دورية أكاديمية
Fgl2 prothrombinase expression in mouse trophoblast and decidua triggers abortion but may be countered by OX-2
| العنوان: | Fgl2 prothrombinase expression in mouse trophoblast and decidua triggers abortion but may be countered by OX-2 |
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| المؤلفون: | Clark, David A., Ding, Jin-Wen, Yu, Gary, Levy, Gary A., Gorczynski, Reginald M. |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2001 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Implantation and pregnancy |
| الوصف: | Spontaneous abortion of normal karyotype embryos in mice and in humans is associated with an increase in uterine T helper (Th) 1 type proinflammatory cytokines, tumour necrosis factor (TNF)-α, interferon-γ and interleukin (IL)-1, and a deficiency of Th2/3 type cytokines, IL-4, IL-10, and transforming growth factor (TGF)-β2. In mice, Th1 cytokines up-regulate a novel prothrombinase, fgl2, which via thrombin, leads to activation of polymorphonuclear leukocytes that terminate the pregnancy. Here we show that Th1 cytokines up-regulate fgl2 mRNA in fetal trophoblast and secondary decidua of CBA/J×DBA/2 and CBA/J×BALB/c matings, and promote fibrin deposition. This pattern is accompanied by a high rate of abortion. However, the spontaneous abortion rates in abortion-prone CBA×DBA/2 matings and in low abortion rate CBA×BALB/c matings were significantly lower than that expected from the frequency of implantations with high levels of fibrin and fgl2 mRNAhi. As the glycoprotein OX-2 occurs in the pregnant rat uterus and can deviate cytokine responses to Th2/3, we investigated OX-2 in pregnant CBA/J mice. We found OX-2 mRNA was present at the same sites as fgl2 mRNA, but was reduced in response to Th1 cytokines. Furthermore, anti-OX-2 raised the abortion rate to predicted levels, while recombinant OX-2 dramatically reduced the abortion rate. Fgl2 prothrombinase may provide a mechanism explaining pregnancy loss, and conversely, successful pregnancy may be due in part to OX-2-dependent activation of maternal tolerance mechanisms at the feto–maternal interface. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://molehr.oxfordjournals.org/cgi/content/short/7/2/185Test; http://dx.doi.org/10.1093/molehr/7.2.185Test |
| DOI: | 10.1093/molehr/7.2.185 |
| الإتاحة: | https://doi.org/10.1093/molehr/7.2.185Test http://molehr.oxfordjournals.org/cgi/content/short/7/2/185Test |
| حقوق: | Copyright (C) 2001, Oxford University Press |
| رقم الانضمام: | edsbas.489878 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/molehr/7.2.185 |
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