المؤلفون: Barnes, Daniel R, Silvestri, Valentina, Leslie, Goska, McGuffog, Lesley, Dennis, Joe, Yang, Xin, Adlard, Julian, Agnarsson, Bjarni A, Ahmed, Munaza, Aittomäki, Kristiina, Andrulis, Irene L, Arason, Adalgeir, Arnold, Norbert, Auber, Bernd, Azzollini, Jacopo, Balmaña, Judith, Barkardottir, Rosa B, Barrowdale, Daniel, Barwell, Julian, Belotti, Muriel, Benitez, Javier, Berthet, Pascaline, Boonen, Susanne E, Borg, Åke, Bozsik, Aniko, Brady, Angela F, Brennan, Paul, Brewer, Carole, Brunet, Joan, Bucalo, Agostino, Buys, Saundra S, Caldés, Trinidad, Caligo, Maria A, Campbell, Ian, Cassingham, Hayley, Christensen, Lise Lotte, Cini, Giulia, Claes, Kathleen B M, Cook, Jackie, Coppa, Anna, Cortesi, Laura, Damante, Giuseppe, Darder, Esther, Davidson, Rosemarie, de la Hoya, Miguel, De Leeneer, Kim, de Putter, Robin, Del Valle, Jesús, Diez, Orland, Ding, Yuan Chun, Domchek, Susan M, Donaldson, Alan, Eason, Jacqueline, Eeles, Ros, Engel, Christoph, Evans, D Gareth, Feliubadaló, Lidia, Fostira, Florentia, Frone, Megan, Frost, Debra, Gallagher, David, Gehrig, Andrea, Giraud, Sophie, Glendon, Gord, Godwin, Andrew K, Goldgar, David E, Greene, Mark H, Gregory, Helen, Gross, Eva, Hahnen, Eric, Hamann, Ute, Hansen, Thomas V O, Hanson, Helen, Hentschel, Julia, Horvath, Judit, Izatt, Louise, Izquierdo, Angel, James, Paul A, Janavicius, Ramunas, Jensen, Uffe Birk, Johannsson, Oskar Th, John, Esther M, Kramer, Gero, Kroeldrup, Lone, Kruse, Torben A, Lautrup, Charlotte, Lazaro, Conxi, Lesueur, Fabienne, Lopez-Fernández, Adria, Mai, Phuong L, Manoukian, Siranoush, Matrai, Zoltan, Matricardi, Laura, Maxwell, Kara N, Mebirouk, Noura, Meindl, Alfons, Montagna, Marco, Monteiro, Alvaro N, Morrison, Patrick J, Muranen, Taru A, Murray, Alex, Nathanson, Katherine L, Neuhausen, Susan L, Nevanlinna, Heli, Nguyen-Dumont, Tu, Niederacher, Dieter, Olah, Edith, Olopade, Olufunmilayo I, Palli, Domenico, Parsons, Michael T, Pedersen, Inge Sokilde, Peissel, Bernard, Perez-Segura, Pedro, Peterlongo, Paolo, Petersen, Annabeth H, Pinto, Pedro, Porteous, Mary E, Pottinger, Caroline, Pujana, Miquel Angel, Radice, Paolo, Ramser, Juliane, Rantala, Johanna, Robson, Mark, Rogers, Mark T, Rønlund, Karina, Rump, Andreas, Sánchez de Abajo, Ana María, Shah, Payal D, Sharif, Saba, Side, Lucy E, Singer, Christian F, Stadler, Zsofia, Steele, Linda, Stoppa-Lyonnet, Dominique, Sutter, Christian, Tan, Yen Yen, Teixeira, Manuel R, Teulé, Alex, Thull, Darcy L, Tischkowitz, Marc, Toland, Amanda E, Tommasi, Stefania, Toss, Angela, Trainer, Alison H, Tripathi, Vishakha, Valentini, Virginia, van Asperen, Christi J, Venturelli, Marta, Viel, Alessandra, Vijai, Joseph, Walker, Lisa, Wang-Gohrke, Shan, Wappenschmidt, Barbara, Whaite, Anna, Zanna, Ines, Offit, Kenneth, Thomassen, Mads, Couch, Fergus J, Schmutzler, Rita K, Simard, Jacques, Easton, Douglas F, Chenevix-Trench, Georgia, Antoniou, Antonis C, Ottini, Laura

المساهمون: 1Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 2Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy. 3Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, UK. 4Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland. 5School of Medicine, University of Iceland, Reykjavik, Iceland. 6North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK. 7Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. 8Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada. 9Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. 10BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 11Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany. 12Institute of Clinical Molecular Biology, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany. 13Department of Human Genetics, Hannover Medical School, Hannover, Germany. 14Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy. 15Hereditary Cancer Genetics Group, Vall d'Hebron Institute of Oncology, Vall d'Hebron Hospital Campus, Barcelona, Spain. 16Department of Medical Oncology, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain. 17Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, Leicester, UK. 18Service de Génétique, Institut Curie, Paris, France. 19Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain. 20Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. 21Département de Biopathologie, Centre François Baclesse, Caen, France. 22Department of Clinical Genetics, Odense University Hospital, Odense, Denmark. 23Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden. 24Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary. 25North West Thames Regional Genetics Service, London North West University Healthcare NHS Trust, Northwick Park Hospital, Harrow, UK. 26Northern Genetics Service, Newcastle Hospitals NHS Foundation Trust, Newcastle, UK. 27Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, UK. 28Hereditary Cancer Program, Oncobell-IDIBELL-IGTP, Catalan Institute of Oncology, CIBERONC, Barcelona, Spain. 29Department of Internal Medicine, Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT, USA. 30Molecular Oncology Laboratory, CIBERONC, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain. 31SOD Genetica Molecolare, University Hospital, Pisa, Italy. 32Peter MacCallum Cancer Center, Melbourne, Victoria, Australia. 33Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia. 34Department of Internal Medicine, Division of Human Genetics, The Ohio State University Wexner Medical Center, Columbus, OH, USA. 35Division of Surgical Oncology, National Cancer Centre, Singapore, Singapore. 36Division of Functional Onco-Genomics and Genetics, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy. 37Centre for Medical Genetics, Ghent University, Gent, Belgium. 38Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, UK. 39Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy. 40Department of Oncology and Haematology, University of Modena and Reggio Emilia, Modena, Italy. 41Department of Medicine, University of Udine, Udine, Italy. 42Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, UK. 43Area of Clinical and Molecular Genetics, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain. 44Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA. 45Basser Center for BRCA, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA. 46Clinical Genetics Department, St Michael's Hospital, Bristol, UK. 47Nottingham Clinical Genetics Service, Nottingham University Hospitals NHS Trust, Nottingham, UK. 48Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK. 49Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. 50LIFE-Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany. 51Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. 52North West Genomics Laboratory Hub, Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. 53Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece. 54Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. 55Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin and St James's Hospital, Dublin, Eire. 56Department of Human Genetics, University Würzburg, Würzburg, Germany. 57Service de Génétique, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France. 58Department of Pathology and Laboratory Medicine, University of Kansas, Medical Center, Kansas City, KS, USA. 59Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA. 60North of Scotland Regional Genetics Service, NHS Grampian & University of Aberdeen, Foresterhill, Aberdeen, UK. 61Department of Gynecology and Obstetrics, University of Munich, Munich, Germany. 62Center for Familial Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. 63Center for Integrated Oncology (CIO), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. 64Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany. 65Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 66Southwest Thames Regional Genetics Service, St George's Hospital, London, UK. 67Institute of Human Genetics, University Hospital Leipzig, Leipzig, Germany. 68Institute of Human Genetics, University of Münster, Münster, Germany. 69Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK. 70Parkville Familial Cancer Centre, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia. 71Faculty of Medicine, Institute of Biomedical Sciences, Department of Human and Medical Genetics, Vilnius University, Vilnius, Lithuania. 72State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania. 73Department of Clinical Genetics, Aarhus University Hospital, Aarhus N, Denmark. 74Department of Oncology, Landspitali University Hospital, Reykjavik, Iceland. 75Department of Epidemiology & Population Health, Stanford University School of Medicine, Stanford, CA, USA. 76Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA. 77Department of Urology, Medical University of Vienna, Vienna, Austria. 78Department of Clinical Genetics, Aalborg University Hospital, Aalborg, Denmark. 79Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark. 80Institut Curie, Paris, France. 81Mines ParisTech, Fontainebleau, France. 82Genetic Epidemiology of Cancer Team, Inserm U900, Paris, France. 83Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. 84Department of Surgery, National Institute of Oncology, Budapest, Hungary. 85Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy. 86Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. 87Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA. 88Northern Ireland Regional Genetics Centre, Belfast City Hospital, Belfast, UK. 89Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. 90All Wales Medical Genetics Services, University Hospital of Wales, Cardiff, UK. 91Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia. 92Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia. 93Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany. 94Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL, USA. 95Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy. 96Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. 97Molecular Diagnostics, Aalborg University Hospital, Aalborg, Denmark. 98Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. 99Genome Diagnostics Program, IFOM-the FIRC Institute of Molecular Oncology, Milan, Italy. 100Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark. 101Department of Genetics, Portuguese Oncology Institute, Porto, Portugal. 102South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, UK. 103Translational Research Laboratory, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, CIBERONC, Barcelona, Spain. 104Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy. 105Division of Gynaecology and Obstetrics, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany. 106Clinical Genetics, Karolinska Institutet, Stockholm, Sweden. 107Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 108Institute for Clinical Genetics, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. 109Servicio de Análisis Clínicos y Bioquímica Clínica, Complejo Hospitalario Universitario Insular Materno-Infantil de Gran Canaria , Las Palmas de Gran Canaría, Spain. 110West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Birmingham, UK. 111Princess Anne Hospital, Southampton, UK. 112Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. 113Department of Tumour Biology, INSERM U830, Paris, France. 114Université Paris Descartes, Paris, France. 115Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany. 116Dept of OB/GYN, Medical University of Vienna, Vienna, Austria. 117Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal. 118Department of Medicine, Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. 119Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, QC, Canada. 120Department of Medical Genetics, University of Cambridge, Cambridge, UK. 121Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA. 122IRCCS Istituto Tumori Giovanni Paolo II, Bari, Italy. 123Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia. 124Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands. 125Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 126Oxford Regional Genetics Service, Churchill Hospital, Oxford, UK. 127Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany. 128Liverpool Centre for Genomic Medicine, Liverpool Women's NHS Foundation Trust, Liverpool, UK. 129Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. 130Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. 131Genomics Center, Centre Hospitalier Universitaire de Québec-Université Laval Research Center, Québec City, QC, Canada. 132Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.

المصدر: Journal of the National Cancer Institute ; 114 ; 1 ; 109 ; 122 ; United States ; United Kingdom

مصطلحات موضوعية: Blöðruhálskirtilskrabbamein, Gen, Genes, BRCA1, BRCA2, Prostatic Neoplasms, Genetic Predisposition to Disease

العلاقة: https://academic.oup.com/jnci/article/114/1/109/6329642Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8755508Test/; Barnes DR, Silvestri V, Leslie G, et al. Breast and Prostate Cancer Risks for Male BRCA1 and BRCA2 Pathogenic Variant Carriers Using Polygenic Risk Scores. J Natl Cancer Inst. 2022;114(1):109-122. doi:10.1093/jnci/djab147; http://hdl.handle.net/2336/622100Test; Journal of the National Cancer Institute

الإتاحة: https://doi.org/10.1093/jnci/djab147Test
http://hdl.handle.net/2336/622100Test

المؤلفون: Lakeman, Inge M M, van den Broek, Alexandra J, Vos, Juliën A M, Barnes, Daniel R, Adlard, Julian, Andrulis, Irene L, Arason, Adalgeir, Arnold, Norbert, Arun, Banu K, Balmaña, Judith, Barrowdale, Daniel, Benitez, Javier, Borg, Ake, Caldés, Trinidad, Caligo, Maria A, Chung, Wendy K, Claes, Kathleen B M, Collée, J Margriet, Couch, Fergus J, Daly, Mary B, Dennis, Joe, Dhawan, Mallika, Domchek, Susan M, Eeles, Ros, Engel, Christoph, Evans, D Gareth, Feliubadaló, Lidia, Foretova, Lenka, Friedman, Eitan, Frost, Debra, Ganz, Patricia A, Garber, Judy, Gayther, Simon A, Gerdes, Anne-Marie, Godwin, Andrew K, Goldgar, David E, Hahnen, Eric, Hake, Christopher R, Hamann, Ute, Hogervorst, Frans B L, Hooning, Maartje J, Hopper, John L, Hulick, Peter J, Imyanitov, Evgeny N, Isaacs, Claudine, Izatt, Louise, Jakubowska, Anna, James, Paul A, Janavicius, Ramunas, Jensen, Uffe Birk, Jiao, Yue, John, Esther M, Joseph, Vijai, Karlan, Beth Y, Kets, Carolien M, Konstantopoulou, Irene, Kwong, Ava, Legrand, Clémentine, Leslie, Goska, Lesueur, Fabienne, Loud, Jennifer T, Lubiński, Jan, Manoukian, Siranoush, McGuffog, Lesley, Miller, Austin, Gomes, Denise Molina, Montagna, Marco, Mouret-Fourme, Emmanuelle, Nathanson, Katherine L, Neuhausen, Susan L, Nevanlinna, Heli, Yie, Joanne Ngeow Yuen, Olah, Edith, Olopade, Olufunmilayo I, Park, Sue K, Parsons, Michael T, Peterlongo, Paolo, Piedmonte, Marion, Radice, Paolo, Rantala, Johanna, Rennert, Gad, Risch, Harvey A, Schmutzler, Rita K, Sharma, Priyanka, Simard, Jacques, Singer, Christian F, Stadler, Zsofia, Stoppa-Lyonnet, Dominique, Sutter, Christian, Tan, Yen Yen, Teixeira, Manuel R, Teo, Soo Hwang, Teulé, Alex, Thomassen, Mads, Thull, Darcy L, Tischkowitz, Marc, Toland, Amanda E, Tung, Nadine, van Rensburg, Elizabeth J, Vega, Ana, Wappenschmidt, Barbara, Devilee, Peter, van Asperen, Christi J, Bernstein, Jonine L, Offit, Kenneth, Easton, Douglas F, Rookus, Matti A, Chenevix-Trench, Georgia, Antoniou, Antonis C, Robson, Mark, Schmidt, Marjanka K

المساهمون: 1Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. 2Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands. 3Division of Molecular Pathology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. 4Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 5Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, UK. 6Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada. 7Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. 8Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland. 9BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 10Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany. 11Institute of Clinical Molecular Biology, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany. 12Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. 13Hereditary cancer Genetics Group, Vall d'Hebron Institute of Oncology, Barcelona, Spain. 14Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, University Hospital of Vall d'Hebron, Barcelona, Spain. 15Centro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, Spain. 16Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. 17Department of Oncology, Lund University and Skåne University Hospital, Lund, Sweden. 18Molecular Oncology Laboratory, CIBERONC, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain. 19SOD Genetica Molecolare. University Hospital, Pisa, Italy. 20Departments of Pediatrics and Medicine, Columbia University, New York, NY, USA. 21Centre for Medical Genetics, Ghent University, Ghent, Belgium. 22Department of Clinical Genetics, Erasmus University Medical Center, CA, Rotterdam, The Netherlands. 23Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. 24Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, USA. 25Cancer Genetics and Prevention Program, University of California San Francisco, San Francisco, CA, USA. 26Basser Center for BRCA, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA. 27Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK. 28Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. 29Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. 30North West Genomics Laboratory Hub, Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. 31Hereditary Cancer Program, ONCOBELL-IDIBELL-IGTP, Catalan Institute of Oncology, CIBERONC, Barcelona, Spain. 32Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic. 33The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel. 34Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel. 35Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Centre, UCLA, Los Angeles, CA, USA. 36Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, MA, USA. 37Center for Bioinformatics and Functional Genomics and the Cedars Sinai Genomics Core. Cedars-Sinai Medical Center, Los Angeles, CA, USA. 38Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 39Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA. 40Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA. 41Center for Familial Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. 42Center for Integrated Oncology (CIO), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. 43Waukesha Memorial Hospital-Pro Health Care, Waukesha, WI, USA. 44Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany. 45Family Cancer Clinic, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. 46Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands. 47Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia. 48Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL, USA. 49The University of Chicago Pritzker School of Medicine, Chicago, IL, USA. 50N.N. Petrov Institute of Oncology, St. Petersburg, Russia. 51Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA. 52Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK. 53Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland. 54Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland. 55Parkville Familial Cancer Centre, Peter MacCallum Cancer Center, Melbourne, VIC, Australia. 56Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia. 57Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania. 58State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania. 59Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark. 60Genetic Epidemiology of Cancer team, Paris, France. 61Institut Curie, Paris, France. 62Mines ParisTech, Fontainebleau, France. 63Department of Epidemiology & Population Health, Stanford University School of Medicine, Stanford, CA, USA. 64Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA. 65Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 66David Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, CA, USA. 67Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece. 68Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Centre, Happy Valley, Hong Kong. 69Department of Surgery, The University of Hong Kong, Pok Fu Lam, Hong Kong. 70Department of Surgery, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong. 71Département de Génétique, CHU de Grenoble, Grenoble, France. 72Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. 73Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy. 74NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, NY, USA. 75Service de Biologie de la reproduction, Cytogénétique et Génétique Médicale, CHI Poissy-Saint Germain, Poissy, France. 76Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy. 77Service de Génétique, Institut Curie, Paris, France. 78Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA. 79Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. 80Cancer Genetics Service, National Cancer Centre, Singapore, Singapore. 81Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. 82Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary. 83Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL, USA. 84Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea. 85Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea. 86Cancer Research Institute, Seoul National University, Seoul, Korea. 87Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. 88Genome Diagnostics Program, IFOM-the FIRC Institute of Molecular Oncology, Milan, Italy. 89Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy. 90Clinical Genetics, Karolinska Institutet, Stockholm, Sweden. 91Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel. 92Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA. 93Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. 94Department of Internal Medicine, Division of Medical Oncology, University of Kansas Medical Center, Westwood, KS, USA. 95Genomics Center, Centre Hospitalier Universitaire de Québec-Université Laval Research Center, Québec City, QC, Canada. 96Dept of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. 97Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 98Department of Tumour Biology, INSERM U830, Paris, France. 99Université Paris Descartes, Paris, France. 100Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany. 101Dept of OB/GYN, Medical University of Vienna, Vienna, Austria. 102Department of Genetics, Portuguese Oncology Institute, Porto, Portugal. 103Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal. 104Breast Cancer Research Programme, Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia. 105Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. 106Department of Clinical Genetics, Odense University Hospital, Odence C, Denmark. 107Department of Medicine, Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. 108Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, QC, Canada. 109Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge. Vol Box 134, Level 6 Addenbrooke's Treatment Centre, Addenbrooke's Hosptital, Cambridge, UK. 110Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA. 111Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA. 112Department of Genetics, University of Pretoria, Arcadia, South Africa. 113Fundación Pública Galega de Medicina Xenómica, Santiago de Compostela, Spain. 114Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain. 115Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. 116Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. 117Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK. 118Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands. 119Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands. mk.schmidt@nki.nl. 120Division of Molecular Pathology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. mk.schmidt@nki.nl. 121Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands. mk.schmidt@nki.nl. #Contributed equally.

المصدر: Genetics in medicine : official journal of the American College of Medical Genetics ; 23 ; 9 ; 1726 ; 1737 ; United Kingdom ; United States ; Canada

مصطلحات موضوعية: Brjóstakrabbamein, Gen, BRCA1 Protein, BRCA2 Protein, Breast Neoplasms, Risk Factors

العلاقة: https://www.nature.com/articles/s41436-021-01198-7Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460445Test/; Lakeman IMM, van den Broek AJ, Vos JAM, Barnes DR, Adlard J, Andrulis IL, Arason A, Arnold N, Arun BK, Balmaña J, Barrowdale D, Benitez J, Borg A, Caldés T, Caligo MA, Chung WK, Claes KBM; GEMO Study Collaborators; EMBRACE Collaborators, Collée JM, Couch FJ, Daly MB, Dennis J, Dhawan M, Domchek SM, Eeles R, Engel C, Evans DG, Feliubadaló L, Foretova L, Friedman E, Frost D, Ganz PA, Garber J, Gayther SA, Gerdes AM, Godwin AK, Goldgar DE, Hahnen E, Hake CR, Hamann U, Hogervorst FBL, Hooning MJ, Hopper JL, Hulick PJ, Imyanitov EN; OCGN Investigators; HEBON Investigators; KconFab Investigators, Isaacs C, Izatt L, Jakubowska A, James PA, Janavicius R, Jensen UB, Jiao Y, John EM, Joseph V, Karlan BY, Kets CM, Konstantopoulou I, Kwong A, Legrand C, Leslie G, Lesueur F, Loud JT, Lubiński J, Manoukian S, McGuffog L, Miller A, Gomes DM, Montagna M, Mouret-Fourme E, Nathanson KL, Neuhausen SL, Nevanlinna H, Yie JNY, Olah E, Olopade OI, Park SK, Parsons MT, Peterlongo P, Piedmonte M, Radice P, Rantala J, Rennert G, Risch HA, Schmutzler RK, Sharma P, Simard J, Singer CF, Stadler Z, Stoppa-Lyonnet D, Sutter C, Tan YY, Teixeira MR, Teo SH, Teulé A, Thomassen M, Thull DL, Tischkowitz M, Toland AE, Tung N, van Rensburg EJ, Vega A, Wappenschmidt B, Devilee P, van Asperen CJ, Bernstein JL, Offit K, Easton DF, Rookus MA, Chenevix-Trench G, Antoniou AC, Robson M, Schmidt MK. The predictive ability of the 313 variant-based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variant. Genet Med. 2021 Sep;23(9):1726-1737. doi:10.1038/s41436-021-01198-7.; http://hdl.handle.net/2336/621933Test; Genetics in medicine : official journal of the American College of Medical Genetics

الإتاحة: https://doi.org/10.1038/s41436-021-01198-7Test
http://hdl.handle.net/2336/621933Test

المؤلفون: Barnes, Daniel R, Rookus, Matti A, McGuffog, Lesley, Leslie, Goska, Mooij, Thea M, Dennis, Joe, Mavaddat, Nasim, Adlard, Julian, Ahmed, Munaza, Aittomäki, Kristiina, Andrieu, Nadine, Andrulis, Irene L, Arnold, Norbert, Arun, Banu K, Azzollini, Jacopo, Balmaña, Judith, Barkardottir, Rosa B, Barrowdale, Daniel, Benitez, Javier, Berthet, Pascaline, Białkowska, Katarzyna, Blanco, Amie M, Blok, Marinus J, Bonanni, Bernardo, Boonen, Susanne E, Borg, Åke, Bozsik, Aniko, Bradbury, Angela R, Brennan, Paul, Brewer, Carole, Brunet, Joan, Buys, Saundra S, Caldés, Trinidad, Caligo, Maria A, Campbell, Ian, Christensen, Lise Lotte, Chung, Wendy K, Claes, Kathleen B M, Colas, Chrystelle, Collonge-Rame, Marie-Agnès, Cook, Jackie, Daly, Mary B, Davidson, Rosemarie, de la Hoya, Miguel, de Putter, Robin, Delnatte, Capucine, Devilee, Peter, Diez, Orland, Ding, Yuan Chun, Domchek, Susan M, Dorfling, Cecilia M, Dumont, Martine, Eeles, Ros, Ejlertsen, Bent, Engel, Christoph, Evans, D Gareth, Faivre, Laurence, Foretova, Lenka, Fostira, Florentia, Friedlander, Michael, Friedman, Eitan, Frost, Debra, Ganz, Patricia A, Garber, Judy, Gehrig, Andrea, Gerdes, Anne-Marie, Gesta, Paul, Giraud, Sophie, Glendon, Gord, Godwin, Andrew K, Goldgar, David E, González-Neira, Anna, Greene, Mark H, Gschwantler-Kaulich, Daphne, Hahnen, Eric, Hamann, Ute, Hanson, Helen, Hentschel, Julia, Hogervorst, Frans B L, Hooning, Maartje J, Horvath, Judit, Hu, Chunling, Hulick, Peter J, Imyanitov, Evgeny N, Isaacs, Claudine, Izatt, Louise, Izquierdo, Angel, Jakubowska, Anna, James, Paul A, Janavicius, Ramunas, John, Esther M, Joseph, Vijai, Karlan, Beth Y, Kast, Karin, Koudijs, Marco, Kruse, Torben A, Kwong, Ava, Laitman, Yael, Lasset, Christine, Lazaro, Conxi, Lester, Jenny, Lesueur, Fabienne, Liljegren, Annelie, Loud, Jennifer T, Lubiński, Jan, Mai, Phuong L, Manoukian, Siranoush, Mari, Véronique, Mebirouk, Noura, Meijers-Heijboer, Hanne E J, Meindl, Alfons, Mensenkamp, Arjen R, Miller, Austin, Montagna, Marco, Mouret-Fourme, Emmanuelle, Mukherjee, Semanti, Mulligan, Anna Marie, Nathanson, Katherine L, Neuhausen, Susan L, Nevanlinna, Heli, Niederacher, Dieter, Nielsen, Finn Cilius, Nikitina-Zake, Liene, Noguès, Catherine, Olah, Edith, Olopade, Olufunmilayo I, Ong, Kai-ren, O'Shaughnessy-Kirwan, Aoife, Osorio, Ana, Ott, Claus-Eric, Papi, Laura, Park, Sue K, Parsons, Michael T, Pedersen, Inge Sokilde, Peissel, Bernard, Peixoto, Ana, Peterlongo, Paolo, Pfeiler, Georg, Phillips, Kelly-Anne, Prajzendanc, Karolina, Pujana, Miquel Angel, Radice, Paolo, Ramser, Juliane, Ramus, Susan J, Rantala, Johanna, Rennert, Gad, Risch, Harvey A, Robson, Mark, Rønlund, Karina, Salani, Ritu, Schuster, Hélène, Senter, Leigha, Shah, Payal D, Sharma, Priyanka, Side, Lucy E, Singer, Christian F, Slavin, Thomas P, Soucy, Penny, Southey, Melissa C, Spurdle, Amanda B, Steinemann, Doris, Steinsnyder, Zoe, Stoppa-Lyonnet, Dominique, Sutter, Christian, Tan, Yen Yen, Teixeira, Manuel R, Teo, Soo Hwang, Thull, Darcy L, Tischkowitz, Marc, Tognazzo, Silvia, Toland, Amanda E, Trainer, Alison H, Tung, Nadine, van Engelen, Klaartje, van Rensburg, Elizabeth J, Vega, Ana, Vierstraete, Jeroen, Wagner, Gabriel, Walker, Lisa, Wang-Gohrke, Shan, Wappenschmidt, Barbara, Weitzel, Jeffrey N, Yadav, Siddhartha, Yang, Xin, Yannoukakos, Drakoulis, Zimbalatti, Dario, Offit, Kenneth, Thomassen, Mads, Couch, Fergus J, Schmutzler, Rita K, Simard, Jacques, Easton, Douglas F, Chenevix-Trench, Georgia, Antoniou, Antonis C

المساهمون: 1Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. drb54@medschl.cam.ac.uk. 2The Netherlands Cancer Institute, Department of Epidemiology (PSOE), Amsterdam, The Netherlands. 3Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 4Chapel Allerton Hospital, Yorkshire Regional Genetics Service, Leeds, UK. 5Great Ormond Street Hospital for Children NHS Trust, North East Thames Regional Genetics Service, London, UK. 6University of Helsinki, Department of Clinical Genetics, Helsinki University Hospital, Helsinki, Finland. 7Inserm U900, Genetic Epidemiology of Cancer team, Paris, France. 8Institut Curie, Paris, France. 9Mines ParisTech, Fontainebleau, France. 10Department of Life & Health Sciences, PSL University, Paris, France. 11Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Fred A. Litwin Center for Cancer Genetics, Toronto, ON, Canada. 12University of Toronto, Department of Molecular Genetics, Toronto, ON, Canada. 13University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Department of Gynaecology and Obstetrics, Kiel, Germany. 14University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Institute of Clinical Molecular Biology, Kiel, Germany. 15University of Texas MD Anderson Cancer Center, Department of Breast Medical Oncology, Houston, TX, USA. 16Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Unit of Medical Genetics, Department of Medical Oncology and Hematology, Milan, Italy. 17Vall d'Hebron Institute of Oncology, High Risk and Cancer Prevention Group, Barcelona, Spain. 18University Hospital of Vall d'Hebron, Department of Medical Oncology, Barcelona, Spain. 19Landspitali University Hospital, Department of Pathology, Reykjavik, Iceland. 20University of Iceland, BMC (Biomedical Centre), Faculty of Medicine, Reykjavik, Iceland. 21Centro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, Spain. 22Spanish National Cancer Research Centre (CNIO), Human Cancer Genetics Programme, Madrid, Spain. 23Centre François Baclesse, Département de Biopathologie, Caen, France. 24Pomeranian Medical University, Department of Genetics and Pathology, Szczecin, Poland. 25University of California San Francisco, Cancer Genetics and Prevention Program, San Francisco, CA, USA. 26Maastricht University Medical Center, Department of Clinical Genetics, Maastricht, The Netherlands. 27IEO, European Institute of Oncology IRCCS, Division of Cancer Prevention and Genetics, Milan, Italy. 28Zealand University Hospital, Clinical Genetic Unit, Department of Paediatrics, Roskilde, Denmark. 29Lund University, Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund, Sweden. 30National Institute of Oncology, Department of Molecular Genetics, Budapest, Hungary. 31Perelman School of Medicine at the University of Pennsylvania, Department of Medicine, Abramson Cancer Center, Philadelphia, PA, USA. 32Institute of Genetic Medicine, International Centre for Life, Northern Genetic Service, Newcastle upon Tyne, UK. 33Royal Devon & Exeter Hospital, Department of Clinical Genetics, Exeter, UK. 34ONCOBELL-IDIBELL-IDIBGI-IGTP, Catalan Institute of Oncology, CIBERONC, Hereditary Cancer Program, Barcelona, Spain. 35Huntsman Cancer Institute, Department of Medicine, Salt Lake City, UT, USA. 36CIBERONC, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Molecular Oncology Laboratory, Madrid, Spain. 37University Hospital, SOD Genetica Molecolare, Pisa, Italy. 38Peter MacCallum Cancer Center, Melbourne, VIC, Australia. 39The University of Melbourne, Sir Peter MacCallum Department of Oncology, Melbourne, VIC, Australia. 40Aarhus University Hospital, Department of Clinical Medicine,, Aarhus, Denmark. 41Columbia University, Departments of Pediatrics and Medicine, New York, NY, USA. 42Ghent University, Centre for Medical Genetics, Ghent, Belgium. 43Institut Curie, Service de Génétique, Paris, France. 44CHU de Besançon, Service de Génétique, Besançon, France. 45Sheffield Children's Hospital, Sheffield Clinical Genetics Service, Sheffield, UK. 46Fox Chase Cancer Center, Department of Clinical Genetics, Philadelphia, PA, USA. 47Queen Elizabeth University Hospitals, Department of Clinical Genetics, Glasgow, UK. 48CHU Nantes, Laboratoire de genetique moleculaire, Nantes, France. 49Leiden University Medical Center, Department of Pathology, Leiden, The Netherlands. 50Leiden University Medical Center, Department of Human Genetics, Leiden, The Netherlands. 51Vall dHebron Institute of Oncology (VHIO), Oncogenetics Group, Barcelona, Spain. 52University Hospital Vall dHebron, Clinical and Molecular Genetics Area, Barcelona, Spain. 53Beckman Research Institute of City of Hope, Department of Population Sciences, Duarte, CA, USA. 54University of Pennsylvania, Basser Center for BRCA, Abramson Cancer Center, Philadelphia, PA, USA. 55University of Pretoria, Department of Genetics, Arcadia, South Africa. 56Centre Hospitalier Universitaire de Québec - Université Laval Research Center, Genomics Center,, Québec City, QC, Canada. 57The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Oncogenetics Team, London, UK. 58Rigshospitalet, Copenhagen University Hospital, Department of Oncology, Copenhagen, Denmark. 59University of Leipzig, Institute for Medical Informatics, Statistics and Epidemiology, Leipzig, Germany. 60The University of Manchester, Manchester Academic Health Science Centre, Manchester Universities Foundation Trust, St. Mary's Hospital, Genomic Medicine, Division of Evolution and Genomic Sciences, Manchester, UK. 61Manchester Academic Health Science Centre, Manchester Universities Foundation Trust, St. Mary's Hospital, Genomic Medicine, North West Genomics hub, Manchester, UK. 62Centre Georges-François Leclerc, Unité d'oncogénétique, Centre de Lutte Contre le Cancer, Dijon, France. 63DHU Dijon, Centre de Génétique, Dijon, France. 64Masaryk Memorial Cancer Institute, Department of Cancer Epidemiology and Genetics, Brno, Czech Republic. 65National Centre for Scientific Research 'Demokritos', Molecular Diagnostics Laboratory, INRASTES, Athens, Greece. 66NHMRC Clinical Trials, ANZ GOTG Coordinating Centre, Camperdown, NSW, Australia. 67Chaim Sheba Medical Center, The Susanne Levy Gertner Oncogenetics Unit, Ramat Gan, Israel. 68Tel Aviv University, Sackler Faculty of Medicine, Ramat Aviv, Israel. 69Jonsson Comprehensive Cancer Centre, UCLA, Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Los Angeles, CA, USA. 70Dana-Farber Cancer Institute, Cancer Risk and Prevention Clinic, Boston, MA, USA. 71University Würzburg, Department of Human Genetics, Würzburg, Germany. 72Rigshospitalet, Copenhagen University Hospital, Department of Clinical Genetics, Copenhagen, Denmark. 73CH Niort, Service Régional Oncogénétique Poitou-Charentes, Niort, France. 74Hospices Civils de Lyon, Department of Genetics, Bron, France. 75University of Kansas Medical Center, Department of Pathology and Laboratory Medicine, Kansas City, KS, USA. 76Huntsman Cancer Institute, University of Utah School of Medicine, Department of Dermatology, Salt Lake City, UT, USA. 77Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. 78Medical University of Vienna, Dept of OB/GYN, Vienna, Austria. 79Faculty of Medicine and University Hospital Cologne, University of Cologne, Center for Familial Breast and Ovarian Cancer, Cologne, Germany. 80Faculty of Medicine and University Hospital Cologne, University of Cologne, Center for Integrated Oncology (CIO), Cologne, Germany. 81German Cancer Research Center (DKFZ), Molecular Genetics of Breast Cancer, Heidelberg, Germany. 82St George's NHS Foundation Trust, Southwest Thames Regional Genetics Service, London, UK. 83University Hospital Leipzig, Institute of Human Genetics, Leipzig, Germany. 84The Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Family Cancer Clinic, Amsterdam, The Netherlands. 85Erasmus MC Cancer Institute, Department of Medical Oncology, Family Cancer Clinic, Rotterdam, The Netherlands. 86University of Münster, Institute of Human Genetics, Münster, Germany. 87Mayo Clinic, Department of Laboratory Medicine and Pathology, Rochester, MN, USA. 88NorthShore University HealthSystem, Center for Medical Genetics, Evanston, IL, USA. 89The University of Chicago Pritzker School of Medicine, Chicago, IL, USA. 90N.N. Petrov Institute of Oncology, St. Petersburg, Russia. 91Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA. 92Guy's and St Thomas' NHS Foundation Trust, Clinical Genetics, London, UK. 93Pomeranian Medical University, Independent Laboratory of Molecular Biology and Genetic Diagnostics, Szczecin, Poland. 94Peter MacCallum Cancer Center, Parkville Familial Cancer Centre, Melbourne, VIC, Australia. 95Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius, Lithuania. 96State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania. 97Stanford Cancer Institute, Stanford University School of Medicine, Department of Medicine, Division of Oncology, Stanford, CA, USA. 98Memorial Sloan-Kettering Cancer Center, Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, New York, NY, USA. 99University of California at Los Angeles, David Geffen School of Medicine, Department of Obstetrics and Gynecology, Los Angeles, CA, USA. 100Cedars-Sinai Medical Center, Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA, USA. 101Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. 102University Medical Center Utrecht, Department of Medical Genetics, Utrecht, The Netherlands. 103Odense University Hospital, Department of Clinical Genetics, Odense, Denmark. 104Cancer Genetics Centre, Hong Kong Hereditary Breast Cancer Family Registry, Happy Valley, Hong Kong. 105The University of Hong Kong, Department of Surgery, Pok Fu Lam, Hong Kong. 106Hong Kong Sanatorium and Hospital, Department of Surgery, Happy Valley, Hong Kong. 107Centre Léon Bérard, Unité de Prévention et d'Epidémiologie Génétique, Lyon, France. 108Lyon University, UMR CNRS 5558, Lyon, France. 109Karolinska Institutet, Department of Oncology, Stockholm, Sweden. 110Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. 111Centre Antoine Lacassagne, Département d'Hématologie-Oncologie Médicale, Nice, France. 112Amsterdam UMC, location AMC, Department of Clinical Genetics, Amsterdam, The Netherlands. 113University of Munich, Campus Großhadern, Department of Gynecology and Obstetrics, Munich, Germany. 114Radboud University Medical Center, Department of Human Genetics, Nijmegen, The Netherlands. 115Roswell Park Cancer Institute, NRG Oncology, Statistics and Data Management Center, Buffalo, NY, USA. 116Veneto Institute of Oncology IOV - IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy. 117Memorial Sloan-Kettering Cancer Center, Clinical Genetics Service, Department of Medicine, New York, NY, USA. 118University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, ON, Canada. 119University Health Network, Laboratory Medicine Program, Toronto, ON, Canada. 120University of Helsinki, Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland. 121University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Department of Gynecology and Obstetrics, Düsseldorf, Germany. 122Rigshospitalet, Copenhagen University Hospital, Center for Genomic Medicine, Copenhagen, Denmark. 123Latvian Biomedical Research and Study Centre, Riga, Latvia. 124Oncogénétique Clinique and Aix Marseille Univ, INSERM, IRD, SESSTIM, Institut Paoli-Calmettes, Département d'Anticipation et de Suivi des Cancers, Marseille, France. 125The University of Chicago, Center for Clinical Cancer Genetics, Chicago, IL, USA. 126Birmingham Women's Hospital Healthcare NHS Trust, West Midlands Regional Genetics Service, Birmingham, UK. 127Cambridge University Hospitals NHS Foundation Trust, East Anglian Medical Genetics Service, Cambridge, UK. 128Campus Virchov Klinikum, Charite, Institute of Human Genetics, Berlin, Germany. 129University of Florence, Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', Medical Genetics Unit, Florence, Italy. 130Seoul National University College of Medicine, Department of Preventive Medicine, Seoul, Korea. 131Seoul National University Graduate School, Department of Biomedical Sciences, Seoul, Korea. 132Seoul National University, Cancer Research Institute, Seoul, Korea. 133QIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology, Brisbane, QLD, Australia. 134Aalborg University Hospital, Molecular Diagnostics, Aalborg, Denmark. 135Aalborg University Hospital, Clinical Cancer Research Center, Aalborg, Denmark. 136Aalborg University, Department of Clinical Medicine, Aalborg, Denmark. 137Portuguese Oncology Institute, Department of Genetics, Porto, Portugal. 138IFOM - the FIRC Institute of Molecular Oncology, Genome Diagnostics Program, Milan, Italy. 139Medical University of Vienna, Dept of OB/GYN and Comprehensive Cancer Center, Vienna, Austria. 140The University of Melbourne, Department of Medicine, St Vincent's Hospital, Fitzroy, VIC, Australia. 141The University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Melbourne, VIC, Australia. 142IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, ProCURE, Barcelona, Spain. 143Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Milan, Italy. 144Klinikum rechts der Isar der Technischen Universität München, Department of Gynaecology and Obstetrics, Munich, Germany. 145University of NSW Sydney, School of Women's and Children's Health, Faculty of Medicine, Sydney, NSW, Australia. 146The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW, Australia. 147University of NSW Sydney, Adult Cancer Program, Lowy Cancer Research Centre, Sydney, NSW, Australia. 148Karolinska Institutet, Clinical Genetics, Stockholm, Sweden. 149Carmel Medical Center and Technion Faculty of Medicine, Clalit National Cancer Control Center, Haifa, Israel. 150Yale School of Medicine, Chronic Disease Epidemiology, New Haven, CT, USA. 151Region of Southern Denmark, Vejle Hospital, Department of Clinical Genetics, Vejle, Denmark. 152Wexner Medical Center, The Ohio State University, Department of Gynecology and Obstetrics, Columbus, OH, USA. 153Unité d'Oncogénétique Centre de Lutte contre le Cancer Paul Strauss, Strasbourg, France. 154Institut de Cancérologie Strasbourg Europe, ICANS, Strasbourg, France. 155Université de Strasbourg, Laboratoire d'ImmunoRhumatologie Moléculaire, Plateforme GENOMAX, INSERM UMR_S 1109, LabEx TRANSPLANTEX, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Faculté de Médecine, Strasbourg, France. 156The Ohio State University, Clinical Cancer Genetics Program, Division of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, Columbus, OH, USA. 157University of Kansas Medical Center, Department of Internal Medicine, Division of Medical Oncology, Westwood, KS, USA. 158Princess Anne Hospital, Southampton, UK. 159City of Hope, Clinical Cancer Genomics, Duarte, CA, USA. 160Monash University, Precision Medicine, School of Clinical Sciences at Monash Health, Clayton, VIC, Australia. 161The University of Melbourne, Department of Clinical Pathology, Melbourne, VIC, Australia. 162Cancer Council Victoria, Cancer Epidemiology Division, Melbourne, VIC, Australia. 163Hannover Medical School, Institute of Human Genetics, Hannover, Germany. 164INSERM U830, Department of Tumour Biology, Paris, France. 165Université Paris Descartes, Paris, France. 166University Hospital Heidelberg, Institute of Human Genetics, Heidelberg, Germany. 167University of Porto, Biomedical Sciences Institute (ICBAS), Porto, Portugal. 168Cancer Research Malaysia, Breast Cancer Research Programme, Subang Jaya, Selangor, Malaysia. 169University of Malaya, Department of Surgery, Faculty of Medicine, Kuala Lumpur, Malaysia. 170Magee-Womens Hospital, University of Pittsburgh School of Medicine, Department of Medicine, Pittsburgh, PA, USA. 171McGill University, Program in Cancer Genetics, Departments of Human Genetics and Oncology, Montréal, QC, Canada. 172University of Cambridge, Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, UK. 173The Ohio State University, Department of Cancer Biology and Genetics, Columbus, OH, USA. 174University Of Melbourne, Department of Medicine, Melbourne, VIC, Australia. 175Beth Israel Deaconess Medical Center, Department of Medical Oncology, Boston, MA, USA. 176Amsterdam UMC, location VUmc, Department of Clinical Genetics, Amsterdam, The Netherlands. 177Fundación Pública Galega de Medicina Xenómica, Santiago de Compostela, Spain. 178Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain. 179Oxford University Hospitals, Oxford Centre for Genomic Medicine, Oxford, UK. 180University Hospital Ulm, Department of Gynaecology and Obstetrics, Ulm, Germany. 181Mayo Clinic, Department of Oncology, Rochester, MN, USA. 182Faculty of Medicine and University Hospital Cologne, University of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany. 183Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.

المصدر: Genetics in medicine : official journal of the American College of Medical Genetics ; United States

مصطلحات موضوعية: BRCA1/2, PRS, breast cancer, genetics, ovarian cancer, Brjóstakrabbamein, Eggjastokkar, Gen, Breast Neoplasms, Genes, BRCA1, BRCA2, Ovarian Neoplasms

العلاقة: https://www.nature.com/articles/s41436-020-0862-xTest; Barnes DR, Rookus MA, McGuffog L, et al. Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants [published online ahead of print, 2020 Jul 15]. Genet Med. 2020;10.1038/s41436-020-0862-x. doi:10.1038/s41436-020-0862-x; http://hdl.handle.net/2336/621505Test; Genetics in medicine : official journal of the American College of Medical Genetics

الإتاحة: https://doi.org/10.1038/s41436-020-0862-xTest
http://hdl.handle.net/2336/621505Test

المؤلفون: Feng, Helian, Gusev, Alexander, Pasaniuc, Bogdan, Wu, Lang, Long, Jirong, Abu-Full, Zomoroda, Aittomäki, Kristiina, Andrulis, Irene L, Anton-Culver, Hoda, Antoniou, Antonis C, Arason, Adalgeir, Arndt, Volker, Aronson, Kristan J, Arun, Banu K, Asseryanis, Ella, Auer, Paul L, Azzollini, Jacopo, Balmaña, Judith, Barkardottir, Rosa B, Barnes, Daniel R, Barrowdale, Daniel, Beckmann, Matthias W, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Białkowska, Katarzyna, Blanco, Ana, Blomqvist, Carl, Boeckx, Bram, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Bonanni, Bernardo, Borg, Ake, Brauch, Hiltrud, Brenner, Hermann, Briceno, Ignacio, Broeks, Annegien, Brüning, Thomas, Burwinkel, Barbara, Cai, Qiuyin, Caldés, Trinidad, Caligo, Maria A, Campbell, Ian, Canisius, Sander, Campa, Daniele, Carter, Brian D, Carter, Jonathan, Castelao, Jose E, Chang-Claude, Jenny, Chanock, Stephen J, Christiansen, Hans, Chung, Wendy K, Claes, Kathleen B M, Clarke, Christine L, Couch, Fergus J, Cox, Angela, Cross, Simon S, Cybulski, Cezary, Czene, Kamila, Daly, Mary B, de la Hoya, Miguel, De Leeneer, Kim, Dennis, Joe, Devilee, Peter, Diez, Orland, Domchek, Susan M, Dörk, Thilo, Dos-Santos-Silva, Isabel, Dunning, Alison M, Dwek, Miriam, Eccles, Diana M, Ejlertsen, Bent, Ellberg, Carolina, Engel, Christoph, Eriksson, Mikael, Fasching, Peter A, Fletcher, Olivia, Flyger, Henrik, Fostira, Florentia, Friedman, Eitan, Fritschi, Lin, Frost, Debra, Gabrielson, Marike, Ganz, Patricia A, Gapstur, Susan M, Garber, Judy, García-Closas, Montserrat, García-Sáenz, José A, Gaudet, Mia M, Giles, Graham G, Glendon, Gord, Godwin, Andrew K, Goldberg, Mark S, Goldgar, David E, González-Neira, Anna, Greene, Mark H, Gronwald, Jacek, Guénel, Pascal, Haiman, Christopher A, Hall, Per, Hamann, Ute, Hake, Christopher, He, Wei, Heyworth, Jane, Hogervorst, Frans B L, Hollestelle, Antoinette, Hooning, Maartje J, Hoover, Robert N, Hopper, John L, Huang, Guanmengqian, Hulick, Peter J, Humphreys, Keith, Imyanitov, Evgeny N, Isaacs, Claudine, Jakimovska, Milena, Jakubowska, Anna, James, Paul, Janavicius, Ramunas, Jankowitz, Rachel C, John, Esther M, Johnson, Nichola, Joseph, Vijai, Jung, Audrey, Karlan, Beth Y, Khusnutdinova, Elza, Kiiski, Johanna I, Konstantopoulou, Irene, Kristensen, Vessela N, Laitman, Yael, Lambrechts, Diether, Lazaro, Conxi, Leroux, Dominique, Leslie, Goska, Lester, Jenny, Lesueur, Fabienne, Lindor, Noralane, Lindström, Sara, Lo, Wing-Yee, Loud, Jennifer T, Lubiński, Jan, Makalic, Enes, Mannermaa, Arto, Manoochehri, Mehdi, Manoukian, Siranoush, Margolin, Sara, Martens, John W M, Martinez, Maria E, Matricardi, Laura, Maurer, Tabea, Mavroudis, Dimitrios, McGuffog, Lesley, Meindl, Alfons, Menon, Usha, Michailidou, Kyriaki, Kapoor, Pooja M, Miller, Austin, Montagna, Marco, Moreno, Fernando, Moserle, Lidia, Mulligan, Anna M, Muranen, Taru A, Nathanson, Katherine L, Neuhausen, Susan L, Nevanlinna, Heli, Nevelsteen, Ines, Nielsen, Finn C, Nikitina-Zake, Liene, Offit, Kenneth, Olah, Edith, Olopade, Olufunmilayo I, Olsson, Håkan, Osorio, Ana, Papp, Janos, Park-Simon, Tjoung-Won, Parsons, Michael T, Pedersen, Inge S, Peixoto, Ana, Peterlongo, Paolo, Peto, Julian, Pharoah, Paul D P, Phillips, Kelly-Anne, Plaseska-Karanfilska, Dijana, Poppe, Bruce, Pradhan, Nisha, Prajzendanc, Karolina, Presneau, Nadege, Punie, Kevin, Pylkäs, Katri, Radice, Paolo, Rantala, Johanna, Rashid, Muhammad Usman, Rennert, Gad, Risch, Harvey A, Robson, Mark, Romero, Atocha, Saloustros, Emmanouil, Sandler, Dale P, Santos, Catarina, Sawyer, Elinor J, Schmidt, Marjanka K, Schmidt, Daniel F, Schmutzler, Rita K, Schoemaker, Minouk J, Scott, Rodney J, Sharma, Priyanka, Shu, Xiao-Ou, Simard, Jacques, Singer, Christian F, Skytte, Anne-Bine, Soucy, Penny, Southey, Melissa C, Spinelli, John J, Spurdle, Amanda B, Stone, Jennifer, Swerdlow, Anthony J, Tapper, William J, Taylor, Jack A, Teixeira, Manuel R, Terry, Mary Beth, Teulé, Alex, Thomassen, Mads, Thöne, Kathrin, Thull, Darcy L, Tischkowitz, Marc, Toland, Amanda E, Tollenaar, Rob A E M, Torres, Diana, Truong, Thérèse, Tung, Nadine, Vachon, Celine M, van Asperen, Christi J, van den Ouweland, Ans M W, van Rensburg, Elizabeth J, Vega, Ana, Viel, Alessandra, Vieiro-Balo, Paula, Wang, Qin, Wappenschmidt, Barbara, Weinberg, Clarice R, Weitzel, Jeffrey N, Wendt, Camilla, Winqvist, Robert, Yang, Xiaohong R, Yannoukakos, Drakoulis, Ziogas, Argyrios, Milne, Roger L, Easton, Douglas F, Chenevix-Trench, Georgia, Zheng, Wei, Kraft, Peter, Jiang, Xia

المساهمون: 1Program in Genetic Epidemiology and Statistical Genetics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts. 2Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts. 3Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts. 4Dana-Farber Cancer Institute, Boston, Massachusetts. 5UCLA Path & Lab Med, Los Angeles, California. 6Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii. 7Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee. 8Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel. 9Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. 10Fred A, Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada. 11Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. 12Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, California. 13Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 14Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland. 15BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 16Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. 17Department of Public Health Sciences, and Cancer Research Institute, Queen's University, Kingston, Ontario, Canada. 18Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. 19Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. 20Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington. 21Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin. 22Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy. 23High Risk and Cancer Prevention Group, Vall d'Hebron Institute of Oncology, Barcelona, Spain. 24Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany. 25Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. 26Centro de Investigaci-n en Red de Enfermedades Raras (CIBERER), Madrid, Spain. 27Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. 28Institute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia. 29Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland. 30Fundaci-n Pœblica Galega Medicina Xen-mica, Santiago De Compostela, Spain. 31Instituto de Investigacion Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain. 32Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. 33Department of Oncology, University Hospital, Karolinska Institute, Stockholm, Sweden. 34VIB Center for Cancer Biology, VIB, Leuven, Belgium. 35Laboratory for Translational Genetics, Department of Human Genetics, University of Leuven, Leuven, Belgium. 36Department of Radiation Oncology, Hannover Medical School, Hannover, Germany. 37Gynaecology Research Unit, Hannover Medical School, Hannover, Germany. 38NN Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus. 39Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark. 40Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark. 41Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. 42Division of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, Milan, Italy. 43Department of Oncology, Lund University and Skåne University Hospital, Lund, Sweden. 44Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany. 45iFIT-Cluster of Excellence, University of Tuebingen, Tuebingen, Germany. 46German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. 47Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany. 48Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, Colombia. 49Medical Faculty, Universidad de La Sabana, Bogota, Colombia. 50Division of Molecular Pathology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. 51Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany. 52Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. 53Molecular Biology of Breast Cancer, University Womens Clinic Heidelberg, University of Heidelberg, Heidelberg, Germany. 54Medical Oncology Department, Hospital Cl'nico San Carlos, Instituto de Investigaci-n Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. 55Section of Molecular Genetics, Dept, of Laboratory Medicine, University Hospital of Pisa, Pisa, Italy. 56Research Department, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia. 57Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia. 58Division of Molecular Carcinogenesis, The Netherlands Cancer Institute-Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands. 59Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. 60Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia. 61Department of Gynaecological Oncology, Chris OÕBrien Lifehouse and The University of Sydney, Camperdown, New South Wales, Australia. 62Oncology and Genetics Unit, Instituto de Investigacion Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS, Vigo, Spain. 63Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. 64Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. 65Departments of Pediatrics and Medicine, Columbia University, New York, New York. 66Centre for Medical Genetics, Ghent University, Gent, Belgium. 67Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia. 68Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota. 69Department of Oncology and Metabolism, Sheffield Institute for Nucleic Acids (SInFoNiA), University of Sheffield, Sheffield, UK. 70Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK. 71Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. 72Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania. 73Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. 74Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. 75Hereditary Cancer Genetics Group, Area of Clinical and Molecular Genetics, Vall dHebron Institute of Oncology (VHIO), University Hospital Vall d'Hebron, Barcelona, Spain. 76Clinical and Molecular Genetics Area, University Hospital Vall dHebron, Barcelona, Spain. 77Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. 78Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK. 79Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK. 80Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, London, UK. 81Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK. 82Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 83Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden. 84Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. 85LIFE - Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany. 86David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California. 87The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK. 88Department of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark. 89Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritosဩ, Athens, Greece. 90The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel. 91Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel. 92School of Public Health, Curtin University, Perth, Western Australia, Australia. 93Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Centre, UCLA, Los Angeles, California. 94Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, Massachusetts. 95Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK. 96Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia. 97Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia. 98Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. 99Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, Kanas. 100Department of Medicine, McGill University, Montreal, Quebec, Canada. 101Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada. 102Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah. 103Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland. 104Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France. 105Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California. 106Department of Oncology, Sšdersjukhuset, Stockholm, Sweden. 107Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany. 108City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California. 109School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia. 110Family Cancer Clinic, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. 111Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands. 112Center for Medical Genetics, NorthShore University HealthSystem, Evanston, Illinois. 113The University of Chicago Pritzker School of Medicine, Chicago, Illinois. 114NN Petrov Institute of Oncology, St. Petersburg, Russia. 115Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia. 116Research Centre for Genetic Engineering and Biotechnology 'Georgi D, Efremov', Macedonian Academy of Sciences and Arts, Skopje Republic of North Macedonia, North Macedonia. 117Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland. 118Parkville Familial Cancer Centre, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia. 119State Research Institute Innovative Medicine Center, Vilnius, Lithuania. 120Department of Medicine, Division of Hematology/Oncology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. 121Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California. 122Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York. 123David Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California, Los Angeles, California. 124Department of Genetics and Fundamental Medicine, Bashkir State Medical University, Ufa, Russia. 125Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. 126Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo, Norway. 127Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. 128Molecular Diagnostic Unit, Hereditary Cancer Program, ICO-IDIBELL (Bellvitge Biomedical Research Institute, Catalan Institute of Oncology), CIBERONC, Barcelona, Spain. 129Departement de Ge netique, CHU de Grenoble, Grenoble, France. 130Institut Curie, Paris, France. 131Mines ParisTech, Fontainebleau, France. 132Genetic Epidemiology of Cancer Team, Inserm U900, Paris, France. 133Department of Health Sciences Research, Mayo Clinic, Scottsdale, Arizona. 134Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington. 135Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. 136Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland. 137Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland. 138Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland. 139Department of Clinical Science and Education, Sšdersjukhuset, Karolinska Institutet, Stockholm, Sweden. 140Moores Cancer Center, University of California San Diego, La Jolla, California. 141Department of Family Medicine and Public Health, University of California San Diego, La Jolla, California. 142Immunology and Molecular Oncology Unit, Veneto Institute of Oncology ÊIOV-IRCCS, Padua, Italy. 143Department of Medical Oncology, University Hospital of Heraklion, Heraklion, Greece. 144Department of Gynecology and Obstetrics, Ludwig Maximilian University of Munich, Munich, Germany. 145MRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, University College London, London, UK. 146Department of Electron Microscopy/Molecular Pathology and The Cyprus School of Molecular Medicine, The Cyprus Institute of Neurology & Genetics, Nicosia, Cyprus. 147Faculty of Medicine, University of Heidelberg, Heidelberg, Germany. 148NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, New York. 149Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. 150Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada. 151Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California. 152Leuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium. 153Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 154Latvian Biomedical Research and Study Centre, Riga, Latvia. 155Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York. 156Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary. 157Center for Clinical Cancer Genetics, The University of Chicago, Chicago, Illinois. 158Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. 159Section of Molecular Diagnostics, Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark. 160Department of Genetics, Portuguese Oncology Institute, Porto, Portugal. 161Genome Diagnostics Program, IFOM-The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy. 162Department of Medicine Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. 163Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland. 164Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre Oulu, Oulu, Finland. 165Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy. 166Clinical Genetics, Karolinska Institutet, Stockholm, Sweden. 167Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH & RC), Lahore, Pakistan. 168Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut. 169Medical Oncology Department, Hospital Universitario Puerta de Hierro, Madrid, Spain. 170Department of Oncology, University Hospital of Larissa, Larissa, Greece. 171Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina. 172Research Oncology, GuyÕs Hospital, King's College London, London, UK. 173Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. 174Faculty of Information Technology, Monash University, Melbourne, Victoria, Australia. 175Center for Hereditary Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. 176Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. 177Division of Molecular Medicine, Pathology North, John Hunter Hospital, Newcastle, New South Wales, Australia. 178Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Callaghan, New South Wales, Australia. 179Hunter Medical Research Institute, John Hunter Hospital, Newcastle, New South Wales, Australia. 180Department of Internal Medicine, Division of Medical Oncology, University of Kansas Medical Center, Westwood, Kanas. 181Genomics Center, Centre Hospitalier Universitaire de Quebec-Universite Laval, Research Center, Quebec City, Qubec, Canada. 182Department of Clinical Genetics, Aarhus University Hospital, Aarhus N, Denmark. 183Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia. 184Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia. 185Population Oncology, BC Cancer, Vancouver, British of Columbia, Canada. 186School of Population and Public Health, University of British Columbia, Vancouver, British of Columbia, Canada. 187The Curtin UWA Centre for Genetic Origins of Health and Disease, Curtin University and University of Western Australia, Perth, Western Australia, Australia. 188Division of Breast Cancer Research, The Institute of Cancer Research, London, UK. 189Faculty of Medicine, University of Southampton, Southampton, UK. 190Epigenetic and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina. 191Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal. 192Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York. 193Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, CIBERONC, Barcelona, Spain. 194Department of Clinical Genetics, Odense University Hospital, Odence C, Denmark. 195Department of Medicine, Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. 196Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada. 197Department of Medical Genetics, University of Cambridge, Cambridge, UK. 198Department of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio. 199Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands. 200Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts. 201Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota. 202Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands. 203Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands. 204Department of Genetics, University of Pretoria, Arcadia, South Africa. 205Division of Functional Onco-genomics and Genetics, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy. 206Hospital Clínico Universitario (SERGAS), Universidad de Santiago de Compostela, CIMUS, Santiago de Compostela, España. 207Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina. 208Clinical Cancer Genomics, City of Hope, Duarte, California.

المصدر: Genetic epidemiology ; 44 ; 5 ; 442 ; 468 ; United Kingdom ; United States

مصطلحات موضوعية: GWAS, TWAS, breast cancer subtype, causal gene, Brjóstakrabbamein, Gen, Genome-Wide Association Study, Breast Neoplasms

العلاقة: Feng H, Gusev A, Pasaniuc B, et al. Transcriptome-wide association study of breast cancer risk by estrogen-receptor status. Genet Epidemiol. 2020;44(5):442-468. doi:10.1002/gepi.22288; http://hdl.handle.net/2336/621480Test; Genetic epidemiology

الإتاحة: https://doi.org/10.1002/gepi.22288Test
http://hdl.handle.net/2336/621480Test

المؤلفون: Fachal, Laura, Aschard, Hugues, Beesley, Jonathan, Barnes, Daniel R, Allen, Jamie, Kar, Siddhartha, Pooley, Karen A, Dennis, Joe, Michailidou, Kyriaki, Turman, Constance, Soucy, Penny, Lemaçon, Audrey, Lush, Michael, Tyrer, Jonathan P, Ghoussaini, Maya, Moradi Marjaneh, Mahdi, Jiang, Xia, Agata, Simona, Aittomäki, Kristiina, Alonso, M Rosario, Andrulis, Irene L, Anton-Culver, Hoda, Antonenkova, Natalia N, Arason, Adalgeir, Arndt, Volker, Aronson, Kristan J, Arun, Banu K, Auber, Bernd, Auer, Paul L, Azzollini, Jacopo, Balmaña, Judith, Barkardottir, Rosa B, Barrowdale, Daniel, Beeghly-Fadiel, Alicia, Benitez, Javier, Bermisheva, Marina, Białkowska, Katarzyna, Blanco, Amie M, Blomqvist, Carl, Blot, William, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Bonanni, Bernardo, Borg, Ake, Bosse, Kristin, Brauch, Hiltrud, Brenner, Hermann, Briceno, Ignacio, Brock, Ian W, Brooks-Wilson, Angela, Brüning, Thomas, Burwinkel, Barbara, Buys, Saundra S, Cai, Qiuyin, Caldés, Trinidad, Caligo, Maria A, Camp, Nicola J, Campbell, Ian, Canzian, Federico, Carroll, Jason S, Carter, Brian D, Castelao, Jose E, Chiquette, Jocelyne, Christiansen, Hans, Chung, Wendy K, Claes, Kathleen B M, Clarke, Christine L, Collée, J Margriet, Cornelissen, Sten, Couch, Fergus J, Cox, Angela, Cross, Simon S, Cybulski, Cezary, Czene, Kamila, Daly, Mary B, de la Hoya, Miguel, Devilee, Peter, Diez, Orland, Ding, Yuan Chun, Dite, Gillian S, Domchek, Susan M, Dörk, Thilo, Dos-Santos-Silva, Isabel, Droit, Arnaud, Dubois, Stéphane, Dumont, Martine, Duran, Mercedes, Durcan, Lorraine, Dwek, Miriam, Eccles, Diana M, Engel, Christoph, Eriksson, Mikael, Evans, D Gareth, Fasching, Peter A, Fletcher, Olivia, Floris, Giuseppe, Flyger, Henrik, Foretova, Lenka, Foulkes, William D, Friedman, Eitan, Fritschi, Lin, Frost, Debra, Gabrielson, Marike, Gago-Dominguez, Manuela, Gambino, Gaetana, Ganz, Patricia A, Gapstur, Susan M, Garber, Judy, García-Sáenz, José A, Gaudet, Mia M, Georgoulias, Vassilios, Giles, Graham G, Glendon, Gord, Godwin, Andrew K, Goldberg, Mark S, Goldgar, David E, González-Neira, Anna, Tibiletti, Maria Grazia, Greene, Mark H, Grip, Mervi, Gronwald, Jacek, Grundy, Anne, Guénel, Pascal, Hahnen, Eric, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Hamann, Ute, Harrington, Patricia A, Hartikainen, Jaana M, Hartman, Mikael, He, Wei, Healey, Catherine S, Heemskerk-Gerritsen, Bernadette A M, Heyworth, Jane, Hillemanns, Peter, Hogervorst, Frans B L, Hollestelle, Antoinette, Hooning, Maartje J, Hopper, John L, Howell, Anthony, Huang, Guanmengqian, Hulick, Peter J, Imyanitov, Evgeny N, Isaacs, Claudine, Iwasaki, Motoki, Jager, Agnes, Jakimovska, Milena, Jakubowska, Anna, James, Paul A, Janavicius, Ramunas, Jankowitz, Rachel C, John, Esther M, Johnson, Nichola, Jones, Michael E, Jukkola-Vuorinen, Arja, Jung, Audrey, Kaaks, Rudolf, Kang, Daehee, Kapoor, Pooja Middha, Karlan, Beth Y, Keeman, Renske, Kerin, Michael J, Khusnutdinova, Elza, Kiiski, Johanna I, Kirk, Judy, Kitahara, Cari M, Ko, Yon-Dschun, Konstantopoulou, Irene, Kosma, Veli-Matti, Koutros, Stella, Kubelka-Sabit, Katerina, Kwong, Ava, Kyriacou, Kyriacos, Laitman, Yael, Lambrechts, Diether, Lee, Eunjung, Leslie, Goska, Lester, Jenny, Lesueur, Fabienne, Lindblom, Annika, Lo, Wing-Yee, Long, Jirong, Lophatananon, Artitaya, Loud, Jennifer T, Lubiński, Jan, MacInnis, Robert J, Maishman, Tom, Makalic, Enes, Mannermaa, Arto, Manoochehri, Mehdi, Manoukian, Siranoush, Margolin, Sara, Martinez, Maria Elena, Matsuo, Keitaro, Maurer, Tabea, Mavroudis, Dimitrios, Mayes, Rebecca, McGuffog, Lesley, McLean, Catriona, Mebirouk, Noura, Meindl, Alfons, Miller, Austin, Miller, Nicola, Montagna, Marco, Moreno, Fernando, Muir, Kenneth, Mulligan, Anna Marie, Muñoz-Garzon, Victor M, Muranen, Taru A, Narod, Steven A, Nassir, Rami, Nathanson, Katherine L, Neuhausen, Susan L, Nevanlinna, Heli, Neven, Patrick, Nielsen, Finn C, Nikitina-Zake, Liene, Norman, Aaron, Offit, Kenneth, Olah, Edith, Olopade, Olufunmilayo I, Olsson, Håkan, Orr, Nick, Osorio, Ana, Pankratz, V Shane, Papp, Janos, Park, Sue K, Park-Simon, Tjoung-Won, Parsons, Michael T, Paul, James, Pedersen, Inge Sokilde, Peissel, Bernard, Peshkin, Beth, Peterlongo, Paolo, Peto, Julian, Plaseska-Karanfilska, Dijana, Prajzendanc, Karolina, Prentice, Ross, Presneau, Nadege, Prokofyeva, Darya, Pujana, Miquel Angel, Pylkäs, Katri, Radice, Paolo, Ramus, Susan J, Rantala, Johanna, Rau-Murthy, Rohini, Rennert, Gad, Risch, Harvey A, Robson, Mark, Romero, Atocha, Rossing, Maria, Saloustros, Emmanouil, Sánchez-Herrero, Estela, Sandler, Dale P, Santamariña, Marta, Saunders, Christobel, Sawyer, Elinor J, Scheuner, Maren T, Schmidt, Daniel F, Schmutzler, Rita K, Schneeweiss, Andreas, Schoemaker, Minouk J, Schöttker, Ben, Schürmann, Peter, Scott, Christopher, Scott, Rodney J, Senter, Leigha, Seynaeve, Caroline M, Shah, Mitul, Sharma, Priyanka, Shen, Chen-Yang, Shu, Xiao-Ou, Singer, Christian F, Slavin, Thomas P, Smichkoska, Snezhana, Southey, Melissa C, Spinelli, John J, Spurdle, Amanda B, Stone, Jennifer, Stoppa-Lyonnet, Dominique, Sutter, Christian, Swerdlow, Anthony J, Tamimi, Rulla M, Tan, Yen Yen, Tapper, William J, Taylor, Jack A, Teixeira, Manuel R, Tengström, Maria, Teo, Soo Hwang, Terry, Mary Beth, Teulé, Alex, Thomassen, Mads, Thull, Darcy L, Tischkowitz, Marc, Toland, Amanda E, Tollenaar, Rob A E M, Tomlinson, Ian, Torres, Diana, Torres-Mejía, Gabriela, Troester, Melissa A, Truong, Thérèse, Tung, Nadine, Tzardi, Maria, Ulmer, Hans-Ulrich, Vachon, Celine M, van Asperen, Christi J, van der Kolk, Lizet E, van Rensburg, Elizabeth J, Vega, Ana, Viel, Alessandra, Vijai, Joseph, Vogel, Maartje J, Wang, Qin, Wappenschmidt, Barbara, Weinberg, Clarice R, Weitzel, Jeffrey N, Wendt, Camilla, Wildiers, Hans, Winqvist, Robert, Wolk, Alicja, Wu, Anna H, Yannoukakos, Drakoulis, Zhang, Yan, Zheng, Wei, Hunter, David, Pharoah, Paul D P, Chang-Claude, Jenny, García-Closas, Montserrat, Schmidt, Marjanka K, Milne, Roger L, Kristensen, Vessela N, French, Juliet D, Edwards, Stacey L, Antoniou, Antonis C, Chenevix-Trench, Georgia, Simard, Jacques, Easton, Douglas F, Kraft, Peter, Dunning, Alison M

المساهمون: Véronique Mari, Pascaline Berthet, Laurent Castera, Dominique Vaur, Hakima Lallaoui, Yves-Jean Bignon, Nancy Uhrhammer, Valérie Bonadona, Christine Lasset, Françoise Révillion, Paul Vennin, Daniele Muller, Denise Molina Gomes, Olivier Ingster, Isabelle Coupier, Pascal Pujol, Marie-Agnès Collonge-Rame, Isabelle Mortemousque, Odile Bera, Mickaelle Rose, Amandine Baurand, Geoffrey Bertolone, Laurence Faivre, Hélène Dreyfus, Dominique Leroux, Laurence Venat-Bouvet, Stéphane Bézieau, Capucine Delnatte, Jean Chiesa, Brigitte Gilbert-Dussardier, Paul Gesta, Fabienne Prieur Prieur, Myriam Bronner, Johanna Sokolowska, Florence Coulet, Nadia Boutry-Kryza, Alain Calender, Sophie Giraud, Mélanie Leone, Sandra Fert-Ferrer, Dominique Stoppa-Lyonnet, Yue Jiao, Fabienne Lesueur Lesueur, Noura Mebirouk, Emmanuelle Barouk-Simonet, Virginie Bubien, Michel Longy, Nicolas Sevenet, Laurence Gladieff, Christine Toulas, Audrey Reimineras, Hagay Sobol, Brigitte Bressac-de Paillerets, Odile Cabaret, Olivier Caron, Marine Guillaud-Bataille, Etienne Rouleau, Muriel Belotti, Bruno Buecher, Sandrine Caputo, Chrystelle Colas, Antoine De Pauw, Emmanuelle Fourme, Marion Gauthier-Villars, Lisa Golmard, Virginie Moncoutier, Claire Saule, Alan Donaldson, Alex Murray, Angela Brady, Carole Brewer, Caroline Pottinger, Clare Miller, David Gallagher, Helen Gregory, Jackie Cook, Jacqueline Eason, Julian Adlard, Julian Barwell, Kai-Ren Ong, Katie Snape, Lisa Walker, Louise Izatt, Lucy Side, Marc Tischkowitz, Mark T Rogers, Mary E Porteous, Munaza Ahmed, Patrick J Morrison, Paul Brennan, Ros Eeles, Rosemarie Davidson, Adrienne Sexton, Alice Christian, Alison Trainer, Allan Spigelman, Andrew Fellows, Andrew Shelling, Anna De Fazio, Anneke Blackburn, Ashley Crook, Bettina Meiser, Briony Patterson, Christine Clarke, Christobel Saunders, Clare Hunt, Clare Scott, David Amor, Deb Marsh, Edward Edkins, Elizabeth Salisbury, Eric Haan, Eveline Neidermayr, Finlay Macrea, Gelareh Farshid, Geoff Lindeman, Georgia Trench, Graham Mann, Graham Giles, Grantley Gill, Heather Thorne, Ian Campbell, Ian Hickie, Ingrid Winship, James Flanagan, James Kollias, Jane Visvader, Jennifer Stone, Jessica Taylor, Jo Burke, Jodi Saunus, John Forbes, John Hopper, Jonathan Beesley, Judy Kirk, Juliet French, Kathy Tucker, Kathy Wu, Kelly Phillips, Lara Lipton, Leslie Andrews, Lizz Lobb, Logan Walker, Maira Kentwell, Mandy Spurdle, Margaret Cummings, Margaret Gleeson, Marion Harris, Mark Jenkins, Mary Anne Young, Martin Delatycki, Mathew Wallis, Matthew Burgess, Melanie Price, Melissa Brown, Melissa Southey, Michael Bogwitz, Michael Field, Michael Friedlander, Michael Gattas, Mona Saleh, Nick Hayward, Nick Pachter, Paul Cohen, Pascal Duijf, Paul James, Pete Simpson, Peter Fong, Phyllis Butow, Rachael Williams, Rick Kefford, Rodney Scott, Roger Milne, Rosemary Balleine, Sarah-Jane Dawson, Sheau Lok, Shona O'Connell, Sian Greening, Sophie Nightingale, Stacey Edwards, Stephen Fox, Sue-Anne McLachlan, Sunil Lakhani, Yoland Antill, Cora Aalfs, Hanne Meijers-Heijboer, Klaartje van Engelen, Hans Gille, Ingrid Boere, Margriet Collée, Carolien van Deurzen, Maartje Hooning, Inge-Marie Obdeijn, Ans van den Ouweland, Caroline Seynaeve, Sabine Siesling, Janneke Verloop, Christi van Asperen, Peter Devilee, Twiggy van Cronenburg, Rien Blok, Maaike de Boer, Encarna Gómez Garcia, Muriel Adank, Frans Hogervorst, Denise Jenner, Flora van Leeuwen, Matti Rookus, Nicola Russell, Marjanka Schmidt, Sandra van den Belt-Dusebout, Carolien Kets, Arjen Mensenkamp, Truuske de Bock, Annemieke van der Hout, Marian Mourits, Jan Oosterwijk, Margreet Ausems, Marco Koudijs, Christine Clarke, Deborah Marsh, Rodney Scott, Robert Baxter, Desmond Yip, Jane Carpenter, Alison Davis, Nirmala Pathmanathan, Peter Simpson, Dinny Graham, Mythily Sachchithananthan

المصدر: Nature genetics ; 52 ; 1 ; 56 ; 73 ; United Kingdom ; United States

مصطلحات موضوعية: Brjóstakrabbamein, Gen, Genome-Wide Association Study, Breast Neoplasms

العلاقة: https://www.nature.com/articles/s41588-019-0537-1Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974400Test/; Fachal L, Aschard H, Beesley J, et al. Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes. Nat Genet. 2020;52(1):56-73. doi:10.1038/s41588-019-0537-1; http://hdl.handle.net/2336/621477Test; Nature genetics

الإتاحة: https://doi.org/10.1038/s41588-019-0537-1Test
http://hdl.handle.net/2336/621477Test

المؤلفون: Patel, Vivek L, Busch, Evan L, Friebel, Tara M, Cronin, Angel, Leslie, Goska, McGuffog, Lesley, Adlard, Julian, Agata, Simona, Agnarsson, Bjarni A, Ahmed, Munaza, Aittomäki, Kristiina, Alducci, Elisa, Andrulis, Irene L, Arason, Adalgeir, Arnold, Norbert, Artioli, Grazia, Arver, Brita, Auber, Bernd, Azzollini, Jacopo, Balmaña, Judith, Barkardottir, Rosa B, Barnes, Daniel R, Barroso, Alicia, Barrowdale, Daniel, Belotti, Muriel, Benitez, Javier, Bertelsen, Brigitte, Blok, Marinus J, Bodrogi, Istvan, Bonadona, Valérie, Bonanni, Bernardo, Bondavalli, Davide, Boonen, Susanne E, Borde, Julika, Borg, Ake, Bradbury, Angela R, Brady, Angela, Brewer, Carole, Brunet, Joan, Buecher, Bruno, Buys, Saundra S, Cabezas-Camarero, Santiago, Caldés, Trinidad, Caliebe, Almuth, Caligo, Maria A, Calvello, Mariarosaria, Campbell, Ian G, Carnevali, Ileana, Carrasco, Estela, Chan, Tsun L, Chu, Annie T W, Chung, Wendy K, Claes, Kathleen B M, Collaborators, Gemo Study, Collaborators, Embrace, Cook, Jackie, Cortesi, Laura, Couch, Fergus J, Daly, Mary B, Damante, Giuseppe, Darder, Esther, Davidson, Rosemarie, de la Hoya, Miguel, Puppa, Lara Della, Dennis, Joe, Díez, Orland, Ding, Yuan Chun, Ditsch, Nina, Domchek, Susan M, Donaldson, Alan, Dworniczak, Bernd, Easton, Douglas F, Eccles, Diana M, Eeles, Rosalind A, Ehrencrona, Hans, Ejlertsen, Bent, Engel, Christoph, Evans, D Gareth, Faivre, Laurence, Faust, Ulrike, Feliubadaló, Lídia, Foretova, Lenka, Fostira, Florentia, Fountzilas, George, Frost, Debra, García-Barberán, Vanesa, Garre, Pilar, Gauthier-Villars, Marion, Géczi, Lajos, Gehrig, Andrea, Gerdes, Anne-Marie, Gesta, Paul, Giannini, Giuseppe, Glendon, Gord, Godwin, Andrew K, Goldgar, David E, Greene, Mark H, Gutierrez-Barrera, Angelica M, Hahnen, Eric, Hamann, Ute, Hauke, Jan, Herold, Natalie, Hogervorst, Frans B L, Honisch, Ellen, Hopper, John L, Hulick, Peter J, Investigators, KConFab, Investigators, Hebon, Izatt, Louise, Jager, Agnes, James, Paul, Janavicius, Ramunas, Jensen, Uffe Birk, Jensen, Thomas Dyrso, Johannsson, Oskar Th, John, Esther M, Joseph, Vijai, Kang, Eunyoung, Kast, Karin, Kiiski, Johanna I, Kim, Sung-Won, Kim, Zisun, Ko, Kwang-Pil, Konstantopoulou, Irene, Kramer, Gero, Krogh, Lotte, Kruse, Torben A, Kwong, Ava, Larsen, Mirjam, Lasset, Christine, Lautrup, Charlotte, Lazaro, Conxi, Lee, Jihyoun, Lee, Jong Won, Lee, Min Hyuk, Lemke, Johannes, Lesueur, Fabienne, Liljegren, Annelie, Lindblom, Annika, Llovet, Patricia, Lopez-Fernández, Adria, Lopez-Perolio, Irene, Lorca, Victor, Loud, Jennifer T, Ma, Edmond S K, Mai, Phuong L, Manoukian, Siranoush, Mari, Veronique, Martin, Lynn, Matricardi, Laura, Mebirouk, Noura, Medici, Veronica, Meijers-Heijboer, Hanne E J, Meindl, Alfons, Mensenkamp, Arjen R, Miller, Clare, Gomes, Denise Molina, Montagna, Marco, Mooij, Thea M, Moserle, Lidia, Mouret-Fourme, Emmanuelle, Mulligan, Anna Marie, Nathanson, Katherine L, Navratilova, Marie, Nevanlinna, Heli, Niederacher, Dieter, Nielsen, Finn C Cilius, Nikitina-Zake, Liene, Offit, Kenneth, Olah, Edith, Olopade, Olufunmilayo I, Ong, Kai-Ren, Osorio, Ana, Ott, Claus-Eric, Palli, Domenico, Park, Sue K, Parsons, Michael T, Pedersen, Inge Sokilde, Peissel, Bernard, Peixoto, Ana, Pérez-Segura, Pedro, Peterlongo, Paolo, Petersen, Annabeth Høgh, Porteous, Mary E, Pujana, Miguel Angel, Radice, Paolo, Ramser, Juliane, Rantala, Johanna, Rashid, Muhammad U, Rhiem, Kerstin, Rizzolo, Piera, Robson, Mark E, Rookus, Matti A, Rossing, Caroline M, Ruddy, Kathryn J, Santos, Catarina, Saule, Claire, Scarpitta, Rosa, Schmutzler, Rita K, Schuster, Hélène, Senter, Leigha, Seynaeve, Caroline M, Shah, Payal D, Sharma, Priyanka, Shin, Vivian Y, Silvestri, Valentina, Simard, Jacques, Singer, Christian F, Skytte, Anne-Bine, Snape, Katie, Solano, Angela R, Soucy, Penny, Southey, Melissa C, Spurdle, Amanda B, Steele, Linda, Steinemann, Doris, Stoppa-Lyonnet, Dominique, Stradella, Agostina, Sunde, Lone, Sutter, Christian, Tan, Yen Y, Teixeira, Manuel R, Teo, Soo Hwang, Thomassen, Mads, Tibiletti, Maria Grazia, Tischkowitz, Marc, Tognazzo, Silvia, Toland, Amanda E, Tommasi, Stefania, Torres, Diana, Toss, Angela, Trainer, Alison H, Tung, Nadine, van Asperen, Christi J, van der Baan, Frederieke H, van der Kolk, Lizet E, van der Luijt, Rob B, van Hest, Liselotte P, Varesco, Liliana, Varon-Mateeva, Raymonda, Viel, Alessandra, Vierstrate, Jeroen, Villa, Roberta, von Wachenfeldt, Anna, Wagner, Philipp, Wang-Gohrke, Shan, Wappenschmidt, Barbara, Weitzel, Jeffrey N, Wieme, Greet, Yadav, Siddhartha, Yannoukakos, Drakoulis, Yoon, Sook-Yee, Zanzottera, Cristina, Zorn, Kristin K, D'Amico, Anthony V, Freedman, Matthew L, Pomerantz, Mark M, Chenevix-Trench, Georgia, Antoniou, Antonis C, Neuhausen, Susan L, Ottini, Laura, Nielsen, Henriette Roed, Rebbeck, Timothy R

المساهمون: 1Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts. 2Harvard T.H. Chan School of Public Health, Boston, Massachusetts. 3Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. 4Dana-Farber Cancer Institute. Boston, Massachusetts. 5Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. 6Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, United Kingdom. 7Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy. 8Department of Pathology, Landspitali University Hospital, 101, Reykjavik, Iceland. 9School of Medicine, University of Iceland, Reykjavik, Iceland. 10North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom. 11Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. 12Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada. 13Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. 14BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 15Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany. 16ULSS 3 Serenissima, U.O.C. Oncologia ed Ematologia Oncologica, Mirano, Venice, Italy. 17Department of Oncology, Karolinska Institutet, Stockholm, Sweden. 18Institute of Human Genetics, Hannover Medical School, Hannover, Germany. 19Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Istituto Nazionale dei Tumori di Milano, Milan, Italy. 20High Risk and Cancer Prevention Group, Vall d'Hebron Institute of Oncology, University Hospital Vall d'Hebron, Barcelona, Spain. 21Human Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. 22Service de Génétique, Institut Curie, Paris, France. 23Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. 24Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain. 25Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 26Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands. 27Department of Chemotherapy, National Institute of Oncology, Budapest, Hungary. 28Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France. 29Division of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, Milan, Italy. 30Clinical Genetic Unit, Department of Paediatrics, Zealand University Hospital, Roskilde, Denmark. 31Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany. 32Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. 33Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany. 34Department of Oncology, Lund University and Skåne University Hospital, Lund, Sweden. 35Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. 36North West Thames Regional Genetics Service, Kennedy Galton Centre, The North West London Hospitals NHS Trust, Middlesex, United Kingdom. 37Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, United Kingdom. 38Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, CIBERONC, Girona, Spain. 39Department of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah. 40Department of Oncology, Hospital Clinico San Carlos, IdISSC, Madrid, Spain. 41Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. 42Institute of Human Genetics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany. 43Section of Molecular Genetics, Department of Laboratory Medicine, University Hospital of Pisa, Pisa, Italy. 44Peter MacCallum Cancer Center, Melbourne, Victoria, Australia. 45Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia. 46UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria, Varese, Italy. 47Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Centre, Happy Valley, Hong Kong. 48Department of Pathology, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong. 49Departments of Pediatrics and Medicine, Columbia University, New York, New York. 50Centre for Medical Genetics, Ghent University, Ghent, Belgium. 51Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, United Kingdom. 52Department of Oncology and Haematology, University of Modena and Reggio Emilia, Modena, Italy. 53Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota. 54Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania. 55Department of Medical and Biological Sciences, University of Udine, Udine, Italy. 56Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, United Kingdom. 57Division of Functional Onco-genomics and Genetics, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy. 58Oncogenetics Group, Clinical and Molecular Genetics Area, Vall d'Hebron Institute of Oncology (VHIO), University Hospital, Barcelona, Spain. 59Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California. 60Department of Gynecology and Obstetrics, Ludwig Maximilian University of Munich, Munich, Germany. 61Clinical Genetics Department, St Michael's Hospital, Bristol, United Kingdom. 62Institute of Human Genetics, University of Münster, Münster, Germany. 63Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom. 64Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. 65Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, United Kingdom. 66Department of Clinical Genetics, Lund University Hospital, Lund, Sweden. 67Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 68Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. 69LIFE - Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany. 70Division of Evolution and Genomic Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health and Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom. 71Manchester Centre for Genomic Medicine, St Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust and Manchester Academic Health Science Centre, Manchester, United Kingdom. 72Unité d'oncogénétique, Centre de Lutte Contre le Cancer, Centre Georges-François Leclerc, Dijon, France. 73Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany. 74Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, CIBERONC, Barcelona, Spain. 75Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic. 76Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research "Demokritos", Athens, Greece. 77Second Department of Medical Oncology, EUROMEDICA General Clinic of Thessaloniki, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece. 78Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University of Würzburg, Würzburg, Germany. 79Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark. 80Service Régional Oncogénétique Poitou-Charentes, CH Niort, Niort, France. 81Department of Molecular Medicine, University La Sapienza, Rome, Italy. 82Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, Kansas. 83Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah. 84Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland. 85Department of Breast Medical Oncology and Clinical Genetics Program, University of Texas MD Anderson Cancer Center, Houston, Texas. 86Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany. 87Family Cancer Clinic, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands. 88Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany. 89Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia. 90Center for Medical Genetics, NorthShore University HealthSystem, Evanston, Illinois. 91The University of Chicago Pritzker School of Medicine, Chicago, Illinois. 92The Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON), Coordinating center: The Netherlands Cancer Institute, Amsterdam, the Netherlands. 93Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom. 94Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands. 95Parkville Familial Cancer Centre, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia. 96Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania. 97Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark. 98Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark. 99Department of Oncology, Landspitali University Hospital, Reykjavik, Iceland. 100Division of Oncology, Department of Medicine, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California. 101Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York. 102Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea. 103Department of Gynecology and Obstetrics, Technical University of Dresden, Dresden, Germany. 104Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. 105Department of Surgery, Daerim Saint Mary's Hospital, Seoul, Korea. 106Department of Surgery, Soonchunhyang University Bucheon Hospital, Bucheon, Korea. 107Department of Preventive Medicine, Gacheon University College of Medicine, Incheon, Republic of Korea. 108Department of Urology, Medical University of Vienna, Vienna, Austria. 109Department of Clinical Genetics, Odense University Hospital, Odense, Denmark. 110Department of Surgery, The University of Hong Kong, Pok Fu Lam, Hong Kong. 111Department of Surgery, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong. 112Department of Clinical Genetics, Aalborg University Hospital, Aalborg, Denmark. 113Department of Surgery, Soonchunhyang University College of Medicine and Soonchunhyang University Hospital, Seoul, Korea. 114Department of Surgery, Ulsan University College of Medicine and Asan Medical Center, Seoul, Korea. 115Institute of Human Genetics, University Hospital Leipzig, Leipzig, Germany. 116Genetic Epidemiology of Cancer Team, Inserm U900, Paris, France. 117Institut Curie, Paris, France. 118Mines ParisTech, Fontainebleau, France. 119Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. 120Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden. 121Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. 122Département d'Hématologie-Oncologie Médicale, Centre Antoine Lacassagne, Nice, France. 123Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom. 124Department of Clinical Genetics, VU University Medical Center, Amsterdam, the Netherlands. 125Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands. 126Department of Clinical Genetics, Alder Hey Hospital, Liverpool, United Kingdom. 127Service de Biologie de la Reproduction, Cytogénétique et Génétique Médicale, CHI Poissy - Saint Germain, Poissy, France. 128Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, the Netherlands. 129Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. 130Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada. 131Latvian Biomedical Research and Study Centre, Riga, Latvia. 132Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York. 133Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary. 134Center for Clinical Cancer Genetics, The University of Chicago, Chicago, Illinois. 135West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Birmingham, United Kingdom. 136Institute for Medical Genetics and Human Genetics, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. 137Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy. 138Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea. 139Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea. 140Cancer Research Institute, Seoul National University, Seoul, Korea. 141Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. 142Section of Molecular Diagnostics, Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark. 143Department of Genetics, Portuguese Oncology Institute, Porto, Portugal. 144Genome Diagnostics Program, IFOM - the FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy. 145South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, United Kingdom. 146Translational Research Laboratory, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, CIBERONC, Barcelona, Spain. 147Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, in Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy. 148Division of Gynaecology and Obstetrics, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany. 149Clinical Genetics, Karolinska Institutet, Stockholm, Sweden. 150Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH & RC), Lahore, Pakistan. 151Department of Oncology, Mayo Clinic, Rochester, Minnesota. 152Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, Pisa, Italy. 153Unité d'Oncogénétique, Centre de Lutte Contre le Cancer Paul Strauss, Strasbourg, France. 154Clinical Cancer Genetics Program, Division of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio. 155Department of Internal Medicine, Division of Oncology, University of Kansas Medical Center, Westwood, Kansas. 156Genomics Center, Centre Hospitalier Universitaire de Québec - Université Laval, Research Centre, Québec City, Québec, Canada. 157Dept of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. 158Medical Genetics Unit, St George's, University of London, London, United Kingdom. 159INBIOMED, Faculty of Medicine/CONICET and CEMIC, Department of Clinical Chemistry, Medical Direction, University of Buenos Aires, Buenos Aires, Argentina. 160Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia. 161Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia. 162Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany. 163Department of Tumour Biology, INSERM U830, Paris, France. 164Université Paris Descartes, Paris, France. 165Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, CIBERONC, Barcelona, Spain. 166Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany. 167Department of OB/GYN, Medical University of Vienna, Vienna, Austria. 168Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal. 169Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia. 170Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia. 171Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, Quebec, Canada. 172Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom. 173Department of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio. 174Istituto Nazionale Tumori 'Giovanni Paolo II, Bari, Italy. 175Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, Colombia. 176Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts. 177Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands. 178Department of Medical Genetics, University Medical Center, Utrecht, the Netherlands. 179Clinical Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. 180Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) AOU San Martino, IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy. 181Department of Women's Health, Tubingen University Hospital, Tubingen, Germany. 182Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany. 183Clinical Cancer Genetics, City of Hope, Duarte, California. 184Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Selangor, Malaysia. 185Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Timothy_Rebbeck@dfci.harvard.edu.

المصدر: Cancer research ; 80 ; 3 ; 624 ; 638 ; United Kingdom ; United States

مصطلحات موضوعية: Gen, Blöðruhálskirtilskrabbamein, Genes, BRCA1, BRCA2, Prostatic Neoplasms

العلاقة: https://cancerres.aacrjournals.org/content/80/3/624.longTest; https://cancerres.aacrjournals.org/content/canres/80/3/624.full.pdfTest; Patel VL, Busch EL, Friebel TM, et al. Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness. Cancer Res. 2020;80(3):624–638. doi:10.1158/0008-5472.CAN-19-1840; http://hdl.handle.net/2336/621345Test; Cancer research

الإتاحة: https://doi.org/10.1158/0008-5472.CAN-19-1840Test
http://hdl.handle.net/2336/621345Test

المؤلفون: Figlioli, Gisella, Bogliolo, Massimo, Catucci, Irene, Caleca, Laura, Lasheras, Sandra Viz, Pujol, Roser, Kiiski, Johanna I, Muranen, Taru A, Barnes, Daniel R, Dennis, Joe, Michailidou, Kyriaki, Bolla, Manjeet K, Leslie, Goska, Aalfs, Cora M, Adank, Muriel A, Adlard, Julian, Agata, Simona, Cadoo, Karen, Agnarsson, Bjarni A, Ahearn, Thomas, Aittomäki, Kristiina, Ambrosone, Christine B, Andrews, Lesley, Anton-Culver, Hoda, Antonenkova, Natalia N, Arndt, Volker, Arnold, Norbert, Aronson, Kristan J, Arun, Banu K, Asseryanis, Ella, Auber, Bernd, Auvinen, Päivi, Azzollini, Jacopo, Balmaña, Judith, Barkardottir, Rosa B, Barrowdale, Daniel, Barwell, Julian, Beane Freeman, Laura E, Beauparlant, Charles Joly, Beckmann, Matthias W, Behrens, Sabine, Benitez, Javier, Berger, Raanan, Bermisheva, Marina, Blanco, Amie M, Blomqvist, Carl, Bogdanova, Natalia V, Bojesen, Anders, Bojesen, Stig E, Bonanni, Bernardo, Borg, Ake, Brady, Angela F, Brauch, Hiltrud, Brenner, Hermann, Brüning, Thomas, Burwinkel, Barbara, Buys, Saundra S, Caldés, Trinidad, Caliebe, Almuth, Caligo, Maria A, Campa, Daniele, Campbell, Ian G, Canzian, Federico, Castelao, Jose E, Chang-Claude, Jenny, Chanock, Stephen J, Claes, Kathleen B M, Clarke, Christine L, Collavoli, Anita, Conner, Thomas A, Cox, David G, Cybulski, Cezary, Czene, Kamila, Daly, Mary B, de la Hoya, Miguel, Devilee, Peter, Diez, Orland, Ding, Yuan Chun, Dite, Gillian S, Ditsch, Nina, Domchek, Susan M, Dorfling, Cecilia M, Dos-Santos-Silva, Isabel, Durda, Katarzyna, Dwek, Miriam, Eccles, Diana M, Ekici, Arif B, Eliassen, A Heather, Ellberg, Carolina, Eriksson, Mikael, Evans, D Gareth, Fasching, Peter A, Figueroa, Jonine, Flyger, Henrik, Foulkes, William D, Friebel, Tara M, Friedman, Eitan, Gabrielson, Marike, Gaddam, Pragna, Gago-Dominguez, Manuela, Gao, Chi, Gapstur, Susan M, Garber, Judy, García-Closas, Montserrat, García-Sáenz, José A, Gaudet, Mia M, Gayther, Simon A, Giles, Graham G, Glendon, Gord, Godwin, Andrew K, Goldberg, Mark S, Goldgar, David E, Guénel, Pascal, Gutierrez-Barrera, Angelica M, Haeberle, Lothar, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Hamann, Ute, Harrington, Patricia A, Hein, Alexander, Heyworth, Jane, Hillemanns, Peter, Hollestelle, Antoinette, Hopper, John L, Hosgood, H Dean, Howell, Anthony, Hu, Chunling, Hulick, Peter J, Hunter, David J, Imyanitov, Evgeny N, Isaacs, Claudine, Jakimovska, Milena, Jakubowska, Anna, James, Paul, Janavicius, Ramunas, Janni, Wolfgang, John, Esther M, Jones, Michael E, Jung, Audrey, Kaaks, Rudolf, Karlan, Beth Y, Khusnutdinova, Elza, Kitahara, Cari M, Konstantopoulou, Irene, Koutros, Stella, Kraft, Peter, Lambrechts, Diether, Lazaro, Conxi, Le Marchand, Loic, Lester, Jenny, Lesueur, Fabienne, Lilyquist, Jenna, Loud, Jennifer T, Lu, Karen H, Luben, Robert N, Lubinski, Jan, Mannermaa, Arto, Manoochehri, Mehdi, Manoukian, Siranoush, Margolin, Sara, Martens, John W M, Maurer, Tabea, Mavroudis, Dimitrios, Mebirouk, Noura, Meindl, Alfons, Menon, Usha, Miller, Austin, Montagna, Marco, Nathanson, Katherine L, Neuhausen, Susan L, Newman, William G, Nguyen-Dumont, Tu, Nielsen, Finn Cilius, Nielsen, Sarah, Nikitina-Zake, Liene, Offit, Kenneth, Olah, Edith, Olopade, Olufunmilayo I, Olshan, Andrew F, Olson, Janet E, Olsson, Håkan, Osorio, Ana, Ottini, Laura, Peissel, Bernard, Peixoto, Ana, Peto, Julian, Plaseska-Karanfilska, Dijana, Pocza, Timea, Presneau, Nadege, Pujana, Miquel Angel, Punie, Kevin, Rack, Brigitte, Rantala, Johanna, Rashid, Muhammad U, Rau-Murthy, Rohini, Rennert, Gad, Lejbkowicz, Flavio, Rhenius, Valerie, Romero, Atocha, Rookus, Matti A, Ross, Eric A, Rossing, Maria, Rudaitis, Vilius, Ruebner, Matthias, Saloustros, Emmanouil, Sanden, Kristin, Santamariña, Marta, Scheuner, Maren T, Schmutzler, Rita K, Schneider, Michael, Scott, Christopher, Senter, Leigha, Shah, Mitul, Sharma, Priyanka, Shu, Xiao-Ou, Simard, Jacques, Singer, Christian F, Sohn, Christof, Soucy, Penny, Southey, Melissa C, Spinelli, John J, Steele, Linda, Stoppa-Lyonnet, Dominique, Tapper, William J, Teixeira, Manuel R, Terry, Mary Beth, Thomassen, Mads, Thompson, Jennifer, Thull, Darcy L, Tischkowitz, Marc, Tollenaar, Rob A E M, Torres, Diana, Troester, Melissa A, Truong, Thérèse, Tung, Nadine, Untch, Michael, Vachon, Celine M, van Rensburg, Elizabeth J, van Veen, Elke M, Vega, Ana, Viel, Alessandra, Wappenschmidt, Barbara, Weitzel, Jeffrey N, Wendt, Camilla, Wieme, Greet, Wolk, Alicja, Yang, Xiaohong R, Zheng, Wei, Ziogas, Argyrios, Zorn, Kristin K, Dunning, Alison M, Lush, Michael, Wang, Qin, McGuffog, Lesley, Parsons, Michael T, Pharoah, Paul D P, Fostira, Florentia, Toland, Amanda E, Andrulis, Irene L, Ramus, Susan J, Swerdlow, Anthony J, Greene, Mark H, Chung, Wendy K, Milne, Roger L, Chenevix-Trench, Georgia, Dörk, Thilo, Schmidt, Marjanka K, Easton, Douglas F, Radice, Paolo, Hahnen, Eric, Antoniou, Antonis C, Couch, Fergus J, Nevanlinna, Heli, Surrallés, Jordi, Peterlongo, Paolo

المساهمون: 1 IFOM - the FIRC Institute for Molecular Oncology, Genome Diagnostics Program, Milan, Italy. 2 2Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Bellaterra, Barcelona Spain. 3 3Center for Biomedical Network Research on Rare Diseases (CIBERER), Madrid, Spain. 4 4Institute of Biomedical Research, Sant Pau Hospital, Barcelona, Spain. 5 Fondazione IRCCS Istituto Nazionale dei Tumori, Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Milan, Italy. 6 University of Helsinki, Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland. 7 7University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, UK. 8 The Cyprus Institute of Neurology & Genetics, Department of Electron Microscopy/Molecular Pathology and The Cyprus School of Molecular Medicine, Nicosia, Cyprus. 9 9Amsterdam UMC, lokatie AMC, Department of Clinical Genetics, Amsterdam, The Netherlands. 10 The Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Family Cancer Clinic, Amsterdam, The Netherlands. 11 Chapel Allerton Hospital, Yorkshire Regional Genetics Service, Leeds, UK. 12 Veneto Institute of Oncology IOV - IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy. 13 Memorial Sloan-Kettering Cancer Center, Department of Medicine, New York, NY USA. 14 Landspitali University Hospital, Department of Pathology, Reykjavik, Iceland. 15 15University of Iceland, School of Medicine, Reykjavik, Iceland. 16 16National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, Bethesda, MD USA. 17 17University of Helsinki, Department of Clinical Genetics, Helsinki University Hospital, Helsinki, Finland. 18 18Roswell Park Cancer Institute, Buffalo, NY USA. 19 Nelune Comprehensive Cancer Care Centre, The Bright Alliance Building, Randwick, NSW Australia. 20 20University of California Irvine, Department of Epidemiology, Genetic Epidemiology Research Institute, Irvine, CA USA. 21 N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus. 22 German Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research, Heidelberg, Germany. 23 University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Department of Gynaecology and Obstetrics, and Institute of Clinical Molecular Biology, Kiel, Germany. 24 Queen's University, Department of Public Health Sciences, and Cancer Research Institute, Kingston, ON Canada. 25 25University of Texas MD Anderson Cancer Center, Department of Breast Medical Oncology, Houston, TX USA. 26 26Medical University of Vienna, Dept of OB/GYN and Comprehensive Cancer Center, Vienna, Austria. 27 27Hannover Medical School, Institute of Human Genetics, Hannover, Germany. 28 28Kuopio University Hospital, Cancer Center, Kuopio, Finland. 29 29University of Eastern Finland, Institute of Clinical Medicine, Oncology, Kuopio, Finland. 30 30University of Eastern Finland, Translational Cancer Research Area, Kuopio, Finland. 31 31Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Department of Medical Oncology and Hematology, Unit of Medical Genetics, Milan, Italy. 32 32Vall d'Hebron Institute of Oncology, High Risk and Cancer Prevention Group, Barcelona, Spain. 33 33University Hospital, Vall d'Hebron, Department of Medical Oncology, Barcelona, Spain. 34 34University of Iceland, BMC (Biomedical Centre), Faculty of Medicine, Reykjavik, Iceland. 35 35University Hospitals of Leicester NHS Trust, Leicestershire Clinical Genetics Service, Leicester, UK. 36 36Centre Hospitalier Universitaire de Québec - Université Laval, Research Center, Genomics Center, Québec City, QC Canada. 37 University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, Erlangen, Germany. 38 German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany. 39 Spanish National Cancer Research Centre (CNIO), Human Genetics Group, Human Cancer Genetics Programme, Madrid, Spain. 40 40Spanish Network on Rare Diseases (CIBERER), Madrid, Spain. 41 41Spanish National Cancer Research Centre (CNIO), Genotyping Unit (CEGEN), Human Cancer Genetics Programme, Madrid, Spain. 42 Chaim Sheba Medical Center, The Institute of Oncology, Ramat Gan, Israel. 43 43Ufa Federal Research Center of the Russian Academy of Sciences, Institute of Biochemistry and Genetics, Ufa, Russia. 44 44University of California San Francisco, Cancer Genetics and Prevention Program, San Francisco, CA USA. 45 University of Helsinki, Department of Oncology, Helsinki University Hospital, Helsinki, Finland. 46 46Örebro University Hospital, Department of Oncology, Örebro, Sweden. 47 Hannover Medical School, Department of Radiation Oncology, Hannover, Germany. 48 Hannover Medical School, Gynaecology Research Unit, Hannover, Germany. 49 49Aarhus University Hospital, Department of Clinical Genetics, Aarhus, Denmark. 50 Copenhagen University Hospital, Copenhagen General Population Study, Herlev and Gentofte Hospital, Herlev, Denmark. 51 Copenhagen University Hospital, Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev, Denmark. 52 52University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark. 53 53IEO, European Institute of Oncology IRCCS, Division of Cancer Prevention and Genetics, Milan, Italy. 54 54Lund University and Skåne University Hospital, Department of Oncology, Lund, Sweden. 55 55London North West University Hospitals NHS Trust, Northwick Park Hospital, North West Thames Regional Genetics Service, Kennedy Galton Centre, Harrow, UK. 56 56Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany. 57 57University of Tübingen, iFIT-Cluster of Excellence, Tübingen, Germany. 58 58German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany. 59 59German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Division of Preventive Oncology, Heidelberg, Germany. 60 60Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum, Germany. 61 61German Cancer Research Center (DKFZ), Molecular Epidemiology Group, C080 Heidelberg, Germany. 62 University of Heidelberg, Molecular Biology of Breast Cancer, University Womens Clinic Heidelberg, Heidelberg, Germany. 63 63Huntsman Cancer Institute, Department of Medicine, Salt Lake City, UT USA. 64 64Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Medical Oncology Department, Hospital Clínico San Carlos, Madrid, Spain. 65 University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Institute of Human Genetics, Kiel, Germany. 66 66University Hospital of Pisa, Section of Molecular Genetics, Dept. of Laboratory Medicine, Pisa, Italy. 67 67University of Pisa, Department of Biology, Pisa, Italy. 68 68Peter MacCallum Cancer Center, Research Division, Melbourne, VIC Australia. 69 69The University of Melbourne, Sir Peter MacCallum Department of Oncology, Melbourne, VIC Australia. 70 70German Cancer Research Center (DKFZ), Genomic Epidemiology Group, Heidelberg, Germany. 71 Instituto de Investigacion Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS, Oncology and Genetics Unit, Vigo, Spain. 72 72University Medical Center Hamburg-Eppendorf, Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), Hamburg, Germany. 73 73Ghent University, Centre for Medical Genetics, Gent, Belgium. 74 74University of Sydney, Westmead Institute for Medical Research, Sydney, NSW Australia. 75 University and University Hospital of Pisa, Section of Genetic Oncology, Dept. of Laboratory Medicine, Pisa, Italy. 76 76Huntsman Cancer Institute, Salt Lake City, UT USA. 77 77Imperial College London, Department of Epidemiology and Biostatistics, School of Public Health, London, UK. 78 78Cancer Research Center of Lyon, INSERM, U1052 Lyon, France. 79 79Pomeranian Medical University, Department of Genetics and Pathology, Szczecin, Poland. 80 80Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden. 81 81Fox Chase Cancer Center, Department of Clinical Genetics, Philadelphia, PA USA. 82 82Leiden University Medical Center, Department of Pathology, Leiden, The Netherlands. 83 83Leiden University Medical Center, Department of Human Genetics, Leiden, The Netherlands. 84 84Vall d'Hebron Institute of Oncology (VHIO), Oncogenetics Group, Barcelona, Spain. 85 85University Hospital Vall d'Hebron, Area of Clinical and Molecular Genetics, Barcelona, Spain. 86 86Beckman Research Institute of City of Hope, Department of Population Sciences, Duarte, CA USA. 87 87The University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Melbourne, Victoria, Australia. 88 88Ludwig Maximilian University of Munich, Department of Gynecology and Obstetrics, Munich, Germany. 89 Perelman School of Medicine at the University of Pennsylvania, Department of Medicine, Abramson Cancer Center, Philadelphia, PA USA. 90 90University of Pretoria, Department of Genetics, Arcadia, South Africa. 91 91London School of Hygiene and Tropical Medicine, Department of Non-Communicable Disease Epidemiology, London, UK. 92 92University of Westminster, Department of Biomedical Sciences, Faculty of Science and Technology, London, UK. 93 93University of Southampton, Cancer Sciences Academic Unit, Faculty of Medicine, Southampton, UK. 94 Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Institute of Human Genetics, University Hospital Erlangen, Erlangen, Germany. 95 95Harvard Medical School, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA USA. 96 96Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA USA. 97 97Lund University, Department of Cancer Epidemiology, Clinical Sciences, Lund, Sweden. 98 98University of Manchester, Division of Evolution and Genomic Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester, UK. 99 99Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester Centre for Genomic Medicine, Manchester, UK. 100 100University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, Los Angeles, CA USA. 101 101The University of Edinburgh Medical School, Usher Institute of Population Health Sciences and Informatics, Edinburgh, UK. 102 Cancer Research UK Edinburgh Centre, Edinburgh, UK. 103 Copenhagen University Hospital, Department of Breast Surgery, Herlev and Gentofte Hospital, Herlev, Denmark. 104 104McGill University, Program in Cancer Genetics, Departments of Human Genetics and Oncology, Montréal, QC Canada. 105 105Harvard T.H. Chan School of Public Health, Boston, MA USA. 106 106Dana-Farber Cancer Institute, Boston, MA USA. 107 107Chaim Sheba Medical Center, The Susanne Levy Gertner Oncogenetics Unit, Ramat Gan, Israel. 108 108Tel Aviv University, Sackler Faculty of Medicine, Ramat Aviv, Israel. 109 109Memorial Sloan-Kettering Cancer Center, Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, New York, NY USA. 110 110Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Genomic Medicine Group, Galician Foundation of Genomic Medicine, Santiago de Compostela, Spain. 111 111University of California San Diego, Moores Cancer Center, La Jolla, CA USA. 112 112Harvard T.H. Chan School of Public Health, Program in Genetic Epidemiology and Statistical Genetics, Boston, MA USA. 113 113American Cancer Society, Epidemiology Research Program, Atlanta, GA USA. 114 Dana-Farber Cancer Institute, Cancer Risk and Prevention Clinic, Boston, MA USA. 115 116Cedars-Sinai Medical Center, The Center for Bioinformatics and Functional Genomics at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA USA. 116 117Cancer Council Victoria, Cancer Epidemiology Division, Melbourne, VIC Australia. 117 118Monash University, Department of Epidemiology and Preventive Medicine, Melbourne, VIC Australia. 118 119Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Fred A. Litwin Center for Cancer Genetics, Toronto, ON Canada. 119 120Kansas University Medical Center, Department of Pathology and Laboratory Medicine, Kansas City, KS USA. 120 121McGill University, Department of Medicine, Montréal, QC Canada. 121 122McGill University, Division of Clinical Epidemiology, Royal Victoria Hospital, Montréal, QC Canada. 122 123Huntsman Cancer Institute, University of Utah School of Medicine, Department of Dermatology, Salt Lake City, UT USA. 123 124INSERM, University Paris-Sud, University Paris-Saclay, Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), Villejuif, France. 124 125University of Texas MD Anderson Cancer Center, Department of Breast Medical Oncology and Clinical Genetics Program, Houston, TX USA. 125 126Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Department of Gynaecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany. 126 127University of Southern California, Department of Preventive Medicine, Keck School of Medicine, Los Angeles, CA USA. 127 128Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden. 128 129Södersjukhuset, Department of Oncology, Stockholm, Sweden. 129 German Cancer Research Center (DKFZ), Molecular Genetics of Breast Cancer, Heidelberg, Germany. 130 131University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge, UK. 131 132The University of Western Australia, School of Population and Global Health, Perth, WA Australia. 132 133Erasmus MC Cancer Institute, Department of Medical Oncology, Family Cancer Clinic, Rotterdam, The Netherlands. 133 134Albert Einstein College of Medicine, Department of Epidemiology and Public Health, Bronx, NY USA. 134 135University of Manchester, Division of Cancer Sciences, Manchester, UK. 135 136Mayo Clinic, Department of Laboratory Medicine and Pathology, Rochester, MN USA. 136 137NorthShore University HealthSystem, Center for Medical Genetics, Evanston, IL USA. 137 138The University of Chicago Pritzker School of Medicine, Chicago, IL USA. 138 139University of Oxford, Nuffield Department of Population Health, Oxford, UK. 139 140N.N. Petrov Institute of Oncology, St. Petersburg, Russia. 140 141Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC USA. 141 142Macedonian Academy of Sciences and Arts, Research Centre for Genetic Engineering and Biotechnology 'Georgi D. Efremov', Skopje, Republic of Macedonia. 142 143Pomeranian Medical University, Independent Laboratory of Molecular Biology and Genetic Diagnostics, Szczecin, Poland. 143 144Peter MacCallum Cancer Center, Parkville Familial Cancer Centre, Melbourne, VIC Australia. 144 145Vilnius University Hospital Santariskiu Clinics, Hematology, oncology and transfusion medicine center, Dept. of Molecular and Regenerative Medicine, Vilnius, Lithuania. 145 State Research Institute Innovative Medicine Center, Vilnius, Lithuania. 146 147University Hospital Ulm, Department of Gynaecology and Obstetrics, Ulm, Germany. 147 148Stanford University School of Medicine, Department of Medicine (Oncology) and Stanford Cancer Institute, Stanford, CA USA. 148 115The Institute of Cancer Research, Division of Genetics and Epidemiology, London, UK. 149 149Cedars-Sinai Medical Center, Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA USA. 150 150Bashkir State Medical University, Department of Medical Genetics, Ufa, Russia. 151 151National Cancer Institute, Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Bethesda, MD USA. 152 152National Centre for Scientific Research 'Demokritos', Molecular Diagnostics Laboratory, INRASTES, Athens, Greece. 153 153VIB, VIB Center for Cancer Biology, Leuven, Belgium. 154 154University of Leuven, Laboratory for Translational Genetics, Department of Human Genetics, Leuven, Belgium. 155 IDIBELL (Bellvitge Biomedical Research Institute),Catalan Institute of Oncology, CIBERONC, Molecular Diagnostic Unit, Hereditary Cancer Program, Barcelona, Spain. 156 156University of Hawaii Cancer Center, Epidemiology Program, Honolulu, HI USA. 157 Inserm U900, Genetic Epidemiology of Cancer team, Paris, France. 158 158PSL University, Paris, France. 159 159Institut Curie, Paris, France. 160 160Mines ParisTech, Fontainebleau, France. 161 161Mayo Clinic, Department of Health Sciences Research, Rochester, MN USA. 162 162National Cancer Institute, Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, Bethesda, MD USA. 163 163University of Texas MD Anderson Cancer Center, Department of Gynecologic Oncology and Clinical Cancer Genetics Program, Houston, TX USA. 164 164University of Cambridge, Clinical Gerontology, Department of Public Health and Primary Care, Cambridge, UK. 165 165University of Eastern Finland, Institute of Clinical Medicine, Pathology and Forensic Medicine, Kuopio, Finland. 166 166Kuopio University Hospital, Imaging Center, Department of Clinical Pathology, Kuopio, Finland. 167 Karolinska Institutet, Department of Clinical Science and Education, Södersjukhuset, Stockholm, Sweden. 168 168University Hospital of Heraklion, Department of Medical Oncology, Heraklion, Greece. 169 University College London, MRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, London, UK. 170 Roswell Park Cancer Institute, NRG Oncology, Clinical Trials Development Division, Buffalo, NY USA. 171 171Monash University, Precision Medicine, School of Clinical Sciences at Monash Health, Clayton, VIC Australia. 172 199The University of Melbourne, Department of Clinical Pathology, Melbourne, VIC Australia. 173 Rigshospitalet, Copenhagen University Hospital, Center for Genomic Medicine, Copenhagen, Denmark. 174 The University of Chicago, Center for Clinical Cancer Genetics, Chicago, IL USA. 175 174Latvian Biomedical Research and Study Centre, Riga, Latvia. 176 175Memorial Sloan-Kettering Cancer Center, Clinical Genetics Service, Department of Medicine, New York, NY USA. 177 176National Institute of Oncology, Department of Molecular Genetics, Budapest, Hungary. 178 177University of North Carolina at Chapel Hill, Department of Epidemiology, Lineberger Comprehensive Cancer Center, Chapel Hill, NC USA. 179 178University La Sapienza, Department of Molecular Medicine, Rome, Italy. 180 179Portuguese Oncology Institute, Department of Genetics, Porto, Portugal. 181 IDIBELL (Bellvitge Biomedical Research Institute),Catalan Institute of Oncology, CIBERONC, ProCURE, Oncobell, Barcelona, Spain. 182 181Leuven Cancer Institute, University Hospitals Leuven, Multidisciplinary Breast Center, Department of General Medical Oncology, Leuven, Belgium. 183 182Karolinska Institutet, Clinical Genetics, Stockholm, Sweden. 184 183Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH & RC), Department of Basic Sciences, Lahore, Pakistan. 185 184Carmel Medical Center and Technion Faculty of Medicine, Clalit National Cancer Control Center, Haifa, Israel. 186 185Hospital Universitario Puerta de Hierro, Medical Oncology Department, Madrid, Spain. 187 186The Netherlands Cancer Institute, Department of Epidemiology, Amsterdam, The Netherlands. 188 187Fox Chase Cancer Center, Biostatistics and Bioinformatics Facility, Philadelphia, PA USA. 189 188Vilnius University, Medical Faculty, Institute of Clinical Medicine, Vilnius, Lithuania. 190 189University Hospital of Larissa, Department of Oncology, Larissa, Greece. 191 190University of Wisconsin, Cancer Center at ProHealth Care, Waukesha, WI USA. 192 191Fundación Pública Galega Medicina Xenómica, Santiago De Compostela, Spain. 193 192Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago De Compostela, Spain. 194 193University Hospital of Cologne, Center for Hereditary Breast and Ovarian Cancer, Cologne, Germany. 195 194University of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany. 196 195The Ohio State University, Clinical Cancer Genetics Program, Division of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, Columbus, OH USA. 197 196University of Kansas Medical Center, Department of Internal Medicine, Division of Oncology, Westwood, KS USA. 198 Vanderbilt University School of Medicine, Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Nashville, TN USA. 199 University of Heidelberg, National Center for Tumor Diseases, Heidelberg, Germany. 200 BC Cancer, Population Oncology, Vancouver, BC Canada. 201 201University of British Columbia, School of Population and Public Health, Vancouver, BC Canada. 202 202Institut Curie, Service de Génétique, Paris, France. 203 INSERM U830, Department of Tumour Biology, Paris, France. 204 204Université Paris Descartes, Paris, France. 205 205University of Southampton, Faculty of Medicine, Southampton, UK. 206 206University of Porto, Biomedical Sciences Institute (ICBAS), Porto, Portugal. 207 207Columbia University, Department of Epidemiology, Mailman School of Public Health, New York, NY USA. 208 208Odense University Hospital, Department of Clinical Genetics, Odence C, Denmark. 209 Magee-Womens Hospital, University of Pittsburgh School of Medicine, Department of Medicine, Pittsburgh, PA USA. 210 210University of Cambridge, Department of Medical Genetics, Cambridge, UK. 211 211Leiden University Medical Center, Department of Surgery, Leiden, The Netherlands. 212 212Pontificia Universidad Javeriana, Institute of Human Genetics, Bogota, Colombia. 213 213Beth Israel Deaconess Medical Center, Department of Medical Oncology, Boston, MA USA. 214 Helios Clinics Berlin-Buch, Department of Gynecology and Obstetrics, Berlin, Germany. 215 215Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Division of Functional onco-genomics and genetics, Aviano, Italy. 216 216City of Hope, Clinical Cancer Genetics, Duarte, CA USA. 217 217Uppsala University, Department of Surgical Sciences, Uppsala, Sweden. 218 Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA USA. 219 219QIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology, Brisbane, QLD Australia. 220 220The Ohio State University, Department of Cancer Biology and Genetics, Columbus, OH USA. 221 221University of Toronto, Department of Molecular Genetics, Toronto, ON Canada. 222 222University of NSW Sydney, School of Women's and Children's Health, Faculty of Medicine, Sydney, NSW Australia. 223 223The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW Australia. 224 The Institute of Cancer Research, Division of Genetics and Epidemiology, London, UK. 225 The Institute of Cancer Research, Division of Breast Cancer Research, London, UK. 226 226Columbia University, Departments of Pediatrics and Medicine, New York, NY USA. 227 227The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Division of Molecular Pathology, Amsterdam, The Netherlands. 228 228The Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Division of Psychosocial Research and Epidemiology, Amsterdam, The Netherlands. 229 229Department of Genetics, Sant Pau Hospital, Barcelona, Spain. # Contributed equally

المصدر: NPJ breast cancer

مصطلحات موضوعية: Cancer genetics, Genes, Neoplasm, Breast Neoplasms

العلاقة: https://www.nature.com/articles/s41523-019-0127-5Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825205Test/; Figlioli, G., Bogliolo, M., Catucci, I. et al. The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer. npj Breast Cancer 5, 38 (2019) doi:10.1038/s41523-019-0127-5; http://hdl.handle.net/2336/621194Test; NPJ Breast Cancer

الإتاحة: https://doi.org/10.1038/s41523-019-0127-5Test
http://hdl.handle.net/2336/621194Test

المؤلفون: Jiang, Xia, Finucane, Hilary K, Schumacher, Fredrick R, Schmit, Stephanie L, Tyrer, Jonathan P, Han, Younghun, Michailidou, Kyriaki, Lesseur, Corina, Kuchenbaecker, Karoline B, Dennis, Joe, Conti, David V, Casey, Graham, Gaudet, Mia M, Huyghe, Jeroen R, Albanes, Demetrius, Aldrich, Melinda C, Andrew, Angeline S, Andrulis, Irene L, Anton-Culver, Hoda, Antoniou, Antonis C, Antonenkova, Natalia N, Arnold, Susanne M, Aronson, Kristan J, Arun, Banu K, Bandera, Elisa V, Barkardottir, Rosa B, Barnes, Daniel R, Batra, Jyotsna, Beckmann, Matthias W, Benitez, Javier, Benlloch, Sara, Berchuck, Andrew, Berndt, Sonja I, Bickeböller, Heike, Bien, Stephanie A, Blomqvist, Carl, Boccia, Stefania, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Brauch, Hiltrud, Brenner, Hermann, Brenton, James D, Brook, Mark N, Brunet, Joan, Brunnström, Hans, Buchanan, Daniel D, Burwinkel, Barbara, Butzow, Ralf, Cadoni, Gabriella, Caldés, Trinidad, Caligo, Maria A, Campbell, Ian, Campbell, Peter T, Cancel-Tassin, Géraldine, Cannon-Albright, Lisa, Campa, Daniele, Caporaso, Neil, Carvalho, André L, Chan, Andrew T, Chang-Claude, Jenny, Chanock, Stephen J, Chen, Chu, Christiani, David C, Claes, Kathleen B M, Claessens, Frank, Clements, Judith, Collée, J Margriet, Correa, Marcia Cruz, Couch, Fergus J, Cox, Angela, Cunningham, Julie M, Cybulski, Cezary, Czene, Kamila, Daly, Mary B, deFazio, Anna, Devilee, Peter, Diez, Orland, Gago-Dominguez, Manuela, Donovan, Jenny L, Dörk, Thilo, Duell, Eric J, Dunning, Alison M, Dwek, Miriam, Eccles, Diana M, Edlund, Christopher K, Edwards, Digna R Velez, Ellberg, Carolina, Evans, D Gareth, Fasching, Peter A, Ferris, Robert L, Liloglou, Triantafillos, Figueiredo, Jane C, Fletcher, Olivia, Fortner, Renée T, Fostira, Florentia, Franceschi, Silvia, Friedman, Eitan, Gallinger, Steven J, Ganz, Patricia A, Garber, Judy, García-Sáenz, José A, Gayther, Simon A, Giles, Graham G, Godwin, Andrew K, Goldberg, Mark S, Goldgar, David E, Goode, Ellen L, Goodman, Marc T, Goodman, Gary, Grankvist, Kjell, Greene, Mark H, Gronberg, Henrik, Gronwald, Jacek, Guénel, Pascal, Håkansson, Niclas, Hall, Per, Hamann, Ute, Hamdy, Freddie C, Hamilton, Robert J, Hampe, Jochen, Haugen, Aage, Heitz, Florian, Herrero, Rolando, Hillemanns, Peter, Hoffmeister, Michael, Høgdall, Estrid, Hong, Yun-Chul, Hopper, John L, Houlston, Richard, Hulick, Peter J, Hunter, David J, Huntsman, David G, Idos, Gregory, Imyanitov, Evgeny N, Ingles, Sue Ann, Isaacs, Claudine, Jakubowska, Anna, James, Paul, Jenkins, Mark A, Johansson, Mattias, Johansson, Mikael, John, Esther M, Joshi, Amit D, Kaneva, Radka, Karlan, Beth Y, Kelemen, Linda E, Kühl, Tabea, Khaw, Kay-Tee, Khusnutdinova, Elza, Kibel, Adam S, Kiemeney, Lambertus A, Kim, Jeri, Kjaer, Susanne K, Knight, Julia A, Kogevinas, Manolis, Kote-Jarai, Zsofia, Koutros, Stella, Kristensen, Vessela N, Kupryjanczyk, Jolanta, Lacko, Martin, Lam, Stephan, Lambrechts, Diether, Landi, Maria Teresa, Lazarus, Philip, Le, Nhu D, Lee, Eunjung, Lejbkowicz, Flavio, Lenz, Heinz-Josef, Leslie, Goska, Lessel, Davor, Lester, Jenny, Levine, Douglas A, Li, Li, Li, Christopher I, Lindblom, Annika, Lindor, Noralane M, Liu, Geoffrey, Loupakis, Fotios, Lubiński, Jan, Maehle, Lovise, Maier, Christiane, Mannermaa, Arto, Marchand, Loic Le, Margolin, Sara, May, Taymaa, McGuffog, Lesley, Meindl, Alfons, Middha, Pooja, Miller, Austin, Milne, Roger L, MacInnis, Robert J, Modugno, Francesmary, Montagna, Marco, Moreno, Victor, Moysich, Kirsten B, Mucci, Lorelei, Muir, Kenneth, Mulligan, Anna Marie, Nathanson, Katherine L, Neal, David E, Ness, Andrew R, Neuhausen, Susan L, Nevanlinna, Heli, Newcomb, Polly A, Newcomb, Lisa F, Nielsen, Finn Cilius, Nikitina-Zake, Liene, Nordestgaard, Børge G, Nussbaum, Robert L, Offit, Kenneth, Olah, Edith, Olama, Ali Amin Al, Olopade, Olufunmilayo I, Olshan, Andrew F, Olsson, Håkan, Osorio, Ana, Pandha, Hardev, Park, Jong Y, Pashayan, Nora, Parsons, Michael T, Pejovic, Tanja, Penney, Kathryn L, Peters, Wilbert H M, Phelan, Catherine M, Phipps, Amanda I, Plaseska-Karanfilska, Dijana, Pring, Miranda, Prokofyeva, Darya, Radice, Paolo, Stefansson, Kari, Ramus, Susan J, Raskin, Leon, Rennert, Gad, Rennert, Hedy S, van Rensburg, Elizabeth J, Riggan, Marjorie J, Risch, Harvey A, Risch, Angela, Roobol, Monique J, Rosenstein, Barry S, Rossing, Mary Anne, De Ruyck, Kim, Saloustros, Emmanouil, Sandler, Dale P, Sawyer, Elinor J, Schabath, Matthew B, Schleutker, Johanna, Schmidt, Marjanka K, Setiawan, V Wendy, Shen, Hongbing, Siegel, Erin M, Sieh, Weiva, Singer, Christian F, Slattery, Martha L, Sorensen, Karina Dalsgaard, Southey, Melissa C, Spurdle, Amanda B, Stanford, Janet L, Stevens, Victoria L, Stintzing, Sebastian, Stone, Jennifer, Sundfeldt, Karin, Sutphen, Rebecca, Swerdlow, Anthony J, Tajara, Eloiza H, Tangen, Catherine M, Tardon, Adonina, Taylor, Jack A, Teare, M Dawn, Teixeira, Manuel R, Terry, Mary Beth, Terry, Kathryn L, Thibodeau, Stephen N, Thomassen, Mads, Bjørge, Line, Tischkowitz, Marc, Toland, Amanda E, Torres, Diana, Townsend, Paul A, Travis, Ruth C, Tung, Nadine, Tworoger, Shelley S, Ulrich, Cornelia M, Usmani, Nawaid, Vachon, Celine M, Van Nieuwenhuysen, Els, Vega, Ana, Aguado-Barrera, Miguel Elías, Wang, Qin, Webb, Penelope M, Weinberg, Clarice R, Weinstein, Stephanie, Weissler, Mark C, Weitzel, Jeffrey N, West, Catharine M L, White, Emily, Whittemore, Alice S, Wichmann, H-Erich, Wiklund, Fredrik, Winqvist, Robert, Wolk, Alicja, Woll, Penella, Woods, Michael, Wu, Anna H, Wu, Xifeng, Yannoukakos, Drakoulis, Zheng, Wei, Zienolddiny, Shanbeh, Ziogas, Argyrios, Zorn, Kristin K, Lane, Jacqueline M, Saxena, Richa, Thomas, Duncan, Hung, Rayjean J, Diergaarde, Brenda, McKay, James, Peters, Ulrike, Hsu, Li, García-Closas, Montserrat, Eeles, Rosalind A, Chenevix-Trench, Georgia, Brennan, Paul J, Haiman, Christopher A, Simard, Jacques, Easton, Douglas F, Gruber, Stephen B, Pharoah, Paul D P, Price, Alkes L, Pasaniuc, Bogdan, Amos, Christopher I, Kraft, Peter, Lindström, Sara

المساهمون: 1 Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA. xiajiang@hsph.harvard.edu. 2 Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Nobels vagen 13, 17177, Stockholm, Sweden. xiajiang@hsph.harvard.edu. 3 Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA. 4 Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, 75 Ames St, Cambridge, MA, 02142, USA. 5 Department of Population and Quantitative Health Sciences, Case Western Reserve University, 10900 Eucid Avenue, Cleveland, OH, 44106, USA. 6 Seidman Cancer Center, University Hospitals, Cleveland, OH, 44106, USA. 7 Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr. MRC-CANCONT, Tampa, FL, 33612, USA. 8 Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr. MRC-CANCONT, Tampa, FL, 33612, USA. 9 Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, 2 Worts' Causeway, Cambridge, CB1 8RN, UK. 10 Department of Biomedical Data Science, The Geisel School of Medicine at Dartmouth, 1 Medical Center Drive, Lebanon, NH, 03756, USA. 11 Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Worts' Causeway, Cambridge, CB1 8RN, UK. 12 Department of Electron Microscopy/Molecular Pathology, The Cyprus Institute of Neurology and Genetics, 1683, Nicosia, Cyprus. 13 Genetic Epidemiology Group, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69008, Lyon, France. 14 Section of Genetics, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008, Lyon, France. 15 Division of Psychiatry, University College London, Maple House, 149 Tottenham Court Road, London, W1T 7NF, UK. 16 UCL Genetics Institute, University College London, Gower Street, London, WC1E 6BT, UK. 17 Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, 48109, USA. 18 Public Health Sciences, University of Virginia, P.O. Box 800717, Charlottesville, VI, 22908, USA. 19 Center for Public Health Genomics, University of Virginia, P.O. Box 800717, Charlottesville, VI, 22908, USA. 20 Epidemiology Research Program, American Cancer Society, 250 Williams Street NW, Atlanta, GA, 30303, USA. 21 Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA, 98109-1024, USA. 22 Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Dr, Rockville, MD, 20850, USA. 23 Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, 609 Oxford House, Nashville, TN, 37232, USA. 24 Department of Neurology, Dartmouth-Hitchcock Medical Center, 7927 Rubin Building, Room 860, One Medical Center Drive, Lebanon, NH, 3756, USA. 25 Fred ALitwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, 600 University Avenue, Toronto, ON, M5G1X5, Canada. 26 Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, ON, M5S1A8, Canada. 27 Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, 224 Irvine Hall, Irvine, CA, 92617, USA. 28 NNAlexandrov Research Institute of Oncology and Medical Radiology, Settlement of Lesnoy-2, 223040, Minsk, Belarus. 29 Markey Cancer Center, University of Kentucky, 800 Rose Street, cc445, Lexington, KY, 40508, USA. 30 Department of Public Health Sciences, and Cancer Research Institute, Queen's University, 10 Stuart Street, Kingston, ON, K7L 3N6, Canada. 31 Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, 1155 Pressler St, Houston, TX, 77030, USA. 32 Cancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, Room 5568, New Brunswick, NJ, 08903, USA. 33 Department of Pathology, Landspitali University Hospital, Hringbraut, Reykjavik, 101, Iceland. 34 BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Vatnsmyrarvegi 16, Reykjavik, 101, Iceland. 35 Australian Prostate Cancer Research Centre-Qld, Translational Research Institute, 37 Kent St, Woolloongabba, QLD, 4102, Australia. 36 Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology, 60 Musk Ave, Kelvin Grove, QLD, 4059, Australia. 37 Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen Nuremberg, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Universitaetsstrasse 21-23, 91054, Erlangen, Germany. 38 Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernández Almagro, 3, 28029, Madrid, Spain. 39 Biomedical Network on Rare Diseases (CIBERER), AvMonforte de Lemos, 3-5Pabellón 11Planta 0, 28029, Madrid, Spain. 40 Division of Genetics and Epidemiology, The Institute of Cancer Research, 15 Cotswold Road, London, SM2 5NG, UK. 41 Department of Obstetrics and Gynecology, Duke University Medical Center, 25171 Morris Bldg, Durham, NC, 27710, USA. 42 Department of Genetic Epidemiology, University Medical Center Goettingen, Humboldtallee 32, 37073, Goettingen, Germany. 43 School of Public Health, University of Washington, 1959 NE Pacific Street, Health Science Buidling, F-350, Seattle, WA, 98195, USA. 44 Department of Oncology, Helsinki University Hospital, University of Helsinki, Haartmaninkatu 4, 00290, Helsinki, Finland. 45 Department of Oncology, Örebro University Hospital, 70185, Örebro, Sweden. 46 Fondazione Policlinico Universitario A. 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69120, Heidelberg, Germany. 56 Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. 57 Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. 58 Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, CB2 0RE, Cambridge, UK. 59 Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, CIBERONC, AvFrança s/n, 17007, Girona, Spain. 60 Clinical Sciences, Lund University, Box 117, 221 00, Lund, Sweden. 61 Department of Genetics and Pathology, Division of Laboratory Medicine, 221 85, Lund, Sweden. 62 University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, VIC, 3010, Australia. 63 Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia. 64 Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, VIC, 3010, Australia. 65 Department of Obstetrics and Gynecology, University of Heidelberg, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany. 66 Molecular Epidemiology Group, C080, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. 67 Department of Pathology, University of Helsinki and Helsinki University Hospital, Biomedicum Helsinki 4th Floor, Haartmaninkatu 8, 00029, Helsinki, Finland. 68 Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Calle del Prof Martín Lagos, 28040, Madrid, Spain. 69 Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, via Roma 67, 56126, Pisa, Italy. 70 Peter MacCallum Cancer Center, 305 Grattan Street, Melbourne, VIC, 3000, Australia. 71 Sir Peter MacCallum Department of Oncology, The University of Melbourne, 305 Grattan Street, Melbourne, VIC, 3000, Australia. 72 Sorbonne Université, GRC N°5 ONCOTYPE-URO, Tenon Hospital, 75020, Paris, France. 73 CeRePP, Tenon Hospital, 75020, Paris, France. 74 Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT, 84112, USA. 75 George EWahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, 84112, USA. 76 Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. 77 Department of Biology, University of Pisa, 56126, Pisa, Italy. 78 Molecular Oncology Research Center, Barretos Cancer Hospital, Rua Antenor Duarte Villela, 1331, Barretos, SP, 784-400, Brazil. 79 Head and Neck Surgery Department, Barretos Cancer Hospital, Pio XII, 1331, Antenor Duarte Villela St, Barretos, SP, 14784-400, Brazil. 80 Division of Gastroenterology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA. 81 Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA. 82 Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany. 83 Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA, 98109, USA. 84 Centre for Medical Genetics, Ghent University, De Pintelaan 185, 9000, Gent, Belgium. 85 Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, 3000, Belgium. 86 Department of Clinical Genetics, Erasmus University Medical Center, Wytemaweg 80, 3015, Rotterdam, CN, The Netherlands. 87 University of Puerto Rico Medical Sciences Campus and Comprehensive Cancer Center, San Juan, PR, 00936, USA. 88 Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First StSW, Rochester, MN, 55905, USA. 89 Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK. 90 International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, ulUnii Lubelskiej 1, 71-252, Szczecin, Poland. 91 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Karolinska Univ Hospital, 171 76, Stockholm, Sweden. 92 Department of Clinical Genetics, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA, 19111, USA. 93 Centre for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, 176 Hawkesbury Rd, Sydney, NSW, 2145, Australia. 94 Department of Gynaecological Oncology, Westmead Hospital, Hawkesbury Rd & Darcy Rd, Sydney, NSW, 2145, Australia. 95 Department of Pathology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. 96 Department of Human Genetics, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. 97 Oncogenetics Group, Clinical and Molecular Genetics Area, Vall d'Hebron Institute of Oncology (VHIO), University Hospital, Vall d'Hebron, Passeig de la Vall d'Hebron 119-129, 08035, Barcelona, Spain. 98 Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Travesía da Choupana S/N, 15706, Santiago de Compostela, Spain. 99 Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, La Jolla, CA, 92037, USA. 100 School of Social and Community Medicine, University of Bristol, Bristol, BS8 1TH, UK. 101 Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), AvGran Via 199-203, L'Hospitalet de Llobregat, 08908, Barcelona, Spain. 102 Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, 309 Regent Street, London, W1B 2HW, UK. 103 Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Tremona Road, Southampton, SO16 6YD, UK. 104 Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA. 105 Vanderbilt Epidemiology Center, Vanderbilt Genetics Institute, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, 2525 West End Avenue, Suite 600, Nashville, TN, 37203, USA. 106 Department of Cancer Epidemiology, Clinical Sciences, Lund University, Barngatan 4, Skånes universitetssjukhus, 222 42, Lund, Sweden. 107 Manchester Centre for Genomic Medicine, Division of Evolution and Genomic Sciences, University of Manchester, St Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Oxford Road, Manchester, M13 9WL, UK. 108 David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, 10833 Le Conte Ave, Los Angeles, CA, 90095, USA. 109 Department of Otolaryngology, UPMC Hillman Cancer Center, Cancer Pavilion, University of Pittsburgh, Suite 500, 5150 Centre Avenue, Pittsburgh, PA, 15232, USA. 110 Molecular and Clinical Cancer Medicine, Roy Castle Lung Cancer Research Programme, The University of Liverpool Institute of Translational Medicine, The Wiliam Duncan Building, 6 West Derby Street, Liverpool, L69 3BX, UK. 111 Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA, 90048, USA. 112 Keck School of Medicine, University of Southern California, 1450 Biggy Street, Los Angeles, CA, 90033, USA. 113 The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK. 114 Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Neapoleos 10, AgParaskevi, Athens, 15310, Greece. 115 Section of Infections, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008, Lyon, France. 116 The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Emek HaEla St 1, 52621, Ramat Gan, Israel. 117 Sackler Faculty of Medicine, Tel Aviv University, Haim Levanon 30, 69978, Ramat Aviv, Israel. 118 Department of Surgery, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, M5G 1X5, Canada. 119 Samuel Lunenfeld Research Institute, 600 University Avenue, Toronto, ON, M5G 1X5, Canada. 120 University Health Network Toronto General Hospital, 200 Elizabeth St, Toronto, ON, M5G 2C4, Canada. 121 Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Centre, UCLA, 650 Charles Young Drive South, Los Angeles, CA, 90095-6900, USA. 122 Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA. 123 Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1975 Zonal Ave, Los Angeles, CA, 90033, USA. 124 Center for Cancer Prevention and Translational Genomics, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Spielberg Building, 8725 Alden Dr, Los Angeles, CA, 90048, USA. 125 Department of Biomedical Sciences, Cedars-Sinai Medical Center, Spielberg Building, 8725 Alden Dr, Los Angeles, CA, 90048, USA. 126 Cancer Epidemiology & Intelligence Division, Cancer Council Victoria, 615 St Kilda Road, Melbourne, VIC, 3004, Australia. 127 Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Level 1, 723 Swanston Street, Melbourne, VIC, 3010, Australia. 128 Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia. 129 Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA. 130 Department of Medicine, McGill University, 1001 Decarie Boulevard, Montréal, QC, H4A3J1, Canada. 131 Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, 1001 Decarie Boulevard, Montréal, QC, H4A3J1, Canada. 132 Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, 2000 Circle of Hope, Salt Lake City, UT, 84112, USA. 133 Department of Health Sciences Research, Mayo Clinic, 200 First StSW, Rochester, MN, 55905, USA. 134 Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Room 1S37, Los Angeles, CA, 90048, USA. 135 Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Room 1S37, Los Angeles, CA, 90048, USA. 136 Public Health Sciences Division, Swedish Cancer Institute, 1221 Madison StSte 300, Seattle, WA, 98109, USA. 137 Unit of Clinical Chemistry, Department of Medical Biosciences, Umeå University, By 6M van 2, Sjukhusomradet, Umea universitet, 901 85, Umea, Sweden. 138 Clinical Genetics Branch, National Cancer Institute, DCEG, 9609 Medical Center Dr, Bethesda, MD, 20850-9772, USA. 139 Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, 94805, Villejuif, France. 140 Department of Environmental Medicine, Division of Nutritional Epidemiology, Karolinska Institutet, Nobels väg 13, SE-171 77, SE-171, Stockholm, Sweden. 141 Department of Oncology, Södersjukhuset, Sjukhusbacken 10, 118 83, Stockholm, Sweden. 142 Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany. 143 Nuffield Department of Surgical Sciences, Faculty of Medical Science, John Radcliffe Hospital, University of Oxford, Oxford, OX1 2JD, UK. 144 Department of Surgical Oncology, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, Ontario, M5G2M9, Canada. 145 Department of Internal Medicine 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden), 01307, Dresden, Germany. 146 National Institute of Occupational Health (STAMI), Gydas vei 8, 0033, Oslo, Norway. 147 Department of Gynecology and Gynecologic Oncology, DrHorst Schmidt Kliniken Wiesbaden, Ludwig-Erhard-Straße 100, 65199, Wiesbaden, Germany. 148 Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte/EvangHuyssens-Stiftung/Knappschaft GmbH, Henricistrasse 92, 45136, Essen, Germany. 149 Early Detection and Prevention Section, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008, Lyon, France. 150 Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Strandboulevarden 49, DK-2100, Copenhagen, Denmark. 151 Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Herlev Ringvej 75, DK-2730, Herlev, Denmark. 152 Preventive Medicine, Seoul National University College of Medicine, 1 Gwanak-ro, Gwanak-gu, Seoul, 151 742, Korea. 153 German Research Center for Environmental Health, Institute for Cancer Research, Ingolstadter Landstr1, London, SM2 5NG, UK. 154 Center for Medical Genetics, NorthShore University HealthSystem, 1000 Central St, Evanston, IL, 60201, USA. 155 The University of Chicago Pritzker School of Medicine, 924 E 57th St, Chicago, IL, 60637, USA. 156 Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA. 157 British Columbia's Ovarian Cancer Research (OVCARE) Program, Vancouver General Hospital, BC Cancer Agency and University of British Columbia, #3427-600 West 10th Avenue, Vancouver, BC, V5Z 4E6, Canada. 158 Department of Molecular Oncology, BC Cancer Agency Research Centre, #3427-600 West 10th Avenue, Vancouver, BC, V5Z 4E6, Canada. 159 Department of Pathology and Laboratory Medicine, University of British Columbia, #3427-600 West 10th Avenue, Vancouver, BC, V5Z 4E6, Canada. 160 NNPetrov Institute of Oncology, Leningradskaya ul, 68, StPetersburg, Russia, 197758. 161 Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road, Washington, DC, 20007, USA. 162 Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Rybacka 1, 70-204, Szczecin, Poland. 163 Parkville Familial Cancer Centre, Peter MacCallum Cancer Center, 305 Grattan Street, Melbourne, VIC, 3000, Australia. 164 Department of Radiation Sciences, Umeå University, By 6M van 2, Sjukhusomradet, Umea universitet, 901 85, Umea, Sweden. 165 Department of Medicine, Division of Oncology and Stanford Cancer Institute, Stanford University School of Medicine, 780 Welch Rd, Stanford, CA, 94304, USA. 166 Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, 02114, Boston, MA, USA. 167 Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical Faculty, Medical University of Sofia, Sofia, 1504, Bulgaria. 168 Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA, 90048, USA. 169 Hollings Cancer Center and Department of Public Health Sciences, Medical University of South Carolina, 68 President Street Bioengineering Building, MSC955, Charleston, SC, 29425, USA. 170 Cancer Epidemiology, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany. 171 Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, 2 Worts' Causeway, Cambridge, CB1 8RN, UK. 172 Department of Genetics and Fundamental Medicine, Bashkir State University, ulZaki Validi 32, Ufa, Russia, 450076. 173 Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, 71 prosp Oktyabrya, Ufa, Russia, 450054. 174 Division of Urologic Surgery, Brigham and Womens Hospital, Boston, Massachusettes, 02115, USA. 175 Radboud Institute for Health Sciences, Radboud University Medical Center, Geert Grooteplein 21, 6525 EZ, Nijmegen, The Netherlands. 176 Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, 1155 Pressler St, Houston, TX, 77030, USA. 177 Department of Gynaecology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK-2100, Copenhagen, Denmark. 178 Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 60 Murray Street, Toronto, Ontario, M5T 3L9, Canada. 179 Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, ON, M5T3M7, Canada. 180 Centre for Research in Environmental Epidemiology (CREAL), ISGlobal, 08036, Barcelona, Spain. 181 IMIM (Hospital del Mar Research Institute), Barcelona, 08003, Spain. 182 Universitat Pompeu Fabra (UPF), Barcelona, 08002, Spain. 183 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 9609 Medical Center Dr, Bethesda, MD, 20892, USA. 184 Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Ullernchausseen 70, 0379, Oslo, Norway. 185 Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Kirkeveien 166, 0450, Oslo, Norway. 186 Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Kirkeveien 166, 0450, Oslo, Norway. 187 Department of Pathology and Laboratory Diagnostics, the Maria Sklodowska-Curie Institute - Oncology Center, Roentgena 5, 02-781, Warsaw, Poland. 188 Head and Neck Surgery, Department of Otorhinolaryngology, Maastricht University Medical Center, PDebyelaan 25, POBox 5800, 6202 AZ, Maastricht, The Netherlands. 189 Department of Integrative Oncology, British Columbia Cancer Agency, Room 10-111 675 West 10th Avenue, Vancouver, BC, V5Z1L3, Canada. 190 VIB Center for Cancer Biology, VIB, Herestraat 49, 3001, Leuven, Belgium. 191 Laboratory for Translational Genetics, Department of Human Genetics, University of Leuven, Oude Markt 13, 3000, Leuven, Belgium. 192 Integrative Tumor Epidemiology Branch, DCEG, National Cancer Institute, 9609 Medical Center Drive, Room SG/7E106, Rockville, MD, 20850, USA. 193 College of Pharmacy, Washington State University, PBS 431 PO Box 1495, Spokane, WA, 99210-1495, USA. 194 Cancer Control Research, BC Cancer Agency, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada. 195 Clalit Health Services, Clalit National Israeli Cancer Control Center, Carmel Medical Center, 2 Horev Street, 3436212, Haifa, Israel. 196 Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany. 197 Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. 198 Gynecologic Oncology, Laura and Isaac Pearlmutter Cancer Center, NYU Langone Medical Center, 240 East 38th Street 19th Floor, New York, NY, 10016, USA. 199 Department of Family Medicine and Community Health, Mary Ann Swetland Center for Environmental Health, Case Western Reserve University, Cleveland, OH, 44106, USA. 200 Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), 15706, Santiago De Compostela, Spain. 201 Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA. 202 Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska Univ Hospital, 171 76, Stockholm, Sweden. 203 Health Sciences Research, Mayo Clinic Arizona, 13400 EShea Blvd, Scottsdale, AZ, 85259, USA. 204 Epidemiology Division, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, ON, M5G2M9, Canada. 205 Unit of Oncology 1, Department of Clinical and Experimental Oncology, Istituto Oncologico Veneto IRCCS, 35122, Padua, Italy. 206 Department of Medical Genetics, Oslo University Hospital, Kirkeveien 166, 0450, Oslo, Norway. 207 Institute of Human Genetics, University Hospital Ulm, Prittwitzstrasse 43, 89075, Ulm, Germany. 208 Translational Cancer Research Area, University of Eastern Finland, Yliopistonranta 1, 70210, Kuopio, Finland. 209 Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Yliopistonranta 1, 70210, Finland. 210 Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Puijonlaaksontie 2, 70210, Kuopio, Finland. 211 Epidemiology Program, University of Hawaii Cancer Center, 701 Ilalo St, Honolulu, HI, 96813, USA. 212 Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, 17177, Sweden. 213 Division of Gynecologic Oncology, University Health Network, Princess Margaret Hospital, 610 University Avenue, OPG Wing, 6-811, Toronto, ON, M5G 2M9, Canada. 214 Division of Gynaecology and Obstetrics, , Technische Universität München, Arcisstraße 21, 80333, Munich, Germany. 215 Faculty of Medicine, University of Heidelberg, In Neuenheimer Feld 672, 69120, Heidelberg, Germany. 216 NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY, 14263, USA. 217 Womens Cancer Research Center, Magee-Womens Research Institute and Hillman Cancer Center, Pittsburgh, PA, 15213, USA. 218 Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, 300 Halket Street, Pittsburgh, PA, 15213, USA. 219 Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Via Gattamelata 64, Padua, 35128, Italy. 220 Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP) and University of Barcelona, Barcelona, 08908, Spain. 221 Division of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY, 14263, USA. 222 Division of Population Health, Health Services Research and Primary Care, University of Manchester, Oxford Road, Manchester, M13 9PL, UK. 223 Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK. 224 Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S1A8, Canada. 225 Laboratory Medicine Program, University Health Network, 200 Elizabeth Street, Toronto, ON, M5G2C4, Canada. 226 Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA. 227 Department of Oncology, Addenbrooke's Hospital, University of Cambridge, Cambridge, CB1 8RN, UK. 228 NIHR Bristol Biomedical Research Centre Nutrition Theme, University of Bristol, Upper Maudlin Street, Bristol, BS2 8AE, UK. 229 Department of Population Sciences, Beckman Research Institute of City of Hope, 1500 E Duarte, Duarte, CA, 91010, USA. 230 Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Haartmaninkatu 8, 00290, Helsinki, Finland. 231 Department of Urology, University of Washington, Seattle, Washington, 98195, USA. 232 Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100, Copenhagen, Denmark. 233 Latvian Biomedical Research and Study Centre, Ratsupites str 1, Riga, LV-1067, Latvia. 234 Cancer Genetics and Prevention Program, University of California San Francisco, 1600 Divisadero St, San Francisco, CA, 94143-1714, USA. 235 Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. 236 Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. 237 Department of Molecular Genetics, National Institute of Oncology, Ráth György u7-9, 1122, Budapest, Hungary. 238 Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK. 239 Center for Clinical Cancer Genetics, The University of Chicago, 5841S Maryland Ave, Chicago, IL, 60637, USA. 240 Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, 135 Dauer Dr, Chapel Hill, NC, 27599-7435, USA. 241 UNC Lineberger Comprehensive Cancer Center, 450 West Dr, Chapell Hill, NC, 27599, USA. 242 The University of Surrey, Guildford, Surrey, GU2 7XH, UK. 243 Department of Cancer Epidemiology, HLee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612, USA. 244 Department of Applied Health Research, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK. 245 Centre for Cancer Genetic Epidemiology, Department of Oncology, Strangeways Laboratory, University of Cambridge, Cambridge, CB1 8RN, UK. 246 Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD, 4006, Australia. 247 Department of Obstetrics and Gynecology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, L-466, Portland, OR, 97239, USA. 248 Knight Cancer Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, L-466, Portland, OR, 97239, USA. 249 Department of Gastroenterology, Radboud University Nijmegen Medical Center, Geert Grooteplein Zuid 10, Internal BOBox 433, 6525 GA, Nijmegen, The Netherlands. 250 Department of Epidemiology, University of Washington School of Public Health, 1959 NE Pacific St, Seattle, WA, 98195, USA. 251 Research Centre for Genetic Engineering and Biotechnology 'Georgi DEfremov', Macedonian Academy of Sciences and Arts, Boulevard Krste Petkov Misirkov, 1000, Skopje, Republic of Macedonia. 252 Bristol Dental School, University of Bristol, Lower Maudlin Street, Bristol, BS1 2LY, UK. 253 Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Via Giacomo Venezian 1, 20133, Milan, Italy. 254 Decode genetics, Sturlugata 8, IS-101 Reykjavik, Reykjavik, Iceland, Iceland. 255 School of Women's and Children's Health, Faculty of Medicine, University of NSW Sydney, 18 High St, Sydney, NSW, 2052, Australia. 256 The Kinghorn Cancer Centre, Garvan Institute of Medical Research, 384 Victoria Street, Sydney, NSW, 2010, Australia. 257 Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, 1161 21st Ave S # D3300, Nashville, TN, 37232, USA. 258 Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, 7 Michal Street, 34362, Haifa, Israel. 259 Department of Genetics, University of Pretoria, Private Bag X323, Arcadia, 0007, South Africa. 260 Department of Chronic Disease Epidemiology, Yale School of Public Health, 60 College St, New Haven, CT, 06510, USA. 261 Cancer Center Cluster Salzburg at PLUS, Department of Molecular Biology, University of Salzburg, Billrothstr11, 5020, Salzburg, Austria. 262 Division of Epigenomics and Cancer Risk Factors, DKFZ - German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. 263 Member of the German Center for Lung Research (DZL), Translational Lung Research Center Heidelberg (TLRC-H), 69120, Heidelberg, Germany. 264 Department of Urology, Erasmus University Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands. 265 Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY, 10029, USA. 266 Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY, 10029, USA. 267 Department of Epidemiology, University of Washington, M4 C308, 1100 Fairview Ave N, Seattle, WA, 98109, USA. 268 Faculty of Medicine and Health Sciences, Basic Medical Sciences, Ghent University, De Pintelaan 185, 9000, Gent, Belgium. 269 Hereditary Cancer Clinic, University Hospital of Heraklion, Voutes, 711 10, Heraklion, Greece. 270 Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, 111TWAlexander Drive, Research Triangle Park, NC, 27709, USA. 271 Research Oncology, Guy's Hospital, King's College London, Guy's Hospital Great Maze Pond, London, SE1 9RT, UK. 272 Institute of Biomedicine, University of Turku, 20014, Turku, Finland. 273 Division of Laboratory, Department of Medical Genetics, Turku University Hospital, 20014, Turku, Finland. 274 Prostate Cancer Research Center, Faculty of Medicine and Life Sciences and BioMediTech Institute, University of Tampere, 33014, Tampere, Finland. 275 Division of Molecular Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. 276 Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. 277 Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1450 Biggy Street, Los Angeles, CA, 90033, USA. 278 Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, 101 Longmian Ave, Jiangning District, 211166, Nanjing, People's Republic of China. 279 Department of Genetics and Genomic Sciences, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, 2nd floor, New York, NY, 10029, USA. 280 Dept of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. 281 Department of Internal Medicine, University of Utah Health Sciences Center, 295 Chipeta Way, Salt Lake City, UT, 84132, USA. 282 Department of Molecular Medicine, Aarhus University Hospital, DK-8200, Aarhus, Denmark. 283 Department of Clinical Medicine, Aarhus University, DK-8200, Aarhus, Denmark. 284 Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, 246 Clayton Road, Clayton, VIC, 3168, Australia. 285 Department of Clinical Pathology, The University of Melbourne, Cnr Grattan Street and Royal Parade, Melbourne, VIC, 3010, Australia. 286 Department of Medicine III, University Hospital, LMU Munich, Marchioninistr15, 81377, Munich, Germany. 287 The Curtin UWA Centre for Genetic Origins of Health and Disease, Curtin University and University of Western Australia, 35 Stirling Hwy, Perth, WA, 6000, Australia. 288 Department of Obstetrics and Gynecology, Sahlgrenska Cancer Center, Inst Clinical Scienses, University of Gothenburg, Blå stråket 6, 41345, Gothenburg, Sweden. 289 Epidemiology Center, College of Medicine, University of South Florida, 3650 Spectrum Blvd, Suite 100, Tampa, FL, 33612, USA. 290 Division of Breast Cancer Research, The Institute of Cancer Research, London, SW7 3RP, UK. 291 Department of Molecular Biology, School of Medicine of São José do Rio Preto, Av Brig Faria Lima 5416 Vila São Pedro, São José do Rio Preto, SP, 15090-000, Brazil. 292 Department of Genetics and Evolutive Biology, Institute of Biosciences, University of São Paulo, Rua do Matão, 321, São Paulo, SP, 05508-090, Brazil. 293 SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, USA. 294 Faculty of Medicine, University of Oviedo and CIBERESP, Campus del Cristo s/n, 33006, Oviedo, Spain. 295 Epigenetic and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, NIH, 111TWAlexander Drive, Research Triangle Park, NC, 27709, USA. 296 Medical Statistics Group, School of Health and Related Research (ScHARR), University of Sheffield, Regent Court, 30 Regent Street, Sheffield, S1 4DA, UK. 297 Department of Genetics, Portuguese Oncology Institute, Rua DrAntónio Bernardino de Almeida 62, 4220-072, Porto, Portugal. 298 Biomedical Sciences Institute (ICBAS), University of Porto, RJorge de Viterbo Ferreira 228, 4050-013, Porto, Portugal. 299 Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th Street, New York, NY, 10032, USA. 300 Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, 221 Longwood Avenue RFB 368, Boston, MA, 02115, USA. 301 Harvard THChan School of Public Health, 221 Longwood Avenue RFB 368, Boston, MA, 02115, USA. 302 Department of Clinical Genetics, Odense University Hospital, Sonder Boulevard 29, 5000, Odence C, Denmark. 303 Department of Gynecology and Obstetrics, Haukeland University Hospital, 5021, Bergen, Norway. 304 Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, 5021, Bergen, Norway. 305 Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, 1001 Decarie Boulevard, Montréal, QC, H4A3J1, Canada. 306 Department of Medical Genetics, Cambridge University, Hills Road, Cambridge, CB2 0QQ, UK. 307 Department of Cancer Biology and Genetics, The Ohio State University, 460W12th Avenue, Columbus, OH, 43210, USA. 308 Institute of Human Genetics, Pontificia Universidad Javeriana, Carrera 7 No40-90, Bogota, Colombia. 309 Division of Cancer Sciences, Manchester Cancer Research Centre, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Health Innovation Manchester, University of Manchester, Manchester, M20 4GJ, UK. 310 Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK. 311 Department of Medical Oncology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, 02215, USA. 312 Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, 2000 Circle of Hope, Rm 4125, Salt Lake City, UT, 84112, USA. 313 Department of Oncology, Cross Cancer Institute, University of Alberta, 116 St & 85 Ave, Edmonton, AB T6G 2R3, Canada. 314 Division of Radiation Oncology, Cross Cancer Institute, University of Alberta, 116 St & 85 Ave, Edmonton, AB T6G 2R3, Canada. 315 Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium. 316 Fundación Pública Galega Medicina Xenómica & Instituto de Investigación Sanitaria de Santiago de Compostela, calle Choupana s/n, 15706, Santiago De Compostela, Spain. 317 Population Health Department, QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD, 4006, Australia. 318 Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NIH, 111TWAlexander Drive, Research Triangle Park, NC, 27709, USA. 319 Department of Otolaryngology/Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, 27514, NC, USA. 320 City of Hope Clinical Cancer Genomics Community Research Network, 1500 East Duarte Road, Duarte, CA, 91010, USA. 321 Division of Cancer Sciences, University of Manchester, Manchester Cancer Research Centre, Manchester Academic Health Science Centre,, The Christie Hospital NHS Foundation Trust, Manchester, M13 9PL, UK. 322 Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA, 98109, USA. 323 Department of Epidemiology, University of Washington, 1100 Fairview Ave N, Seattle, WA, 98109, USA. 324 Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, 259 Campus Drive, Stanford, CA, 94305, USA. 325 Department of Biomedical Data Science, Stanford University School of Medicine, 259 Campus Drive, Stanford, CA, 94305, USA. 326 Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig Maximilians University, Neuherberg D-85764, Munich, 803539, Bavaria, Germany. 327 Helmholtz Zentrum Munchen, German Research Center for Environmental Health (GmbH), Institute of Epidemiology, Ingolstadter Landstr1, 85764, Neuherberg, Germany. 328 Institute of Medical Statistics and Epidemiology, Technical University Munich, Munich, 80333, Germany. 329 Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Aapistie 5A, 90220, Oulu, Finland. 330 Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre Oulu, Aapistie 5A, 90220, Oulu, Finland. 331 Department of Surgical Sciences, Uppsala University, 751 85, Uppsala, Sweden. 332 Academic Unit of Clinical Oncology, University of Sheffield, Weston Park Hospital, Whitham Road, Sheffield, S10 2SJ, UK. 333 Discipline of Genetics, Memorial University of Newfoundland, StJohn's, NL, A1C 5S7, Canada. 334 Department of Epidemiology, Division of Cancer Prevention and Population Science, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA. 335 Magee-Womens Hospital, University of Pittsburgh School of Medicine, 300 Halket St, Pittsburgh, PA, 15213, USA. 336 Center for Genomic Medicine and Department of Anasthesia, Massachusetts General Hospital, Boston, MA, 02114, USA. 337 Human Genetics, Graduate School of Public Health, University of Pittsburgh, UPMC Cancer Pavilion, Suite 4C, Office # 467, 5150 Centre Avenue, Pittsburgh, PA, 15232, USA. 338 UPMC Hillman Cancer Center, Pittsburgh, 15232, PA, USA. 339 Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008, Lyon, France. 340 Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Downs Road, Sutton, SM2 5NG, UK. 341 Genomics Center, Centre Hospitalier Universitaire de Québec - Université Laval Research Center, 2705 Laurier Boulevard, Québec City, QC, G1V4G2, Canada. 342 UCLA Path and Lab Med, University of California, 10833 Le Conte Ave, Los Angeles, CA, 190095, USA. 343 Department of Medicine, Epidemiology Section, Institute for Clinical and Translational Research, Baylor Medical College, One Baylor Plaza, MS: BCM451, Suite 100D, Houston, TX, 77030-3411, USA. 344 Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA. pkraft@hsph.harvard.edu. 345 Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA. pkraft@hsph.harvard.edu. 346 Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA, 98109-1024, USA. saralind@uw.edu. 347 Department of Epidemiology, University of Washington School of Public Health, 1959 NE Pacific St, Seattle, WA, 98195, USA. saralind@uw.edu.

المصدر: Nature communications

العلاقة: https://www.nature.com/articles/s41467-019-12095-8Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757065Test/; Publisher Correction: Shared heritability and functional enrichment across six solid cancers. 2019, 10(1):4386. doi:10.1038/s41467-019-12095-8 Nat Commun; http://hdl.handle.net/2336/621109Test; Nature Communications

الإتاحة: https://doi.org/10.1038/s41467-019-12095-8Test
http://hdl.handle.net/2336/621109Test

المؤلفون: Qian, Frank, Rookus, Matti A, Leslie, Goska, Risch, Harvey A, Greene, Mark H, Aalfs, Cora M, Adank, Muriel A, Adlard, Julian, Agnarsson, Bjarni A, Ahmed, Munaza, Aittomäki, Kristiina, Andrulis, Irene L, Arnold, Norbert, Arun, Banu K, Ausems, Margreet G E M, Azzollini, Jacopo, Barrowdale, Daniel, Barwell, Julian, Benitez, Javier, Białkowska, Katarzyna, Bonadona, Valérie, Borde, Julika, Borg, Ake, Bradbury, Angela R, Brunet, Joan, Buys, Saundra S, Caldés, Trinidad, Caligo, Maria A, Campbell, Ian, Carter, Jonathan, Chiquette, Jocelyne, Chung, Wendy K, Claes, Kathleen B M, Collée, J Margriet, Collonge-Rame, Marie-Agnès, Couch, Fergus J, Daly, Mary B, Delnatte, Capucine, Diez, Orland, Domchek, Susan M, Dorfling, Cecilia M, Eason, Jacqueline, Easton, Douglas F, Eeles, Ros, Engel, Christoph, Evans, D Gareth, Faivre, Laurence, Feliubadaló, Lidia, Foretova, Lenka, Friedman, Eitan, Frost, Debra, Ganz, Patricia A, Garber, Judy, Garcia-Barberan, Vanesa, Gehrig, Andrea, Glendon, Gord, Godwin, Andrew K, Gómez Garcia, Encarna B, Hamann, Ute, Hauke, Jan, Hopper, John L, Hulick, Peter J, Imyanitov, Evgeny N, Isaacs, Claudine, Izatt, Louise, Jakubowska, Anna, Janavicius, Ramunas, John, Esther M, Karlan, Beth Y, Kets, Carolien M, Laitman, Yael, Lázaro, Conxi, Leroux, Dominique, Lester, Jenny, Lesueur, Fabienne, Loud, Jennifer T, Lubiński, Jan, Łukomska, Alicja, McGuffog, Lesley, Mebirouk, Noura, Meijers-Heijboer, Hanne E J, Meindl, Alfons, Miller, Austin, Montagna, Marco, Mooij, Thea M, Mouret-Fourme, Emmanuelle, Nathanson, Katherine L, Nehoray, Bita, Neuhausen, Susan L, Nevanlinna, Heli, Nielsen, Finn C, Offit, Kenneth, Olah, Edith, Ong, Kai-ren, Oosterwijk, Jan C, Ottini, Laura, Parsons, Michael T, Peterlongo, Paolo, Pfeiler, Georg, Pradhan, Nisha, Radice, Paolo, Ramus, Susan J, Rantala, Johanna, Rennert, Gad, Robson, Mark, Rodriguez, Gustavo C, Salani, Ritu, Scheuner, Maren T, Schmutzler, Rita K, Shah, Payal D, Side, Lucy E, Simard, Jacques, Singer, Christian F, Steinemann, Doris, Stoppa-Lyonnet, Dominique, Tan, Yen Yen, Teixeira, Manuel R, Terry, Mary Beth, Thomassen, Mads, Tischkowitz, Marc, Tognazzo, Silvia, Toland, Amanda E, Tung, Nadine, van Asperen, Christi J, van Engelen, Klaartje, van Rensburg, Elizabeth J, Venat-Bouvet, Laurence, Vierstraete, Jeroen, Wagner, Gabriel, Walker, Lisa, Weitzel, Jeffrey N, Yannoukakos, Drakoulis, Antoniou, Antonis C, Goldgar, David E, Olopade, Olufunmilayo I, Chenevix-Trench, Georgia, Rebbeck, Timothy R, Huo, Dezheng

المساهمون: 1 Department of Medicine, University of Chicago, Chicago, IL, USA. 2 Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. 3 Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 4 Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA. 5 Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. 6 Department of Clinical Genetics, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands. 7 Family Cancer Clinic, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. 8 Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, UK. 9 Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland. 10 School of Medicine, University of Iceland, Reykjavik, Iceland. 11 North East Thames Regional Genetics Service, Great Ormond Street Hospital, London, UK. 12 Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. 13 Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada. 14 Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. 15 Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany. 16 Institute of Clinical Molecular Biology, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany. 17 Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. 18 Division Laboratories, Pharmacy and Biomedical Genetics, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands. 19 Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy. 20 Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, Leicester, UK. 21 Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. 22 Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain. 23 Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland. 24 Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France. 25 Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany. 26 Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. 27 Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany. 28 Department of Oncology, Lund University and Skåne University Hospital, Lund, Sweden. 29 Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. 30 Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, CIBERONC, Girona, Spain. 31 Department of Medicine, Huntsman Cancer Institute, Salt Lake City, UT, USA. 32 Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. 33 Section of Molecular Genetics, Dept. of Laboratory Medicine, University Hospital of Pisa, Pisa, Italy. 34 Peter MacCallum Cancer Center, Melbourne, Victoria, Australia. 35 Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia. 36 Department of Gynaecological Oncology, Chris O'Brien Lifehouse and The University of Sydney, Camperdown, NSW, Australia. 37 CRCHU de Québec- oncologie, Centre des maladies du sein Deschênes-Fabia, Hôpital du Saint-Sacrement, Québec, QC, Canada. 38 Departments of Pediatrics and Medicine, Columbia University, New York, NY, USA. 39 Centre for Medical Genetics, Ghent University, Gent, Belgium. 40 Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands. 41 Service de Génétique, CHU de Besançon, Besançon, France. 42 Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. 43 Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, USA. 44 Unité d'Oncogénétique, ICO-Centre René Gauducheau, Saint Herblain, France. 45 Oncogenetics Group, Clinical and Molecular Genetics Area, Vall d'Hebron Institute of Oncology (VHIO), University Hospital Vall d'Hebron, Barcelona, Spain. 46 Department of Genetics, University of Pretoria, Arcadia, South Africa. 47 Nottingham Clinical Genetics Service, Nottingham University Hospitals NHS Trust, Nottingham, UK. 48 Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK. 49 Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK. 50 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. 51 Division of Evolution and Genomic Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. 52 Manchester Centre for Genomic Medicine, St Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. 53 Unité d'oncogénétique, Centre de Lutte Contre le Cancer, Centre Georges-François Leclerc, Dijon, France. 54 Centre de Génétique, CHU Dijon, Dijon, France. 55 Molecular Diagnostic Unit, Hereditary Cancer Program, ICO-IDIBELL (Bellvitge Biomedical Research Institute, Catalan Institute of Oncology), CIBERONC, Barcelona, Spain. 56 Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic. 57 The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel. 58 Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel. 59 Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Centre, UCLA, Los Angeles, CA, USA. 60 Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, MA, USA. 61 Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Würzburg, Germany. 62 Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, KS, USA. 63 Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands. 64 Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany. 65 Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia. 66 Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL, USA. 67 The University of Chicago Pritzker School of Medicine, Chicago, IL, USA. 68 N.N. Petrov Institute of Oncology, St. Petersburg, Russia. 69 Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA. 70 Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK. 71 Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland. 72 Hematology, oncology and transfusion medicine center, Dept. of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania. 73 State Research Institute, Innovative Medicine Center, Vilnius, CA, Lithuania. 74 Department of Medicine, Division of Oncology, and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA. 75 Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. 76 Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands. 77 Département de Génétique, CHU de Grenoble, Grenoble, France. 78 Genetic Epidemiology of Cancer team, Inserm U900, Paris, France. 79 Institut Curie, Paris, France. 80 Mines ParisTech, Fontainebleau, France. 81 Department of Clinical Genetics, Amsterdam UMC, Location VU University Medical Center, Amsterdam, The Netherlands. 82 Department of Gynecology and Obstetrics, Ludwig Maximilian University of Munich, Munich, Germany. 83 NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, NY, USA. 84 Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy. 85 Service de Génétique, Institut Curie, Paris, France. 86 Clinical Cancer Genomics, City of Hope, Duarte, CA, USA. 87 Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA. 88 Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. 89 Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 90 Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. 91 Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. 92 Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary. 93 West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Birmingham, UK. 94 Department of Genetics, University Medical Center Groningen, University Groningen, Groningen, The Netherlands. 95 Department of Molecular Medicine, University La Sapienza, Rome, Italy. 96 Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. 97 Genome Diagnostics Program, IFOM - the FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy. 98 Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. 99 Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy. 100 School of Women's and Children's Health, Faculty of Medicine, University of NSW Sydney, Sydney, NSW, Australia. 101 The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW, Australia. 102 Clinical Genetics, Karolinska Institutet, Stockholm, Sweden. 103 Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel. 104 Division of Gynecologic Oncology, NorthShore University HealthSystem, University of Chicago, Evanston, IL, USA. 105 Wexner Medical Center, The Ohio State University, Columbus, OH, USA. 106 Cancer Genetics and Prevention Program, University of California San Francisco, San Francisco, CA, USA. 107 Wessex Clinical Genetics Service, University Hospitals Southampton NHS Trust, Southampton, UK. 108 Genomics Center, Centre Hospitalier Universitaire de Québec - Université Laval, Research Center, Québec City, QC, Canada. 109 Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany. 110 Department of Tumour Biology, INSERM U830, Paris, France. 111 Université Paris Descartes, Paris, France. 112 Department of Genetics, Portuguese Oncology Institute, Porto, Portugal. 113 Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal. 114 Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA. 115 Department of Clinical Genetics, Odense University Hospital, Odence C, Denmark. 116 Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, QC, Canada. 117 Department of Medical Genetics, University of Cambridge, Cambridge, UK. 118 Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA. 119 Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA. 120 Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands. 121 Department of Clinical Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. 122 Department of Medical Oncology, CHU Dupuytren, Limoges, France. 123 Oxford Regional Genetics Service, Churchill Hospital, Oxford, UK. 124 Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece. 125 Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA. 126 Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL, USA. 127 Harvard T.H. Chan School of Public Health, Boston, MA, USA. 128 Dana-Farber Cancer Institute, Boston, MA, USA. 129 Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL, USA. dhuo@health.bsd.uchicago.edu. 130 Department of Public Health Sciences, University of Chicago, Chicago, IL, USA. dhuo@health.bsd.uchicago.edu.

المصدر: British journal of cancer

مصطلحات موضوعية: Eggjastokkar, Krabbamein, Gen, Líkamsþyngdarstuðull, Líkamsþyngd, Líkamshæð, Body Mass Index, Body Height, Ovarian Neoplasms, Genes, BRCA1, BRCA2

العلاقة: https://www.nature.com/articles/s41416-019-0492-8Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738050Test/; Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers. 2019, 121(2):180-192 Br J Cancer; http://hdl.handle.net/2336/621058Test; British Journal of Cancer

الإتاحة: https://doi.org/10.1038/s41416-019-0492-8Test
http://hdl.handle.net/2336/621058Test

المؤلفون: Ferreira, Manuel A, Gamazon, Eric R, Al-Ejeh, Fares, Aittomäki, Kristiina, Andrulis, Irene L, Anton-Culver, Hoda, Arason, Adalgeir, Arndt, Volker, Aronson, Kristan J, Arun, Banu K, Asseryanis, Ella, Azzollini, Jacopo, Balmaña, Judith, Barnes, Daniel R, Barrowdale, Daniel, Beckmann, Matthias W, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Białkowska, Katarzyna, Blomqvist, Carl, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Borg, Ake, Brauch, Hiltrud, Brenner, Hermann, Broeks, Annegien, Burwinkel, Barbara, Caldés, Trinidad, Caligo, Maria A, Campa, Daniele, Campbell, Ian, Canzian, Federico, Carter, Jonathan, Carter, Brian D, Castelao, Jose E, Chang-Claude, Jenny, Chanock, Stephen J, Christiansen, Hans, Chung, Wendy K, Claes, Kathleen B M, Clarke, Christine L, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Daly, Mary B, De la Hoya, Miguel, Dennis, Joe, Devilee, Peter, Diez, Orland, Dörk, Thilo, Dunning, Alison M, Dwek, Miriam, Eccles, Diana M, Ejlertsen, Bent, Ellberg, Carolina, Engel, Christoph, Eriksson, Mikael, Fasching, Peter A, Fletcher, Olivia, Flyger, Henrik, Friedman, Eitan, Frost, Debra, Gabrielson, Marike, Gago-Dominguez, Manuela, Ganz, Patricia A, Gapstur, Susan M, Garber, Judy, García-Closas, Montserrat, García-Sáenz, José A, Gaudet, Mia M, Giles, Graham G, Glendon, Gord, Godwin, Andrew K, Goldberg, Mark S, Goldgar, David E, González-Neira, Anna, Greene, Mark H, Gronwald, Jacek, Guénel, Pascal, Haiman, Christopher A, Hall, Per, Hamann, Ute, He, Wei, Heyworth, Jane, Hogervorst, Frans B L, Hollestelle, Antoinette, Hoover, Robert N, Hopper, John L, Hulick, Peter J, Humphreys, Keith, Imyanitov, Evgeny N, Isaacs, Claudine, Jakimovska, Milena, Jakubowska, Anna, James, Paul A, Janavicius, Ramunas, Jankowitz, Rachel C, John, Esther M, Johnson, Nichola, Joseph, Vijai, Karlan, Beth Y, Khusnutdinova, Elza, Kiiski, Johanna I, Ko, Yon-Dschun, Jones, Michael E, Konstantopoulou, Irene, Kristensen, Vessela N, Laitman, Yael, Lambrechts, Diether, Lazaro, Conxi, Leslie, Goska, Lester, Jenny, Lesueur, Fabienne, Lindström, Sara, Long, Jirong, Loud, Jennifer T, Lubiński, Jan, Makalic, Enes, Mannermaa, Arto, Manoochehri, Mehdi, Margolin, Sara, Maurer, Tabea, Mavroudis, Dimitrios, McGuffog, Lesley, Meindl, Alfons, Menon, Usha, Michailidou, Kyriaki, Miller, Austin, Montagna, Marco, Moreno, Fernando, Moserle, Lidia, Mulligan, Anna Marie, Nathanson, Katherine L, Neuhausen, Susan L, Nevanlinna, Heli, Nevelsteen, Ines, Nielsen, Finn C, Nikitina-Zake, Liene, Nussbaum, Robert L, Offit, Kenneth, Olah, Edith, Olopade, Olufunmilayo I, Olsson, Håkan, Osorio, Ana, Papp, Janos, Park-Simon, Tjoung-Won, Parsons, Michael T, Pedersen, Inge Sokilde, Peixoto, Ana, Peterlongo, Paolo, Pharoah, Paul D P, Plaseska-Karanfilska, Dijana, Poppe, Bruce, Presneau, Nadege, Radice, Paolo, Rantala, Johanna, Rennert, Gad, Risch, Harvey A, Saloustros, Emmanouil, Sanden, Kristin, Sawyer, Elinor J, Schmidt, Marjanka K, Schmutzler, Rita K, Sharma, Priyanka, Shu, Xiao-Ou, Simard, Jacques, Singer, Christian F, Soucy, Penny, Southey, Melissa C, Spinelli, John J, Spurdle, Amanda B, Stone, Jennifer, Swerdlow, Anthony J, Tapper, William J, Taylor, Jack A, Teixeira, Manuel R, Terry, Mary Beth, Teulé, Alex, Thomassen, Mads, Thöne, Kathrin, Thull, Darcy L, Tischkowitz, Marc, Toland, Amanda E, Torres, Diana, Truong, Thérèse, Tung, Nadine, Vachon, Celine M, van Asperen, Christi J, van den Ouweland, Ans M W, van Rensburg, Elizabeth J, Vega, Ana, Viel, Alessandra, Wang, Qin, Wappenschmidt, Barbara, Weitzel, Jeffrey N, Wendt, Camilla, Winqvist, Robert, Yang, Xiaohong R, Yannoukakos, Drakoulis, Ziogas, Argyrios, Kraft, Peter, Antoniou, Antonis C, Zheng, Wei, Easton, Douglas F, Milne, Roger L, Beesley, Jonathan, Chenevix-Trench, Georgia

المساهمون: 1 Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia. Manuel.Ferreira@qimr.edu.au. 2 Division of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, 37235, USA. 3 Clare Hall, University of Cambridge, Cambridge, CB3 9AL, UK. 4 Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia. 5 Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, 00290, Helsinki, Finland. 6 Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada. 7 Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada. 8 Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA, USA, 92617. 9 Department of Pathology, Landspitali University Hospital, 101, Reykjavik, Iceland. 10 BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, 101, Reykjavik, Iceland. 11 Division of Clinical Epidemiology and Aging Research, C070, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. 12 Department of Public Health Sciences, and Cancer Research Institute, Queen's University, Kingston, ON, K7L 3N6, Canada. 13 Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. 14 Dept of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, 1090, Vienna, Austria. 15 Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), 20133, Milan, Italy. 16 Oncogenetics Group, Vall dHebron Institute of Oncology (VHIO), 8035, Barcelona, Spain. 17 Department of Medical Oncology, Vall d'Hebron Institute of Oncology (VHIO), University Hospital, Vall d'Hebron, 08035, Barcelona, Spain. 18 Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK. 19 Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, 91054, Erlangen, Germany. 20 Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. 21 Centro de Investigación en Red de Enfermedades Raras (CIBERER), 46010, Valencia, Spain. 22 Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), 28029, Madrid, Spain. 23 Institute of Biochemistry and Genetics, Ufa Federal Research Centre of Russian Academy of Sciences, 450054, Ufa, Russia. 24 Department of Genetics and Pathology, Pomeranian Medical University, 71-252, Szczecin, Poland. 25 Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, 00290, Finland. 26 Department of Oncology, Örebro University Hospital, 70185, Örebro, Sweden. 27 Department of Radiation Oncology, Hannover Medical School, 30625, Hannover, Germany. 28 Gynaecology Research Unit, Hannover Medical School, 30625, Hannover, Germany. 29 N.N. Alexandrov Research Institute of Oncology and Medical Radiology, 223040, Minsk, Belarus. 30 Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, 2730, Herlev, Denmark. 31 Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, 2730, Herlev, Denmark. 32 Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark. 33 Department of Oncology, Lund University and Skåne University Hospital, 222 41, Lund, Sweden. 34 Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376, Stuttgart, Germany. 35 University of Tübingen, 72074, Tübingen, Germany. 36 German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. 37 Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), 69120, Heidelberg, Germany. 38 Division of Molecular Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, 1066 CX, Amsterdam, The Netherlands. 39 Molecular Epidemiology Group, C080, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. 40 Molecular Biology of Breast Cancer, University Womens Clinic Heidelberg, University of Heidelberg, 69120, Heidelberg, Germany. 41 Molecular Oncology Laboratory, CIBERONC, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), 28040, Madrid, Spain. 42 Section of Molecular Genetics, Dept. of Laboratory Medicine, University Hospital of Pisa, 56126, Pisa, Italy. 43 Department of Biology, University of Pisa, 56126, Pisa, Italy. 44 Research Department, Peter MacCallum Cancer Center, Melbourne, VIC, 3000, Australia. 45 Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, 3000, Australia. 46 Genomic Epidemiology Group, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. 47 Department of Gynaecological Oncology, Chris O'Brien Lifehouse and The University of Sydney, Camperdown, NSW, 2050, Australia. 48 Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA, 30303. 49 Oncology and Genetics Unit, Instituto de Investigacion Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS, 36312, Vigo, Spain. 50 Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany. 51 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, 20850, USA. 52 Departments of Pediatrics and Medicine, Columbia University, New York, NY, 10032, USA. 53 Centre for Medical Genetics, Ghent University, Gent, 9000, Belgium. 54 Westmead Institute for Medical Research, University of Sydney, Sydney, NSW, 2145, Australia. 55 Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA. 56 Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Sheffield, S10 2TN, UK. 57 Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, S10 2TN, UK. 58 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 65, Stockholm, Sweden. 59 Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA. 60 Department of Pathology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands. 61 Department of Human Genetics, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands. 62 Clinical and Molecular Genetics Area, University Hospital Vall dHebron, Barcelona, 08035, Spain. 63 Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK. 64 Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, London, W1B 2HW, UK. 65 Faculty of Medicine, University of Southampton, Southampton, SO17 1BJ, UK. 66 Department of Oncology, Rigshospitalet, Copenhagen University Hospital, DK-2100, Copenhagen, Denmark. 67 Department of Cancer Epidemiology, Clinical Sciences, Lund University, 222 42, Lund, Sweden. 68 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04107, Leipzig, Germany. 69 David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA, 90095, USA. 70 The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW7 3RP, UK. 71 Department of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, 2730, Herlev, Denmark. 72 The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, 52621, Ramat Gan, Israel. 73 Sackler Faculty of Medicine, Tel Aviv University, 69978, Ramat Aviv, Israel. 74 Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, 15706, Santiago de Compostela, Spain. 75 Moores Cancer Center, University of California San Diego, La Jolla, CA, 92037, USA. 76 Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Centre, UCLA, Los Angeles, CA, 90096-6900, USA. 77 Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, MA, 02215, USA. 78 Division of Genetics and Epidemiology, Institute of Cancer Research, London, SM2 5NG, UK. 79 Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), 28040, Madrid, Spain. 80 Cancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, VIC, 3004, Australia. 81 Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, 3010, Australia. 82 Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia. 83 Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, KS, 66160, USA. 84 Department of Medicine, McGill University, Montréal, QC, H4A 3J1, Canada. 85 Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montréal, QC, H4A 3J1, Canada. 86 Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, 84112, USA. 87 Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20850-9772, USA. 88 Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, 94805, Villejuif, France. 89 Department of Preventive Medicine, Keck School of 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Petrov Institute of Oncology. St., Petersburg, 197758, Russia. 98 Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, 20007, USA. 99 Research Centre for Genetic Engineering and Biotechnology 'Georgi D. Efremov', Macedonian Academy of Sciences and Arts, Skopje, 1000, Republic of Macedonia. 100 Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, 71-252, Poland. 101 Parkville Familial Cancer Centre, Peter MacCallum Cancer Center, Melbourne, VIC, 3000, Australia. 102 Hematology, oncology and transfusion medicine center, Dept. of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Vilnius, 08410, Lithuania. 103 Department of Medicine, Division of Hematology/Oncology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15232, USA. 104 Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, 94304, USA. 105 Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA. 106 David Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, CA, 90095, USA. 107 Department of Genetics and Fundamental Medicine, Bashkir State Medical University, 450076, Ufa, Russia. 108 Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, 00290, Finland. 109 Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, 53177, Germany. 110 Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SM2 5NG, UK. 111 Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, 15310, Greece. 112 Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo, 0379, Norway. 113 Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, 0450, Norway. 114 VIB Center for Cancer Biology, VIB, Leuven, 3001, Belgium. 115 Laboratory for Translational Genetics, Department of Human Genetics, University of Leuven, Leuven, 3000, Belgium. 116 Molecular Diagnostic Unit, Hereditary Cancer Program, ICO-IDIBELL (Bellvitge Biomedical Research Institute, Catalan Institute of Oncology), CIBERONC, Barcelona, 08908, Spain. 117 Genetic Epidemiology of Cancer team, Inserm U900, Paris, 75005, France. 118 Institut Curie, Paris, 75005, France. 119 Mines ParisTech, Fontainebleau, 77305, France. 120 Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, 98195, USA. 121 Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA. 122 Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA. 123 Translational Cancer Research Area, University of Eastern Finland, Kuopio, 70210, Finland. 124 Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, 70210, Finland. 125 Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, 70210, Finland. 126 Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, 118 83, Sweden. 127 Department of Medical Oncology, University Hospital of Heraklion, Heraklion, 711 10, Greece. 128 Department of Gynecology and Obstetrics, University of Munich, Campus Großhadern, Munich, 81377, Germany. 129 MRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, University College London, London, WC1V 6LJ, UK. 130 Department of Electron Microscopy/Molecular Pathology and The Cyprus School of Molecular Medicine, The Cyprus Institute of Neurology & Genetics, Nicosia, 1683, Cyprus. 131 NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, NY, 14263, USA. 132 Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - 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Université Laval, Research Center, Québec City, QC, G1V 4G2, Canada. 161 Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, 3168, Australia. 162 Department of Clinical Pathology, The University of Melbourne, Melbourne, VIC, 3010, Australia. 163 Population Oncology, BC Cancer, Vancouver, BC, V5Z 1G1, Canada. 164 School of Population and Public Health, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada. 165 The Curtin UWA Centre for Genetic Origins of Health and Disease, Curtin University and University of Western Australia, Perth, WA, 6000, Australia. 166 Division of Breast Cancer Research, The Institute of Cancer Research, London, SW7 3RP, UK. 167 Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, 27709, USA. 168 Epigenetic and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, 27709, USA. 169 Biomedical Sciences Institute (ICBAS), University of Porto, Porto, 4050-013, Portugal. 170 Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, 10032, USA. 171 Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute),Catalan Institute of Oncology, CIBERONC, Barcelona, 08908, Spain. 172 Department of Clinical Genetics, Odense University Hospital, Odence C, 5000, Denmark. 173 Department of Medicine, Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA. 174 Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, QC, H4A 3J1, Canada. 175 Department of Medical Genetics, University of Cambridge, Cambridge, CB2 0QQ, UK. 176 Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, 43210, USA. 177 Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, 110231, Colombia. 178 Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA. 179 Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, 55905, USA. 180 Department of Clinical Genetics, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands. 181 Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, 3015 CN, The Netherlands. 182 Department of Genetics, University of Pretoria, Arcadia, 0007, South Africa. 183 Fundación Pública galega Medicina Xenómica-SERGAS, Grupo de Medicina Xenómica-USC, CIBERER, IDIS, Santiago de Compostela, Spain. 184 Division of Functional onco-genomics and genetics, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, 33081, Italy. 185 Clinical Cancer Genomics, City of Hope, Duarte, CA, 91010, USA. 186 Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, 90570, Finland. 187 Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre Oulu, Oulu, 90570, Finland. 188 Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. 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المصدر: Nature communications

مصطلحات موضوعية: Brjóstakrabbamein, Gen, Breast Neoplasms, Genome-Wide Association Study, Genetics

العلاقة: https://www.nature.com/articles/s41467-018-08053-5Test; Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer. 2019, 10(1):1741. doi:10.1038/s41467-018-08053-5.; http://hdl.handle.net/2336/621016Test; Nature Communications

الإتاحة: https://doi.org/10.1038/s41467-018-08053-5Test
http://hdl.handle.net/2336/621016Test