دورية أكاديمية
Elemental maps in human allantochorial placental vessels cells: 2. MgCl2 and MgSO4 effects
| العنوان: | Elemental maps in human allantochorial placental vessels cells: 2. MgCl2 and MgSO4 effects |
|---|---|
| المؤلفون: | Michelet-Habchi, C., Barberet, P., Dutta, R.K., Moretto, Ph., Guiet-Bara, A., Bara, M. |
| المساهمون: | Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Physiologie et physiopathologie (PP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 0953-1424 ; Magnesium Research ; https://hal.in2p3.fr/in2p3-00410280Test ; Magnesium Research, 2003, 16, pp.171-175. |
| بيانات النشر: | HAL CCSD John Libbey Eurotext |
| سنة النشر: | 2003 |
| المجموعة: | HAL-IN2P3 (Institut national de physique nucléaire et de physique des particules) |
| مصطلحات موضوعية: | ionic channels, magnesium chloride, magnesium sulfate, microanalysis, micro-PIXE, placental vessels, scanning proton microprobe, [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph] |
| الوصف: | Extracellular magnesium salts are known to interfere with ionic channels in the cellular membranes. The membrane potential, a regulator of vascular tone, is a function of the physiological activities of ionic channels (particularly, K+ and Ca2+ channels in these cells). These channels regulate the ionic distribution into these cells. Micro-Particule, Induced X-ray Emission (PIXE) analysis was applied to determine the ionic composition of vascular smooth muscle cells (VSMC) and of vascular endothelial cells (VEC) in the placental human allantochorial vessels in a physiological medium (Hanks' solution) modified by the addition of 2 MM MgCl2 or 2 mM MgSO4 which block the calcium-sensitive K+ channels (K-Ca) the ATP-sensitive K+ channels (K-ATP) and the voltage-sensitive K+ (Kdf) and Ca2+ channels. In VSMC (media layer), the addition of MgCl2 induced no modification of the K, Cl, P, S and Ca concentrations but increased the Na and Mg concentrations and the addition of MgSO4 only significantly increased the Mg concentration, the other ion concentrations remaining constant. In endothelium (VEC), MgCl2 or MgSO4 addition implicated the same observations as in VSMC. These results confirmed the blockage of Kdf, K-Ca, K-ATP and Ca channels in VSMC and VEC by magnesium salts, the relationship between Mg2+ ions and internal Na and demonstrated the possible intervention of a Na+/Mg2+ exchanger. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | in2p3-00410280; https://hal.in2p3.fr/in2p3-00410280Test |
| الإتاحة: | https://hal.in2p3.fr/in2p3-00410280Test |
| رقم الانضمام: | edsbas.87EE33E2 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |