دورية أكاديمية
Cooperative action of Sox9, Snail2 and PKA signaling in early neural crest development
| العنوان: | Cooperative action of Sox9, Snail2 and PKA signaling in early neural crest development |
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| المؤلفون: | Sakai, Daisuke, Suzuki, Takashi, Osumi, Noriko, Wakamatsu, Yoshio |
| بيانات النشر: | Company of Biologists |
| سنة النشر: | 2006 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Research article |
| الوصف: | In neural crest formation, transcription factors, such as group E Sox and Snail1 / Snail2 ( Slug ) regulate subsequent epithelial-mesenchymal transition (EMT) and migration. In particular, Sox9 has a strong effect on neural crest formation, EMT and differentiation of crest-derived cartilages in the cranium. It remains unclear, however, how Sox9 functions in these events, and how Sox9 activity is regulated. In this study, our gain-of-function and loss-of-function experiments reveal that Sox9 is essential for BMP signal-mediated induction of Snail2 and subsequent EMT in avian neural crest. We also show that Snail2 activates the Snail2 promoter, although Snail family proteins have been known as a repressor. Consistently, Sox9 directly activates the Snail2 promoter in synergy with, and through a direct binding to, Snail2. Finally, functions of these transcription factors in neural crest cells are enhanced by PKA signaling. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://dev.biologists.org/cgi/content/short/dev.02297v1Test; http://dx.doi.org/10.1242/dev.02297Test |
| DOI: | 10.1242/dev.02297 |
| الإتاحة: | https://doi.org/10.1242/dev.02297Test http://dev.biologists.org/cgi/content/short/dev.02297v1Test |
| حقوق: | Copyright (C) 2006, Company of Biologists |
| رقم الانضمام: | edsbas.673501C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1242/dev.02297 |
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