دورية أكاديمية
Glucose-induced inhibition: how many ionic mechanisms?
| العنوان: | Glucose-induced inhibition: how many ionic mechanisms? |
|---|---|
| المؤلفون: | Burdakov, D., Lesage, F. |
| المساهمون: | Department of Pharmacology, University of Cambridge UK (CAM), Institut de pharmacologie moléculaire et cellulaire (IPMC), Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 1748-1708. |
| بيانات النشر: | HAL CCSD Wiley |
| سنة النشر: | 2009 |
| المجموعة: | HAL Université Côte d'Azur |
| مصطلحات موضوعية: | appetite, glucose, hypocretin, hypothalamus, orexin, sleep, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] |
| الوصف: | International audience ; Abstract Sensing of sugar by specialized 'glucose-inhibited' cells helps organisms to counteract swings in their internal energy levels. Evidence from several cell types in both vertebrates and invertebrates suggests that this process involves sugar-induced stimulation of plasma membrane K(+) currents. However, the molecular composition and the mechanism of activation of the underlying channel(s) remain controversial. In mouse hypothalamic neurones and neurosecretory cells of the crab Cancer borealis, glucose stimulates K(+) currents displaying leak-like properties. Yet knockout of some of the candidate 'leak' channel subunits encoded by the KCNK gene family so far failed to abolish glucose inhibition of hypothalamic cells. Moreover, in other tissues, such as the carotid body, glucose-stimulated K(+) channels appear to be not leak-like but voltage-gated, suggesting that glucose-induced inhibition may engage multiple types of K(+) channels. Other mechanisms of glucose-induced inhibition, such as hyperpolarization mediated by opening of Cl(-) channels and depolarization block caused by closure of K(ATP) channels have also been proposed. Here we review known ionic and pharmacological features of glucose-induced inhibition in different cell types, which may help to identify its molecular correlates. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/19473131; hal-00418405; https://hal.science/hal-00418405Test; PUBMED: 19473131; PUBMEDCENTRAL: PMC5767112 |
| DOI: | 10.1111/j.1748-1716.2009.02005.x |
| الإتاحة: | https://doi.org/10.1111/j.1748-1716.2009.02005.xTest https://hal.science/hal-00418405Test |
| رقم الانضمام: | edsbas.DF170DF8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1748-1716.2009.02005.x |
|---|