دورية أكاديمية
Polydopamine inner wall-coated hypodermic needle as microextraction device and electrospray emitter for the direct analysis of illicit drugs in oral fluid by ambient mass spectrometry
| العنوان: | Polydopamine inner wall-coated hypodermic needle as microextraction device and electrospray emitter for the direct analysis of illicit drugs in oral fluid by ambient mass spectrometry |
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| المؤلفون: | Véjar-Vivar, C., Millán-Santiago, Jaime, Mardones, C., Lucena, Rafael, Cárdenas, Soledad |
| المصدر: | Talanta 249, 123693 (2022) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2022 |
| المجموعة: | Helvia - Repositorio Institucional de la Universidad de Córdoba |
| مصطلحات موضوعية: | Illicit drugs, Oral fluid, Polydopamine modified hypodermic needles, Electrospray emitter, Ambient ionization mass spectrometry |
| الوصف: | Embargado hasta 01/11/2024 ; In this article, polydopamine inner wall-coated hypodermic needles (PDA-HNs) are evaluated as both microextraction devices and electrospray ionization (ESI) emitters for determining selected illicit drugs (methamphetamine, cocaine, and methadone) in oral fluid samples. The PDA film, located in the inner wall of the needle, allows the extraction of the analytes at alkaline pH, where their hydrophobic character is promoted. The extracted analytes are finally eluted in a methanol/formic acid mixture that also acts as ESI solution. For this purpose, a dedicated interface based on the connection of a PEEK tube with the needle hub is proposed. This assembly allows delivering the ESI solution by the infusion syringe pump of the mass spectrometer, providing an efficient ESI on the tip of the needle. The double use of the PDA-HNs as microextraction devices and ESI emitters permits the determination of the target analytes with limits of detection and precision (expressed as relative standard deviation) values better than 2.4 μg/L and 17.6%, respectively. The accuracy was evaluated by analyzing independent spiked oral fluid samples, obtaining good results. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1016/j.talanta.2022.123693Test; Gobierno de España. PID2020-112862RB-I00; Gobierno de España. MCIN/AEI/10.13039/501100011033; Gobierno de España. FPU19/01488; http://hdl.handle.net/10396/23304Test |
| الإتاحة: | https://doi.org/10.1016/j.talanta.2022.123693Test http://hdl.handle.net/10396/23304Test |
| حقوق: | https://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; info:eu-repo/semantics/embargoedAccess |
| رقم الانضمام: | edsbas.4F21ADAE |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |