دورية أكاديمية
Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits.
| العنوان: | Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits. |
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| المؤلفون: | Hammerschlag, Anke R, Stringer, Sven, de Leeuw, Christiaan A, Sniekers, Suzanne, Taskesen, Erdogan, Watanabe, Kyoko, Blanken, Tessa F, Dekker, Kim, Te Lindert, Bart H W, Wassing, Rick, Jonsdottir, Ingileif, Thorleifsson, Gudmar, Stefansson, Hreinn, Gislason, Thorarinn, Berger, Klaus, Schormair, Barbara, Wellmann, Juergen, Winkelmann, Juliane, Stefansson, Kari, Oexle, Konrad, Van Someren, Eus J W, Posthuma, Danielle |
| المساهمون: | 1 Vrije Univ Amsterdam, Amsterdam Neurosci, Ctr Neurogen & Cognit Res, Dept Complex Trait Genet, Amsterdam, Netherlands Show more 2 Vrije Univ Amsterdam, Med Ctr, Dept Neurol, Amsterdam Neurosci, Amsterdam, Netherlands Show more 3 Netherlands Inst Neurosci, Dept Sleep & Cognit, Amsterdam, Netherlands Show more 4 Vrije Univ Amsterdam, Amsterdam Neurosci, Dept Integrat Neurophysiol, Amsterdam, Netherlands Show more 5 Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Amsterdam, Netherlands 6 Amgen Inc, deCODE Genet, Reykjavik, Iceland Show more 7 Univ Iceland, Sch Hlth Sci, Fac Med, Reykjavik, Iceland 8 Natl Univ Hosp Iceland, Dept Resp Med & Sleep, Landspitali, Reykjavik, Iceland Show more 9 Univ Munster, Inst Epidemiol & Social Med, Munster, Germany Show more 10 Helmholtz Zentrum Munchen, Inst Neurogen, Munich, Germany Show more 11 Tech Univ Munich, Inst Human Genet, Munich, Germany Show more 12 Tech Univ Munich, Klinikum Rechts Isar, Neurol Klin & Poliklin, Munich, Germany 13 Munich Cluster Syst Neurol SyNergy, Munich, Germany Show more 14 Vrije Univ Amsterdam, Med Ctr, Amsterdam Neurosci, Dept Clin Genet, Amsterdam, Netherlands |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2018 |
| المجموعة: | Hirsla - Landspítali University Hospital research archive |
| مصطلحات موضوعية: | Svefntruflanir, Svefnleysi, Gen, PAD12, AAI12, Adult, Alleles, Chromosome Mapping, Educational Status, Female, Gene Expression, Gene Frequency, Gene Regulatory Networks, Genetic Loci, Genetic Predisposition to Disease, Genome, Human, Genome-Wide Association Study, Homeodomain Proteins, Humans, Male, Myeloid Ecotropic Viral Integration Site 1 Protein, Neoplasm Proteins, Polymorphism, Single Nucleotide, Protein Interaction Mapping, Quality of Life, Restless Legs Syndrome, Sex Factors, Sleep Initiation and Maintenance Disorders |
| الوصف: | To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files ; Persistent insomnia is among the most frequent complaints in general practice. To identify genetic factors for insomnia complaints, we performed a genome-wide association study (GWAS) and a genome-wide gene-based association study (GWGAS) in 113,006 individuals. We identify three loci and seven genes associated with insomnia complaints, with the associations for one locus and five genes supported by joint analysis with an independent sample (n = 7,565). Our top association (MEIS1, P < 5 × 10-8) has previously been implicated in restless legs syndrome (RLS). Additional analyses favor the hypothesis that MEIS1 exhibits pleiotropy for insomnia and RLS and show that the observed association with insomnia complaints cannot be explained only by the presence of an RLS subgroup within the cases. Sex-specific analyses suggest that there are different genetic architectures between the sexes in addition to shared genetic factors. We show substantial positive genetic correlation of insomnia complaints with internalizing personality traits and metabolic traits and negative correlation with subjective well-being and educational attainment. These findings provide new insight into the genetic architecture of insomnia. ; Netherlands Organization for Scientific Research NWO Brain & Cognition 433-09-228 European Research Council ERC-ADG-2014-671084 INSOMNIA Netherlands Scientific Organization (NWO) VU University (Amsterdam, the Netherlands) Dutch Brain Foundation Helmholtz Zentrum Munchen - German Federal Ministry of Education and Research state of Bavaria German Migraine & Headache Society (DMKG) Almirall AstraZeneca Berlin Chemie Boehringer Boots Health Care GlaxoSmithKline Janssen Cilag McNeil Pharma MSD Sharp Dohme Pfizer Institute of Epidemiology and Social Medicine at the University of Munster German Ministry of Education and Research ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1546-1718 |
| العلاقة: | https://www.nature.com/articles/ng.3888.pdfTest; Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits. 2017, 49 (11):1584-1592 Nat. Genet.; http://hdl.handle.net/2336/620516Test; Nature genetics |
| DOI: | 10.1038/ng.3888 |
| الإتاحة: | https://doi.org/10.1038/ng.3888Test http://hdl.handle.net/2336/620516Test |
| حقوق: | Archived with thanks to Nature genetics ; Open Access - Opinn aðgangur |
| رقم الانضمام: | edsbas.D75CEFC1 |
| قاعدة البيانات: | BASE |
| تدمد: | 15461718 |
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| DOI: | 10.1038/ng.3888 |