دورية أكاديمية
Sub-chronic exposure to toluene at 40 ppm alters the monoamine biosynthesis rate in discrete brain areas
| العنوان: | Sub-chronic exposure to toluene at 40 ppm alters the monoamine biosynthesis rate in discrete brain areas |
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| المؤلفون: | Soulage, C., Perrin, D., Berenguer, P., Pequignot, J.M. |
| المساهمون: | Physiologie intégrative, cellulaire et moléculaire (PICM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Neurodégénérescence : modèles et stratégies thérapeutiques, Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 0300-483X ; Toxicology ; https://hal.science/hal-00069352Test ; Toxicology, 2004, 196, pp.21-30. ⟨10.1016/j.tox.2003.10.003⟩. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2004 |
| المجموعة: | HAL Lyon 1 (University Claude Bernard Lyon 1) |
| مصطلحات موضوعية: | Toluene, Low Dose, Tyrosine Hydroxylase, Tryptophane hydroxylase, Brain, Nucleus Tractus Solitarius, Central Nervous System, Dorsal Raphe Nucleus, Long Term Regulation, Stem Cell Groups, Electrochemical Detection, Serotonergic Projections, Tryptophan Hydroxylase, Electrical Stimulation, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT] |
| الوصف: | Effects of long-term exposure to a sub-toxic concentration of toluene (40 ppm, 104 h per week, 16 weeks) have been studied on monoamine biosypthesis rate in rat. The activities of the rate limiting enzymes in catecholamine and 5-hydroxytryptamine biosynthesis tyrosine and tryptophan hydroxylase, respectively, were estimated in vivo by measuring the accumulation of L-dihyqroxypheliylalanine and 5-hydroxytryptophan after pharmacological blockade Of L-aromatic acid decarboxylases by NSD-1015 (100mg kg(-1) ip). The sub-chronic exposure to toluene led to a significant and gender dependent alteration in both catecholamine band 5 hydroxytryptamine biosynthesis rate in brainstem catecholaminergic cell, groups and hypothalamus. In females exposed to toluene, changes in tryptophan hydroxylation were found in rostral subset of A2C2 (+41%) and in A I C 1 (+41%) while a decrease in A5 (-44%) and an increase in A2C2(+28%) were found in tyrosine hydroxylation. In males, an increase in tryptophane hydroxylation was observed in rostral subset of A2C2 (+35%) while a decrease was observed in ventro-median hypothalamus (-17%). These results suggest that toluene exposure to a dose generally recognized as sub-toxic (40 ppm, no observed adverse effect level) leads to adverse effects' on monoaminergic systems. Therefore, the neurotoxicity of toluene should be carefully re-evaluated taking into account not only the exposure level but also the duration. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-00069352; https://hal.science/hal-00069352Test |
| DOI: | 10.1016/j.tox.2003.10.003 |
| الإتاحة: | https://doi.org/10.1016/j.tox.2003.10.003Test https://hal.science/hal-00069352Test |
| رقم الانضمام: | edsbas.44EFA2E1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.tox.2003.10.003 |
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