Characteristics and outcome according to underlying disease in non-AIDS patients with acute respiratory failure due to Pneumocystis pneumonia

التفاصيل البيبلوغرافية
العنوان:	Characteristics and outcome according to underlying disease in non-AIDS patients with acute respiratory failure due to Pneumocystis pneumonia
المؤلفون:	Burghi, Gaston, Biard, Lucie, Roux, Antoine, Valade, Sandrine, Robert-Gangneux, Florence, Hamane, Samia, Maubon, Danièle, Debourgogne, Anne, Le Gal, Solene, Dalle, Frédéric, Leterrier, Marion, Toubas, Dominique, Pomares, Christelle, Bellanger, Anne Pauline, Bonhomme, Julie, Berry, Antoine, Iriart, Xavier, Durand-Joly, Isabelle, Magne, Denis, Pons, Denis, Hennequin, Christophe, Maury, Eric, Azoulay, Elie, Lemiale, Virginie
المساهمون:	Université Paris Diderot - Paris 7 (UPD7), Hopital Saint-Louis AP-HP (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de biostatistique et information médicale de l’hôpital Saint Louis (Equipe ECSTRA) (SBIM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut national du cancer (INCa)-Hopital Saint-Louis AP-HP (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Cité (UPCité), Hôpital Foch Suresnes, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique EHESP (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre Hospitalier Universitaire CHU Grenoble (CHUGA), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Procédés Alimentaires et Microbiologiques Dijon (PAM), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université Bourgogne Franche-Comté COMUE (UBFC), Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Hôpital universitaire Robert Debré Reims (CHU Reims), Hôpital Pasteur Nice (CHU), Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UniCA), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Hôpital Claude Huriez Lille, Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), CHU Saint-Antoine AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Gabriel Montpied Clermont-Ferrand, CHU Clermont-Ferrand, Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), French ministry of health
المصدر:	ISSN: 0934-9723.
بيانات النشر:	HAL CCSD Springer Verlag
سنة النشر:	2021
المجموعة:	HAL Université Côte d'Azur
مصطلحات موضوعية:	Pneumocystis, ICU, Immunosuppression, Outcome, [SDV]Life Sciences [q-bio]
الوصف:	International audience ; In the non-AIDS group, several underlying conditions and immune defects could lead to different PCP presentations. This study compared PCP presentation and outcome according to the underlying disease. A secondary analysis of a previously published prospective observational study including 544 PCP patients was done. Only non-AIDS patients were included. Underlying disease was defined as chronic lymphocytic leukemia (CLL), organ transplantation, solid cancer, allogeneic hematopoietic stem cell transplant (AHSCT), other hematological diseases, and immunosuppressive treatment. Clinical characteristics and outcomes were compared between groups. Multiple correspondent analyses compared clinical characteristics at diagnosis. Day 30 mortality was analyzed. Three hundred and twenty-one patients were included in the study. The underlying diseases were hematological malignancy (n = 75), AHSCT (n = 14), CLL (n = 19), solid organ transplant (n = 94), solid tumor (n = 39), and immunosuppressive treatment (n = 57). Compared with other underlying diseases, PCP related to CLL was closer to PCP related to AIDS presentation (long duration of symptoms before diagnosis, high level of dyspnea, and low oxygen saturation at diagnosis). Day 30 mortality was associated with underlying disease, oxygen flow, and shock at ICU admission. PCP presentations may vary according to the underlying reason for immunosuppression. Response to treatment and adjuvant steroid therapy should be analyzed regarding this result.
نوع الوثيقة:	article in journal/newspaper
اللغة:	English
العلاقة:	info:eu-repo/semantics/altIdentifier/pmid/33411170; hal-03131261; https://hal.science/hal-03131261Test; https://hal.science/hal-03131261/documentTest; https://hal.science/hal-03131261/file/Burghi-2021-Characteristics%20and%20outcome%20according%20to%20underlying%20disease%20in%20non-1%20AIDS%20patients%20withpdf.pdfTest; PUBMED: 33411170
DOI:	10.1007/s10096-020-04118-w
الإتاحة:	https://doi.org/10.1007/s10096-020-04118-wTest https://hal.science/hal-03131261Test https://hal.science/hal-03131261/documentTest https://hal.science/hal-03131261/file/Burghi-2021-Characteristics%20and%20outcome%20according%20to%20underlying%20disease%20in%20non-1%20AIDS%20patients%20withpdf.pdfTest
حقوق:	info:eu-repo/semantics/OpenAccess
رقم الانضمام:	edsbas.B3C87D18
قاعدة البيانات:	BASE

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الوصف
DOI:	10.1007/s10096-020-04118-w