دورية أكاديمية
Development and validation of the Food Allergy Severity Score.
| العنوان: | Development and validation of the Food Allergy Severity Score. |
|---|---|
| المؤلفون: | Fernández-Rivas, Montserrat, Gómez García, Ismael, Gonzalo-Fernández, Alejandro, Fuentes Ferrer, Manuel, Dölle-Bierke, Sabine, Marco-Martín, Guadalupe, Ballmer-Weber, Barbara K, Asero, Riccardo, Belohlavkova, Simona, Beyer, Kirsten, de Blay, Frédéric, Clausen, Michael, Datema, Mareen R, Dubakiene, Ruta, Grimshaw, Kate E C, Hoffmann-Sommergruber, Karin, Hourihane, Jonathan O'B, Jedrzejczak-Czechowicz, Monika, Knulst, André C, Kralimarkova, Tanya, Le, Thuy-My, Papadopoulos, Nikolaos G, Popov, Todor A, Poulsen, Lars K, Purohit, Ashok, Seneviratne, Suranjith L, Simpson, Angela, Sinaniotis, Atanasios, Turkalji, Mirjana, Vázquez-Cortés, Sonia, Vera-Berrios, Rosialzira N, Muraro, Antonella, Worm, Margitta, Roberts, Graham, van Ree, Ronald, Fernández-Pérez, Cristina, Turner, Paul J, Mills, Elizabeth N Clare |
| المساهمون: | 1Allergy Department, Hospital Clínico San Carlos, Facultad de Medicina, Universidad Complutense (UCM), IdISSC, ARADyAL, Madrid, Spain. 2Grupo de Investigación en Alergia, IdISSC, Madrid, Spain. 3Unidad de Apoyo a la Investigación, Preventive Medicine Department, Hospital Clínico San Carlos, IdISSC, Universidad Alfonso X El Sabio, Madrid, Spain. 4Division of Allergy and Immunology, Department of Dermatology, Venerology and Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. 5Allergy Department, Hospital Clínico San Carlos, IdISSC, ARADyAL, Madrid, Spain. 6Department of Dermatology, University Hospital Zurich, Zurich, Switzerland. 7Clinic for Dermatology and Allergology, Kantonsspital St Gallen, St Gallen, Switzerland. 8Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Milan, Italy. 9Medical Faculty and Faculty Hospital Pilsen, Pilsen, Czech Republic. 10Department of Pediatric Respiratory Medicine, Immunology and Intensive Care Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany. 11Chest Diseases Department, Strasbourg University Hospital, Federation of Translational Medicine, University of Strasbourg, Strasbourg, France. 12Children's Hospital and Department of Allergy, Landspitali University Hospital, Reykjavik, Iceland. 13Department of Experimental Immunology, and Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam University Medical Center, Amsterdam, The Netherlands. 14Medical Faculty, Vilnius University, Vilnius, Lithuania. 15Department of Dietetics, Salford Royal NHS Foundation Trust, Salford, UK. 16Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK. 17Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria. 18Royal College of Surgeons in Ireland, Children's Health Ireland at Temple Street, Dublin, Ireland. 19Department of Allergy and Immunology, Medical University of Lodz, Lodz, Poland. 20Dept. Dermatology/Allergology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. 21Clinic of Allergy and Asthma, Medical University in Sofia, Sofia, Bulgaria. 22Allergy Dpt, 2nd Pediatric clinic, University of Athens, Athens, Greece. 23Division of Infection, Immunity & Respiratory Medicine, University of Manchester, Manchester, UK. 24University Hospital Sv. Ivan Rilski, Sofia, Bulgaria. 25Allergy Clinic, Copenhagen University Hospital at Herlev-Gentofte, Copenhagen, Denmark. 26Allergy Division, Chest Disease Department, University Hospital of Strasbourg, Strasbourg, France. 27Department of Clinical Immunology and Allergy, Central Manchester and Manchester Children's University Hospitals NHS Trust, Manchester, UK. 28Institute of Immunity and Transplantation, Royal Free Hospital and University College London, London, UK. 29Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, and Manchester University NHS Foundation Trust, The University of Manchester, Manchester, UK. 30Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece. 31Allergy Department, Sotiria Chest Diseases Hospital, Athens, Greece. 32Srebrnjak Children's Hospital Zagreb, Catholic University of Croatia Zagreb, and Medical Faculty Osijek, J.J.Strossmayer University, Osijek, Croatia. 33Food Allergy Referral Centre Veneto Region, Department of Women and Child Health, Padua General University Hospital, Padua, Italy. 34NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK. 35Clinical and Experimental Sciences and Human Development in Health, Faculty of Medicine, University of Southampton, Southampton, UK. 36The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Isle of Wight, UK. 37Departments of Experimental Immunology and of Otorhinoraryngology, Amsterdam University Medical Centers, Amsterdam, The Netherlands. 38Preventive Medicine Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain. 39Preventive Medicine Department, Complejo Hospitalario Universitario Santiago de Compostela, Santiago de Compostela, Spain. 40National Heart & Lung Institute, Imperial College London, London, UK. 41Division of Infection, Immunity and Respiratory Medicine, Manchester Academic Health Sciences Centre, Manchester Institute of Biotechnology, University of Manchester, Manchester, UK. |
| المصدر: | Allergy ; Denmark |
| بيانات النشر: | Wiley |
| سنة النشر: | 2022 |
| المجموعة: | Hirsla - Landspítali University Hospital research archive |
| مصطلحات موضوعية: | allergic reactions, anaphylaxis, food allergy, score, severity, Fæðuofnæmi, Food Hypersensitivity |
| الوصف: | To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Download ; Background: The heterogeneity and lack of validation of existing severity scores for food allergic reactions limit standardization of case management and research advances. We aimed to develop and validate a severity score for food allergic reactions. Methods: Following a multidisciplinary experts consensus, it was decided to develop a food allergy severity score (FASS) with ordinal (oFASS) and numerical (nFASS) formats. oFASS with 3 and 5 grades were generated through expert consensus, and nFASS by mathematical modeling. Evaluation was performed in the EuroPrevall outpatient clinic cohort (8232 food reactions) by logistic regression with request of emergency care and medications used as outcomes. Discrimination, classification, and calibration were calculated. Bootstrapping internal validation was followed by external validation (logistic regression) in 5 cohorts (3622 food reactions). Correlation of nFASS with the severity classification done by expert allergy clinicians by Best-Worst Scaling of 32 food reactions was calculated. Results: oFASS and nFASS map consistently, with nFASS having greater granularity. With the outcomes emergency care, adrenaline and critical medical treatment, oFASS and nFASS had a good discrimination (receiver operating characteristic area under the curve [ROC-AUC]>0.80), classification (sensitivity 0.87-0.92, specificity 0.73-0.78), and calibration. Bootstrapping over ROC-AUC showed negligible biases (1.0 × 10-6 -1.23 × 10-3 ). In external validation, nFASS performed best with higher ROC-AUC. nFASS was strongly correlated (R 0.89) to best-worst scoring of 334 expert clinicians. Conclusion: FASS is a validated and reliable method to measure severity of food allergic reactions. The ordinal and numerical versions that map onto each other are suitable for use by different stakeholders in different settings. ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1398-9995 |
| العلاقة: | Fernández-Rivas M, Gómez García I, Gonzalo-Fernández A, et al. Development and validation of the Food Allergy Severity Score [published online ahead of print, 2021 Oct 30]. Allergy. 2021;10.1111/all.15165. doi:10.1111/all.15165; http://hdl.handle.net/2336/622047Test; Allergy |
| DOI: | 10.1111/all.15165 |
| الإتاحة: | https://doi.org/10.1111/all.15165Test http://hdl.handle.net/2336/622047Test |
| حقوق: | © 2021 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. ; Open Access - Opinn aðgangur |
| رقم الانضمام: | edsbas.71EE2172 |
| قاعدة البيانات: | BASE |
| تدمد: | 13989995 |
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| DOI: | 10.1111/all.15165 |