دورية أكاديمية
APC/C-CCS52A complexes control meristem maintenance in the Arabidopsis root.
| العنوان: | APC/C-CCS52A complexes control meristem maintenance in the Arabidopsis root. |
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| المؤلفون: | Vanstraelen, Marleen, Baloban, Mikhail, da Ines, Olivier, Cultrone, Antonietta, Lammens, Tim, Boudolf, Véronique, Brown, Spencer C, de Veylder, Lieven, Mergaert, Peter, Kondorosi, Eva |
| المساهمون: | Biologie végétale et microbiologie environnementale - UMR7265 (BVME), Institut de Biosciences et Biotechnologies d'Aix-Marseille (ex-IBEB) (BIAM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institute of Biochemical Plant Pathology, German Research Center for Environmental Health - Helmholtz Center München (GmbH), Institut des sciences du végétal (ISV), Centre National de la Recherche Scientifique (CNRS), Center for Plant Systems Biology (PSB Center), Vlaams Instituut voor Biotechnologie Ghent, Belgique (VIB) |
| المصدر: | ISSN: 0027-8424. |
| بيانات النشر: | HAL CCSD National Academy of Sciences |
| سنة النشر: | 2009 |
| المجموعة: | HAL-CEA (Commissariat à l'énergie atomique et aux énergies alternatives) |
| مصطلحات موضوعية: | MESH: Arabidopsis, MESH: Arabidopsis Proteins, MESH: Protein Isoforms, MESH: Reverse Transcriptase Polymerase Chain Reaction, MESH: Ubiquitin-Protein Ligase Complexes, MESH: Cell Cycle Proteins, MESH: Cell Proliferation, MESH: Flow Cytometry, MESH: Genetic Vectors, MESH: In Situ Hybridization, MESH: Meristem, MESH: Mitosis, MESH: Plant Roots, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology |
| الوصف: | International audience ; Plant organs originate from meristems where stem cells are maintained to produce continuously daughter cells that are the source of different cell types. The cell cycle switch gene CCS52A, a substrate specific activator of the anaphase promoting complex/cyclosome (APC/C), controls the mitotic arrest and the transition of mitotic cycles to endoreduplication (ER) cycles as part of cell differentiation. Arabidopsis, unlike other organisms, contains 2 CCS52A isoforms. Here, we show that both of them are active and regulate meristem maintenance in the root tip, although through different mechanisms. The CCS52A1 activity in the elongation zone of the root stimulates ER and mitotic exit, and contributes to the border delineation between dividing and expanding cells. In contrast, CCS52A2 acts directly in the distal region of the root meristem to control identity of the quiescent center (QC) cells and stem cell maintenance. Cell proliferation assays in roots suggest that this control involves CCS52A2 mediated repression of mitotic activity in the QC cells. The data indicate that the CCS52A genes favor a low mitotic state in different cell types of the root tip that is required for meristem maintenance, and reveal a previously undescribed mechanism for APC/C mediated control in plant development. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/19553203; hal-00856118; https://hal.science/hal-00856118Test; PUBMED: 19553203; PUBMEDCENTRAL: PMC2710644 |
| DOI: | 10.1073/pnas.0901193106 |
| الإتاحة: | https://doi.org/10.1073/pnas.0901193106Test https://hal.science/hal-00856118Test |
| رقم الانضمام: | edsbas.5F34CDA8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1073/pnas.0901193106 |
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