostatistics, University of Liverpool, Liverpool, UK. 49 Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland. 50 Department of Computational Biology, University of Lausanne, Lausanne, Switzerland. 51 Swiss Institute of Bioinformatics, Lausanne, Switzerland. 52 Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK. 53 Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands. 54 Section of Nephrology, Department of Internal Medicine, Leiden University Medical Centre, Leiden, The Netherlands. 55 Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany. 56 Department of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany. 57 Centre for Pediatric Research, University of Leipzig, Leipzig, Germany. 58 Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA. 59 Intensive Care Medicine, Charité, Berlin, Germany. 60 Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany. 61 Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany. 62 The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. 63 Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. 64 Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland. 65 Internal Medicine - Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA. 66 Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, USA. 67 Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala, Sweden. 68 Icelandic Heart Association, Kopavogur, Iceland. 69 Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. 70 Montreal University Hospital Research Centre, CHUM, Montreal, QC, Canada. 71 Medpharmgene, Montreal, QC, Canada. 72 Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA. 73 NHLBI's Framingham Heart Study, Framingham, MA, USA. 74 The Centre for Population Studies, NHLBI, Framingham, MA, USA. 75 Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA. 76 Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA. 77 Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. 78 Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA. 79 Icelandic Heart Association, Holtasmari 1, Kopavogur, IS-201, Iceland. 80 The Centre of Public Health Sciences, University of Iceland, Sturlugata 8, Reykjavík, IS-101, Iceland. 81 Geisinger Research, Biomedical and Translational Informatics Institute, Rockville, MD, USA. 82 Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland. 83 Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. 84 Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore. 85 Deutsches Herzzentrum München, Technische Universität München, Munich, Germany. 86 DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany. 87 Institute of Epidemiology and Biostatistics, University of Ulm, Ulm, Germany. 88 Integrated Research and Treatment Centre Adiposity Diseases, University of Leipzig, Leipzig, Germany. 89 Division of Nephrology and Hypertension, Loyola University Chicago, Chicago, IL, USA. 90 5th Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. 91 Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria. 92 Division of Biomedical Informatics and Personalized Medicine, School of Medicine, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, USA. 93 Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. 94 Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. 95 Institute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany. 96 Diabetes Centre, Khoo Teck Puat Hospital, Singapore, Singapore. 97 Cardiovascular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. 98 Nuffield Department of Medicine, University of Oxford, Oxford, UK. 99 Broad Institute of Harvard and MIT, Cambridge, MA, USA. 100 Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore. 101 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. 102 Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. 103 MRL, Merck & Co., Inc., Kenilworth, NJ, USA. 104 Celgene Inc., Cambridge, MA, USA. 105 Vanderbilt University School of Medicine, Nashville, TN, USA. 106 Independent Research Group Clinical Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany. 107 Chair of Epidemiology Ludwig- Maximilians-Universität München at UNIKA-T Augsburg, Augsburg, Germany. 108 Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany. 109 Institute of Human Genetics, Technische Universität München, Munich, Germany. 110 Department of Public Health and Primary Care, Leiden University Medical Centre, Leiden, The Netherlands. 111 Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany. 112 Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU, Munich, Germany. 113 Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, Germany. 114 Centre for Public Health Genomics, University of Virginia, Charlottesville, VA, USA. 115 Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany. 116 Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland. 117 Department of Cardiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. 118 Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. 119 Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Centre, Leiden, The Netherlands. 120 University of Maryland School of Medicine, Baltimore, MD, USA. 121 Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland. 122 Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA. 123 Institute of Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany. 124 German Center for Diabetes Research (DZD), Neuherberg, Germany. 125 Service de Néphrologie, Geneva University Hospitals, Geneva, Switzerland. 126 Einthoven Laboratory of Experimental Vascular Research, Leiden University Medical Centre, Leiden, The Netherlands. 127 Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. 128 Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany. 129 Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. 130 Biogen Inc., Cambridge, MA, USA. 131 Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA. 132 Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany. 133 Duke-NUS Medical School, Singapore, Singapore. 134 The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. 135 Heart Centre Leipzig, Leipzig, Germany. 136 Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany. 137 CRCHUM, Montreal, QC, Canada. 138 Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 139 Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 140 Durrer Centre for Cardiovascular Research, The Netherlands Heart Institute, Utrecht, The Netherlands. 141 Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany. 142 Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany. 143 School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 144 Vanderbilt University Medical Centre, Division of Nephrology & Hypertension, Nashville, TN, USA. 145 Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan. 146 Anatomic Pathology, University of Washington Medical Center, Seattle, WA, USA. 147 Department of Nephrology, Diabetology and Rheumatology, Kliniken Südostbayern, Traunstein, Germany. 148 Institute of Physiology, University of Zurich, Zurich, Switzerland. 149 Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Centre, Nashville, TN, USA. 150 Department of Veteran's Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA. 151 Kidney Health Research Institute (KHRI), Geisinger, Danville, PA, USA. 152 Department of Nephrology, Geisinger, Danville, PA, USA. 153 Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. 154 Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. 155 Geisinger Research, Biomedical and Translational Informatics Institute, Danville, PA, USA. 156 Cardiovascular Health Research Unit, Department of Medicine, Department of Epidemiology, Department of Health Service, University of Washington, Seattle, WA, USA. 157 Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA. 158 Department of Pediatrics, Harbor-UCLA Medical Centre, Torrance, CA, USA. 159 Department of Medicine, Harbor-UCLA Medical Centre, Torrance, CA, USA. 160 Department of Physiology and Biophysics, University of Mississippi Medical Centre, Jackson, MS, USA. 161 National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK. 162 Eurac Research, Institute for Biomedicine (affiliated to the University of Lübeck), Bolzano, Italy. cristian.pattaro@eurac.edu. 163 Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany. anna.koettgen@uniklinik-freiburg.de. 164 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. anna.koettgen@uniklinik-freiburg.de.

المصدر: Nature communications

مصطلحات موضوعية: Nýrnasjúkdómar, Gen, Albuminuria, Kidney Diseases, Genome-Wide Association Study

العلاقة: https://www.nature.com/articles/s41467-019-11576-0Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739370Test/; Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria. 2019, 10(1):4130. doi:10.1038/s41467-019-11576-0 Nat Commun; http://hdl.handle.net/2336/621097Test; Nature Communications

الإتاحة: https://doi.org/10.1038/s41467-019-11576-0Test
http://hdl.handle.net/2336/621097Test

المؤلفون: Teumer, Alexander, Li, Yong, Ghasemi, Sahar, Prins, Bram P, Wuttke, Matthias, Hermle, Tobias, Giri, Ayush, Sieber, Karsten B, Qiu, Chengxiang, Kirsten, Holger, Tin, Adrienne, Chu, Audrey Y, Bansal, Nisha, Feitosa, Mary F, Wang, Lihua, Chai, Jin-Fang, Cocca, Massimiliano, Fuchsberger, Christian, Gorski, Mathias, Hoppmann, Anselm, Horn, Katrin, Li, Man, Marten, Jonathan, Noce, Damia, Nutile, Teresa, Sedaghat, Sanaz, Sveinbjornsson, Gardar, Tayo, Bamidele O, van der Most, Peter J, Xu, Yizhe, Yu, Zhi, Gerstner, Lea, Ärnlöv, Johan, Bakker, Stephan J L, Baptista, Daniela, Biggs, Mary L, Boerwinkle, Eric, Brenner, Hermann, Burkhardt, Ralph, Carroll, Robert J, Chee, Miao-Li, Chee, Miao-Ling, Chen, Mengmeng, Cheng, Ching-Yu, Cook, James P, Coresh, Josef, Corre, Tanguy, Danesh, John, de Borst, Martin H, De Grandi, Alessandro, de Mutsert, Renée, de Vries, Aiko P J, Degenhardt, Frauke, Dittrich, Katalin, Divers, Jasmin, Eckardt, Kai-Uwe, Ehret, Georg, Endlich, Karlhans, Felix, Janine F, Franco, Oscar H, Franke, Andre, Freedman, Barry I, Freitag-Wolf, Sandra, Gansevoort, Ron T, Giedraitis, Vilmantas, Gögele, Martin, Grundner-Culemann, Franziska, Gudbjartsson, Daniel F, Gudnason, Vilmundur, Hamet, Pavel, Harris, Tamara B, Hicks, Andrew A, Holm, Hilma, Foo, Valencia Hui Xian, Hwang, Shih-Jen, Ikram, M Arfan, Ingelsson, Erik, Jaddoe, Vincent W V, Jakobsdottir, Johanna, Josyula, Navya Shilpa, Jung, Bettina, Kähönen, Mika, Khor, Chiea-Chuen, Kiess, Wieland, Koenig, Wolfgang, Körner, Antje, Kovacs, Peter, Kramer, Holly, Krämer, Bernhard K, Kronenberg, Florian, Lange, Leslie A, Langefeld, Carl D, Lee, Jeannette Jen-Mai, Lehtimäki, Terho, Lieb, Wolfgang, Lim, Su-Chi, Lind, Lars, Lindgren, Cecilia M, Liu, Jianjun, Loeffler, Markus, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Maranville, Joseph C, Mascalzoni, Deborah, McMullen, Barbara, Meisinger, Christa, Meitinger, Thomas, Miliku, Kozeta, Mook-Kanamori, Dennis O, Müller-Nurasyid, Martina, Mychaleckyj, Josyf C, Nauck, Matthias, Nikus, Kjell, Ning, Boting, Noordam, Raymond, Connell, Jeffrey O', Olafsson, Isleifur, Palmer, Nicholette D, Peters, Annette, Podgornaia, Anna I, Ponte, Belen, Poulain, Tanja, Pramstaller, Peter P, Rabelink, Ton J, Raffield, Laura M, Reilly, Dermot F, Rettig, Rainer, Rheinberger, Myriam, Rice, Kenneth M, Rivadeneira, Fernando, Runz, Heiko, Ryan, Kathleen A, Sabanayagam, Charumathi, Saum, Kai-Uwe, Schöttker, Ben, Shaffer, Christian M, Shi, Yuan, Smith, Albert V, Strauch, Konstantin, Stumvoll, Michael, Sun, Benjamin B, Szymczak, Silke, Tai, E-Shyong, Tan, Nicholas Y Q, Taylor, Kent D, Teren, Andrej, Tham, Yih-Chung, Thiery, Joachim, Thio, Chris H L, Thomsen, Hauke, Thorsteinsdottir, Unnur, Tönjes, Anke, Tremblay, Johanne, Uitterlinden, André G, van der Harst, Pim, Verweij, Niek, Vogelezang, Suzanne, Völker, Uwe, Waldenberger, Melanie, Wang, Chaolong, Wilson, Otis D, Wong, Charlene, Wong, Tien-Yin, Yang, Qiong, Yasuda, Masayuki, Akilesh, Shreeram, Bochud, Murielle, Böger, Carsten A, Devuyst, Olivier, Edwards, Todd L, Ho, Kevin, Morris, Andrew P, Parsa, Afshin, Pendergrass, Sarah A, Psaty, Bruce M, Rotter, Jerome I, Stefansson, Kari, Wilson, James G, Susztak, Katalin, Snieder, Harold, Heid, Iris M, Scholz, Markus, Butterworth, Adam S, Hung, Adriana M, Pattaro, Cristian, Köttgen, Anna

المساهمون: 1 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. ateumer@uni-greifswald.de. 2 DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany. ateumer@uni-greifswald.de. 3 Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany. 4 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. 5 DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany. 6 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 7 Renal Division, Department of Medicine, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany. 8 Division of Quantitative Sciences, Department of Obstetrics & Gynecology, Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA. 9 Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA. 10 Target Sciences - Genetics, GlaxoSmithKline, Collegeville, PA, USA. 11 Renal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA. 12 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. 13 LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany. 14 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 15 Epidemiology and Clinical Research, Welch Centre for Prevention, Baltimore, MD, USA. 16 Genetics, Merck & Co., Inc., Kenilworth, NJ, USA. 17 Division of Nephrology, University of Washington, Seattle, WA, USA. 18 Kidney Research Institute, University of Washington, Seattle, WA, USA. 19 Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. 20 Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore. 21 Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy. 22 Eurac Research, Institute for Biomedicine (affiliated to the University of Lübeck), Bolzano, Italy. 23 Department of Nephrology, University Hospital Regensburg, Regensburg, Germany. 24 Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. 25 Department of Medicine, Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT, USA. 26 Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. 27 Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" - CNR, Naples, Italy. 28 Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. 29 deCODE Genetics, Amgen Inc., Reykjavik, Iceland. 30 Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA. 31 Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 32 Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 33 Department of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden. 34 School of Health and Social Studies, Dalarna University, Falun, Sweden. 35 Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 36 Cardiology, Geneva University Hospitals, Geneva, Switzerland. 37 Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. 38 Department of Biostatistics, University of Washington, Seattle, WA, USA. 39 Human Genetics Centre, University of Texas Health Science Centre, Houston, TX, USA. 40 Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany. 41 Network Aging Research, University of Heidelberg, Heidelberg, Germany. 42 Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany. 43 Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany. 44 Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA. 45 Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. 46 Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore. 47 Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore. 48 Department of Biostatistics, University of Liverpool, Liverpool, UK. 49 Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland. 50 Department of Computational Biology, University of Lausanne, Lausanne, Switzerland. 51 Swiss Institute of Bioinformatics, Lausanne, Switzerland. 52 Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK. 53 Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands. 54 Section of Nephrology, Department of Internal Medicine, Leiden University Medical Centre, Leiden, The Netherlands. 55 Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany. 56 Department of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany. 57 Centre for Pediatric Research, University of Leipzig, Leipzig, Germany. 58 Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA. 59 Intensive Care Medicine, Charité, Berlin, Germany. 60 Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany. 61 Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany. 62 The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. 63 Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. 64 Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland. 65 Internal Medicine - Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA. 66 Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, USA. 67 Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala, Sweden. 68 Icelandic Heart Association, Kopavogur, Iceland. 69 Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. 70 Montreal University Hospital Research Centre, CHUM, Montreal, QC, Canada. 71 Medpharmgene, Montreal, QC, Canada. 72 Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA. 73 NHLBI's Framingham Heart Study, Framingham, MA, USA. 74 The Centre for Population Studies, NHLBI, Framingham, MA, USA. 75 Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA. 76 Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA. 77 Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. 78 Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA. 79 Icelandic Heart Association, Holtasmari 1, Kopavogur, IS-201, Iceland. 80 The Centre of Public Health Sciences, University of Iceland, Sturlugata 8, Reykjavík, IS-101, Iceland. 81 Geisinger Research, Biomedical and Translational Informatics Institute, Rockville, MD, USA. 82 Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland. 83 Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. 84 Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore. 85 Deutsches Herzzentrum München, Technische Universität München, Munich, Germany. 86 DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany. 87 Institute of Epidemiology and Biostatistics, University of Ulm, Ulm, Germany. 88 Integrated Research and Treatment Centre Adiposity Diseases, University of Leipzig, Leipzig, Germany. 89 Division of Nephrology and Hypertension, Loyola University Chicago, Chicago, IL, USA. 90 5th Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. 91 Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria. 92 Division of Biomedical Informatics and Personalized Medicine, School of Medicine, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, USA. 93 Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. 94 Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. 95 Institute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany. 96 Diabetes Centre, Khoo Teck Puat Hospital, Singapore, Singapore. 97 Cardiovascular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. 98 Nuffield Department of Medicine, University of Oxford, Oxford, UK. 99 Broad Institute of Harvard and MIT, Cambridge, MA, USA. 100 Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore. 101 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. 102 Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. 103 MRL, Merck & Co., Inc., Kenilworth, NJ, USA. 104 Celgene Inc., Cambridge, MA, USA. 105 Vanderbilt University School of Medicine, Nashville, TN, USA. 106 Independent Research Group Clinical Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany. 107 Chair of Epidemiology Ludwig- Maximilians-Universität München at UNIKA-T Augsburg, Augsburg, Germany. 108 Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany. 109 Institute of Human Genetics, Technische Universität München, Munich, Germany. 110 Department of Public Health and Primary Care, Leiden University Medical Centre, Leiden, The Netherlands. 111 Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany. 112 Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU, Munich, Germany. 113 Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, Germany. 114 Centre for Public Health Genomics, University of Virginia, Charlottesville, VA, USA. 115 Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany. 116 Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland. 117 Department of Cardiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. 118 Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. 119 Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Centre, Leiden, The Netherlands. 120 University of Maryland School of Medicine, Baltimore, MD, USA. 121 Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland. 122 Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA. 123 Institute of Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany. 124 German Center for Diabetes Research (DZD), Neuherberg, Germany. 125 Service de Néphrologie, Geneva University Hospitals, Geneva, Switzerland. 126 Einthoven Laboratory of Experimental Vascular Research, Leiden University Medical Centre, Leiden, The Netherlands. 127 Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. 128 Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany. 129 Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. 130 Biogen Inc., Cambridge, MA, USA. 131 Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA. 132 Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany. 133 Duke-NUS Medical School, Singapore, Singapore. 134 The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. 135 Heart Centre Leipzig, Leipzig, Germany. 136 Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany. 137 CRCHUM, Montreal, QC, Canada. 138 Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 139 Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 140 Durrer Centre for Cardiovascular Research, The Netherlands Heart Institute, Utrecht, The Netherlands. 141 Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany. 142 Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany. 143 School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 144 Vanderbilt University Medical Centre, Division of Nephrology & Hypertension, Nashville, TN, USA. 145 Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan. 146 Anatomic Pathology, University of Washington Medical Center, Seattle, WA, USA. 147 Department of Nephrology, Diabetology and Rheumatology, Kliniken Südostbayern, Traunstein, Germany. 148 Institute of Physiology, University of Zurich, Zurich, Switzerland. 149 Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Centre, Nashville, TN, USA. 150 Department of Veteran's Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA. 151 Kidney Health Research Institute (KHRI), Geisinger, Danville, PA, USA. 152 Department of Nephrology, Geisinger, Danville, PA, USA. 153 Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. 154 Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. 155 Geisinger Research, Biomedical and Translational Informatics Institute, Danville, PA, USA. 156 Cardiovascular Health Research Unit, Department of Medicine, Department of Epidemiology, Department of Health Service, University of Washington, Seattle, WA, USA. 157 Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA. 158 Department of Pediatrics, Harbor-UCLA Medical Centre, Torrance, CA, USA. 159 Department of Medicine, Harbor-UCLA Medical Centre, Torrance, CA, USA. 160 Department of Physiology and Biophysics, University of Mississippi Medical Centre, Jackson, MS, USA. 161 National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK. 162 Eurac Research, Institute for Biomedicine (affiliated to the University of Lübeck), Bolzano, Italy. cristian.pattaro@eurac.edu. 163 Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany. anna.koettgen@uniklinik-freiburg.de. 164 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. anna.koettgen@uniklinik-freiburg.de

المصدر: Nature communications

مصطلحات موضوعية: Nýrnasjúkdómar, Prótín, Þvag, Albuminuria, Kidney Diseases

العلاقة: https://www.nature.com/articles/s41467-019-11576-0Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739370Test/; Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria. 2019, 10(1):4130 Nat Commun; http://hdl.handle.net/2336/621103Test; Nature Communications

الإتاحة: https://doi.org/10.1038/s41467-019-11576-0Test
http://hdl.handle.net/2336/621103Test

المؤلفون: Wuttke, Matthias, Li, Yong, Li, Man, Sieber, Karsten B, Feitosa, Mary F, Gorski, Mathias, Tin, Adrienne, Wang, Lihua, Chu, Audrey Y, Hoppmann, Anselm, Kirsten, Holger, Giri, Ayush, Chai, Jin-Fang, Sveinbjornsson, Gardar, Tayo, Bamidele O, Nutile, Teresa, Fuchsberger, Christian, Marten, Jonathan, Cocca, Massimiliano, Ghasemi, Sahar, Xu, Yizhe, Horn, Katrin, Noce, Damia, van der Most, Peter J, Sedaghat, Sanaz, Yu, Zhi, Akiyama, Masato, Afaq, Saima, Ahluwalia, Tarunveer S, Almgren, Peter, Amin, Najaf, Ärnlöv, Johan, Bakker, Stephan J L, Bansal, Nisha, Baptista, Daniela, Bergmann, Sven, Biggs, Mary L, Biino, Ginevra, Boehnke, Michael, Boerwinkle, Eric, Boissel, Mathilde, Bottinger, Erwin P, Boutin, Thibaud S, Brenner, Hermann, Brumat, Marco, Burkhardt, Ralph, Butterworth, Adam S, Campana, Eric, Campbell, Archie, Campbell, Harry, Canouil, Mickaël, Carroll, Robert J, Catamo, Eulalia, Chambers, John C, Chee, Miao-Ling, Chee, Miao-Li, Chen, Xu, Cheng, Ching-Yu, Cheng, Yurong, Christensen, Kaare, Cifkova, Renata, Ciullo, Marina, Concas, Maria Pina, Cook, James P, Coresh, Josef, Corre, Tanguy, Sala, Cinzia Felicita, Cusi, Daniele, Danesh, John, Daw, E Warwick, de Borst, Martin H, De Grandi, Alessandro, de Mutsert, Renée, de Vries, Aiko P J, Degenhardt, Frauke, Delgado, Graciela, Demirkan, Ayse, Di Angelantonio, Emanuele, Dittrich, Katalin, Divers, Jasmin, Dorajoo, Rajkumar, Eckardt, Kai-Uwe, Ehret, Georg, Elliott, Paul, Endlich, Karlhans, Evans, Michele K, Felix, Janine F, Foo, Valencia Hui Xian, Franco, Oscar H, Franke, Andre, Freedman, Barry I, Freitag-Wolf, Sandra, Friedlander, Yechiel, Froguel, Philippe, Gansevoort, Ron T, Gao, He, Gasparini, Paolo, Gaziano, J Michael, Giedraitis, Vilmantas, Gieger, Christian, Girotto, Giorgia, Giulianini, Franco, Gögele, Martin, Gordon, Scott D, Gudbjartsson, Daniel F, Gudnason, Vilmundur, Haller, Toomas, Hamet, Pavel, Harris, Tamara B, Hartman, Catharina A, Hayward, Caroline, Hellwege, Jacklyn N, Heng, Chew-Kiat, Hicks, Andrew A, Hofer, Edith, Huang, Wei, Hutri-Kähönen, Nina, Hwang, Shih-Jen, Ikram, M Arfan, Indridason, Olafur S, Ingelsson, Erik, Ising, Marcus, Jaddoe, Vincent W V, Jakobsdottir, Johanna, Jonas, Jost B, Joshi, Peter K, Josyula, Navya Shilpa, Jung, Bettina, Kähönen, Mika, Kamatani, Yoichiro, Kammerer, Candace M, Kanai, Masahiro, Kastarinen, Mika, Kerr, Shona M, Khor, Chiea-Chuen, Kiess, Wieland, Kleber, Marcus E, Koenig, Wolfgang, Kooner, Jaspal S, Körner, Antje, Kovacs, Peter, Kraja, Aldi T, Krajcoviechova, Alena, Kramer, Holly, Krämer, Bernhard K, Kronenberg, Florian, Kubo, Michiaki, Kühnel, Brigitte, Kuokkanen, Mikko, Kuusisto, Johanna, La Bianca, Martina, Laakso, Markku, Lange, Leslie A, Langefeld, Carl D, Lee, Jeannette Jen-Mai, Lehne, Benjamin, Lehtimäki, Terho, Lieb, Wolfgang, Lim, Su-Chi, Lind, Lars, Lindgren, Cecilia M, Liu, Jun, Liu, Jianjun, Loeffler, Markus, Loos, Ruth J F, Lucae, Susanne, Lukas, Mary Ann, Lyytikäinen, Leo-Pekka, Mägi, Reedik, Magnusson, Patrik K E, Mahajan, Anubha, Martin, Nicholas G, Martins, Jade, März, Winfried, Mascalzoni, Deborah, Matsuda, Koichi, Meisinger, Christa, Meitinger, Thomas, Melander, Olle, Metspalu, Andres, Mikaelsdottir, Evgenia K, Milaneschi, Yuri, Miliku, Kozeta, Mishra, Pashupati P, Mohlke, Karen L, Mononen, Nina, Montgomery, Grant W, Mook-Kanamori, Dennis O, Mychaleckyj, Josyf C, Nadkarni, Girish N, Nalls, Mike A, Nauck, Matthias, Nikus, Kjell, Ning, Boting, Nolte, Ilja M, Noordam, Raymond, O'Connell, Jeffrey, O'Donoghue, Michelle L, Olafsson, Isleifur, Oldehinkel, Albertine J, Orho-Melander, Marju, Ouwehand, Willem H, Padmanabhan, Sandosh, Palmer, Nicholette D, Palsson, Runolfur, Penninx, Brenda W J H, Perls, Thomas, Perola, Markus, Pirastu, Mario, Pirastu, Nicola, Pistis, Giorgio, Podgornaia, Anna I, Polasek, Ozren, Ponte, Belen, Porteous, David J, Poulain, Tanja, Pramstaller, Peter P, Preuss, Michael H, Prins, Bram P, Province, Michael A, Rabelink, Ton J, Raffield, Laura M, Raitakari, Olli T, Reilly, Dermot F, Rettig, Rainer, Rheinberger, Myriam, Rice, Kenneth M, Ridker, Paul M, Rivadeneira, Fernando, Rizzi, Federica, Roberts, David J, Robino, Antonietta, Rossing, Peter, Rudan, Igor, Rueedi, Rico, Ruggiero, Daniela, Ryan, Kathleen A, Saba, Yasaman, Sabanayagam, Charumathi, Salomaa, Veikko, Salvi, Erika, Saum, Kai-Uwe, Schmidt, Helena, Schmidt, Reinhold, Schöttker, Ben, Schulz, Christina-Alexandra, Schupf, Nicole, Shaffer, Christian M, Shi, Yuan, Smith, Albert V, Smith, Blair H, Soranzo, Nicole, Spracklen, Cassandra N, Strauch, Konstantin, Stringham, Heather M, Stumvoll, Michael, Svensson, Per O, Szymczak, Silke, Tai, E-Shyong, Tajuddin, Salman M, Tan, Nicholas Y Q, Taylor, Kent D, Teren, Andrej, Tham, Yih-Chung, Thiery, Joachim, Thio, Chris H L, Thomsen, Hauke, Thorleifsson, Gudmar, Toniolo, Daniela, Tönjes, Anke, Tremblay, Johanne, Tzoulaki, Ioanna, Uitterlinden, André G, Vaccargiu, Simona, van Dam, Rob M, van der Harst, Pim, van Duijn, Cornelia M, Velez Edward, Digna R, Verweij, Niek, Vogelezang, Suzanne, Völker, Uwe, Vollenweider, Peter, Waeber, Gerard, Waldenberger, Melanie, Wallentin, Lars, Wang, Ya Xing, Wang, Chaolong, Waterworth, Dawn M, Bin Wei, Wen, White, Harvey, Whitfield, John B, Wild, Sarah H, Wilson, James F, Wojczynski, Mary K, Wong, Charlene, Wong, Tien-Yin, Xu, Liang, Yang, Qiong, Yasuda, Masayuki, Yerges-Armstrong, Laura M, Zhang, Weihua, Zonderman, Alan B, Rotter, Jerome I, Bochud, Murielle, Psaty, Bruce M, Vitart, Veronique, Wilson, James G, Dehghan, Abbas, Parsa, Afshin, Chasman, Daniel I, Ho, Kevin, Morris, Andrew P, Devuyst, Olivier, Akilesh, Shreeram, Pendergrass, Sarah A, Sim, Xueling, Böger, Carsten A, Okada, Yukinori, Edwards, Todd L, Snieder, Harold, Stefansson, Kari, Hung, Adriana M, Heid, Iris M, Scholz, Markus, Teumer, Alexander, Köttgen, Anna, Pattaro, Cristian

المساهمون: 1 Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. 2 Renal Division, Department of Medicine IV, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. 3 Division of Nephrology and Hypertension, Department of Medicine, University of Utah, Salt Lake City, USA. 4 Target Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA. 5 Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. 6 Department of Nephrology, University Hospital Regensburg, Regensburg, Germany. 7 Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. 8 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 9 Welch Center for Prevention, Epidemiology and Clinical Research, Baltimore, MD, USA. 10 Genetics, Merck & Co., Inc, Kenilworth, NJ, USA. 11 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. 12 LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. 13 Division of Quantitative Sciences, Department of Obstetrics & Gynecology, Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA. 14 Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA. 15 Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore. 16 deCODE Genetics/Amgen, Inc., Reykjavik, Iceland. 17 Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA. 18 Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy. 19 Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy. 20 Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. 21 Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy. 22 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. 23 DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. 24 Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. 25 Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. 26 Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 27 Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan. 28 Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 29 Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK. 30 Institute of Public Health & Social Sciences, Khyber Medical University, Peshawar, Pakistan. 31 Steno Diabetes Center Copenhagen, Gentofte, Denmark. 32 Diabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clincial Sciences in Malmö, Lund University, Malmö, Sweden. 33 Division of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. 34 School of Health and Social Studies, Dalarna University, Stockholm, Sweden. 35 Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. 36 Division of Nephrology, University of Washington, Seattle, WA, USA. 37 Kidney Research Institute, University of Washington, Seattle, WA, USA. 38 Cardiology, Geneva University Hospitals, Geneva, Switzerland. 39 Department of Computational Biology, University of Lausanne, Lausanne, Switzerland. 40 Swiss Institute of Bioinformatics, Lausanne, Switzerland. 41 Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa. 42 Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. 43 Department of Biostatistics, University of Washington, Seattle, WA, USA. 44 Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy. 45 Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. 46 Human Genetics Center, University of Texas Health Science Center, Houston, TX, USA. 47 CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France. 48 Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 49 Digital Health Center, Hasso Plattner Institute and University of Potsdam, Potsdam, Germany. 50 Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. 51 Network Aging Research, University of Heidelberg, Heidelberg, Germany. 52 Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy. 53 Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany. 54 Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany. 55 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 56 National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK. 57 Center for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. 58 Center for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. 59 Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA. 60 Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. 61 Department of Cardiology, Ealing Hospital, Middlesex, UK. 62 Imperial College Healthcare NHS Trust, Imperial College London, London, UK. 63 MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK. 64 Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore. 65 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. 66 Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore. 67 Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore. 68 Unit of Epidemiology, Biostatistics and Biodemography, Department of Public Health, Southern Denmark University, Odense, Denmark. 69 Center for Cardiovascular Prevention, Charles University in Prague, First Faculty of Medicine and Thomayer Hospital, Prague, Czech Republic. 70 Department of Medicine II, Charles University in Prague, First Faculty of Medicine, Prague, Czech Republic. 71 IRCCS Neuromed, Pozzilli, Italy. 72 Department of Biostatistics, University of Liverpool, Liverpool, UK. 73 Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland. 74 San Raffaele Research Institute, Milan, Italy. 75 Institute of Biomedical Technologies, National Research Council of Italy, Milan, Italy. 76 Bio4Dreams-Business Nursery for Life Sciences, Milan, Italy. 77 Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK. 78 Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands. 79 Section of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands. 80 Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany. 81 Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. 82 Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 83 NHS Blood and Transplant, Cambridge, UK. 84 Department of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany. 85 Center for Pediatric Research, University of Leipzig, Leipzig, Germany. 86 Public Health Sciences-Biostatistics, Wake Forest School of Medicine, Winston-Salem, NC, USA. 87 Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore. 88 Intensive Care Medicine, Charité, Berlin, Germany. 89 Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany. 90 Department of Epidemiology and Biostatistics, MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK. 91 Imperial College NIHR Biomedical Research Center, Imperial College London, London, UK. 92 Dementia Research Institute, Imperial College London, London, UK. 93 Health Data Research UK-London, London, UK. 94 Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany. 95 Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Baltimore, MD, USA. 96 Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. 97 Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. 98 Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland. 99 Section on Nephrology, Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. 100 Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany. 101 School of Public Health and Community Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. 102 Department of Genomics of Common Disease, Imperial College London, London, UK. 103 Massachusetts Veterans Epidemiology Research and Information Center, VA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA, USA. 104 Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. 105 Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. 106 Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. 107 German Center for Diabetes Research (DZD), Neuherberg, Germany. 108 Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA. 109 QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. 110 Icelandic Heart Association, Kopavogur, Iceland. 111 Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. 112 Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia. 113 Montreal University Hospital Research Center, CHUM, Montreal, Quebec, Canada. 114 Medpharmgene, Montreal, Quebec, Canada. 115 Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Bethesda, MD, USA. 116 Interdisciplinary Center of Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. 117 Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA. 118 Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA. 119 Department of Veteran's Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA. 120 Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. 121 Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore. 122 Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria. 123 Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria. 124 Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center, Shanghai, China. 125 Shanghai Industrial Technology Institute, Shanghai, China. 126 Department of Pediatrics, Tampere University Hospital, Tampere, Finland. 127 Department of Pediatrics, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. 128 NHLBI's Framingham Heart Study, Framingham, MA, USA. 129 The Center for Population Studies, NHLBI, Framingham, MA, USA. 130 Division of Nephrology, Internal Medicine Services, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland. 131 Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. 132 Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA. 133 Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. 134 Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA. 135 Max Planck Institute of Psychiatry, Munich, Germany. 136 The Center of Public Health Sciences, University of Iceland, Reykjavík, Iceland. 137 Department of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany. 138 Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing, China. 139 Geisinger Research, Biomedical and Translational Informatics Institute, Rockville, MD, USA. 140 Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland. 141 Department of Clinical Physiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. 142 Kyoto-McGill International Collaborative School in Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. 143 Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. 144 Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. 145 Department of Medicine, Kuopio University Hospital, Kuopio, Finland. 146 Deutsches Herzzentrum München, Technische Universität München, Munich, Germany. 147 DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany. 148 Institute of Epidemiology and Biostatistics, University of Ulm, Ulm, Germany. 149 National Heart and Lung Institute, Imperial College London, London, UK. 150 Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Leipzig, Germany. 151 Division of Nephrology and Hypertension, Loyola University Chicago, Chicago, IL, USA. 152 Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria. 153 RIKEN Center for Integrative Medical Sciences (IMS), Yokohama (Kanagawa), Japan. 154 The Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland. 155 Diabetes and Obesity Research Program, University of Helsinki, Helsinki, Finland. 156 Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland. 157 Division of Biomedical Informatics and Personalized Medicine, School of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, CO, USA. 158 Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. 159 Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. 160 Institute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany. 161 Diabetes Center, Khoo Teck Puat Hospital, Singapore, Singapore. 162 Cardiovascular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. 163 Nuffield Department of Medicine, University of Oxford, Oxford, UK. 164 Broad Institute of Harvard and MIT, Cambridge, MA, USA. 165 Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore. 166 The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 167 Target Sciences-Genetics, GlaxoSmithKline, Albuquerque, NM, USA. 168 Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK. 169 Oxford Center for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. 170 Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany. 171 Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany. 172 Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria. 173 Medical Clinic V, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. 174 Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan. 175 Independent Research Group Clinical Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. 176 Chair of Epidemiology, Ludwig- Maximilians-Universität München at UNIKA-T Augsburg, Augsburg, Germany. 177 Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany. 178 Institute of Human Genetics, Technische Universität München, Munich, Germany. 179 Hypertension and Cardiovascular Disease, Department of Clincial Sciences Malmö, Lund University, Malmö, Sweden. 180 Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands. 181 Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. 182 Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland, Australia. 183 Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands. 184 Center for Public Health Genomics, University of Virginia, Charlottesville, Charlottesville, VA, USA. 185 Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 186 Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. 187 Data Tecnica International, Glen Echo, MD, USA. 188 Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany. 189 Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland. 190 Department of Cardiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, Tampere University, Tampere, Finland. 191 Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. 192 Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands. 193 University of Maryland School of Medicine, Baltimore, MD, USA. 194 Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA. 195 TIMI Study Group, Boston, MA, USA. 196 Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland. 197 Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. 198 Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA. 199 Department of Medicine, Geriatrics Section, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA. 200 National Institute for Health and Welfare, Helsinki, Finland. 201 Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Li Punti, Sassari, Italy. 202 Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland. 203 Faculty of Medicine, University of Split, Split, Croatia. 204 Gen-info Ltd, Zagreb, Croatia. 205 Service de Néphrologie, Geneva University Hospitals, Geneva, Switzerland. 206 Center for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. 207 Einthoven Laboratory of Experimental Vascular Research, Leiden University Medical Center, Leiden, the Netherlands. 208 Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. 209 Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. 210 Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany. 211 Harvard Medical School, Boston, MA, USA. 212 Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. 213 Department of Health Sciences, University of Milan, Milano, Italy. 214 ePhood Scientific Unit, ePhood SRL, Milano, Italy. 215 NHS Blood and Transplant, BRC Oxford Haematology Theme, Nuffield Division of Clinical Laboratory Sciences, University of Oxford, Oxford, UK. 216 Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA. 217 Molecular Biology and Biochemistry, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria. 218 Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy. 219 Institute of Molecular Biology and Biochemistry, Center for Molecular Medicine, Medical University of Graz, Graz, Austria. 220 Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA. 221 Gertrude H. Sergievsky Center, Columbia University Medical Center, New York, NY, USA. 222 Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, USA. 223 Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK. 224 Human Genetics, Wellcome Sanger Institute, Hinxton, UK. 225 Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. 226 Chair of Genetic Epidemiology, IBE, Faculty of Medicine, Ludwig-Maximilians-Universität München, München, Germany. 227 Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany. 228 Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden. 229 Department of Cardiology, Södersjukhuset, Stockholm, Sweden. 230 Duke-NUS Medical School, Singapore, Singapore. 231 The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. 232 Heart Center Leipzig, Leipzig, Germany. 233 Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. 234 CRCHUM, Montreal, Canada. 235 Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece. 236 Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. 237 Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. 238 Durrer Center for Cardiovascular Research, The Netherlands Heart Institute, Utrecht, the Netherlands. 239 Department of Obstetrics and Gynecology, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA. 240 Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany. 241 Internal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland. 242 Cardiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. 243 Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden. 244 School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 245 Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China. 246 Green Lane Cardiovascular Service, Auckland City Hospital and University of Auckland, Auckland, New Zealand. 247 Center for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. 248 Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan. 249 Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA. 250 Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA. 251 Cardiovascular Health Research Unit, Department of Medicine, Department of Epidemiology, Department of Health Service, University of Washington, Seattle, WA, USA. 252 Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA. 253 Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA. 254 Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. 255 Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. 256 Kidney Health Research Institute (KHRI), Geisinger, Danville, PA, USA. 257 Department of Nephrology, Geisinger, Danville, PA, USA. 258 Institute of Physiology, University of Zurich, Zurich, Switzerland. 259 Anatomic Pathology, University of Washington Medical Center, Seattle, WA, USA. 260 Geisinger Research, Biomedical and Translational Informatics Institute, Danville, PA, USA. 261 Department of Nephrology and Rheumatology, Kliniken Südostbayern, Regensburg, Germany. 262 Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Osaka, Japan. 263 Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan. 264 Vanderbilt University Medical Center, Division of Nephrology & Hypertension, Nashville, TN, USA. 265 Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. anna.koettgen@uniklinik-freiburg.de. 266 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. anna.koettgen@uniklinik-freiburg.de. 267 Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy. cristian.pattaro@eurac.edu

المصدر: Nature genetics

مصطلحات موضوعية: Nýrnasjúkdómar, Gen, Kidney Function Tests, Chromosome Mapping, Genome-Wide Association Study, Renal Insufficiency, Genetic Predisposition to Disease

العلاقة: https://www.nature.com/articles/s41588-019-0407-xTest; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698888Test/; A catalog of genetic loci associated with kidney function from analyses of a million individuals. 2019, 51(6): 957-972 Nat Genet; http://hdl.handle.net/2336/621022Test; Nature Genetics

الإتاحة: https://doi.org/10.1038/s41588-019-0407-xTest
http://hdl.handle.net/2336/621022Test

المؤلفون: Wuttke, Matthias, Li, Yong, Li, Man, Sieber, Karsten B, Feitosa, Mary F, Gorski, Mathias, Tin, Adrienne, Wang, Lihua, Chu, Audrey Y, Hoppmann, Anselm, Kirsten, Holger, Giri, Ayush, Chai, Jin-Fang, Sveinbjornsson, Gardar, Tayo, Bamidele O, Nutile, Teresa, Fuchsberger, Christian, Marten, Jonathan, Cocca, Massimiliano, Ghasemi, Sahar, Xu, Yizhe, Horn, Katrin, Noce, Damia, van der Most, Peter J, Sedaghat, Sanaz, Yu, Zhi, Akiyama, Masato, Afaq, Saima, Ahluwalia, Tarunveer S, Almgren, Peter, Amin, Najaf, Ärnlöv, Johan, Bakker, Stephan J L, Bansal, Nisha, Baptista, Daniela, Bergmann, Sven, Biggs, Mary L, Biino, Ginevra, Boehnke, Michael, Boerwinkle, Eric, Boissel, Mathilde, Bottinger, Erwin P, Boutin, Thibaud S, Brenner, Hermann, Brumat, Marco, Burkhardt, Ralph, Butterworth, Adam S, Campana, Eric, Campbell, Archie, Campbell, Harry, Canouil, Mickaël, Carroll, Robert J, Catamo, Eulalia, Chambers, John C, Chee, Miao-Ling, Chee, Miao-Li, Chen, Xu, Cheng, Ching-Yu, Cheng, Yurong, Christensen, Kaare, Cifkova, Renata, Ciullo, Marina, Concas, Maria Pina, Cook, James P, Coresh, Josef, Corre, Tanguy, Sala, Cinzia Felicita, Cusi, Daniele, Danesh, John, Daw, E Warwick, de Borst, Martin H, De Grandi, Alessandro, de Mutsert, Renée, de Vries, Aiko P J, Degenhardt, Frauke, Delgado, Graciela, Demirkan, Ayse, Di Angelantonio, Emanuele, Dittrich, Katalin, Divers, Jasmin, Dorajoo, Rajkumar, Eckardt, Kai-Uwe, Ehret, Georg, Elliott, Paul, Endlich, Karlhans, Evans, Michele K, Felix, Janine F, Foo, Valencia Hui Xian, Franco, Oscar H, Franke, Andre, Freedman, Barry I, Freitag-Wolf, Sandra, Friedlander, Yechiel, Froguel, Philippe, Gansevoort, Ron T, Gao, He, Gasparini, Paolo, Gaziano, J Michael, Giedraitis, Vilmantas, Gieger, Christian, Girotto, Giorgia, Giulianini, Franco, Gögele, Martin, Gordon, Scott D, Gudbjartsson, Daniel F, Gudnason, Vilmundur, Haller, Toomas, Hamet, Pavel, Harris, Tamara B, Hartman, Catharina A, Hayward, Caroline, Hellwege, Jacklyn N, Heng, Chew-Kiat, Hicks, Andrew A, Hofer, Edith, Huang, Wei, Hutri-Kähönen, Nina, Hwang, Shih-Jen, Ikram, M Arfan, Indridason, Olafur S, Ingelsson, Erik, Ising, Marcus, Jaddoe, Vincent W V, Jakobsdottir, Johanna, Jonas, Jost B, Joshi, Peter K, Josyula, Navya Shilpa, Jung, Bettina, Kähönen, Mika, Kamatani, Yoichiro, Kammerer, Candace M, Kanai, Masahiro, Kastarinen, Mika, Kerr, Shona M, Khor, Chiea-Chuen, Kiess, Wieland, Kleber, Marcus E, Koenig, Wolfgang, Kooner, Jaspal S, Körner, Antje, Kovacs, Peter, Kraja, Aldi T, Krajcoviechova, Alena, Kramer, Holly, Krämer, Bernhard K, Kronenberg, Florian, Kubo, Michiaki, Kühnel, Brigitte, Kuokkanen, Mikko, Kuusisto, Johanna, La Bianca, Martina, Laakso, Markku, Lange, Leslie A, Langefeld, Carl D, Lee, Jeannette Jen-Mai, Lehne, Benjamin, Lehtimäki, Terho, Lieb, Wolfgang, Lim, Su-Chi, Lind, Lars, Lindgren, Cecilia M, Liu, Jun, Liu, Jianjun, Loeffler, Markus, Loos, Ruth J F, Lucae, Susanne, Lukas, Mary Ann, Lyytikäinen, Leo-Pekka, Mägi, Reedik, Magnusson, Patrik K E, Mahajan, Anubha, Martin, Nicholas G, Martins, Jade, März, Winfried, Mascalzoni, Deborah, Matsuda, Koichi, Meisinger, Christa, Meitinger, Thomas, Melander, Olle, Metspalu, Andres, Mikaelsdottir, Evgenia K, Milaneschi, Yuri, Miliku, Kozeta, Mishra, Pashupati P, Mohlke, Karen L, Mononen, Nina, Montgomery, Grant W, Mook-Kanamori, Dennis O, Mychaleckyj, Josyf C, Nadkarni, Girish N, Nalls, Mike A, Nauck, Matthias, Nikus, Kjell, Ning, Boting, Nolte, Ilja M, Noordam, Raymond, O'Connell, Jeffrey, O'Donoghue, Michelle L, Olafsson, Isleifur, Oldehinkel, Albertine J, Orho-Melander, Marju, Ouwehand, Willem H, Padmanabhan, Sandosh, Palmer, Nicholette D, Palsson, Runolfur, Penninx, Brenda W J H, Perls, Thomas, Perola, Markus, Pirastu, Mario, Pirastu, Nicola, Pistis, Giorgio, Podgornaia, Anna I, Polasek, Ozren, Ponte, Belen, Porteous, David J, Poulain, Tanja, Pramstaller, Peter P, Preuss, Michael H, Prins, Bram P, Province, Michael A, Rabelink, Ton J, Raffield, Laura M, Raitakari, Olli T, Reilly, Dermot F, Rettig, Rainer, Rheinberger, Myriam, Rice, Kenneth M, Ridker, Paul M, Rivadeneira, Fernando, Rizzi, Federica, Roberts, David J, Robino, Antonietta, Rossing, Peter, Rudan, Igor, Rueedi, Rico, Ruggiero, Daniela, Ryan, Kathleen A, Saba, Yasaman, Sabanayagam, Charumathi, Salomaa, Veikko, Salvi, Erika, Saum, Kai-Uwe, Schmidt, Helena, Schmidt, Reinhold, Schöttker, Ben, Schulz, Christina-Alexandra, Schupf, Nicole, Shaffer, Christian M, Shi, Yuan, Smith, Albert V, Smith, Blair H, Soranzo, Nicole, Spracklen, Cassandra N, Strauch, Konstantin, Stringham, Heather M, Stumvoll, Michael, Svensson, Per O, Szymczak, Silke, Tai, E-Shyong, Tajuddin, Salman M, Tan, Nicholas Y Q, Taylor, Kent D, Teren, Andrej, Tham, Yih-Chung, Thiery, Joachim, Thio, Chris H L, Thomsen, Hauke, Thorleifsson, Gudmar, Toniolo, Daniela, Tönjes, Anke, Tremblay, Johanne, Tzoulaki, Ioanna, Uitterlinden, André G, Vaccargiu, Simona, van Dam, Rob M, van der Harst, Pim, van Duijn, Cornelia M, Velez Edward, Digna R, Verweij, Niek, Vogelezang, Suzanne, Völker, Uwe, Vollenweider, Peter, Waeber, Gerard, Waldenberger, Melanie, Wallentin, Lars, Wang, Ya Xing, Wang, Chaolong, Waterworth, Dawn M, Bin Wei, Wen, White, Harvey, Whitfield, John B, Wild, Sarah H, Wilson, James F, Wojczynski, Mary K, Wong, Charlene, Wong, Tien-Yin, Xu, Liang, Yang, Qiong, Yasuda, Masayuki, Yerges-Armstrong, Laura M, Zhang, Weihua, Zonderman, Alan B, Rotter, Jerome I, Bochud, Murielle, Psaty, Bruce M, Vitart, Veronique, Wilson, James G, Dehghan, Abbas, Parsa, Afshin, Chasman, Daniel I, Ho, Kevin, Morris, Andrew P, Devuyst, Olivier, Akilesh, Shreeram, Pendergrass, Sarah A, Sim, Xueling, Böger, Carsten A, Okada, Yukinori, Edwards, Todd L, Snieder, Harold, Stefansson, Kari, Hung, Adriana M, Heid, Iris M, Scholz, Markus, Teumer, Alexander, Köttgen, Anna, Pattaro, Cristian

المساهمون: 1 Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. 2 Renal Division, Department of Medicine IV, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. 3 Division of Nephrology and Hypertension, Department of Medicine, University of Utah, Salt Lake City, USA. 4 Target Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA. 5 Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. 6 Department of Nephrology, University Hospital Regensburg, Regensburg, Germany. 7 Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. 8 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 9 Welch Center for Prevention, Epidemiology and Clinical Research, Baltimore, MD, USA. 10 Genetics, Merck & Co., Inc, Kenilworth, NJ, USA. 11 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. 12 LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. 13 Division of Quantitative Sciences, Department of Obstetrics & Gynecology, Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA. 14 Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA. 15 Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore. 16 deCODE Genetics/Amgen, Inc., Reykjavik, Iceland. 17 Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA. 18 Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy. 19 Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy. 20 Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. 21 Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy. 22 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. 23 DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. 24 Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. 25 Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. 26 Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 27 Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan. 28 Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 29 Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK. 30 Institute of Public Health & Social Sciences, Khyber Medical University, Peshawar, Pakistan. 31 Steno Diabetes Center Copenhagen, Gentofte, Denmark. 32 Diabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clincial Sciences in Malmö, Lund University, Malmö, Sweden. 33 Division of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. 34 School of Health and Social Studies, Dalarna University, Stockholm, Sweden. 35 Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. 36 Division of Nephrology, University of Washington, Seattle, WA, USA. 37 Kidney Research Institute, University of Washington, Seattle, WA, USA. 38 Cardiology, Geneva University Hospitals, Geneva, Switzerland. 39 Department of Computational Biology, University of Lausanne, Lausanne, Switzerland. 40 Swiss Institute of Bioinformatics, Lausanne, Switzerland. 41 Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa. 42 Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. 43 Department of Biostatistics, University of Washington, Seattle, WA, USA. 44 Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy. 45 Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. 46 Human Genetics Center, University of Texas Health Science Center, Houston, TX, USA. 47 CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France. 48 Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 49 Digital Health Center, Hasso Plattner Institute and University of Potsdam, Potsdam, Germany. 50 Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. 51 Network Aging Research, University of Heidelberg, Heidelberg, Germany. 52 Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy. 53 Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany. 54 Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany. 55 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 56 National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK. 57 Center for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. 58 Center for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. 59 Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA. 60 Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. 61 Department of Cardiology, Ealing Hospital, Middlesex, UK. 62 Imperial College Healthcare NHS Trust, Imperial College London, London, UK. 63 MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK. 64 Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore. 65 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. 66 Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore. 67 Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore. 68 Unit of Epidemiology, Biostatistics and Biodemography, Department of Public Health, Southern Denmark University, Odense, Denmark. 69 Center for Cardiovascular Prevention, Charles University in Prague, First Faculty of Medicine and Thomayer Hospital, Prague, Czech Republic. 70 Department of Medicine II, Charles University in Prague, First Faculty of Medicine, Prague, Czech Republic. 71 IRCCS Neuromed, Pozzilli, Italy. 72 Department of Biostatistics, University of Liverpool, Liverpool, UK. 73 Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland. 74 San Raffaele Research Institute, Milan, Italy. 75 Institute of Biomedical Technologies, National Research Council of Italy, Milan, Italy. 76 Bio4Dreams-Business Nursery for Life Sciences, Milan, Italy. 77 Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK. 78 Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands. 79 Section of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands. 80 Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany. 81 Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. 82 Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 83 NHS Blood and Transplant, Cambridge, UK. 84 Department of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany. 85 Center for Pediatric Research, University of Leipzig, Leipzig, Germany. 86 Public Health Sciences-Biostatistics, Wake Forest School of Medicine, Winston-Salem, NC, USA. 87 Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore. 88 Intensive Care Medicine, Charité, Berlin, Germany. 89 Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany. 90 Department of Epidemiology and Biostatistics, MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK. 91 Imperial College NIHR Biomedical Research Center, Imperial College London, London, UK. 92 Dementia Research Institute, Imperial College London, London, UK. 93 Health Data Research UK-London, London, UK. 94 Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany. 95 Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Baltimore, MD, USA. 96 Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. 97 Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. 98 Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland. 99 Section on Nephrology, Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. 100 Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany. 101 School of Public Health and Community Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. 102 Department of Genomics of Common Disease, Imperial College London, London, UK. 103 Massachusetts Veterans Epidemiology Research and Information Center, VA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA, USA. 104 Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. 105 Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. 106 Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. 107 German Center for Diabetes Research (DZD), Neuherberg, Germany. 108 Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA. 109 QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. 110 Icelandic Heart Association, Kopavogur, Iceland. 111 Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. 112 Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia. 113 Montreal University Hospital Research Center, CHUM, Montreal, Quebec, Canada. 114 Medpharmgene, Montreal, Quebec, Canada. 115 Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Bethesda, MD, USA. 116 Interdisciplinary Center of Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. 117 Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA. 118 Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA. 119 Department of Veteran's Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA. 120 Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. 121 Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore. 122 Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria. 123 Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria. 124 Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center, Shanghai, China. 125 Shanghai Industrial Technology Institute, Shanghai, China. 126 Department of Pediatrics, Tampere University Hospital, Tampere, Finland. 127 Department of Pediatrics, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. 128 NHLBI's Framingham Heart Study, Framingham, MA, USA. 129 The Center for Population Studies, NHLBI, Framingham, MA, USA. 130 Division of Nephrology, Internal Medicine Services, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland. 131 Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. 132 Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA. 133 Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. 134 Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA. 135 Max Planck Institute of Psychiatry, Munich, Germany. 136 The Center of Public Health Sciences, University of Iceland, Reykjavík, Iceland. 137 Department of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany. 138 Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing, China. 139 Geisinger Research, Biomedical and Translational Informatics Institute, Rockville, MD, USA. 140 Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland. 141 Department of Clinical Physiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. 142 Kyoto-McGill International Collaborative School in Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. 143 Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. 144 Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. 145 Department of Medicine, Kuopio University Hospital, Kuopio, Finland. 146 Deutsches Herzzentrum München, Technische Universität München, Munich, Germany. 147 DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany. 148 Institute of Epidemiology and Biostatistics, University of Ulm, Ulm, Germany. 149 National Heart and Lung Institute, Imperial College London, London, UK. 150 Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Leipzig, Germany. 151 Division of Nephrology and Hypertension, Loyola University Chicago, Chicago, IL, USA. 152 Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria. 153 RIKEN Center for Integrative Medical Sciences (IMS), Yokohama (Kanagawa), Japan. 154 The Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland. 155 Diabetes and Obesity Research Program, University of Helsinki, Helsinki, Finland. 156 Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland. 157 Division of Biomedical Informatics and Personalized Medicine, School of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, CO, USA. 158 Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. 159 Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. 160 Institute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany. 161 Diabetes Center, Khoo Teck Puat Hospital, Singapore, Singapore. 162 Cardiovascular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. 163 Nuffield Department of Medicine, University of Oxford, Oxford, UK. 164 Broad Institute of Harvard and MIT, Cambridge, MA, USA. 165 Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore. 166 The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 167 Target Sciences-Genetics, GlaxoSmithKline, Albuquerque, NM, USA. 168 Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK. 169 Oxford Center for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. 170 Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany. 171 Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany. 172 Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria. 173 Medical Clinic V, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. 174 Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan. 175 Independent Research Group Clinical Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. 176 Chair of Epidemiology, Ludwig- Maximilians-Universität München at UNIKA-T Augsburg, Augsburg, Germany. 177 Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany. 178 Institute of Human Genetics, Technische Universität München, Munich, Germany. 179 Hypertension and Cardiovascular Disease, Department of Clincial Sciences Malmö, Lund University, Malmö, Sweden. 180 Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands. 181 Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. 182 Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland, Australia. 183 Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands. 184 Center for Public Health Genomics, University of Virginia, Charlottesville, Charlottesville, VA, USA. 185 Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 186 Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. 187 Data Tecnica International, Glen Echo, MD, USA. 188 Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany. 189 Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland. 190 Department of Cardiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, Tampere University, Tampere, Finland. 191 Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. 192 Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands. 193 University of Maryland School of Medicine, Baltimore, MD, USA. 194 Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA. 195 TIMI Study Group, Boston, MA, USA. 196 Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland. 197 Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. 198 Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA. 199 Department of Medicine, Geriatrics Section, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA. 200 National Institute for Health and Welfare, Helsinki, Finland. 201 Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Li Punti, Sassari, Italy. 202 Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland. 203 Faculty of Medicine, University of Split, Split, Croatia. 204 Gen-info Ltd, Zagreb, Croatia. 205 Service de Néphrologie, Geneva University Hospitals, Geneva, Switzerland. 206 Center for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. 207 Einthoven Laboratory of Experimental Vascular Research, Leiden University Medical Center, Leiden, the Netherlands. 208 Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. 209 Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. 210 Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany. 211 Harvard Medical School, Boston, MA, USA. 212 Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. 213 Department of Health Sciences, University of Milan, Milano, Italy. 214 ePhood Scientific Unit, ePhood SRL, Milano, Italy. 215 NHS Blood and Transplant, BRC Oxford Haematology Theme, Nuffield Division of Clinical Laboratory Sciences, University of Oxford, Oxford, UK. 216 Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA. 217 Molecular Biology and Biochemistry, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria. 218 Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy. 219 Institute of Molecular Biology and Biochemistry, Center for Molecular Medicine, Medical University of Graz, Graz, Austria. 220 Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA. 221 Gertrude H. Sergievsky Center, Columbia University Medical Center, New York, NY, USA. 222 Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, USA. 223 Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK. 224 Human Genetics, Wellcome Sanger Institute, Hinxton, UK. 225 Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. 226 Chair of Genetic Epidemiology, IBE, Faculty of Medicine, Ludwig-Maximilians-Universität München, München, Germany. 227 Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany. 228 Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden. 229 Department of Cardiology, Södersjukhuset, Stockholm, Sweden. 230 Duke-NUS Medical School, Singapore, Singapore. 231 The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. 232 Heart Center Leipzig, Leipzig, Germany. 233 Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. 234 CRCHUM, Montreal, Canada. 235 Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece. 236 Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. 237 Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. 238 Durrer Center for Cardiovascular Research, The Netherlands Heart Institute, Utrecht, the Netherlands. 239 Department of Obstetrics and Gynecology, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA. 240 Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany. 241 Internal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland. 242 Cardiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. 243 Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden. 244 School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 245 Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China. 246 Green Lane Cardiovascular Service, Auckland City Hospital and University of Auckland, Auckland, New Zealand. 247 Center for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. 248 Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan. 249 Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA. 250 Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA. 251 Cardiovascular Health Research Unit, Department of Medicine, Department of Epidemiology, Department of Health Service, University of Washington, Seattle, WA, USA. 252 Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA. 253 Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA. 254 Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. 255 Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. 256 Kidney Health Research Institute (KHRI), Geisinger, Danville, PA, USA. 257 Department of Nephrology, Geisinger, Danville, PA, USA. 258 Institute of Physiology, University of Zurich, Zurich, Switzerland. 259 Anatomic Pathology, University of Washington Medical Center, Seattle, WA, USA. 260 Geisinger Research, Biomedical and Translational Informatics Institute, Danville, PA, USA. 261 Department of Nephrology and Rheumatology, Kliniken Südostbayern, Regensburg, Germany. 262 Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Osaka, Japan. 263 Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan. 264 Vanderbilt University Medical Center, Division of Nephrology & Hypertension, Nashville, TN, USA. 265 Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. anna.koettgen@uniklinik-freiburg.de. 266 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. anna.koettgen@uniklinik-freiburg.de. 267 Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy. cristian.pattaro@eurac.edu.

المصدر: Nature genetics

مصطلحات موضوعية: Nýrnasjúkdómar, Nýru, Gen, Kidney Diseases, Kidney, Genome-Wide Association Study

العلاقة: https://www.nature.com/articles/s41588-019-0407-xTest; https://search.proquest.com/publication/33429Test; A catalog of genetic loci associated with kidney function from analyses of a million individuals. 2019, 51(6):957-972 Nat Genet; http://hdl.handle.net/2336/620965Test; Nature genetics

الإتاحة: https://doi.org/10.1038/s41588-019-0407-xTest
http://hdl.handle.net/2336/620965Test