دورية أكاديمية
Association of glial and neuronal degeneration markers with Alzheimer's disease cerebrospinal fluid profile and cognitive functions.
| العنوان: | Association of glial and neuronal degeneration markers with Alzheimer's disease cerebrospinal fluid profile and cognitive functions. |
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| المؤلفون: | Teitsdottir, Unnur D, Jonsdottir, Maria K, Lund, Sigrun H, Darreh-Shori, Taher, Snaedal, Jon, Petersen, Petur H |
| المساهمون: | 1Faculty of Medicine, Department of Anatomy, Biomedical Center, University of Iceland, Reykjavik, Iceland. udt1@hi.is. 2Department of Psychology, Reykjavik University, Reykjavik, Iceland. 3Department of Psychiatry, Landspitali - National University Hospital, Reykjavik, Iceland. 4deCODE genetics/Amgen, Inc., Reykjavik, Iceland. 5Division of Clinical Geriatrics, Center for Alzheimer Research, NVS Department, Karolinska Institutet, Huddinge, Sweden. 6Memory clinic, Department of Geriatric Medicine, Landspitali - National University Hospital, Reykjavik, Iceland. 7Faculty of Medicine, Department of Anatomy, Biomedical Center, University of Iceland, Reykjavik, Iceland. |
| المصدر: | Alzheimer's research & therapy ; 12 ; 1 ; 92 ; England |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2020 |
| المجموعة: | Hirsla - Landspítali University Hospital research archive |
| مصطلحات موضوعية: | AD biomarker profile, Alzheimer’s disease, Cerebrospinal fluid, Cognitive domains, Glial fibrillary acidic protein, Neurofilament light, S100 calcium-binding protein B, YKL-40, Alzheimer sjúkdómur |
| الوصف: | To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Download ; Background: Neuroinflammation has gained increasing attention as a potential contributing factor in the onset and progression of Alzheimer's disease (AD). The objective of this study was to examine the association of selected cerebrospinal fluid (CSF) inflammatory and neuronal degeneration markers with signature CSF AD profile and cognitive functions among subjects at the symptomatic pre- and early dementia stages. Methods: In this cross-sectional study, 52 subjects were selected from an Icelandic memory clinic cohort. Subjects were classified as having AD (n = 28, age = 70, 39% female, Mini-Mental State Examination [MMSE] = 27) or non-AD (n = 24, age = 67, 33% female, MMSE = 28) profile based on the ratio between CSF total-tau (T-tau) and amyloid-β1-42 (Aβ42) values (cut-off point chosen as 0.52). Novel CSF biomarkers included neurofilament light (NFL), YKL-40, S100 calcium-binding protein B (S100B) and glial fibrillary acidic protein (GFAP), measured with enzyme-linked immunosorbent assays (ELISAs). Subjects underwent neuropsychological assessment for evaluation of different cognitive domains, including verbal episodic memory, non-verbal episodic memory, language, processing speed, and executive functions. Results: Accuracy coefficient for distinguishing between the two CSF profiles was calculated for each CSF marker and test. Novel CSF markers performed poorly (area under curve [AUC] coefficients ranging from 0.61 to 0.64) compared to tests reflecting verbal episodic memory, which all performed fair (AUC > 70). LASSO regression with a stability approach was applied for the selection of CSF markers and demographic variables predicting performance on each cognitive domain, both among all subjects and only those with a CSF AD profile. Relationships between CSF markers and cognitive domains, where the CSF marker reached stability ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1758-9193 |
| العلاقة: | https://alzres.biomedcentral.com/articles/10.1186/s13195-020-00657-8Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404927Test/; Teitsdottir UD, Jonsdottir MK, Lund SH, Darreh-Shori T, Snaedal J, Petersen PH. Association of glial and neuronal degeneration markers with Alzheimer's disease cerebrospinal fluid profile and cognitive functions. Alzheimers Res Ther. 2020;12(1):92. Published 2020 Aug 4. doi:10.1186/s13195-020-00657-8; http://hdl.handle.net/2336/621521Test; Alzheimer's research & therapy |
| DOI: | 10.1186/s13195-020-00657-8 |
| الإتاحة: | https://doi.org/10.1186/s13195-020-00657-8Test http://hdl.handle.net/2336/621521Test |
| حقوق: | Open Access - Opinn aðgangur |
| رقم الانضمام: | edsbas.DAA94EC4 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17589193 |
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| DOI: | 10.1186/s13195-020-00657-8 |