دورية أكاديمية
Hepatitis B virus infection in Chinese patients with hepatitis C virus infection: prevalence, clinical characteristics, viral interactions and host genotypes: a nationwide cross-sectional study
| العنوان: | Hepatitis B virus infection in Chinese patients with hepatitis C virus infection: prevalence, clinical characteristics, viral interactions and host genotypes: a nationwide cross-sectional study |
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| المؤلفون: | Yan, Li-Bo, Rao, Hui-Ying, Ma, Yuan-Ji, Bai, Lang, Chen, En-Qiang, Du, Ling-Yao, Yang, Rui-Feng, Wei, Lai, Tang, Hong, CCgenos Study Group |
| بيانات النشر: | BMJ Publishing Group Ltd |
| سنة النشر: | 2016 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Research |
| الوصف: | Objectives Little is known about hepatitis B virus (HBV) infection in patients with hepatitis C virus (HCV) infection in China. This study aimed to evaluate the prevalence, clinical characteristics, viral interactions and host genotypes of HBV/HCV dual infection compared with HCV monoinfection. Study design A cross-sectional study. Setting China. Participants and methods 997 patients with HCV from 28 university-affiliated hospitals in China were enrolled in this research. Patients were divided into two subgroups. Results The prevalence of HBV infection in patients with HCV was 4.11% (41/997). The age-specific prevalence of HBsAg was 0.70%, 3.97% and 5.85% in groups aged 18–30, 30–50 and >50 years old (p=0.057), respectively. Patients with HBV/HCV dual infection and patients with HCV monoinfection had similar HCV viral loads (5.80±0.89 vs 5.83±1.00 log10 IU/mL, p=0.904). The dominant HCV genotype was 1b in both groups (53.65% vs 56.90%, p=0.493). The protective C allele in IL-28B (rs12979860) was also the dominant allele type in both patient groups (85.36% vs 83.99%, p=0.814). Patients with HBV/HCV dual infection had a higher ratio of liver cirrhosis and hepatic decompensation than patients with HCV monoinfection (39.02% vs 17.69%, p=0.001; 31.70% vs 12.13%, p=0.001). Conclusions The HBV burden was moderate in HCV-infected patients in China. Liver cirrhosis was more common in patients with HBV/HCV dual infection, suggesting the need for closer monitoring of dual-infected individuals. Trial registration number NCT01293279 ; Post-results. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://bmjopen.bmj.com/cgi/content/short/6/10/e012016Test; http://dx.doi.org/10.1136/bmjopen-2016-012016Test |
| DOI: | 10.1136/bmjopen-2016-012016 |
| الإتاحة: | https://doi.org/10.1136/bmjopen-2016-012016Test http://bmjopen.bmj.com/cgi/content/short/6/10/e012016Test |
| حقوق: | Copyright (C) 2016, British Medical Journal Publishing Group |
| رقم الانضمام: | edsbas.8E33C94A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/bmjopen-2016-012016 |
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