رسالة جامعية
Functional and metabolic impact of heart rate reduction induced by a selective inhibitor of pacemaker current If, ivabradine : experimental approach in pig and mouse model ; Impact fonctionnel et métabolique d’une réduction de la fréquence cardiaque induite par un inhibiteur du courant If, l’ivabradine : approche expérimentale chez le porc et la souris
| العنوان: | Functional and metabolic impact of heart rate reduction induced by a selective inhibitor of pacemaker current If, ivabradine : experimental approach in pig and mouse model ; Impact fonctionnel et métabolique d’une réduction de la fréquence cardiaque induite par un inhibiteur du courant If, l’ivabradine : approche expérimentale chez le porc et la souris |
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| المؤلفون: | Vaillant, Fanny |
| المساهمون: | Agressions vasculaires et réponses tissulaires, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Claude Bernard - Lyon I, Institut de cardiologie (Montréal, Canada), Quadiri Timour, Christine Des Rosiers |
| المصدر: | https://theses.hal.science/tel-00817208Test ; Médecine humaine et pathologie. Université Claude Bernard - Lyon I; Institut de cardiologie (Montréal, Canada), 2010. Français. ⟨NNT : 2010LYO10225⟩. |
| بيانات النشر: | HAL CCSD |
| سنة النشر: | 2010 |
| المجموعة: | HAL Lyon 1 (University Claude Bernard Lyon 1) |
| مصطلحات موضوعية: | Primary ventricular fibrillation, Acute myocardial ischemia, Heart rate, Ivabradine, Myocardial energetic metabolism, Cardioprotection, Fibrillation ventriculaire primaire, Ischémie myocardique aigue, Fréquence cardiaque, Métabolisme énergétique myocardique, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | Ischemic cardiopathies are a major cause of cardiovascular mortality potentially leading tosudden death by ventricular fibrillation (VF). In patients with coronary disease, onetherapeutic goal is to reduce oxygen requirements via slowing of heart rate (SHR). Severalmedicinal drugs, such as beta-blockers and calcium inhibitors can achieve this goal, but canresult in altered cardiac contractility and various adverse effects, which restricts their use. Wefocused our interest on the effects of a selective inhibitor of the pacemaker current If, namelyivabradine (IVA), which can reduce sinusal heart rate. The aim of the present work was toevaluate the impact of SHR on the propensity to VF and to better understand thephysiological and metabolism mechanisms involved. The first study was performed on a pigmodel of acute myocardial ischemia leading to VF. In the second study, the impact of SHRwas evaluated using a mouse model of isolated perfused working heart. Our resultsdemonstrated that IVA induced SHR in both models and this was associated in vivo withenhanced coronary flow, conservation of mitochondrial structure and myocardial energeticstatus, thus reducing the risk of triggering ischemia-induced VF. Moreover, ex vivo, theobserved SHR did not change the selection of substrates for energy production. From atherapeutic point of view, it is critical to improve the conditions within tissues and to reducethe loss of substrates during myocardial ischemia. IVA apparently met this goal. Indeed, viaspecific effects on sinusal automaticity, it can act both preventively and curatively ; Les cardiopathies ischémiques sont une cause majeure de mortalité cardiovasculaire pouvantaboutir à la mort subite par fibrillation ventriculaire (FV). Un des objectifs thérapeutiqueschez les coronariens est de diminuer la demande en O2 par réduction de la fréquencecardiaque (RFC). Plusieurs médicaments dont les bêta-bloquants et inhibiteurs calciquesrépondent à cet objectif, mais peuvent être responsable d’altération de la ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| اللغة: | French |
| العلاقة: | NNT: 2010LYO10225; tel-00817208; https://theses.hal.science/tel-00817208Test; https://theses.hal.science/tel-00817208/documentTest; https://theses.hal.science/tel-00817208/file/TH2010_Vaillant_-_Fanny.pdfTest |
| الإتاحة: | https://theses.hal.science/tel-00817208Test https://theses.hal.science/tel-00817208/documentTest https://theses.hal.science/tel-00817208/file/TH2010_Vaillant_-_Fanny.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.E3707D29 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |