التفاصيل البيبلوغرافية
| العنوان: |
Genetic Polymorphisms of Multidrug Resistance Gene-1 (MDR1/ABCB1) and Glutathione S-Transferase Gene and the Risk of Inflammatory Bowel Disease among Moroccan Patients |
| المؤلفون: |
Nezha Senhaji, Yaya Kassogue, Mina Fahimi, Nadia Serbati, Wafaa Badre, Sellama Nadifi |
| بيانات النشر: |
Mediators of Inflammation |
| سنة النشر: |
2015 |
| المجموعة: |
Hindawi Publishing Corporation |
| الوصف: |
Inflammatory bowel diseases (IBD) are multifactorial disorders resulting from environmental and genetic factors. Polymorphisms in MDR1 and GSTs genes might explain individual differences in susceptibility to IBD. We carried out a case-control study to examine the association of MDR1 (C1236T and C3435T), GSTT1, and GSTM1 polymorphisms with the risk of IBD. Subjects were genotyped using PCR-RFLP for MDR1 gene and multiplex PCR for GSTT1 and GSTM1. Meta-analysis was performed to test the association of variant allele carriage with IBD risk. We report that GSTT1 null genotype is significantly associated with the risk of CD (OR: 2.5, CI: 1.2–5, P=0.013) and UC (OR: 3.5, CI: 1.5–8.5, P=0.004) and can influence Crohn’s disease behavior. The interaction between GSTT1 and GSTM1 genes showed that the combined null genotypes were associated with the risk of UC (OR: 3.1, CI: 1.1–9, P=0.049). Furthermore, when compared to combined 1236CC/CT genotypes, the 1236TT genotype of MDR1 gene was associated with the risk of UC (OR: 3.7, CI: 1.3–10.7, P=0.03). Meta-analysis demonstrated significantly higher frequencies of 3435T carriage in IBD patients. Our results show that GSTT1 null and MDR1 polymorphisms could play a role in susceptibility to IBD. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
https://doi.org/10.1155/2015/248060Test |
| DOI: |
10.1155/2015/248060 |
| الإتاحة: |
https://doi.org/10.1155/2015/248060Test |
| حقوق: |
Copyright © 2015 Nezha Senhaji et al. |
| رقم الانضمام: |
edsbas.20A5DA67 |
| قاعدة البيانات: |
BASE |
