التفاصيل البيبلوغرافية
| العنوان: |
Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress |
| المؤلفون: |
Alba Naudi, Mariona Jove, Victoria Ayala, Anna Cassanye, Jose Serrano, Hugo Gonzalo, Jordi Boada, Joan Prat, Manuel Portero-Otin, Reinald Pamplona |
| بيانات النشر: |
Experimental Diabetes Research |
| سنة النشر: |
2012 |
| المجموعة: |
Hindawi Publishing Corporation |
| الوصف: |
Oxidative stress has been implicated in diabetes long-term complications. In this paper, we summarize the growing evidence suggesting that hyperglycemia-induced overproduction of superoxide by mitochondrial electron transport chain triggers a maladaptive response by affecting several metabolic and signaling pathways involved in the pathophysiology of cellular dysfunction and diabetic complications. In particular, it is our goal to describe physiological mechanisms underlying the mitochondrial free radical production and regulation to explain the oxidative stress derived from a high intracellular glucose concentration and the resulting maladaptive response that leads to a cellular dysfunction and pathological state. Finally, we outline potential therapies for diabetes focused to the prevention of mitochondrial oxidative damage. |
| نوع الوثيقة: |
review |
| اللغة: |
English |
| العلاقة: |
https://doi.org/10.1155/2012/696215Test |
| DOI: |
10.1155/2012/696215 |
| الإتاحة: |
https://doi.org/10.1155/2012/696215Test |
| حقوق: |
Copyright © 2012 Alba Naudi et al. |
| رقم الانضمام: |
edsbas.951194CC |
| قاعدة البيانات: |
BASE |
