التفاصيل البيبلوغرافية
| العنوان: |
Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed |
| المؤلفون: |
Taub, Margaret A, Conomos, Matthew P, Keener, Rebecca, Iyer, Kruthika R, Weinstock, Joshua S, Yanek, Lisa R, Lane, John, Miller-Fleming, Tyne W, Brody, Jennifer A, Raffield, Laura M, McHugh, Caitlin P, Jain, Deepti, Gogarten, Stephanie M, Laurie, Cecelia A, Keramati, Ali, Arvanitis, Marios, Smith, Albert V, Heavner, Benjamin, Barwick, Lucas, Becker, Lewis C, Bis, Joshua C, Blangero, John, Bleecker, Eugene R, Burchard, Esteban G, Celedón, Juan C, Chang, Yen Pei C, Custer, Brian, Darbar, Dawood, de Las Fuentes, Lisa, DeMeo, Dawn L, Freedman, Barry I, Garrett, Melanie E, Gladwin, Mark T, Heckbert, Susan R, Hidalgo, Bertha A, Irvin, Marguerite R, Islam, Talat, Johnson, W. Craig, Kaab, Stefan, Launer, Lenore, Lee, Jiwon, Liu, Simin, Moscati, Arden, North, Kari E, Peyser, Patricia A, Rafaels, Nicholas, Seidman, Christine, Weeks, Daniel E, Wen, Fayun, Wheeler, Marsha M, Williams, Keoki L, Yang, Ivana V, Zhao, Wei, Aslibekyan, Stella, Auer, Paul L, Bowden, Donald W, Cade, Brian E, Chen, Zhanghua, Cho, Michael H, Cupples, L. Adrienne, Curran, Joanne E, Daya, Michelle, Deka, Ranjan, Eng, Celeste, Fingerlin, Tasha E, Guo, Xiuqing, Hou, Lifang, Hwang, Shih-Jen, Johnsen, Jill M, Kenny, Eimear E, Levin, Albert M, Liu, Chunyu, Minster, Ryan L, Naseri, Take, Nouraie, Mehdi, Reupena, Muagututi'a Sefuiva, Sabino, Ester C, Smith, Jennifer A, Smith, Nicholas L, Su, Jessica Lasky, Taylor, James G, Telen, Marilyn J, Tiwari, Hemant K, Tracy, Russell P, White, Marquitta J, Zhang, Yingze, Wiggins, Kerri L, Weiss, Scott T, Vasan, Ramachandran S, Taylor, Kent D, Sinner, Moritz F, Silverman, Edwin K, Shoemaker, M. Benjamin, Sheu, Wayne H-H, Sciurba, Frank, Schwartz, David A, Rotter, Jerome I, Roden, Daniel, Redline, Susan, Raby, Benjamin A, Psaty, Bruce M, Peralta, Juan M, Palmer, Nicholette D, Nekhai, Sergei, Montgomery, Courtney G, Mitchell, Braxton D, Meyers, Deborah A, McGarvey, Stephen T, Mak, Angel, Loos, Ruth, Kumar, Rajesh, Kooperberg, Barbara A, Konkle, Barbara A, Kelly, Sharon, Kardia, Sharon L, Kaplan, Robert, He, Jiang, Gui, Hongsheng, Gilliland, Bruce D, Gelb, Bruce D, Fornage, Patrick T, Ellinor, Patrick T, de Andrade, Mariza, Correa, Adolfo, Chen, Yii-Der Ida, Boerwinkle, Kathleen C, Barnes, Allison E, Ashley-Koch, Donna K, Arnett, Cathy C, Laurie, Stephen S, Abecasis, Goncalo, Nickerson, Deborah A, Wilson, James G, Rich, Thomas, Levy, Daniel, Ruczinski, Ingo, Aviv, Abraham, Blackwell, Thomas W, Thornton, Timothy, O'Connell, Jeff, Cox, Nancy J, Perry, James A, Armanios, Mary, Battle, Alexis, Pankratz, Nathan, Reiner, Alexander P, Mathias, Rasika A |
| المصدر: |
Public Health Sciences Articles |
| بيانات النشر: |
Henry Ford Health Scholarly Commons |
| سنة النشر: |
2022 |
| المجموعة: |
Henry Ford Health System Scholarly Commons |
| الوصف: |
Genetic studies on telomere length are important for understanding age-related diseases. Prior GWAS for leukocyte TL have been limited to European and Asian populations. Here, we report the first sequencing-based association study for TL across ancestrally-diverse individuals (European, African, Asian and Hispanic/Latino) from the NHLBI Trans-Omics for Precision Medicine (TOPMed) program. We used whole genome sequencing (WGS) of whole blood for variant genotype calling and the bioinformatic estimation of telomere length in n=109,122 individuals. We identified 59 sentinel variants (p-value OBFC1indicated the independent signals colocalized with cell-type specific eQTLs for OBFC1 (STN1). Using a multi-variant gene-based approach, we identified two genes newly implicated in telomere length, DCLRE1B (SNM1B) and PARN. In PheWAS, we demonstrated our TL polygenic trait scores (PTS) were associated with increased risk of cancer-related phenotypes. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
https://scholarlycommons.henryford.com/publichealthsciences_articles/391Test; https://scholarlycommons.henryford.com/context/publichealthsciences_articles/article/1390/viewcontent/main__7_.pdfTest |
| الإتاحة: |
https://scholarlycommons.henryford.com/publichealthsciences_articles/391Test
https://scholarlycommons.henryford.com/context/publichealthsciences_articles/article/1390/viewcontent/main__7_.pdfTest |
| رقم الانضمام: |
edsbas.C67E0F47 |
| قاعدة البيانات: |
BASE |
