دورية أكاديمية
A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis
| العنوان: | A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis |
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| المؤلفون: | Ríos-Tamayo, Rafael, Lupiañez, Carmen Belén, Campa, Daniele, Hielscher, Thomas, Weinhold, Niels, Martínez-López, Joaquin, Jerez, Andrés, Landi, Stefano, Jamroziak, Krzysztof, Dumontet, Charles, Wątek, Marzena, Lesueur, Fabienne, Reis, Rui Manuel, Marques, Herlander, Jurczyszyn, Artur, Vogel, Ulla, Buda, Gabriele, García-Sanz, Ramón, Orciuolo, Enrico, Petrini, Mario, Vangsted, Annette J., Gemignani, Federica, Försti, Asta, Goldschmidt, Hartmut, Hemminki, Kari, Canzian, Federico, Jurado, Manuel, Sainz, Juan |
| المساهمون: | University of Pisa - Università di Pisa, German Cancer Research Center - Deutsches Krebsforschungszentrum Heidelberg (DKFZ), Universität Heidelberg Heidelberg = Heidelberg University, Medical University of Łódź (MUL), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard Lyon -Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe, Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut Curie Paris -Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Curie Paris, Université Paris Sciences et Lettres (PSL), Life and Health Sciences Research Institute Braga (ICVS), Universidade do Minho = University of Minho Braga, Rigshospitalet Copenhagen, Copenhagen University Hospital, Department of Internal Medicine V, National Center for Tumor Diseases (NCTD) |
| المصدر: | ISSN: 1949-2553 ; Oncotarget ; https://hal.science/hal-01800024Test ; Oncotarget, 2016, 7 (37), pp.59029-59048. ⟨10.18632/oncotarget.10665⟩. |
| بيانات النشر: | HAL CCSD Impact journals |
| سنة النشر: | 2016 |
| المجموعة: | HAL Lyon 1 (University Claude Bernard Lyon 1) |
| مصطلحات موضوعية: | Medical Oncology, Laboratories, Italy, Patients, Risk, Medicine, Brazil, Environment, epidemiology, France, Genomics, Germany, Multiple Myeloma, Survival, [SDV.CAN]Life Sciences [q-bio]/Cancer |
| الوصف: | International audience ; Diabetogenic single nucleotide polymorphisms (SNPs) have recently been associated with multiple myeloma (MM) risk but their impact on overall survival (OS) of MM patients has not been analysed yet. In order to investigate the impact of 58 GWAS-identified variants for type 2 diabetes (T2D) on OS of patients with MM, we analysed genotyping data of 936 MM patients collected by the International Multiple Myeloma rESEarch (IMMENSE) consortium and an independent set of 700 MM patients recruited by the University Clinic of Heidelberg. A meta-analysis of the cox regression results of the two sets showed that rs7501939 located in the HNF1B gene negatively impacted OS (HRRec= 1.44, 95% CI = 1.18-1.76, P = 0.0001). The meta-analysis also showed a noteworthy gender-specific association of the SLC30A8rs13266634 SNP with OS. The presence of each additional copy of the minor allele at rs13266634 was associated with poor OS in men whereas no association was seen in women (HRMen-Add = 1.32, 95% CI 1.13-1.54, P = 0.0003). In conclusion, these data suggest that the HNF1Brs7501939 SNP confers poor OS in patients with MM and that a SNP in SLC30A8 affect OS in men |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/27437873; hal-01800024; https://hal.science/hal-01800024Test; PUBMED: 27437873; PUBMEDCENTRAL: PMC5312293 |
| DOI: | 10.18632/oncotarget.10665 |
| الإتاحة: | https://doi.org/10.18632/oncotarget.10665Test https://hal.science/hal-01800024Test |
| رقم الانضمام: | edsbas.1A54F73E |
| قاعدة البيانات: | BASE |
| DOI: | 10.18632/oncotarget.10665 |
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