دورية أكاديمية
Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis
| العنوان: | Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis |
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| المؤلفون: | Ben-Othman, Nouha, Vieira, Andhira, Courtney, Monica, Record, Fabien, Gjernes, Elisabet, Avolio, Fabio, Hadzic, Biljana, Druelle, Noémie, Napolitano, Tiziana, Navarro-Sanz, Sergi, Silvano, Serena, Al-Hasani, Keith, Pfeifer, Anja, Lacas-Gervais, Sandra, Leuckx, Gunter, Marroquí, Laura, Thèvenet, Julien, Madsen, Ole Dragsbaek, Eizirik, Decio Laks, Heimberg, Harry, Kerr-Conte, Julie, Pattou, François, Mansouri, Ahmed, Collombat, Patrick |
| المساهمون: | Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UniCA), Centre Commun de Microscopie Appliquée (CCMA), Université Nice Sophia Antipolis (1965 - 2019) (UNS), Beta Cell Neogenesis Lab, Vrije Universiteit Brussel (VUB), Université libre de Bruxelles (ULB), Recherche translationnelle sur le diabète - U 1190 (RTD), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), Department of Molecular Cell Biology Göttingen, Max Planck Institute for Biophysical Chemistry (MPI-BPC), Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, ANR-11-LABX-0028,SIGNALIFE,Réseau d'Innovation sur les Voies de Signalisation en Sciences de la Vie(2011) |
| المصدر: | ISSN: 0092-8674. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2017 |
| المجموعة: | HAL Université Côte d'Azur |
| مصطلحات موضوعية: | Arx, GABA, Pax4, diabetes, endocrine pancreas, mouse, β cell regeneration, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; The recent discovery that genetically modified α cells can regenerate and convert into β-like cells in vivo holds great promise for diabetes research. However, to eventually translate these findings to human, it is crucial to discover compounds with similar activities. Herein, we report the identification of GABA as an inducer of α-to-β-like cell conversion in vivo. This conversion induces α cell replacement mechanisms through the mobilization of duct-lining precursor cells that adopt an α cell identity prior to being converted into β-like cells, solely upon sustained GABA exposure. Importantly, these neo-generated β-like cells are functional and can repeatedly reverse chemically induced diabetes in vivo. Similarly, the treatment of transplanted human islets with GABA results in a loss of α cells and a concomitant increase in β-like cell counts, suggestive of α-to-β-like cell conversion processes also in humans. This newly discovered GABA-induced α cell-mediated β-like cell neogenesis could therefore represent an unprecedented hope toward improved therapies for diabetes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/27916274; hal-02108550; https://hal.science/hal-02108550Test; PUBMED: 27916274 |
| DOI: | 10.1016/j.cell.2016.11.002 |
| الإتاحة: | https://doi.org/10.1016/j.cell.2016.11.002Test https://hal.science/hal-02108550Test |
| رقم الانضمام: | edsbas.13033BC7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.cell.2016.11.002 |
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