دورية أكاديمية
Recombinant Vascular Endothelial Growth Factor 121 Attenuates Autoantibody-Induced Features of Pre-eclampsia in Pregnant Mice
| العنوان: | Recombinant Vascular Endothelial Growth Factor 121 Attenuates Autoantibody-Induced Features of Pre-eclampsia in Pregnant Mice |
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| المؤلفون: | Siddiqui, Athar H., Irani, Roxanna A., Zhang, Yujin, Dai, Yingbo, Blackwell, Sean C., Ramin, Susan M., Kellems, Rodney E., Xia, Yang |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2011 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Pregnancy |
| الوصف: | Background Pre-eclampsia (PE) is a serious hypertensive disorder of pregnancy characterized by excessive production of a soluble form of the vascular endothelial growth factor (VEGF) receptor-1, termed soluble fms-like tyrosine kinase-1 (sFlt-1). This placental-derived factor is believed to be a key contributor to the clinical features of PE. Women with PE are also characterized by the presence of autoantibodies, termed angiotensin type 1 receptor activating autoantibody (AT 1 -AA), that activate the major angiotensin receptor, AT 1 . These autoantibodies cause clinical features of PE and elevated s Flt-1 when injected into pregnant mice. The research reported here used this autoantibody-injection model of PE to assess the therapeutic potential of recombinant VEGF 121 , a relatively stable form of the natural ligand. Methods Immunoglobulin G (IgG) from women with PE was injected into pregnant mice with or without continuous infusion of recombinant VEGF 121 . Injected mice were monitored for symptoms of PE. Results As a result of infusion of recombinant VEGF 121 autoantibody-induced hypertension (systolic blood pressure) was reduced from 159 ± 5 to 124 ± 5 mm Hg, protein uria from 111 ± 16 to 40 ± 5 mg protein/mg creatinine and blood urea nitrogen levels from 31 ± 1 mg/dl to 18 ± 2 mg/dl, P < 0.05. Histological analysis revealed that autoantibody-induced glomerular damage including the narrowing of Bowman’s space and occlusion of capillary loop spaces waslargely prevented by VEGF 121 infusion. Finally, impaired placental angiogenesis resulting from AT 1 -AA injection was significantly improved by VEGF 121 infusion. Conclusions The infusion of recombinant VEGF 121 significantly attenuated autoantibody-induced features of PE. American Journal of Hypertension , advance online publication 23 December 2010; doi:10.1038/ajh.2010.247 |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://ajh.oxfordjournals.org/cgi/content/short/24/5/606Test; http://dx.doi.org/10.1038/ajh.2010.247Test |
| DOI: | 10.1038/ajh.2010.247 |
| الإتاحة: | https://doi.org/10.1038/ajh.2010.247Test http://ajh.oxfordjournals.org/cgi/content/short/24/5/606Test |
| حقوق: | Copyright (C) 2011, American Journal of Hypertension, Ltd. |
| رقم الانضمام: | edsbas.1218F0A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/ajh.2010.247 |
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