دورية أكاديمية
Brainstem Glioblastoma Multiforme in a Patient with NF1
| العنوان: | Brainstem Glioblastoma Multiforme in a Patient with NF1 |
|---|---|
| المؤلفون: | Fortunato, John T, Reys, Brian, Singh, Pawan, Pan, Edward |
| المصدر: | Neurology Articles |
| بيانات النشر: | Henry Ford Health Scholarly Commons |
| سنة النشر: | 2018 |
| المجموعة: | Henry Ford Health System Scholarly Commons |
| مصطلحات موضوعية: | Adult, Antineoplastic Agents, Alkylating, Astrocytoma, Brain Stem, Brain Stem Neoplasms, Chemoradiotherapy, Codon, Nonsense, Dacarbazine, Glioblastoma, Humans, Male, Neurofibromin 1, Temozolomide, Young Adult |
| الوصف: | This case report presents the first known case of a brainstem glioblastoma multiforme (GBM) in a patient with neurofibromatosis type 1 (NF1). While research has proposed that larger germ-line mutations in NF1 may be the driving factor that predisposes patients with NF1 to high-grade astrocytomas, this patient had a nonsense mutation in the NF1 gene, suggesting a variant tumorigenesis. Limited data on targeted immunotherapy for NF1 patients with a GBM have been reported and more data are required before targeted therapies could be proven as second-line treatment options. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://scholarlycommons.henryford.com/neurology_articles/71Test; http://sfxhosted.exlibrisgroup.com/hfhs?sid=Entrez:PubMed&id=pmid:30061266Test |
| الإتاحة: | https://scholarlycommons.henryford.com/neurology_articles/71Test http://sfxhosted.exlibrisgroup.com/hfhs?sid=Entrez:PubMed&id=pmid:30061266Test |
| رقم الانضمام: | edsbas.CD505D7C |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |