دورية أكاديمية
Autophagy is essential for optimal translocation of iron to seeds in Arabidopsis
| العنوان: | Autophagy is essential for optimal translocation of iron to seeds in Arabidopsis |
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| المؤلفون: | Pottier, Mathieu, Dumont, Jean, Masclaux-Daubresse, Céline, Thomine, Sébastien |
| المساهمون: | Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut Jean-Pierre Bourgin (IJPB), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Université Paris-Saclay, Approches intégratives du Transport Ionique (MINION), Département Biologie Cellulaire (BioCell), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Département Biochimie, Biophysique et Biologie Structurale (B3S), ANR-16-CE20-0019,ISISTOR,Amélioration du contenu en fer de la graine(2016) |
| المصدر: | ISSN: 0022-0957. |
| بيانات النشر: | HAL CCSD Oxford University Press (OUP) |
| سنة النشر: | 2019 |
| المجموعة: | HAL-CEA (Commissariat à l'énergie atomique et aux énergies alternatives) |
| مصطلحات موضوعية: | iron loading, iron recycling, leaf senescence, metal, remobilization, 57Fe, premature senescence, [SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics |
| الوصف: | International audience ; Micronutrient deficiencies affect a large part of the world’s population. These deficiencies are mostly due to the consumption of grains with insufficient content of iron (Fe) or zinc (Zn). Both de novo uptake by roots and recycling from leaves may provide seeds with nutrients. Autophagy, which is a conserved mechanism for nutrient recycling in eukaryotes, was shown to be involved in nitrogen remobilization to seeds. Here, we have investigated the role of this mechanism in micronutrient translocation to seeds. We found that Arabidopsis thaliana plants impaired in autophagy display defects in nutrient remobilization to seeds. In the atg5-1 mutant, which is completely defective in autophagy, the efficiency of Fe translocation from vegetative organs to seeds was severely decreased even when Fe was provided during seed formation. Combining atg5-1 with the sid2 mutation that counteracts premature senescence associated with autophagy deficiency and using 57Fe pulse labeling, we propose a two-step mechanism in which Fe taken up de novo during seed formation is first accumulated in vegetative organs and subsequently remobilized to seeds. Finally, we show that translocation of Zn and manganese (Mn) to seeds is also dependent on autophagy. Fine-tuning autophagy during seed formation opens up new possibilities to improve micronutrient remobilization to seeds |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/30395253; hal-02173634; https://hal.science/hal-02173634Test; https://hal.science/hal-02173634/documentTest; https://hal.science/hal-02173634/file/ery388.pdfTest; PRODINRA: 468557; PUBMED: 30395253; PUBMEDCENTRAL: PMC6363094; WOS: 000459350700013 |
| DOI: | 10.1093/jxb/ery388 |
| الإتاحة: | https://doi.org/10.1093/jxb/ery388Test https://hal.science/hal-02173634Test https://hal.science/hal-02173634/documentTest https://hal.science/hal-02173634/file/ery388.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.B8EC9360 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/jxb/ery388 |
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