دورية أكاديمية
Successful Mercaptopurine Usage despite Azathioprine-Induced Pancreatitis in Paediatric Crohn's Disease
| العنوان: | Successful Mercaptopurine Usage despite Azathioprine-Induced Pancreatitis in Paediatric Crohn's Disease |
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| المؤلفون: | Gallego-Gutiérrez, Silvia, Navas-López, Víctor Manuel, Kolorz, Michal, Bartosova, Ladislava, Lukac, Katerina, Luque-Pérez, Silvia, Núñez-Caro, Leticia, García-Galán, Paloma, Fernández-Crehuet, Francisco Girón, Blasco-Alonso, Javier, Serrano-Nieto, María Juliana, Sierra-Salinas, Carlos |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2015 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Short Report |
| الوصف: | Background: Azathioprine [AZA] and mercaptopurine [MP] are recommended for maintenance of steroid-free remission in children with Crohn`s disease [CD]. Azathioprine-induced pancreatitis, an idiosyncratic and major side effect, has been considered as an absolute contraindication for the use of a second thiopurine in IBD patients. Materials and Methods: We describe two children with CD in whom MP were successfully trialled after a confirmed azathioprine-induced pancreatitis, being well tolerated in both cases. Results: Two boys [13 and 10 years old] started exclusive enteral nutrition after diagnosis of moderate (Pediatric Crohn′s Disease Activity Index [wPCDAI] = 45) and mild [wPCDAI = 35] CD. Both developed an acute mild to moderate pancreatitis after 2 and 3 weeks, respectively, of AZA treatment but recovered fully in hospital after AZA withdrawal. They started on MP treatment without any adverse effect. They were tested for the presence of polymorphisms 238G>C, 460G>A, and 719A>G in the TPMT gene and 94C>A and 21>C in the ITPase. Both patients were wild-type for all tested polymorphisms. Conclusions: Azathioprine-induced acute pancreatitis should not be considered as an absolute contraindication for the use of MP. Further investigation is required to create a better understanding of the mechanism underlying the adverse events and to allow more possibilities for personalised therapy. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://ecco-jcc.oxfordjournals.org/cgi/content/short/9/8/676Test; http://dx.doi.org/10.1093/ecco-jcc/jjv086Test |
| DOI: | 10.1093/ecco-jcc/jjv086 |
| الإتاحة: | https://doi.org/10.1093/ecco-jcc/jjv086Test http://ecco-jcc.oxfordjournals.org/cgi/content/short/9/8/676Test |
| حقوق: | Copyright (C) 2015, Oxford University Press |
| رقم الانضمام: | edsbas.878F4643 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ecco-jcc/jjv086 |
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