دورية أكاديمية
Is 2,3,5-pyrroletricarboxylic acid in hair a better risk indicator for melanoma than traditional epidemiologic measures for skin phenotype?
| العنوان: | Is 2,3,5-pyrroletricarboxylic acid in hair a better risk indicator for melanoma than traditional epidemiologic measures for skin phenotype? |
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| المؤلفون: | Rosso, Stefano, Zanetti, Roberto, Sánchez, Maria José, Nieto, Adoración, Miranda, Ana, Mercier, Mariette, Loria, Dora, Østerlind, Anne, Greinert, Rüdiger, Chirlaque, Maria-Dolores, Fabbrocini, Gabriella, Barbera, Cesare, Sancho-Garnier, Hélène, Lauria, Carmela, Balzi, Daniela, Zoccola, Marina, Renseigné, Non |
| المساهمون: | Registo Oncológico Regional-Sul, Instituto Português de Oncologia do Porto / Portuguese Oncology Institute of Porto (IPO Porto), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181) (CEF2P / CARCINO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté COMUE (UBFC)-Université Bourgogne Franche-Comté COMUE (UBFC), Laboratoire Pierre Süe (LPS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 0002-9262. |
| بيانات النشر: | HAL CCSD Oxford University Press (OUP) |
| سنة النشر: | 2007 |
| المجموعة: | HAL-CEA (Commissariat à l'énergie atomique et aux énergies alternatives) |
| مصطلحات موضوعية: | MESH: Adult, MESH: Aged, MESH: Humans, MESH: Male, MESH: Melanins, MESH: Melanoma, MESH: Middle Aged, MESH: Phenotype, MESH: Pyrroles, MESH: Risk Factors, MESH: Skin Neoplasms, MESH: Spectroscopy, Near-Infrared, MESH: Bayes Theorem, MESH: Case-Control Studies, MESH: Hair, [SDV.CAN]Life Sciences [q-bio]/Cancer |
| الوصف: | International audience ; This study aims to assess type of melanin as a risk indicator for skin tumors, in a sample of melanoma cases and controls within a larger multicenter study (Helios 2), held in Europe and South America in 2001-2002. In each case and control, the melanin content in hair was assessed by three methods: 1) the amount of 2,3,5-pyrroletricarboxylic acid (PTCA); 2) the absorbance ratio with ultraviolet spectroscopy; and 3) the spectra of near-infrared spectroscopy. Statistical analysis was performed in a Bayesian setting, defining priors for confounders and effect modifiers from the larger study data set. Subjects with values of PTCA of less than 85 ng/mg carried an increased risk (26 vs. seven discordant pairs: odds ratio = 4.4, 95% confidence interval: 1.52, 14.54), adjusted by hair color, eye color, and number of nevi (n = > or =40). The absorbance ratio showed a weaker and nonsignificant odds ratio of 1.5. After correction by misclassification, near-infrared spectroscopy was associated with an odds ratio of 2.3 (95% confidence interval: 1.36, 4.22). The amount of PTCA is thus a strong and independent risk indicator for melanoma. Incorporating PTCA determination into epidemiologic studies is therefore recommended. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/17339384; hal-00492594; https://hal.science/hal-00492594Test; PUBMED: 17339384 |
| DOI: | 10.1093/aje/kwm018 |
| الإتاحة: | https://doi.org/10.1093/aje/kwm018Test https://hal.science/hal-00492594Test |
| رقم الانضمام: | edsbas.6D8487CE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/aje/kwm018 |
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