دورية أكاديمية
At-risk variant in TCF7L2 for type II diabetes increases risk of schizophrenia.
| العنوان: | At-risk variant in TCF7L2 for type II diabetes increases risk of schizophrenia. |
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| المؤلفون: | Hansen, Thomas, Ingason, Andrés, Djurovic, Srdjan, Melle, Ingrid, Fenger, Mogens, Gustafsson, Omar, Jakobsen, Klaus D, Rasmussen, Henrik B, Tosato, Sarah, Rietschel, Marcella, Frank, Josef, Owen, Mike, Bonetto, Chiara, Suvisaari, Jaana, Thygesen, Johan Hilge, Pétursson, Hannes, Lönnqvist, Jouko, Sigurdsson, Engilbert, Giegling, Ina, Craddock, Nick, O'Donovan, Michael C, Ruggeri, Mirella, Cichon, Sven, Ophoff, Roel A, Pietiläinen, Olli, Peltonen, Leena, Nöthen, Markus M, Rujescu, Dan, St Clair, David, Collier, David A, Andreassen, Ole A, Werge, Thomas |
| المساهمون: | Mental Health Centre Sct. Hans, Copenhagen University Hospital, Research Institute of Biological Psychiatry, Roskilde, Denmark, Copenhagen University, Center for Pharmacogenomics, Copenhagen, Denmark. |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2012 |
| المجموعة: | Hirsla - Landspítali University Hospital research archive |
| مصطلحات موضوعية: | Alleles, Case-Control Studies, Diabetes Mellitus, Type 2, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Humans, Male, Polymorphism, Single Nucleotide, Schizophrenia, Transcription Factor 7-Like 2 Protein |
| الوصف: | To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. ; BACKGROUND: Schizophrenia is associated with increased risk of type II diabetes and metabolic disorders. However, it is unclear whether this comorbidity reflects shared genetic risk factors, at-risk lifestyle, or side effects of antipsychotic medication. METHODS: Eleven known risk variants of type II diabetes were genotyped in patients with schizophrenia in a sample of 410 Danish patients, each matched with two healthy control subjects on sex, birth year, and month. Replication was carried out in a large multinational European sample of 4089 patients with schizophrenia and 17,597 controls (SGENE+) using Mantel-Haenszel test. RESULTS: One type II diabetes at-risk allele located in TCF7L2, rs7903146 [T], was associated with schizophrenia in the discovery sample (p = .0052) and in the replication with an odds ratio of 1.07 (95% confidence interval 1.01-1.14, p = .033). CONCLUSION: The association reported here with a well-known diabetes variant suggests that the observed comorbidity is partially caused by genetic risk variants. This study also demonstrates how genetic studies can successfully examine an epidemiologically derived hypothesis of comorbidity. ; European Union LSHM-CT-2006-037761 info:eu-repo/grantAgreement/EC/FP7/218251 Copenhagen Hospital Corporation Danish National Psychiatric Research Foundation Danish Agency for Science, Technology and Innovation (Centre for Pharmacogenomics) Danish Medical Research Council Research Council of Norway 167153/v50 163070/V50 Norwegian South-Eastern Health Authority 123-2004 University of Oslo Oslo University Hospital Eli Lilly, Inc. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1873-2402 |
| العلاقة: | info:eu-repo/grantAgreement/EC/FP7/218251; http://dx.doi.org/10.1016/j.biopsych.2011.01.031Test; Biol. Psychiatry 2011, 70(1):59-63; http://hdl.handle.net/2336/225277Test; Biological psychiatry |
| DOI: | 10.1016/j.biopsych.2011.01.031 |
| الإتاحة: | https://doi.org/10.1016/j.biopsych.2011.01.031Test http://hdl.handle.net/2336/225277Test |
| حقوق: | Archived with thanks to Biological psychiatry |
| رقم الانضمام: | edsbas.5F01DC70 |
| قاعدة البيانات: | BASE |
| تدمد: | 18732402 |
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| DOI: | 10.1016/j.biopsych.2011.01.031 |