دورية أكاديمية
Tumor lysis syndrome in a patient with metastatic cholangiocarcinoma
| العنوان: | Tumor lysis syndrome in a patient with metastatic cholangiocarcinoma |
|---|---|
| المؤلفون: | Madi, Mahmoud Y, Shahwan, Manar Y, Abughanimeh, Omar K, Ghanimeh, Mouhanna A |
| المصدر: | Gastroenterology Meeting Abstracts |
| بيانات النشر: | Henry Ford Health Scholarly Commons |
| سنة النشر: | 2021 |
| المجموعة: | Henry Ford Health System Scholarly Commons |
| مصطلحات موضوعية: | CA 19-9 antigen, electrolyte, endogenous compound, fluorouracil, folinic acid, oxaliplatin, rasburicase, abdominal pain, acute kidney failure, adenocarcinoma, adult, ascites, bile duct carcinoma, body weight loss, cancer chemotherapy, cancer patient, case report, clinical article, colon cancer, complication, computer assisted tomography, conference abstract, continuous renal replacement therapy, diagnosis, drug combination, drug therapy, edema, emergency ward, exertional dyspnea, gastroenterologist |
| الوصف: | Introduction: Tumor lysis syndrome (TLS) is an oncological emergency of various types of cancers and their treatments. It is commonly reported in patients with hematological malignancies with high cellular turnover including leukemias and lymphomas. We present a case of a 33-year-old man who developed TLS two weeks after initiating chemotherapeutic treatment for metastatic cholangiocarcinoma, a treatment regimen, and a tumor with rare incidence of this complication. Case Description/Methods: A 33-year-old man presented with abdominal pain and progressive weight loss. Physical examination revealed distended abdomen without signs for ascites and hepatomegaly. Laboratory work-up included AFP of 1.7 ng/mL, CA 19-9 of 177 unit/mL, CEA of 8.1 ng/mL. Computed tomography (CT) scan of the abdomen demonstrated extensive hepatic metastasis with portal adenopathy (Image 1). A biopsy from a liver lesion showed invasive moderately differentiated adenocarcinoma with immunohistochemistry stains suggesting cholangiocarcinoma. The patient was started on chemotherapy with folinic acid, 5-fluorouracil, and oxaliplatin (FOLFOX) while arranging for further diagnostic testing. He received the first dose of cycle one, but at the time of day 14 dose, he presented to the emergency room with dyspnea on exertion, and severe bilateral lower extremities edema. His blood tests on the first day of chemotherapy and on the fourteenth day are summarized in Table 1. He was diagnosed with TLS and treatment with intravenous rasburicase was started with minimal improvement in his electrolyte abnormalities. Continuous renal replacement therapy (CRRT) was then restarted. During the next week, his condition improved clinically, and he was transitioned to intermittent hemodialysis. Discussion: TLS is a life-threatening complication of various malignancies and their treatments. The case we presented is for an unfortunate 33-year-old man who was found to have metastatic cholangiocarcinoma. Laboratory evaluation two weeks after initiating FOLFOX therapy ... |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://scholarlycommons.henryford.com/gastroenterology_mtgabstracts/187Test; https://sladenlibrary.hfhs.org/login?url=https://www.embase.com/search/results?subaction=viewrecord&id=L636472226&from=exportTest |
| الإتاحة: | https://scholarlycommons.henryford.com/gastroenterology_mtgabstracts/187Test https://sladenlibrary.hfhs.org/login?url=https://www.embase.com/search/results?subaction=viewrecord&id=L636472226&from=exportTest |
| رقم الانضمام: | edsbas.62313F6F |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |