دورية أكاديمية
Common variants on 8p12 and 1q24.2 confer risk of schizophrenia.
| العنوان: | Common variants on 8p12 and 1q24.2 confer risk of schizophrenia. |
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| المؤلفون: | Shi, Yongyong, Li, Zhiqiang, Xu, Qi, Wang, Ti, Li, Tao, Shen, Jiawei, Zhang, Fengyu, Chen, Jianhua, Zhou, Guoquan, Ji, Weidong, Li, Baojie, Xu, Yifeng, Liu, Dengtang, Wang, Peng, Yang, Ping, Liu, Benxiu, Sun, Wensheng, Wan, Chunling, Qin, Shengying, He, Guang, Steinberg, Stacy, Cichon, Sven, Werge, Thomas, Sigurdsson, Engilbert, Tosato, Sarah, Palotie, Aarno, Nöthen, Markus M, Rietschel, Marcella, Ophoff, Roel A, Collier, David A, Rujescu, Dan, Clair, David St, Stefansson, Hreinn, Stefansson, Kari, Ji, Jue, Wang, Qingzhong, Li, Wenjin, Zheng, Linqing, Zhang, Hairong, Feng, Guoyin, He, Lin |
| المساهمون: | Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, China. shiyongyong@gmail.com |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2012 |
| المجموعة: | Hirsla - Landspítali University Hospital research archive |
| مصطلحات موضوعية: | Adult, Aged, Asian Continental Ancestry Group, Case-Control Studies, Chromosomes, Human, Pair 1, Pair 8, Female, Genetic Loci, Genome-Wide Association Study, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Principal Component Analysis, Risk Factors, Schizophrenia, Young Adult |
| الوصف: | To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. ; Schizophrenia is a severe mental disorder affecting ∼1% of the world population, with heritability of up to 80%. To identify new common genetic risk factors, we performed a genome-wide association study (GWAS) in the Han Chinese population. The discovery sample set consisted of 3,750 individuals with schizophrenia and 6,468 healthy controls (1,578 cases and 1,592 controls from northern Han Chinese, 1,238 cases and 2,856 controls from central Han Chinese, and 934 cases and 2,020 controls from the southern Han Chinese). We further analyzed the strongest association signals in an additional independent cohort of 4,383 cases and 4,539 controls from the Han Chinese population. Meta-analysis identified common SNPs that associated with schizophrenia with genome-wide significance on 8p12 (rs16887244, P = 1.27 × 10(-10)) and 1q24.2 (rs10489202, P = 9.50 × 10(-9)). Our findings provide new insights into the pathogenesis of schizophrenia. ; 973 Program 2010CB529600 2009AA022701 2006AA02A407 Natural Science Foundation of China 81130022 81121001 31000553 Foundation for the Author of National Excellent Doctoral Dissertation of China 201026 Program for New Century Excellent Talents in University NCET-09-0550 Shanghai Municipal Health Bureau 2008095 Shanghai Changning Health Bureau 2008406002 Shanghai Municipal Commission 09DJ1400601 National Key Technology RD Program 2006BAI05A09 Shanghai Leading Academic Discipline Project 205 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1546-1718 |
| العلاقة: | http://dx.doi.org/10.1038/ng.980Test; Nat. Genet. 2011, 43(12):1224-7; http://hdl.handle.net/2336/227803Test; Nature genetics |
| DOI: | 10.1038/ng.980 |
| الإتاحة: | https://doi.org/10.1038/ng.980Test http://hdl.handle.net/2336/227803Test |
| حقوق: | Archived with thanks to Nature genetics |
| رقم الانضمام: | edsbas.B0B3C3F3 |
| قاعدة البيانات: | BASE |
| تدمد: | 15461718 |
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| DOI: | 10.1038/ng.980 |