التفاصيل البيبلوغرافية
| العنوان: |
Autophagy in HCV Infection: Keeping Fat and Inflammation at Bay |
| المؤلفون: |
Tiziana Vescovo, Giulia Refolo, Alessandra Romagnoli, Fabiola Ciccosanti, Marco Corazzari, Tonino Alonzi, Gian Maria Fimia |
| بيانات النشر: |
BioMed Research International |
| سنة النشر: |
2014 |
| المجموعة: |
Hindawi Publishing Corporation |
| مصطلحات موضوعية: |
Hepatology |
| الوصف: |
Hepatitis C virus (HCV) infection is one of the main causes of chronic liver disease. Viral persistence and pathogenesis rely mainly on the ability of HCV to deregulate specific host processes, including lipid metabolism and innate immunity. Recently, autophagy has emerged as a cellular pathway, playing a role in several aspects of HCV infection. This review summarizes current knowledge on the molecular mechanisms that link the HCV life cycle with autophagy machinery. In particular, we discuss the role of HCV/autophagy interaction in dysregulating inflammation and lipid homeostasis and its potential for translational applications in the treatment of HCV-infected patients. |
| نوع الوثيقة: |
review |
| اللغة: |
English |
| العلاقة: |
https://doi.org/10.1155/2014/265353Test |
| DOI: |
10.1155/2014/265353 |
| الإتاحة: |
https://doi.org/10.1155/2014/265353Test |
| حقوق: |
Copyright © 2014 Tiziana Vescovo et al. |
| رقم الانضمام: |
edsbas.D4C7ED64 |
| قاعدة البيانات: |
BASE |
