دورية أكاديمية

Neuronal activity correlated with checking behaviour in the subthalamic nucleus of patients with obsessive-compulsive disorder

التفاصيل البيبلوغرافية
العنوان: Neuronal activity correlated with checking behaviour in the subthalamic nucleus of patients with obsessive-compulsive disorder
المؤلفون: Burbaud, Pierre, Clair, Anne-Hélène, Langbour, Nicolas, Fernandez-Vidal, Sara, Goillandeau, Michel, Michelet, Thomas, Bardinet, Eric, Chéreau, Isabelle, Durif, Franck, Polosan, Mircea, Chabardès, Stephan, Fontaine, Denys, Magnié-Mauro, Marie-Noelle, Houeto, Jean-Luc, Bataille, Benoît, Millet, Bruno, Vérin, Marc, Baup, Nicolas, Krebs, Marie-Odile, Cornu, Philippe, Pelissolo, Antoine, Arbus, Christophe, Simonetta-Moreau, Marion, Yelnik, Jérôme, Welter, Marie-Laure, Mallet, Luc, for the French ‘Stimulation dans le Trouble Obsessionnel Compulsif (STOC)’Study Group
بيانات النشر: Oxford University Press
سنة النشر: 2013
المجموعة: HighWire Press (Stanford University)
مصطلحات موضوعية: Original Articles
الوصف: Doubt, and its behavioural correlate, checking, is a normal phenomenon of human cognition that is dramatically exacerbated in obsessive–compulsive disorder. We recently showed that deep brain stimulation in the associative-limbic area of the subthalamic nucleus, a central core of the basal ganglia, improved obsessive–compulsive disorder. To understand the physiological bases of symptoms in such patients, we recorded the activity of individual neurons in the therapeutic target during surgery while subjects performed a cognitive task that gave them the possibility of unrestricted repetitive checking after they had made a choice. We postulated that the activity of neurons in this region could be influenced by doubt and checking behaviour. Among the 63/87 task-related neurons recorded in 10 patients, 60% responded to various combinations of instructions, delay, movement or feedback, thus highlighting their role in the integration of different types of information. In addition, task-related activity directed towards decision-making increased during trials with checking in comparison with those without checking. These results suggest that the associative-limbic subthalamic nucleus plays a role in doubt-related repetitive thoughts. Overall, our results not only provide new insight into the role of the subthalamic nucleus in human cognition but also support the fact that subthalamic nucleus modulation by deep brain stimulation reduced compulsive behaviour in patients with obsessive–compulsive disorder.
نوع الوثيقة: text
وصف الملف: text/html
اللغة: English
العلاقة: http://brain.oxfordjournals.org/cgi/content/short/136/1/304Test; http://dx.doi.org/10.1093/brain/aws306Test
DOI: 10.1093/brain/aws306
الإتاحة: https://doi.org/10.1093/brain/aws306Test
http://brain.oxfordjournals.org/cgi/content/short/136/1/304Test
حقوق: Copyright (C) 2013, Oxford University Press
رقم الانضمام: edsbas.5A73CF78
قاعدة البيانات: BASE