دورية أكاديمية
Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?
| العنوان: | Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space? |
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| المؤلفون: | Birkholtz, Lyn-Marie, Bastien, Olivier, Wells, Gordon, Grando, Delphine, Joubert, Fourie, Kasam, Vinod, Zimmermann, Marc, Ortet, Philippe, Jacq, Nicolas, Saïdani, Nadia, Roy, Sylvaine, Hofmann-Apitius, Martin, Breton, Vincent, Louw, Abraham I, Maréchal, Eric |
| المساهمون: | African Centre for Gene Technologies, Faculty of Natural and Agricultural Sciences-University of Pretoria South Africa, Laboratoire Adaptation et pathogénie des micro-organismes Grenoble (LAPM), Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Bioinformatics and Computational Biology Unit, Laboratoire de physiologie cellulaire végétale (LPCV), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Fraunhofer Institute for Algorithms and Scientific Computing (Fraunhofer SCAI), Fraunhofer (Fraunhofer-Gesellschaft), Protéines de Protection des Végétaux (PPV), Institut de Biosciences et Biotechnologies d'Aix-Marseille (ex-IBEB) (BIAM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Dynamique moléculaire des interactions membranaires (DMIM), Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Biologie-Informatique-Mathématique (LBIM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA) |
| المصدر: | ISSN: 1475-2875 ; Malaria Journal ; https://hal.science/hal-00121210Test ; Malaria Journal, 2006, 5 (1), pp.110. ⟨10.1186/1475-2875-5-110⟩. |
| بيانات النشر: | HAL CCSD BioMed Central |
| سنة النشر: | 2006 |
| المجموعة: | HAL-CEA (Commissariat à l'énergie atomique et aux énergies alternatives) |
| مصطلحات موضوعية: | genome, data mining, protein sequence comparison, molecular phylogeny, metabolic pathway, protein structure prediction, drug target, chemogenomics, statistics, malaria, Plasmodium falciparum, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology |
| الوصف: | The organization and mining of malaria genomic and post-genomic data is important to significantly increase the knowledge of the biology of its causative agents, and is motivated, on a longer term, by the necessity to predict and characterize new biological targets and new drugs. Biological targets are sought in a biological space designed from the genomic data from Plasmodium falciparum, but using also the millions of genomic data from other species. Drug candidates are sought in a chemical space containing the millions of small molecules stored in public and private chemolibraries. Data management should, therefore, be as reliable and versatile as possible. In this context, five aspects of the organization and mining of malaria genomic and post-genomic data were examined: 1) the comparison of protein sequences including compositionally atypical malaria sequences, 2) the high throughput reconstruction of molecular phylogenies, 3) the representation of biological processes, particularly metabolic pathways, 4) the versatile methods to integrate genomic data, biological representations and functional profiling obtained from X-omic experiments after drug treatments and 5) the determination and prediction of protein structures and their molecular docking with drug candidate structures. Recent progress towards a grid-enabled chemogenomic knowledge space is discussed. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/arxiv/q-bio.QM/0611053; info:eu-repo/semantics/altIdentifier/pmid/17112376; hal-00121210; https://hal.science/hal-00121210Test; https://hal.science/hal-00121210/documentTest; https://hal.science/hal-00121210/file/Birkholtz_-_Malaria_J._-_2006.pdfTest; ARXIV: q-bio.QM/0611053; PRODINRA: 250760; PUBMED: 17112376 |
| DOI: | 10.1186/1475-2875-5-110 |
| الإتاحة: | https://doi.org/10.1186/1475-2875-5-110Test https://hal.science/hal-00121210Test https://hal.science/hal-00121210/documentTest https://hal.science/hal-00121210/file/Birkholtz_-_Malaria_J._-_2006.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.D16AF3DD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/1475-2875-5-110 |
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